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1. 发明授权

EP2389242B1 SORPTIONSMITTEL FÜR ENDOTOXINE 有权
标题翻译：脱氯剂内毒素
公开(公告)号：EP2389242B1
公开(公告)日：2015-10-21
申请号：EP10706472.7
申请日：2010-01-20
申请人： Fresenius Medical Care Deutschland GmbH
发明人： FALKENHAGEN, Dieter , WEBER, Viktoria
IPC分类号： A61M1/36 , B01D15/00 , B01D15/08 , B01J20/28 , B01J20/32
CPC分类号： B01J20/3253 , A61M1/3679 , B01D15/00 , B01D15/08 , B01J20/28004 , B01J20/28023 , B01J20/28085 , B01J20/321 , B01J20/3255 , B01J2220/58

2. 发明公开

EP2866929A1 EXTRAKORPORALE PERFUSIONSVORRICHTUNG 有权
公开(公告)号：EP2866929A1
公开(公告)日：2015-05-06
申请号：EP13736512.8
申请日：2013-06-27
申请人： Fresenius Medical Care Deutschland GmbH
发明人： FALKENHAGEN, Dieter , HARTMANN, Jens , HARM, Stephan
IPC分类号： B01J20/28 , B01J20/32 , B01J20/26 , A61K31/745 , A61M1/36
CPC分类号： A61M1/3472 , A61K31/745 , A61K38/12 , A61M1/3486 , A61M1/3679 , A61M2202/0413 , A61M2202/0456 , A61M2202/049 , A61M2205/3303 , A61M2205/75 , B01J20/261 , B01J20/264 , B01J20/28004 , B01J20/28016 , B01J20/28019 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28083 , B01J20/28085 , B01J20/321 , B01J20/3214 , B01J20/3246 , B01J20/3274
摘要： The invention relates to an extracorporeal perfusion apparatus (100, 200, 300, 400, 500, 600, 700) comprising an extracorporeal blood circulation system (102, 202, 302, 402, 502, 602, 702) for conveying blood, a filtrate circulation system (105, 205, 305, 405, 505, 605, 705) for conveying blood plasma, and a controller (110, 210, 310, 410, 510, 610, 710), the filtrate circulation system (105, 205,...705) being connected to the extracorporeal blood circulation system (102, 202,...702) by means of a filter (104, 204, 304, 404, 504, 604, 704), the filter (104, 204...704) having a sieving coefficient of 5% for substances having a molar mass of 340,000 g/mol (relative molecular mass of 340 kDa), and there being arranged in the filtrate circulation system (105, 205,...705) a depletion agent (107, 207, 307, 407, 507, 607, 707) comprising a first carrier (107a, 207a, 307a, 407a, 507a, 607a, 707a) having a neutral, hydrophobic surface, the perfusion apparatus comprising a dispensing means (107, 207, 308, 408, 508, 607, 708) for supplying an endotoxin-binding lipopeptide into the extracorporeal blood circulation system (102, 202,...702), the endotoxin-binding lipopeptide being selected from the group consisting of polymyxins, polymyxin derivatives, prodrugs thereof and a combination thereof.

3. 发明授权

EP2585132B1 NEUARTIGES SORPTIONSMITTEL FÜR ENDOTOXINE 有权
标题翻译：小说改编脱氯剂内毒素
公开(公告)号：EP2585132B1
公开(公告)日：2015-04-22
申请号：EP11736265.7
申请日：2011-06-22
申请人： Fresenius Medical Care Deutschland GmbH
发明人： FALKENHAGEN, Dieter , HARM, Stephan , HARTMANN, Jens , WEBER, Viktoria
IPC分类号： A61M1/34 , A61M1/36 , B01D15/00 , B01J20/26 , B01J20/28 , B01J20/32
CPC分类号： A61M1/36 , A61M1/3472 , A61M1/3486 , B01J20/267 , B01J20/28004 , B01J20/28078 , B01J20/321 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3274 , B01J20/3285

4. 发明公开

EP2838579A1 SICHERHEITSEINRICHTUNG FÜR EINE EXTRAKORPORALE BLUTBEHANDLUNG 有权
标题翻译： SICHERHEITSEINRICHTUNGFÜREINE EXTRAKORPORALE BLUTBEHANDLUNG
公开(公告)号：EP2838579A1
公开(公告)日：2015-02-25
申请号：EP13718152.5
申请日：2013-04-15
申请人： Fresenius Medical Care Deutschland GmbH
发明人： BRANDL, Martin , FALKENHAGEN, Dieter , HARTMANN, Jens
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/1603 , A61M1/16 , A61M1/1609 , A61M1/361 , A61M1/3612 , A61M1/3621 , A61M1/3672 , A61M1/3675 , A61M2205/18 , A61M2205/3324 , A61M2230/202 , A61M2230/208 , B01D61/30 , B01D61/32 , F04C2270/0421
摘要： Blood purification device (100, 200) having an extracorporeal blood stream (102, 202) with a blood inflow (103, 203) to a dialysis unit (105, 205) for blood removed from a patient and a blood outflow (104, 204) from the dialysis unit (105, 205) for blood being guided back into the patient, wherein the dialysis unit (105, 205) comprises an inflow (107, 207) for a dialysis solution and a dialysate outflow (108, 208), characterized by a control loop for closed-loop control of the acid/base equilibrium of the blood, wherein bicarbonate is supplied to the blood by means of an aqueous bicarbonate-containing solution, wherein at least one measuring means (124, 124a, 224, 224a) for measuring a blood buffer parameter is associated with the control loop, wherein the blood buffer parameter is selected from the group consisting of bicarbonate concentration and CO
2 partial pressure, and wherein a signal corresponding to the measured actual value of the blood buffer parameter can be supplied to a closed-loop control apparatus (125, 225), which regulates the actual value of the blood buffer parameter by the supply of the bicarbonate to a predeterminable intended value or intended value range, and at least one pH-measuring means (150a, 250a), which is arranged upstream of the dialysis unit (105, 205) in the extracorporeal blood stream (102, 202), wherein a signal corresponding to the pH-value can be supplied to an alarm apparatus (130, 230), which triggers an alarm signal if a predeterminable pH-value or pH-value range is exceeded or undershot.
摘要翻译：装置（100）具有测量从碳酸氢盐浓度和二氧化碳分压组成的组中选出的测量单元的血液缓冲参数的控制电路（124,124a）。将血液缓冲参数信号的测量值提供给控制装置（125），将血液缓冲参数的实际值调整为预设值范围。 pH测量单元（150a）设置在透析单元（105）的上游，以向报警单元（130）提供pH值信号以触发超过或低于特定pH范围的报警信号。

6. 发明授权

EP2389206B1 SORPTIONSMITTEL ZUM ENTFERNEN PROTEINGEBUNDENER SUBSTANZEN 有权
标题翻译：脱氯剂脱除蛋白偶联物质
公开(公告)号：EP2389206B1
公开(公告)日：2016-07-06
申请号：EP10705777.0
申请日：2010-01-20
申请人： Fresenius Medical Care Deutschland GmbH
发明人： FALKENHAGEN, Dieter , HARTMANN, Jens , WEBER, Viktoria
IPC分类号： A61M1/36
CPC分类号： A61M1/3679 , B01D15/00 , B01D15/08 , B01J20/264 , B01J20/265 , B01J20/28004 , B01J20/28023 , B01J20/28083 , B01J20/28085 , B01J20/285 , B01J20/321 , B01J20/3253 , B01J20/3255 , B01J20/3274 , B01J2220/58

7. 发明授权

EP2838579B1 SICHERHEITSEINRICHTUNG FÜR EINE EXTRAKORPORALE BLUTBEHANDLUNG 有权
标题翻译：安全装置一个体外血液处理
公开(公告)号：EP2838579B1
公开(公告)日：2016-03-02
申请号：EP13718152.5
申请日：2013-04-15
申请人： Fresenius Medical Care Deutschland GmbH
发明人： BRANDL, Martin , FALKENHAGEN, Dieter , HARTMANN, Jens
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/1603 , A61M1/16 , A61M1/1609 , A61M1/361 , A61M1/3612 , A61M1/3621 , A61M1/3672 , A61M1/3675 , A61M2205/18 , A61M2205/3324 , A61M2230/202 , A61M2230/208 , B01D61/30 , B01D61/32 , F04C2270/0421

8. 发明公开

EP2585132A1 NEUARTIGES SORPTIONSMITTEL FÜR ENDOTOXINE 有权
标题翻译：小说改编脱氯剂内毒素
公开(公告)号：EP2585132A1
公开(公告)日：2013-05-01
申请号：EP11736265.7
申请日：2011-06-22
申请人： Fresenius Medical Care Deutschland GmbH
发明人： FALKENHAGEN, Dieter , HARM, Stephan , HARTMANN, Jens , WEBER, Viktoria
IPC分类号： A61M1/36 , B01D15/00 , B01J20/26 , B01J20/32
CPC分类号： A61M1/36 , A61M1/3472 , A61M1/3486 , B01J20/267 , B01J20/28004 , B01J20/28078 , B01J20/321 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3274 , B01J20/3285
摘要： The invention relates to a sorbent for removing endotoxins from a biological liquid, comprising a water-insoluble, porous substrate having a neutral, hydrophobic surface, wherein the surface of the substrate has an adsorbent coating made of polymyxin and albumin, wherein polymyxin and albumin are bonded to the surface of the substrate in a noncovalent manner. The invention further relates to a method for producing such a sorbent. The sorbent is used in extracorporeal blood purification, in particular in order to treat individuals who have sepsis.

9. 发明公开

EP2389242A2 SORPTIONSMITTEL FÜR ENDOTOXINE 有权
标题翻译：脱氯剂内毒素
公开(公告)号：EP2389242A2
公开(公告)日：2011-11-30
申请号：EP10706472.7
申请日：2010-01-20
申请人： Fresenius Medical Care Deutschland GmbH
发明人： FALKENHAGEN, Dieter , WEBER, Viktoria
IPC分类号： B01J20/32 , B01D15/00 , A61M1/36 , B01J20/26
CPC分类号： B01J20/3253 , A61M1/3679 , B01D15/00 , B01D15/08 , B01J20/28004 , B01J20/28023 , B01J20/28085 , B01J20/321 , B01J20/3255 , B01J2220/58
摘要： The invention relates to a sorbent for removing endotoxins from a biological liquid, the sorbent comprising a water-insoluble, porous support and polymyxin which is immobilized on the support, said support having a neutral, hydrophobic surface and the polymyxin being immobilized on the surface of the support via hydrophobic interaction. The sorbent is especially used in extracorporeal blood purification, especially for the treatment of individuals suffering from a sepsis.

10. 发明公开

EP2389206A1 SORPTIONSMITTEL ZUM ENTFERNEN PROTEINGEBUNDENER SUBSTANZEN 有权
标题翻译：脱氯剂脱除蛋白偶联物质
公开(公告)号：EP2389206A1
公开(公告)日：2011-11-30
申请号：EP10705777.0
申请日：2010-01-20
申请人： Fresenius Medical Care Deutschland GmbH
发明人： FALKENHAGEN, Dieter , HARTMANN, Jens , WEBER, Viktoria
IPC分类号： A61M1/36
CPC分类号： A61M1/3679 , B01D15/00 , B01D15/08 , B01J20/264 , B01J20/265 , B01J20/28004 , B01J20/28023 , B01J20/28083 , B01J20/28085 , B01J20/285 , B01J20/321 , B01J20/3253 , B01J20/3255 , B01J20/3274 , B01J2220/58
摘要： The invention relates to a sorbent having improved selective properties for removing protein-bound substances from a biological liquid, especially blood or blood plasma of patients suffering from severe disorders of the liver function or liver failure or renal insufficiency, the sorbent comprising: (a) a porous, neutral, hydrophobic polymer and (b) a polypeptide layer which is adsorbed to the polymer, the neutral, hydrophobic polymer having an average pore size of at least 15 nm. The invention further relates to methods and uses in conjunction with such a sorbent. The invention is especially used in the extracorporeal liver support.

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