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1. 发明授权

EP2106678B1 ION ACCELERATION SYSTEM FOR MEDICAL AND/OR OTHER APPLICATIONS 有权转让
标题翻译： ION加速系统用于医疗和/或其他应用程序
公开(公告)号：EP2106678B1
公开(公告)日：2010-05-19
申请号：EP06842809.3
申请日：2006-12-28
申请人： Fondazione per Adroterapia Oncologica - Tera
发明人： AMALDI, Ugo , BRACCINI, Saverio , MAGRIN, Giulio , PEARCE, Peter , ZENNARO, Riccardo
IPC分类号： H05H7/22 , H05H9/00 , A61N5/01
CPC分类号： H05H9/00 , A61N5/10 , A61N5/1081 , A61N2005/1087 , G21K5/04 , G21K5/10 , H05H7/22

2. 发明公开

EP2106678A1 ION ACCELERATION SYSTEM FOR MEDICAL AND/OR OTHER APPLICATIONS 有权转让
标题翻译： ION加速系统用于医疗和/或其他应用程序
公开(公告)号：EP2106678A1
公开(公告)日：2009-10-07
申请号：EP06842809.3
申请日：2006-12-28
申请人： Fondazione per Adroterapia Oncologica - Tera
发明人： AMALDI, Ugo , BRACCINI, Saverio , MAGRIN, Giulio , PEARCE, Peter , ZENNARO, Riccardo
IPC分类号： H05H7/22 , H05H9/00 , A61N5/01
CPC分类号： H05H9/00 , A61N5/10 , A61N5/1081 , A61N2005/1087 , G21K5/04 , G21K5/10 , H05H7/22
摘要： The ion acceleration system or complex (T) for medical and/or other applications is composed in essence by an ion source (1), a pre-accelerator (3) and one or more linear accelerators or linacs (6, 8, 10, 13), at least one of which is mounted on a rotating mechanical gantry-like structure (17). Said isocentrical gantry (17) is equipped with a beam delivery system, which can be either 'active' or 'passive', for medical and/or other applications. The ion source (1) and the pre-accelerator (3) can be either installed on the floor, which is connected with the gantry basement, or mounted, fully or partially, on the rotating mechanical structure (17). The output beam can vary in energy and intensity pulse-by-pulse by adjusting the radio-frequency field in the accelerating modules of the linac(s) and the beam parameters at the input of the linear accelerators.

3. 发明公开

EP1989929A1 PROTON ACCELERATOR COMPLEX FOR RADIO-ISOTOPES AND THERAPY 审中-公开
标题翻译：质子加速器复杂，放射性同位素和治疗
公开(公告)号：EP1989929A1
公开(公告)日：2008-11-12
申请号：EP06753944.5
申请日：2006-05-29
申请人： Fondazione per Adroterapia Oncologica - Tera
发明人： AMALDI, Ugo
IPC分类号： H05H9/04 , H05H13/00
CPC分类号： H05H6/00 , A61N2005/1087
摘要： A complex of proton accelerators, particularly devoted to medical applications, is disclosed comprising the following functionally interconnected components: a proton source, a cyclotron, at least one target, located either internally or externally to said cyclotron, a medium energy beam transport magnetic channel (MEBT), a radiofrequency linear accelerator (linac), a high energy beam transport channel (HEBT) towards an area dedicated to the irradiation of tumours with proton beams, as well as a modular system for supplying radio frequency (RF) power capable of feeding, independently two or more accelerating modules of said linac. An integrated computerized system controls said complex of accelerators so to carry out, either in alternation or simultaneously, both the production of radioisotopes - for medical, industrial and therapeutical purposes - and the therapeutical irradiation of, even deep seated tumours. Said complex of accelerators produces proton beams which, applying the recently developped 'spot scanning' technique, are more suited for the tumour irradiation than the ones produced by cyclotrons and synchrotrons. Moreover the proposed complex of accelerators requires a reduced energy consumption and, given its dual nature and presents a remarkable compactness that eases its installation in hospital and in research facilities dedicated to tumour diagnostics, brachitherapy and teletherapy.

4. 发明公开

EP3810267A1 BEAM TRANSPORT LINE FOR RADIOTHERAPY SYSTEMS AND RADIOTHERAPY SYSTEM THEREOF 有权转让
公开(公告)号：EP3810267A1
公开(公告)日：2021-04-28
申请号：EP19744855.8
申请日：2019-06-19
申请人： Fondazione per Adroterapia Oncologica - Tera
发明人： AMALDI, Ugo
IPC分类号： A61N5/10 , H05H13/00 , H05H13/04 , H05H9/00 , H05H7/04 , H05H13/02

5. 发明公开

EP3036978A1 USE OF LINEAR ION ACCELERATORS FOR THE TREATMENT OF ATRIAL FIBRILLATION AND ION ACCELERATOR SYSTEM THERE FOR 无效转让
标题翻译：的线性离子加速器心房颤动和离子加速器系统及其治疗中的应用
公开(公告)号：EP3036978A1
公开(公告)日：2016-06-29
申请号：EP14780553.5
申请日：2014-08-13
申请人： Fondazione per Adroterapia Oncologica - Tera
发明人： AMALDI, Ugo
IPC分类号： H05H7/22 , H05H9/04
CPC分类号： A61N5/1064 , A61N5/1067 , A61N2005/1087 , H05H7/22 , H05H9/041 , H05H2277/11
摘要： The application of a system (12) is proposed for the acceleration of ions to treat Atrial Fibrillation (AF), arteriovenous malformations (AVMS) and focal epileptic lesions; this system (12) is composed of a pulsed ion source (1), a pre-accelerator (3) and one or more linear accelerators or linacs (5, 6, 7) operating at frequencies above 1 GHz with a repetition rate between 1 Hz and 500 Hz. The particle beam coming out of the complex (12) can vary in intensity (i), (acting on the ion source (1) ), (ii) in deposition depth (by independently adjusting the radiofrequency of the power sources that feed the linac accelerators units) and (iii) transversally with respect to the central beam direction (by varying the current in the coils of two orthogonal scanning magnets placed upstream of the patient). The possibility of adjusting in a few milliseconds and in three orthogonal directions, the location of each energy deposition in the body of the patient makes that system of accelerators (12) perfectly suited to irradiation of a beating heart.

6. 发明授权

EP1847160B1 ION ACCELERATION SYSTEM FOR HADRONTHERAPY 有权转让
标题翻译： ION加速系统的治疗HADRON
公开(公告)号：EP1847160B1
公开(公告)日：2014-02-19
申请号：EP05809917.7
申请日：2005-10-28
申请人： Fondazione per Adroterapia Oncologica - Tera
发明人： AMALDI, Ugo , CRESCENTI, Massimo , ZENNARO, Riccardo
IPC分类号： H05H9/04 , H05H13/00
CPC分类号： H05H13/00 , G21K5/04 , H05H9/04

7. 发明授权

EP1584221B1 LINAC FOR ION BEAM ACCELERATION 有权
标题翻译：直线加速器离子束加速
公开(公告)号：EP1584221B1
公开(公告)日：2012-08-08
申请号：EP03812572.0
申请日：2003-06-13
申请人： Fondazione per Adroterapia Oncologica - Tera
发明人： AMALDI, Ugo , CRESCENTI, Massimo , ZENNARO, Riccardo
IPC分类号： H05H9/04 , H05H7/22
CPC分类号： H05H9/00 , H05H7/22
摘要： A drift tube (15) linear accelerator (linac) (4) that can be used for the acceleration of low energy ion beams is disclosed. The particles enter the linac (4) at low energy and are accelerated and focused along a straight line in a plurality of resonant accelerating structures (8) interposed by coupling structures (9) up to the desired energy, for instance for therapeutic needs. In the accelerating structures (8), excited by an H-type resonant electromagnetic field, a plurality of accelerating gaps (20) is provided between said drift tubes (15), said drift tubes being supported by stems, for instance alternatively horizontally (16) and vertically (17) disposed. A basic module (7) is disclosed, composed of two accelerating structures (8) and an interposed coupling structure (9), or if necessary a modified coupling structure (9A) connected to a RF power generator (11), being linked if necessary to a vacuum system (13 ) and equipped if necessary with one or more quadrupoles (18). Said basic module (7) can be expanded to get modules (7A) that present an odd number n of coupling structures (9, 9A) which still if necessary are equipped with one or more quadrupoles (18), and an even number N = n + 1 of accelerating structures (8). The proposed linac (4) contains one or more modules (7, 7A) and allows obtaining a large accelerating gradient and a very compact structure.

8. 发明公开

EP1847160A1 ION ACCELERATION SYSTEM FOR HADRONTHERAPY 有权转让
标题翻译： ION加速系统的治疗HADRON
公开(公告)号：EP1847160A1
公开(公告)日：2007-10-24
申请号：EP05809917.7
申请日：2005-10-28
申请人： Fondazione per Adroterapia Oncologica - Tera
发明人： AMALDI, Ugo , CRESCENTI, Massimo , ZENNARO, Riccardo
IPC分类号： H05H9/04 , H05H13/00
CPC分类号： H05H13/00 , G21K5/04 , H05H9/04
摘要： System for ion acceleration for medical purposes comprising a conventional or superconducting cyclotron, a radiofrequency linear accelerator (Linac), a Medium Energy Beam Transport line (MEBT) connected, at the low energy side, to the exit of the cyclotron, and at the other side, to the entrance of the linear radiofrequency accelerator, as well as a High Energy Beam Transport line (HEBT) connected at high energy side to the radiofrequency linear accelerator exit and at the other end, to a system for the dose distribution to the patient. The high frequency of operation of the Linac allows for a reduced consumption and a remarkable compactness facilitating its installation in hospital structures. The use of a modular LINAC allows varying in active way the energy and the current of the therapeutic beam, having a small emittance and a time structure adapted to the dose distribution based on the technique known as the 'spot scanning'.

9. 发明公开

EP1584221A1 LINAC FOR ION BEAM ACCELERATION 有权
标题翻译：直线加速器离子束加速
公开(公告)号：EP1584221A1
公开(公告)日：2005-10-12
申请号：EP03812572.0
申请日：2003-06-13
申请人： Fondazione per Adroterapia Oncologica - Tera
发明人： AMALDI, Ugo , CRESCENTI, Massimo , ZENNARO, Riccardo
IPC分类号： H05H9/04 , H05H7/22
CPC分类号： H05H9/00 , H05H7/22
摘要： A drift tube (15) linear accelerator (linac) (4) that can be used for the acceleration of low energy ion beams is disclosed. The particles enter the linac (4) at low energy and are accelerated and focused along a straight line in a plurality of resonant accelerating structures (8) interposed by coupling structures (9) up to the desired energy, for instance for therapeutic needs. In the accelerating structures (8), excited by an H-type resonant electromagnetic field, a plurality of accelerating gaps (20) is provided between said drift tubes (15), said drift tubes being supported by stems, for instance alternatively horizontally (16) and vertically (17) disposed. A basic module (7) is disclosed, composed of two accelerating structures (8) and an interposed coupling structure (9), or if necessary a modified coupling structure (9A) connected to a RF power generator (11), being linked if necessary to a vacuum system (13 ) and equipped if necessary with one or more quadrupoles (18). Said basic module (7) can be expanded to get modules (7A) that present an odd number n of coupling structures (9, 9A) which still if necessary are equipped with one or more quadrupoles (18), and an even number N = n + 1 of accelerating structures (8). The proposed linac (4) contains one or more modules (7, 7A) and allows obtaining a large accelerating gradient and a very compact structure.

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