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1. 发明授权

EP3146041B1 LILRB2 AND NOTCH-MEDIATED EXPANSION OF HEMATOPOIETIC PRECURSOR CELLS 有权
公开(公告)号：EP3146041B1
公开(公告)日：2019-03-27
申请号：EP15727783.1
申请日：2015-05-21
申请人： Fred Hutchinson Cancer Research Center , Board of Regents of the University of Texas System
发明人： BERNSTEIN, Irwin, D. , ZHANG, Chengcheng , DENG, Mi , ZHENG, Junke , LU, Zhigang
IPC分类号： G01N33/569 , C12N5/0789

2. 发明公开

EP3146041A1 LILRB2 AND NOTCH-MEDIATED EXPANSION OF HEMATOPOIETIC PRECURSOR CELLS 审中-公开
标题翻译： LILRB2-发动机 - VERMITTELTE扩展VONHÄMATOPOETISCHENVORLÄUFERZELLEN
公开(公告)号：EP3146041A1
公开(公告)日：2017-03-29
申请号：EP15727783.1
申请日：2015-05-21
申请人： Fred Hutchinson Cancer Research Center , Board of Regents of the University of Texas System
发明人： BERNSTEIN, Irwin, D. , ZHANG, Chengcheng , DENG, Mi , ZHENG, Junke , LU, Zhigang
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , C12N2500/90 , C12N2501/113 , C12N2501/125 , C12N2501/145 , C12N2501/17 , C12N2501/2303 , C12N2501/2306 , C12N2501/26 , C12N2501/42 , C12N2501/599 , C12N2501/91 , G01N33/56966
摘要： The current disclosure describes methods of expanding precursor cells for hematopoietic transplantation in subjects. The methods culture precursor cells in media containing an immobilized high molecular weight LILRB2 agonist or an LILRB2 agonist in combination with a Notch agonist. The expanded cells can be used to treat a variety of hematopoietic disorders.
摘要翻译：目前的公开内容描述了在受试者中扩大前体细胞用于造血移植的方法。在含有固定化高分子量LILRB2激动剂或LILRB2激动剂与Notch激动剂组合的培养基中培养前体细胞的方法。扩大的细胞可用于治疗各种造血障碍。

3. 发明公开

EP2788476A1 COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS 审中-公开
标题翻译：组合物和方法的造血干/祖细胞的增加的生产
公开(公告)号：EP2788476A1
公开(公告)日：2014-10-15
申请号：EP12806795.6
申请日：2012-12-07
申请人： Fred Hutchinson Cancer Research Center , Novartis Institute For Functional Genomics, Inc. d/b/a The Genomics Institute of the Novartis Research Foundation (GNF)
发明人： BERNSTEIN, Irwin, D. , BOITANO, Anthony, E. , COOKE, Michael
IPC分类号： C12N5/0789 , A61K35/12
CPC分类号： C12N5/0647 , A61K35/28 , A61K2035/124 , C12N2501/125 , C12N2501/145 , C12N2501/2303 , C12N2501/2306 , C12N2501/26 , C12N2501/38 , C12N2501/42 , C12N2501/60 , C12N2501/999
摘要： The present invention relates to methods, kits and compositions for expansion of hematopoietic stem/progenitor cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. Also provided herein are methods for expanding the hematopoietic stem/progenitor cells using kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. The hematopoietic stem/progenitor cells expanded using the disclosed kits, compositions and methods include human umbilical cord blood stem/progenitor cells, placental cord blood stem/progenitor cells and peripheral blood stem cells. The present invention also relates to administering hematopoietic stem/progenitor cells expanded using a combination of a Notch agonist and an aryl hydrocarbon receptor antagonist to a patient for short-term and/or long-term in vivo repopulation benefits.
摘要翻译：本发明涉及一种方法，试剂盒和组合物的造血干/祖细胞和造血功能提供对人类患者需要其的膨胀。在一个方面，它涉及试剂盒和组合物，包含一陷波激动剂芳香烃受体拮抗剂和。所以提供了用于使用试剂盒扩大的造血干/祖细胞和组合物，其包括的Notch激动剂芳香烃受体拮抗剂和方法。使用盘扩大了的造血干/祖细胞的试剂盒游离缺失，组合物和方法包括人脐血干/祖细胞，胎盘脐带血干细胞/祖细胞和外周血干细胞。因此，本发明涉及管理使用的Notch激动剂和芳香烃受体拮抗剂的组合，以在体内再增殖好处短期和/或长期的患者扩增的造血干/祖细胞。

4. 发明授权

EP2788476B1 COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS 有权
公开(公告)号：EP2788476B1
公开(公告)日：2019-05-22
申请号：EP12806795.6
申请日：2012-12-07
申请人： Fred Hutchinson Cancer Research Center , Novartis AG
发明人： BERNSTEIN, Irwin, D. , BOITANO, Anthony, E. , COOKE, Michael , DELANEY, Colleen
IPC分类号： C12N5/0789 , A61K35/12

5. 发明公开

EP3844266A1 METHODS AND COMPOSITIONS FOR ADOPTIVE T CELL THERAPY INCORPORATING INDUCED NOTCH SIGNALING 无效转让
公开(公告)号：EP3844266A1
公开(公告)日：2021-07-07
申请号：EP19769614.9
申请日：2019-08-28
申请人： Fred Hutchinson Cancer Research Center
发明人： RIDDELL, Stanley, R. , BERNSTEIN, Irwin, D. , PONT, Margot, J.
IPC分类号： C12N5/0783

6. 发明授权

EP3097917B1 COMPOSITIONS AND METHODS FOR PROVIDING HEMATOPOIETIC FUNCTION WITHOUT HLA MATCHING 有权
公开(公告)号：EP3097917B1
公开(公告)日：2019-08-14
申请号：EP16166225.9
申请日：2011-04-11
申请人： Fred Hutchinson Cancer Research Center
发明人： BERNSTEIN, Irwin, D. , DELANEY, Colleen
IPC分类号： A61K35/50 , A61K35/51 , C12N5/0789 , A61P7/00 , A61P35/02

7. 发明公开

EP3152301A1 EXPANSION AND ENGRAFTMENT OF STEM CELLS USING NOTCH 1 AND/OR NOTCH 2 AGONISTS 有权转让
标题翻译：扩大转基因维生素MIT NOTCH-1- UND / ODER NOTCH-2-AGONISTEN
公开(公告)号：EP3152301A1
公开(公告)日：2017-04-12
申请号：EP15729698.9
申请日：2015-06-03
申请人： Fred Hutchinson Cancer Research Center
发明人： BERNSTEIN, Irwin, D.
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , C12N2501/42
摘要： The present disclosure provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, the methods comprising culturing the precursor cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist (and, in particular embodiments, one or more growth factors) that support the proliferation but not differentiation of the non-terminally differentiated cells. The present disclosure further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the disclosure can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs. The disclosure further provides a cell culture comprising a population of non-terminally differentiated cells immortalized by the methods of the present disclosure and kits comprising reagents that promote the immortalization of precursor cells.
摘要翻译：本公开提供了用于永生化非终末分化细胞例如干细胞的前体细胞的方法，所述方法包括在Notch1激动剂Notch2激动剂或Notch1激动剂和Notch2激动剂存在下培养前体细胞（和，在具体实施方案中，一种或多种生长因子），其支持非终末分化细胞的增殖但不分化。本公开进一步提供了诱导永生化细胞分化的方法，包括在Notch1激动剂Notch2激动剂或Notch1激动剂和Notch2激动剂存在下培养细胞，以及至少一种支持分化的生长因子细胞变成更特殊的细胞类型。本公开的永生化和/或分化的细胞可以用于重建已经减少的细胞群体，例如作为感染或暴露于某些药物的结果。本公开进一步提供了包含通过本公开的方法永生化的非终末分化细胞群的细胞培养物和包含促进前体细胞永生化的试剂的试剂盒。

8. 发明公开

EP2943566A1 COMPOSITIONS AND METHODS FOR EXPANSION OF EMBRYONIC HEMATOPOIETIC STEM CELLS 审中-公开
标题翻译：组合物和方法进行扩展胚胎干细胞对造血
公开(公告)号：EP2943566A1
公开(公告)日：2015-11-18
申请号：EP14702339.4
申请日：2014-01-07
申请人： Fred Hutchinson Cancer Research Center
发明人： BERNSTEIN, Irwin, D. , HADLAND, Brandon, K.
IPC分类号： C12N5/0789 , A61K35/28
CPC分类号： A61K35/28 , A61K2035/124 , C07K14/475 , C07K14/52 , C07K14/54 , C07K14/5403 , C07K14/5412 , C07K14/5431 , C12N5/0606 , C12N5/0647 , C12N2501/10 , C12N2501/125 , C12N2501/145 , C12N2501/15 , C12N2501/2301 , C12N2501/2303 , C12N2501/2306 , C12N2501/2311 , C12N2501/26 , C12N2501/42 , C12N2533/52
摘要： The present invention relates to methods, kits and compositions for expansion of embryonic hematopoietic stem cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist, one or more growth factors, and, optionally, an inhibitor of the TGFp pathway. Also provided herein are methods for expanding embryonic hematopoietic stem cells using kits and compositions comprising a Notch agonist, one or more growth factors, and, optionally, an inhibitor of the TOP&bgr; pathway. The embryonic hematopoietic stem cells expanded using the disclosed kits, compositions and methods include cells derived from an embryo (e.g., aorta-gonad-mesonephros region of the embryo), embryonic stem cells, induced pluripotent stem cells, or reprogrammed cells of other types. The present invention also relates to administering the embryonic hematopoietic stem cells expanded using a combination of a Notch agonist, one or more growth factors, and, optionally, an inhibitor of the TGFp pathway to a patient for short-term and/or long-term in vivo repopulation benefits.

9. 发明公开

EP3097917A1 COMPOSITIONS AND METHODS FOR PROVIDING HEMATOPOIETIC FUNCTION WITHOUT HLA MATCHING 有权
标题翻译：组合物和一种用于提供造血功能，无需HLA-合规
公开(公告)号：EP3097917A1
公开(公告)日：2016-11-30
申请号：EP16166225.9
申请日：2011-04-11
申请人： Fred Hutchinson Cancer Research Center
发明人： BERNSTEIN, Irwin, D. , DELANEY, Colleen
IPC分类号： A61K35/14 , A61K35/44 , A61K35/50 , C07K16/28 , C12N5/0797 , A61P7/00 , A61P35/02
CPC分类号： A61K35/51 , A61K35/50 , C12N5/0647 , C12N2501/125 , C12N2501/145 , C12N2501/2303 , C12N2501/26 , C12N2501/42 , G06F19/34 , Y02A90/22
摘要： The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem/progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
摘要翻译：本发明涉及一种用于在免疫缺陷的人患者提供的造血功能，通过选择经扩增人类脐带血干/祖细胞样品的方法和组合物没有考虑到的扩增人类脐带血干细胞/祖样品或的HLA类型 HLA类型的患者的; 和管理所选扩增人类脐带血干细胞/祖细胞样品的患者。用于获得扩增人类脐带血干细胞/祖细胞样品的方法，冷冻库扩增人类脐带血干细胞/祖细胞的样品，和用于生产银行检查方法中因此提供。

10. 发明公开

EP2555782A1 COMPOSITIONS AND METHODS FOR PROVIDING HEMATOPOIETIC FUNCTION WITHOUT HLA MATCHING 审中-公开
标题翻译：组合物和一种用于提供造血功能，无需HLA-合规
公开(公告)号：EP2555782A1
公开(公告)日：2013-02-13
申请号：EP11717379.9
申请日：2011-04-11
申请人： Fred Hutchinson Cancer Research Center
发明人： BERNSTEIN, Irwin, D. , DELANEY, Colleen
IPC分类号： A61K35/14 , A61K35/44 , A61K35/50 , C07K16/28 , C12N5/0797 , A61P7/00 , A61P35/02
CPC分类号： A61K35/51 , A61K35/50 , C12N5/0647 , C12N2501/125 , C12N2501/145 , C12N2501/2303 , C12N2501/26 , C12N2501/42 , G06F19/34 , Y02A90/22
摘要： The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem/progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.

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