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1. 发明公开

EP0133766A2 Coumarin derivatives, pharmaceutical compositions containing the same, and the use thereof in the treatment of cancer 失效
标题翻译：香豆素衍生物，含有它们的以及它们在癌症的治疗中使用的药物组合物。
公开(公告)号：EP0133766A2
公开(公告)日：1985-03-06
申请号：EP84304976.8
申请日：1984-07-20
申请人： FIDIA S.p.A.
发明人： della Valle, Francesco , Romeo, Aurelio
IPC分类号： C07D311/16 , A61K31/37 , C07D405/06
CPC分类号： C07D311/16
摘要： A compound having the formula:
wherein R 1 is naiogen or a substituted or unsubstituted hydrocarbon group; R 2 , R 6 and R 7 , which may be the same or different, each represents hydrogen or a substituted or unsubstituted hydrocarbon group, or R 6 and R 7 take together may represent a hetero group having one or more hetero atoms; R 3 and R 4 which may be the same or different each represents a substituted or unsubstituted hydrocarbon group; or R 3 and R 4 taken together may represent an alkylene group or a hetero group having one or more hetero atoms and R s is hydrogen, a substituted or unsubstituted hydrocarbon group, halogen or a free or protected hydroxy group, or a pharmaceutically acceptable salt thereof. The compounds have antiaggregating properties and some of them also have antitumor and antimetastatic activity.

2. 发明公开

EP0327769A3 Novel neuronotrophic factor 失效
标题翻译：新型神经营养因子
公开(公告)号：EP0327769A3
公开(公告)日：1989-10-18
申请号：EP88400365.8
申请日：1988-02-17
申请人： FIDIA S.p.A.
发明人： della Valle, Francesco
IPC分类号： C07K3/02 , C07K15/06 , A61K37/02
CPC分类号： C07K14/475 , A61K35/30 , A61K38/00
摘要： A novel neuronotrophic factor having a molecular weight of about 14,000 to 17,000 daltons and an isoelectric point of about 10 is prepared by homogenization of mammalian brain tissue, particularly bovine brain tissue, acid precipitation of the homogenate thus produced, dialysis of the resulting supernatant with dialysis membranes having a molecular weight cut-off of between 5 and 10 kilodaltons and chromatographic fractionation upon molecular weight permeation of the dialyzed supernatant thus produced. The neuronotrophically active fractions may be further purified by cation exchange chromatography with a gradient of ammonium acetate buffer. The neuronotrophic factor of the invention is useful in the treatment of various neuropathological conditions.
摘要翻译：分子量约为14,000至17,000道尔顿，等电点约为10的新型神经元营养因子通过哺乳动物脑组织，特别是牛脑组织的匀浆，由此产生的匀浆酸沉淀，用透析透析所得上清液具有5至10千道尔顿分子量截止值的膜和通过如此产生的透析上清液的分子量渗透进行色谱分级分离。神经营养活性级分可以通过阳离子交换色谱用乙酸铵缓冲液梯度进一步纯化。本发明的神经营养因子可用于治疗各种神经病理状况。

3. 发明公开

EP0251298A2 Use of exogenous gangliosides for the preparation of a medicament for use in tumoral diseases as a protective factor against toxicity by antitumor drugs 失效
标题翻译：用于制备药物用于肿瘤疾病作为对抗癌药物的毒性的保护剂使用外源性神经节苷脂的应用。
公开(公告)号：EP0251298A2
公开(公告)日：1988-01-07
申请号：EP87109415.7
申请日：1987-06-30
申请人： FIDIA S.p.A.
发明人： della Valle, Francesco
IPC分类号： A61K37/20
CPC分类号： A61K33/24 , A61K31/715 , A61K31/675 , A61K31/70 , A61K31/475 , A61K2300/00
摘要： The invention relates to the use of a mixture of gangliosides GM₁, GD 1a , GD 1b and GT 1b for the manufacture of a pharmaceutical composition for the prevention or the prophylactic treatment of general toxic effects or chronic neurotoxic effects caused by the subsequent administration of antineoplastic agents.
摘要翻译：本发明涉及使用神经节苷脂混合物的GM1，GD 1a中，GD 1b和GT 1b的用于预防或一般毒性作用或通过抗肿瘤剂的后续给药引起的慢性神经毒性作用的预防性治疗的药物组合物中的用途。

4. 发明授权

EP0251298B1 Use of exogenous gangliosides for the preparation of a medicament for use in tumoral diseases as a protective factor against toxicity by antitumor drugs 失效
标题翻译：用于制备用于肿瘤疾病的药物的外源性抗坏血酸作为抗癌药物对抗毒性的保护因子的使用
公开(公告)号：EP0251298B1
公开(公告)日：1991-11-13
申请号：EP87109415.7
申请日：1987-06-30
申请人： FIDIA S.p.A.
发明人： della Valle, Francesco
IPC分类号： A61K37/20
CPC分类号： A61K33/24 , A61K31/715 , A61K31/675 , A61K31/70 , A61K31/475 , A61K2300/00

5. 发明授权

EP0146923B1 Preparation of halogenated phenols 失效
标题翻译：氢化酚的制备
公开(公告)号：EP0146923B1
公开(公告)日：1991-07-10
申请号：EP84115842.1
申请日：1984-12-19
申请人： FIDIA S.p.A.
发明人： della Valle, Francesco , Romeo, Aurelio
IPC分类号： C07C39/27 , C07C37/00 , C07C309/01
CPC分类号： C07C37/62 , C07C37/00 , C07C309/00 , C07C39/245

6. 发明公开

EP0327769A2 Novel neuronotrophic factor 失效
标题翻译：神经营养因子Faktor。
公开(公告)号：EP0327769A2
公开(公告)日：1989-08-16
申请号：EP88400365.8
申请日：1988-02-17
申请人： FIDIA S.p.A.
发明人： della Valle, Francesco
IPC分类号： C07K3/02 , C07K15/06 , A61K37/02
CPC分类号： C07K14/475 , A61K35/30 , A61K38/00
摘要： A novel neuronotrophic factor having a molecular weight of about 14,000 to 17,000 daltons and an isoelectric point of about 10 is prepared by homogenization of mammalian brain tissue, particularly bovine brain tissue, acid precipitation of the homogenate thus produced, dialysis of the resulting supernatant with dialysis membranes having a molecular weight cut-off of between 5 and 10 kilodaltons and chromatographic fractionation upon molecular weight permeation of the dialyzed supernatant thus produced. The neuronotrophically active fractions may be further purified by cation exchange chromatography with a gradient of ammonium acetate buffer. The neuronotrophic factor of the invention is useful in the treatment of various neuropathological conditions.
摘要翻译：通过哺乳动物脑组织，特别是牛脑组织的均质化，通过如此制备的匀浆的酸沉淀，通过透析所得上清液的透析来制备分子量为约14,000至17,000道尔顿和等电点约10的新型神经营养因子分子量截留值在5至10千道尔顿之间的膜，以及如此生产的透析上清液的分子量渗透色谱分离。神经营养活性级分可以通过用乙酸铵缓冲液梯度的阳离子交换层析进一步纯化。本发明的神经营养因子可用于治疗各种神经病理学病症。

7. 发明公开

EP0251298A3 Use of exogenous gangliosides in tumoral diseases as a protective factor against toxicity by antitumor drugs 失效
标题翻译：在肿瘤病毒中使用外源性抗坏血酸作为抗菌药物对抗毒性的保护因子
公开(公告)号：EP0251298A3
公开(公告)日：1988-10-26
申请号：EP87109415
申请日：1987-06-30
申请人： FIDIA S.p.A.
发明人： della Valle, Francesco
IPC分类号： A61K37/20
CPC分类号： A61K33/24 , A61K31/715 , A61K31/675 , A61K31/70 , A61K31/475 , A61K2300/00
摘要： The invention relates to the use of a mixture of gangliosides GM₁, GD 1a , GD 1b and GT 1b for the manufacture of a pharmaceutical composition for the prevention or the prophylactic treatment of general toxic effects or chronic neurotoxic effects caused by the subsequent administration of antineoplastic agents.

8. 发明公开

EP0138572A3 Hyaluronic acid fractions having pharmaceutical activity, methods for preparation thereof, and pharmaceutical compositions containing the same 失效
$Hyaluronic acid fractions having pharmaceutical activity, methods for preparation thereof, and pharmaceutical compositions containing the same$
标题翻译：具有药物活性的羟丙酸酯类，其制备方法和含有其的药物组合物
公开(公告)号：EP0138572A3
公开(公告)日：1986-02-05
申请号：EP84306914
申请日：1984-10-10
申请人： FIDIA S.p.A.
发明人： della Valle, Francesco , Romeo, Aurelio , Lorenzi, Silvana
IPC分类号： C08B37/08 , A61K31/73
CPC分类号： A61K31/715 , A61K9/0048 , A61K38/1808 , A61K45/06 , A61K47/36 , C08B37/0072 , A61K31/70 , A61K31/415 , A61K31/57 , A61K2300/00
摘要： Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intra- articular injections. The fractions of hyaluronic acid are further useful as vehicles for opthalmic drugs, provided formulations compatible with the corneal epithelium and enhancing in vivo activity of such drugs.

9. 发明授权

EP0133766B1 Coumarin derivatives, pharmaceutical compositions containing the same, and the use thereof in the treatment of cancer 失效
标题翻译： COUMARIN衍生物，含有它们的药物组合物及其在治疗癌症中的用途
公开(公告)号：EP0133766B1
公开(公告)日：1991-01-23
申请号：EP84304976.8
申请日：1984-07-20
申请人： FIDIA S.p.A.
发明人： della Valle, Francesco , Romeo, Aurelio
IPC分类号： C07D311/16 , A61K31/37 , C07D405/06
CPC分类号： C07D311/16

10. 发明授权

EP0138572B1 Hyaluronic acid fractions having pharmaceutical activity, methods for preparation thereof, and pharmaceutical compositions containing the same 失效
$Hyaluronic acid fractions having pharmaceutical activity, methods for preparation thereof, and pharmaceutical compositions containing the same$
标题翻译：具有药物活性的羟尿酸酯类，其制备方法和含有其的药物组合物
公开(公告)号：EP0138572B1
公开(公告)日：1990-07-25
申请号：EP84306914.7
申请日：1984-10-10
申请人： FIDIA S.p.A.
发明人： della Valle, Francesco , Romeo, Aurelio , Lorenzi, Silvana
IPC分类号： C08B37/08 , A61K31/73
CPC分类号： A61K31/715 , A61K9/0048 , A61K38/1808 , A61K45/06 , A61K47/36 , C08B37/0072 , A61K31/70 , A61K31/415 , A61K31/57 , A61K2300/00

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