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1. 发明公开

EP3202395A1 SOFT CAPSULE COATING FILM 审中-公开
标题翻译：软胶囊包衣膜
公开(公告)号：EP3202395A1
公开(公告)日：2017-08-09
申请号：EP15847633.3
申请日：2015-10-01
申请人： Fuji Capsule Co., Ltd.
发明人： WATANABE, Kazuhiko , KONDO, Yosuke , SHIMOKAWA, Yoshiyuki , KATO, Kenji
IPC分类号： A61K9/62 , A61K47/36
CPC分类号： C08L3/04 , A23L29/256 , A23P10/30 , A23V2002/00 , A61K8/0204 , A61K8/11 , A61K8/73 , A61K8/732 , A61K9/4816 , A61K47/36 , A61K2800/10 , A61Q19/00 , B01J13/04 , B29D22/00 , B29K2003/00 , B29K2405/00 , C08L3/10 , C08L5/00 , C08L2201/06 , C08L2203/02 , C08L2205/025 , C08L2205/03
摘要： Provided are a plant-derived soft capsule shell having high shell sheet strength, good adhesive property, and good shell performance, and a soft capsule.
A soft capsule shell comprising: (A) iota carrageenan; and (B) waxy corn starch having undergone a heat-moisture treatment in the presence of a salt, the soft capsule shell having a content mass ratio [(A)/(B)] of the component (A) to the component (B) of 0.4 to 3, the soft capsule shell having a content mass ratio [carrageenan/starch] of carrageenan including the component (A) to starch including the component (B) of 0.29 to 1.
摘要翻译：本发明提供壳层强度高，粘附性好，壳性好的植物性软胶囊壳和软胶囊。一种软胶囊壳，包含：（A）ι角叉菜胶; 和（B）在盐存在下进行热湿处理的蜡质玉米淀粉，所述软胶囊壳具有组分（A）与组分（B）的含量质量比[（A）/（B））为0.4〜3的软胶囊壳，其中包含组分（A）的角叉菜胶的含量质量比[角叉菜胶/淀粉]与包含组分（B）的淀粉的含量质量比为0.29:1。

2. 发明公开

EP3023096A1 SOFT CAPSULE COATING 无效
标题翻译： WEICHKAPSELBESCHICHTUNG
公开(公告)号：EP3023096A1
公开(公告)日：2016-05-25
申请号：EP14825991.4
申请日：2014-07-15
申请人： Fuji Capsule Co., Ltd.
发明人： KATO, Kenji , WATANABE, Kazuhiko , INOUE, Takashi , KONDO, Yosuke
IPC分类号： A61K9/48 , A61K8/73 , A61K47/36 , A23L5/00
CPC分类号： A61K9/4816 , A23L29/256 , A23P10/30 , A23V2002/00 , A61K8/02 , A61K8/73 , A61K8/732 , A61K9/4891 , A61K2800/82
摘要： Provided are a plant-derived soft capsule shell having a high shell sheet strength, a good adhesive property, and excellent shell performance, and a soft capsule. The soft capsule shell comprises: (A) iota carrageenan; and (B) a starch dispersion obtained by ultrasonically treating a starch paste solution.
摘要翻译：提供具有高的壳片强度，良好的粘合性能和优异的壳性能的植物来源的软胶囊壳和软胶囊。软胶囊壳包括：（A）ι角叉菜胶; 和（B）通过超声处理淀粉糊溶液获得的淀粉分散体。

3. 发明授权

EP3100721B1 CAPSULE FORMULATION 有权
公开(公告)号：EP3100721B1
公开(公告)日：2020-08-26
申请号：EP15742744.4
申请日：2015-01-22
申请人： Fuji Capsule Co., Ltd.
发明人： NAKANO, Hiroshi , NISHIMURA, Naoki , MASUDA, Koji , SHIMOKAWA, Yoshiyuki , KATO, Kenji
IPC分类号： A61K9/66 , A61K9/48 , A61K47/04 , A61K47/44 , A61K31/714

4. 发明公开

EP3205338A1 METHOD OF PRODUCING ENTERIC SOFT CAPSULE 有权
标题翻译：生产肠溶软胶囊的方法
公开(公告)号：EP3205338A1
公开(公告)日：2017-08-16
申请号：EP15848429.5
申请日：2015-10-06
申请人： Fuji Capsule Co., Ltd.
发明人： WATANABE, Kazuhiko , HASEGAWA, Hiroaki , INABA, Nahonori , SHIMOKAWA, Yoshiyuki , KATO, Kenji
IPC分类号： A61K9/52 , A61K47/10 , A61K47/36 , A61K47/42
CPC分类号： A61K9/4833 , A61K9/4816 , A61K9/4825 , A61K31/202 , A61K47/10 , A61K47/36 , A61K47/42
摘要： An object is to provide a method of manufacturing a soft capsule that is enteric and excellent in formulation properties. An enteric soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxyl pectin having a degree of amidation of 5 to 25%, and (b) encapsulating capsule fills using the enteric capsule shell liquid prepared in the step (a) by stamping. Preferably, the jelly strength of the gelatin is 160 to 300 Bloom, the degree of esterification of the low methoxy pectin is 20 to 40%, and the enteric capsule shell liquid comprises 30 to 35 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin.
摘要翻译：一个目的是提供一种制造肠溶且配方性能优异的软胶囊的方法。通过以下步骤（a）和（b）制备肠溶软胶囊：（a）制备包含酰胺化度为5至25％的明胶和低甲氧基果胶的肠溶胶囊壳体液体，和（b）包封胶囊使用步骤（a）中制备的肠溶胶囊壳液通过冲压填充。优选地，明胶的凝胶强度为160至300Bloom，低甲氧基果胶的酯化度为20至40％，并且肠溶胶囊壳液包含30至35质量份的低甲氧基果胶/ 100份按质量计明胶。

5. 发明公开

EP3100721A1 CAPSULE FORMULATION 有权
标题翻译： KAPSELFORMULIERUNG
公开(公告)号：EP3100721A1
公开(公告)日：2016-12-07
申请号：EP15742744.4
申请日：2015-01-22
申请人： Fuji Capsule Co., Ltd.
发明人： NAKANO, Hiroshi , NISHIMURA, Naoki , MASUDA, Koji , SHIMOKAWA, Yoshiyuki , KATO, Kenji
IPC分类号： A61K9/66 , A61K47/04 , A61K47/44
CPC分类号： A61K9/5089 , A61K9/4833 , A61K9/485 , A61K9/4858 , A61K9/4891 , A61K31/555 , A61K31/714
摘要： Provided is a capsule formulation capable of retaining a hydrophilic substance over a long period of time and also capable of containing incompatible components, in a single capsule.
A capsule formulation is produced by encapsulating with a hydrophilic film, a capsule content formed by enclosing an aqueous solution in an oily substance containing a porous microparticulate powder. The capsule formulation preferably comprises 0.1 to 20 parts by weight of the porous microparticulate powder based on 100 parts by weight of the oily substance, and it is preferably a soft capsule formulation.
摘要翻译：本发明提供能够在一个胶囊中长期保持亲水性物质并能够含有不相容组分的胶囊制剂。通过用亲水膜包封胶囊制剂，通过将水溶液包封在含有多孔微粒粉末的油状物质中形成的胶囊内容物。胶囊制剂优选含有0.1〜20重量份的多孔微粒粉末，基于100重量份的油状物质，优选软胶囊剂。

6. 发明公开

EP3205339A1 METHOD OF PRODUCING ENTERIC-COATED SEAMLESS SOFT CAPSULE 有权
标题翻译：生产肠溶包衣的无胶软胶囊的方法
公开(公告)号：EP3205339A1
公开(公告)日：2017-08-16
申请号：EP15848818.9
申请日：2015-10-06
申请人： Fuji Capsule Co., Ltd.
发明人： MASUDA, Koji , NISHIMURA, Naoki , HAYANO, Akihiko , SHIMOKAWA, Yoshiyuki , KATO, Kenji
IPC分类号： A61K9/52 , A61K47/10 , A61K47/36 , A61K47/42
CPC分类号： A61K9/4833 , A61K9/4825 , A61K9/4866 , A61K31/202 , A61K47/10 , A61K47/36 , A61K47/42
摘要： An object is to provide a method of manufacturing a seamless soft capsule that is enteric and excellent in formulation properties. An enteric seamless soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxy pectin having a degree of esterification of 0 to 40% and a degree of amidation of 0 to 25%, the enteric capsule shell liquid having a viscosity at 50°C of 60 to 127 mPa•s; and (b) encapsulating capsule fills with the enteric capsule shell liquid prepared in the step (a) by dripping. Preferably, the jelly strength of the gelatin is 180 to 330 Bloom, an aqueous solution of the low methoxy pectin at a concentration of 2 mass% has a viscosity at 35°C of 8 to 15 mPa•s, and the enteric capsule shell liquid comprises 10 to 20 parts by mass of the low methoxy pectin per 100 parts by mass of gelatin.
摘要翻译：一个目的是提供一种制造无肠软胶囊的方法，所述无胶软胶囊是肠溶的且具有优异的制剂性质。通过以下步骤（a）和（b）制备肠溶无缝软胶囊：（a）制备包含明胶和低甲氧基果胶的肠溶胶囊壳液，其酯化度为0至40％，酰胺化度为 0至25％，所述肠溶胶囊壳液在50℃下的粘度为60至127mPa·s; 和（b）用步骤（a）中制备的肠溶胶囊壳液滴下胶囊填充物。优选明胶的凝胶强度为180〜330Bloom，浓度2质量％的低甲氧基果胶的水溶液的35℃下的粘度为8〜15mPa·s，肠溶胶囊壳液相对于100质量份明胶，含有10〜20质量份低甲氧基果胶。

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