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1. 发明公开

EP4355893A1 ENZYMATIC METHOD FOR THE PRODUCTION OF L-GLUFOSINATE-P ALKYL ESTERS 审中-实审
公开(公告)号：EP4355893A1
公开(公告)日：2024-04-24
申请号：EP22731552.0
申请日：2022-05-31
申请人： Evonik Operations GmbH
发明人： LAUTENSCHÜTZ, Ludger , OßWALD, Steffen , PÖTTER, Markus , MÜLLER, Jakob
IPC分类号： C12P13/04 , C12P17/10
CPC分类号： C12P13/04 , C12Y305/01087 , C12Y305/02002 , C12Y501/99005 , C12P17/10

2. 发明公开

EP4105335A1 ENZYMATIC METHOD FOR THE PRODUCTION OF L-GLUFOSINATE P-ALKYL ESTERS 无效
公开(公告)号：EP4105335A1
公开(公告)日：2022-12-21
申请号：EP21179773.3
申请日：2021-06-16
申请人： Evonik Operations GmbH
发明人： LAUTENSCHÜTZ, Ludger , OSSWALD, Steffen , PÖTTER, Markus , MÜLLER, Jakob
IPC分类号： C12P13/04 , C12P17/10
摘要： The present invention relates in a first aspect to an enzymatic method for the production of an L-glufosinate P -alkyl ester. This method is characterized by a step (c) in which an L-glufosinate P -alkyl ester carbamoylate is reacted to give the corresponding L-glufosinate P -alkyl ester. This step (c) is catalyzed by a carbamoylase, preferably by an L-enantioselective carbamoylase. The L-glufosinate P -alkyl ester carbamoylate employed in step (c) may be obtained by reaction from the corresponding L-glufosinate hydantoin P -alkyl ester. This optional, antecedent step (b) is catalyzed by a hydantoinase, preferably an L-enantioselective hydantoinase. Even more preferred, the L-glufosinate hydantoin P -alkyl ester employed in step (b) may be obtained by reaction from the corresponding D-glufosinate hydantoin P -alkyl ester. This optional, antecedent step (a) is preferably catalyzed by a hydantoin racemase.
In a second aspect, the present invention relates to an enzymatic method for enantioselective production of an L-glufosinate P -alkyl ester from a mixture M IIIA of L- and D-glufosinate P-alkyl ester hydantoins. In the method according to the second aspect of the invention, the mixture M IIIA is provided in a step (i-A) and employed in steps (ii) and (iii). Steps (ii) and (iii) correspond to steps (b) and (c) described above, respectively, wherein in step (c), an L-carbamoylase is employed. In an optional, preferred step (i-B) of the method according to the second aspect of the invention, corresponding to preferred step (a) described above, a hydantoin racemase is preferably used to convert at least a part of the D-glufosinate P -alkyl ester hydantoin in the mixture M IIIA into its corresponding L-enantiomer, giving a mixture M IIIS , which is then employed in steps (ii) and (iii). The L-glufosinate P -alkyl ester obtained in the methods according to the first or second aspect of the invention may be saponified to give L-glufosinate.

3. 发明公开

EP3689451A1 CATALYST FOR THE SYNTHESIS OF ALKYL MERCAPTAN AND PROCESS FOR ITS PREPARATION 审中-公开
公开(公告)号：EP3689451A1
公开(公告)日：2020-08-05
申请号：EP19154123.4
申请日：2019-01-29
申请人： Evonik Operations GmbH , Technische Universität München
发明人： LAUTENSCHÜTZ, Ludger , DUERR, Nadine , FISCHER, Achim , WEBER-STOCKBAUER, Manuel , GUTIERREZ-TINOCO, Oliver Yair , BERMEJO DEVAL, Ricardo , LERCHER, Johannes A.
IPC分类号： B01J23/04 , B01J21/06 , B01J27/04 , B01J35/00 , B01J37/20 , C07C319/08
摘要： The present invention relates to a catalyst comprising a support and a promoter, wherein the support comprises titanium dioxide, zirconium dioxide, and/or a mixture thereof, and the promoter is an alkali metal in oxidized and/or sulfide form; a process for its preparation and a process for the preparation of alkyl mercaptans in the presence of said catalyst or the catalyst obtained by said process.

4. 发明公开

EP4151643A1 IMPROVED PROCESS FOR PRODUCTION OF PHOSPHOESTERS OF GLUFOSINATE PRECURSORS 无效
公开(公告)号：EP4151643A1
公开(公告)日：2023-03-22
申请号：EP21197104.9
申请日：2021-09-16
申请人： Evonik Operations GmbH
发明人： LAUTENSCHÜTZ, Ludger , BRAUNE, Sascha , PÖTTER, Markus
IPC分类号： C07F9/32 , C07F9/6506
摘要： Summary
The present invention relates to a method for production of a compound according to formula (I):

wherein R is alkyl, aryl, alkaryl, aralkyl,
and wherein X is selected from the following structures (I-A), (I-B):

wherein R 1 , R 2 are independently selected from the group consisting of alkyl, aryl, alkaryl, aralkyl.
The compounds according to formula (I) are important precursors in the synthesis of glufosinate, in particular L-glufosinate. In the method according to the present invention, easily accessible starting materials are employed. Thus, the method overcomes the disadvantages of prior art syntheses of L-glufosinate and its intermediates.

5. 发明公开

EP3917667A1 CATALYST FOR THE SYNTHESIS OF ALKYL MERCAPTAN AND PROCESS FOR ITS PREPARATION 有权
公开(公告)号：EP3917667A1
公开(公告)日：2021-12-08
申请号：EP20701220.4
申请日：2020-01-27
申请人： Evonik Operations GmbH
发明人： LAUTENSCHÜTZ, Ludger , DUERR, Nadine , FISCHER, Achim , WEBER-STOCKBAUER, Manuel , GUTIERREZ-TINOCO, Oliver Yair , BERMEJO DEVAL, Ricardo , LERCHER, Johannes A.
IPC分类号： B01J23/04 , B01J21/06 , B01J27/04 , B01J35/00 , B01J37/20 , C07C319/08 , B01J37/02

6. 发明公开

EP4312558A1 ENZYMATIC METHOD FOR PRODUCING L-GLUFOSINATE AND ITS PHOSPHOESTERS 审中-实审
公开(公告)号：EP4312558A1
公开(公告)日：2024-02-07
申请号：EP22713426.9
申请日：2022-03-28
申请人： Evonik Operations GmbH
发明人： PÖTTER, Markus , LAUTENSCHÜTZ, Ludger , FISCHER, Daniel , MÜLLER, Jakob
IPC分类号： A01N57/20 , C12N9/10 , C12P13/04 , C08K5/5313

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