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1. 发明公开

EP2689010A1 METHOD AND COMPOSITIONS FOR CELLULAR IMMUNOTHERAPY 有权转让
标题翻译： VERFAHREN UND ZUSAMMENSETZUNGENFÜREINE ZELL-IMMUNTHERAPIE
公开(公告)号：EP2689010A1
公开(公告)日：2014-01-29
申请号：EP12725893.7
申请日：2012-03-23
申请人： Fred Hutchinson Cancer Research Center
发明人： RIDDELL, Stanley, R. , HUDECEK, Michael
IPC分类号： C12N5/0783 , C07K16/28 , C07K16/30 , C07K14/705 , A61P35/00
摘要： The present invention provides methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring genetically modified tumor specific CD8+ T cells in the presence of tumor-specific, subset specific genetically modified CD4+ T cells, wherein the CD4+ T cells confer and/or augment a CD8+ T cells ability to sustain anti-tumor reactivity and increase and/or maximize tumor-specific proliferation of the tumor-specific CD8+ T cells of interest. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.
摘要翻译：本发明提供了赋予和/或增加由细胞免疫治疗介导的免疫应答的方法和组合物，例如通过在肿瘤特异性亚型特异性遗传修饰的CD4 + T细胞的存在下过度转移遗传修饰的肿瘤特异性CD8 + T细胞，其中 CD4 + T细胞赋予和/或增强CD8 + T细胞维持抗肿瘤反应性的能力，并且增加和/或最大化所关注的肿瘤特异性CD8 + T细胞的肿瘤特异性增殖。还描述了通过该方法制备的药物制剂及其使用方法。

2. 发明授权

EP2689010B1 METHOD AND COMPOSITIONS FOR CELLULAR IMMUNOTHERAPY 有权转让
公开(公告)号：EP2689010B1
公开(公告)日：2020-11-18
申请号：EP12725893.7
申请日：2012-03-23
申请人： Fred Hutchinson Cancer Research Center
发明人： RIDDELL, Stanley, R. , HUDECEK, Michael
IPC分类号： C12N5/0783 , C07K16/28 , C07K16/30 , C07K14/705 , A61P35/00 , C07K14/725 , A61K39/00 , A61P1/16 , A61P31/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/00 , A61P35/02 , A61P37/04 , A61P43/00

3. 发明授权

EP2884999B1 METHOD AND COMPOSITIONS FOR CELLULAR IMMUNOTHERAPY 有权转让
公开(公告)号：EP2884999B1
公开(公告)日：2020-11-04
申请号：EP13753495.4
申请日：2013-08-20
申请人： Fred Hutchinson Cancer Research Center , Seattle Children's Hospital, dba Seattle Children's Research Institute
发明人： RIDDELL, Stanley, R. , HUDECEK, Michael , JENSEN, Michael
IPC分类号： C07K14/725 , C07K16/28 , C07K16/32 , C07K14/715 , C07K14/705

4. 发明公开

EP2884999A1 METHOD AND COMPOSITIONS FOR CELLULAR IMMUNOTHERAPY 有权转让
标题翻译： VERFAHREN UND ZUSAMMENSETZUNGENFÜREINE ZELL-IMMUNTHERAPIE
公开(公告)号：EP2884999A1
公开(公告)日：2015-06-24
申请号：EP13753495.4
申请日：2013-08-20
申请人： Fred Hutchinson Cancer Research Center , Seattle Children's Hospital, dba Seattle Children's Research Institute
发明人： RIDDELL, Stanley, R. , HUDECEK, Michael , JENSEN, Michael
IPC分类号： A61K39/395 , C07K14/705 , C12N5/10 , C12N15/62
摘要： The present invention provides nucleic acids, vectors, host cells, methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring CD8+ central memory T cells or combinations of central memory T cells with CD4+ T cells that are genetically modified to express a chimeric receptor. In embodiments the genetically modified host cell comprises a nucleic acid comprising a polynucleotide coding for a ligand binding domain, a polynucleotide comprising a customized spacer region, a polynucleotide comprising a transmembrane domain, and a polynucleotide comprising an intracellular signaling domain. It has been surprisingly found that the length of the spacer region can affects the ability of chimeric receptor modified T cells to recognize target cells in vitro and affects in vivo efficacy of the chimeric receptor modified T cells. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.
摘要翻译：本发明提供核酸，载体，宿主细胞，赋予和/或增加由细胞免疫治疗介导的免疫应答的方法和组合物，例如通过过继转移CD8 +中央记忆T细胞或中央记忆T细胞与CD4 + T细胞的组合，被遗传修饰以表达嵌合受体。在实施方案中，遗传修饰的宿主细胞包含核酸，其包含编码配体结合结构域的多核苷酸，包含定制的间隔区的多核苷酸，包含跨膜结构域的多核苷酸和包含细胞内信号结构域的多核苷酸。已经令人惊奇地发现，间隔区的长度可以影响嵌合受体修饰的T细胞在体外识别靶细胞的能力并影响嵌合受体修饰的T细胞的体内功效。还描述了通过该方法制备的药物制剂及其使用方法。

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