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1. 发明公开

EP4355893A1 ENZYMATIC METHOD FOR THE PRODUCTION OF L-GLUFOSINATE-P ALKYL ESTERS 审中-实审
公开(公告)号：EP4355893A1
公开(公告)日：2024-04-24
申请号：EP22731552.0
申请日：2022-05-31
申请人： Evonik Operations GmbH
发明人： LAUTENSCHÜTZ, Ludger , OßWALD, Steffen , PÖTTER, Markus , MÜLLER, Jakob
IPC分类号： C12P13/04 , C12P17/10
CPC分类号： C12P13/04 , C12Y305/01087 , C12Y305/02002 , C12Y501/99005 , C12P17/10

2. 发明公开

EP4151643A1 IMPROVED PROCESS FOR PRODUCTION OF PHOSPHOESTERS OF GLUFOSINATE PRECURSORS 无效
公开(公告)号：EP4151643A1
公开(公告)日：2023-03-22
申请号：EP21197104.9
申请日：2021-09-16
申请人： Evonik Operations GmbH
发明人： LAUTENSCHÜTZ, Ludger , BRAUNE, Sascha , PÖTTER, Markus
IPC分类号： C07F9/32 , C07F9/6506
摘要： Summary
The present invention relates to a method for production of a compound according to formula (I):

wherein R is alkyl, aryl, alkaryl, aralkyl,
and wherein X is selected from the following structures (I-A), (I-B):

wherein R 1 , R 2 are independently selected from the group consisting of alkyl, aryl, alkaryl, aralkyl.
The compounds according to formula (I) are important precursors in the synthesis of glufosinate, in particular L-glufosinate. In the method according to the present invention, easily accessible starting materials are employed. Thus, the method overcomes the disadvantages of prior art syntheses of L-glufosinate and its intermediates.

3. 发明公开

EP3917667A1 CATALYST FOR THE SYNTHESIS OF ALKYL MERCAPTAN AND PROCESS FOR ITS PREPARATION 有权
公开(公告)号：EP3917667A1
公开(公告)日：2021-12-08
申请号：EP20701220.4
申请日：2020-01-27
申请人： Evonik Operations GmbH
发明人： LAUTENSCHÜTZ, Ludger , DUERR, Nadine , FISCHER, Achim , WEBER-STOCKBAUER, Manuel , GUTIERREZ-TINOCO, Oliver Yair , BERMEJO DEVAL, Ricardo , LERCHER, Johannes A.
IPC分类号： B01J23/04 , B01J21/06 , B01J27/04 , B01J35/00 , B01J37/20 , C07C319/08 , B01J37/02

4. 发明公开

EP4105335A1 ENZYMATIC METHOD FOR THE PRODUCTION OF L-GLUFOSINATE P-ALKYL ESTERS 无效
公开(公告)号：EP4105335A1
公开(公告)日：2022-12-21
申请号：EP21179773.3
申请日：2021-06-16
申请人： Evonik Operations GmbH
发明人： LAUTENSCHÜTZ, Ludger , OSSWALD, Steffen , PÖTTER, Markus , MÜLLER, Jakob
IPC分类号： C12P13/04 , C12P17/10
摘要： The present invention relates in a first aspect to an enzymatic method for the production of an L-glufosinate P -alkyl ester. This method is characterized by a step (c) in which an L-glufosinate P -alkyl ester carbamoylate is reacted to give the corresponding L-glufosinate P -alkyl ester. This step (c) is catalyzed by a carbamoylase, preferably by an L-enantioselective carbamoylase. The L-glufosinate P -alkyl ester carbamoylate employed in step (c) may be obtained by reaction from the corresponding L-glufosinate hydantoin P -alkyl ester. This optional, antecedent step (b) is catalyzed by a hydantoinase, preferably an L-enantioselective hydantoinase. Even more preferred, the L-glufosinate hydantoin P -alkyl ester employed in step (b) may be obtained by reaction from the corresponding D-glufosinate hydantoin P -alkyl ester. This optional, antecedent step (a) is preferably catalyzed by a hydantoin racemase.
In a second aspect, the present invention relates to an enzymatic method for enantioselective production of an L-glufosinate P -alkyl ester from a mixture M IIIA of L- and D-glufosinate P-alkyl ester hydantoins. In the method according to the second aspect of the invention, the mixture M IIIA is provided in a step (i-A) and employed in steps (ii) and (iii). Steps (ii) and (iii) correspond to steps (b) and (c) described above, respectively, wherein in step (c), an L-carbamoylase is employed. In an optional, preferred step (i-B) of the method according to the second aspect of the invention, corresponding to preferred step (a) described above, a hydantoin racemase is preferably used to convert at least a part of the D-glufosinate P -alkyl ester hydantoin in the mixture M IIIA into its corresponding L-enantiomer, giving a mixture M IIIS , which is then employed in steps (ii) and (iii). The L-glufosinate P -alkyl ester obtained in the methods according to the first or second aspect of the invention may be saponified to give L-glufosinate.

5. 发明公开

EP3689451A1 CATALYST FOR THE SYNTHESIS OF ALKYL MERCAPTAN AND PROCESS FOR ITS PREPARATION 审中-公开
公开(公告)号：EP3689451A1
公开(公告)日：2020-08-05
申请号：EP19154123.4
申请日：2019-01-29
申请人： Evonik Operations GmbH , Technische Universität München
发明人： LAUTENSCHÜTZ, Ludger , DUERR, Nadine , FISCHER, Achim , WEBER-STOCKBAUER, Manuel , GUTIERREZ-TINOCO, Oliver Yair , BERMEJO DEVAL, Ricardo , LERCHER, Johannes A.
IPC分类号： B01J23/04 , B01J21/06 , B01J27/04 , B01J35/00 , B01J37/20 , C07C319/08
摘要： The present invention relates to a catalyst comprising a support and a promoter, wherein the support comprises titanium dioxide, zirconium dioxide, and/or a mixture thereof, and the promoter is an alkali metal in oxidized and/or sulfide form; a process for its preparation and a process for the preparation of alkyl mercaptans in the presence of said catalyst or the catalyst obtained by said process.

6. 发明公开

EP4312558A1 ENZYMATIC METHOD FOR PRODUCING L-GLUFOSINATE AND ITS PHOSPHOESTERS 审中-实审
公开(公告)号：EP4312558A1
公开(公告)日：2024-02-07
申请号：EP22713426.9
申请日：2022-03-28
申请人： Evonik Operations GmbH
发明人： PÖTTER, Markus , LAUTENSCHÜTZ, Ludger , FISCHER, Daniel , MÜLLER, Jakob
IPC分类号： A01N57/20 , C12N9/10 , C12P13/04 , C08K5/5313

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