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1. 发明公开

EP3132773A1 DEVICE FOR REPLACING MITRAL VALVE 有权
标题翻译： VORRICHTUNG ZUM AUSTAUSCH EINER MITRALKLAPPE
公开(公告)号：EP3132773A1
公开(公告)日：2017-02-22
申请号：EP16002081.4
申请日：2009-04-27
申请人： Edwards Lifesciences Corporation
发明人： ROWE, Stanton, J. , CHAU, Mark , NGUYEN, Son, V.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61B17/0401 , A61B2017/00243 , A61B2017/0417 , A61B2017/0496 , A61F2/2427 , A61F2/2436 , A61F2/2457 , A61F2/90 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2250/0039 , A61L27/3625 , A61L27/50 , A61L2430/20
摘要： The invention relates to a system for treating a native mitral valve, comprising, a delivery catheter (124); a prosthetic mitral valve assembly (260) comprising a self-expanding stent (10) and a valve (18) made from pericardial tissue, the valve mounted within the stent (10) and forming collapsible leaflets (62) for replacing the function of the native mitral valve, the stent having a substantially D-shape cross-section configured to conform to the natural opening of the native mitral valve, the stent including an upper portion (12) having an enlarged or flared end (14) that tapers to a lower portion (16) having a reduced diameter, the enlarged or flared end (14) being sized to be positioned above an annulus (30) of the native mitral valve (24); and a tether (80) coupled between a lower portion of the prosthetic mitral valve assembly and a wall of the heart for preventing upward movement of the prosthetic mitral valve assembly (260); wherein the prosthetic mitral valve assembly (260) is adapted to be advanced in a radially compressed state along a distal end of the delivery catheter (124) for insertion through the wall of the heart.
摘要翻译：本发明涉及一种用于治疗天然二尖瓣的系统，包括：输送导管（124）; 包括自扩张支架（10）和由心包组织制成的阀（18）的假体二尖瓣组件（260），所述瓣膜安装在所述支架（10）内并形成可折叠小叶（62），用于替代原位二尖瓣，所述支架具有被配置为符合天然二尖瓣的天然开口的基本上D形的横截面，所述支架包括具有逐渐变细的末端（14）的上部（12）具有减小的直径的下部（16），所述扩大或扩张的端部（14）的尺寸设置成位于所述天然二尖瓣（24）的环形空间（30）上方; 以及联接在所述假体二尖瓣组件的下部和心脏壁之间的系绳（80），用于防止所述假体二尖瓣组件（260）向上运动; 其中所述假体二尖瓣组件（260）适于沿着所述输送导管（124）的远端沿径向压缩状态前进，以插入通过所述心脏壁。

2. 发明公开

EP2849681A1 DEVICES AND METHODS FOR REDUCING CARDIAC VALVE REGURGITATION 有权
标题翻译： Vorrichtungen zur Reduzierung von Herzklappenregurgitation
公开(公告)号：EP2849681A1
公开(公告)日：2015-03-25
申请号：EP13791015.4
申请日：2013-05-16
申请人： Edwards Lifesciences Corporation
发明人： ROWE, Stanton, J. , SCHWARTZ, Robert , VAN TASSEL, Robert , KHALIL, Vivian , SPINNER, Erin , ZIMMERMAN, Neil , SIEGEL, Alexander, J. , NGUYEN, Son, V.
IPC分类号： A61F2/24 , A61M39/22 , A61F2/02
CPC分类号： A61F2/2427 , A61F2/2424 , A61F2/2454 , A61F2/246 , A61F2/2463 , A61F2/2466 , A61F2210/0061 , A61F2230/0023 , A61F2250/0003 , A61F2250/001
摘要： The present invention relates to devices and methods for improving the function of a defective heart valve, and particularly for reducing regurgitation through an atrioventricular heart valve - i.e., the mitral valve and the tricuspid valve. For a tricuspid repair, the device includes an anchor deployed in the tissue of the right ventricle, in an orifice opening to the right atrium, or anchored to the tricuspid valve. A flexible anchor rail connects to the anchor and a coaptation element on a catheter rides over the anchor rail. The catheter attaches to the proximal end of the coaptation element, and a locking mechanism fixes the position of the coaptation element relative to the anchor rail. Finally, there is a proximal anchoring feature to fix the proximal end of the coaptation catheter subcutaneously adjacent the subclavian vein. The coaptation element includes an inert covering and helps reduce regurgitation through contact with the valve leaflets.
摘要翻译：本发明涉及用于改善有缺陷心脏瓣膜功能的装置和方法，特别是涉及通过房室心脏瓣膜（即二尖瓣和三尖瓣瓣）来减少反流。对于三尖瓣修复，该装置包括部署在右心室的组织中的锚定件，在通向右心房的孔中，或锚定到三尖瓣。柔性锚杆连接到锚固件上，并且导管上的接合元件越过锚杆。导管附接到接合元件的近端，并且锁定机构固定接合元件相对于锚固轨道的位置。最后，有一个近端锚固特征，用于将接合导管的近端固定在毗邻锁骨下静脉的位置。接合元件包括惰性覆盖物，有助于通过与瓣膜传递接触来减少反流。

3. 发明公开

EP2849680A2 SYSTEMS AND METHODS FOR PLACING A COAPTING MEMBER BETWEEN VALVULAR LEAFLETS 有权
标题翻译：系统和方法心脏瓣膜之间KOAPTATIONSELEMENTS帆船PLACEMENT
公开(公告)号：EP2849680A2
公开(公告)日：2015-03-25
申请号：EP13790562.6
申请日：2013-05-16
申请人： Edwards Lifesciences Corporation
发明人： KHALIL, Vivian , SPINNER, Erin , ZIMMERMAN, Neil , NGUYEN, Son, V. , SIEGEL, Alexander J.
IPC分类号： A61F2/24 , A61M39/22 , A61M25/01 , A61F2/82
CPC分类号： A61F2/2427 , A61F2/2424 , A61F2/2454 , A61F2/246 , A61F2/2463 , A61F2/2466 , A61F2210/0061 , A61F2230/0023 , A61F2250/0003 , A61F2250/001
摘要： The present invention relates to devices and methods for improving the function of a defective heart valve, and particularly for reducing regurgitation through an atrioventricular heart valve—i.e., the mitral valve and the tricuspid valve. For a tricuspid repair, the device includes an anchor deployed in the tissue of the right ventricle, in an orifice opening to the right atrium, or anchored to the tricuspid valve. A flexible anchor rail connects to the anchor and a coaptation element on a catheter rides over the anchor rail. The catheter attaches to the proximal end of the coaptation element, and a locking mechanism fixes the position of the coaptation element relative to the anchor rail. Finally, there is a proximal anchoring feature to fix the proximal end of the coaptation catheter subcutaneously adjacent the subclavian vein. The coaptation element includes an inert covering and helps reduce regurgitation through contact with the valve leaflets.

4. 发明公开

EP2624785A2 PROSTHETIC HEART VALVE 有权
标题翻译：人造心脏瓣膜
公开(公告)号：EP2624785A2
公开(公告)日：2013-08-14
申请号：EP11831542.3
申请日：2011-10-05
申请人： Edwards Lifesciences Corporation
发明人： LEVI, Tamir , NGUYEN, Son, V. , BENICHOU, Netanel , MAIMON, David , YOHANAN, Ziv , GUROVICH, Nik , FELSEN, Bella , DADONKIN, Larisa
IPC分类号： A61F2/24 , A61M29/02
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2220/0075 , A61F2230/0054 , A61F2250/0036 , A61F2250/0097
摘要： Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
摘要翻译：公开了径向可折叠和可扩张假体心脏瓣膜的实施例。阀框架在安装在输送轴上时可具有锥形轮廓，其中流入端部的直径小于流出端部的直径。瓣膜可以包括大致V形小叶，从而减少了在框架流入端内的物质。外裙部可以固定到框架的流入端部的外侧，当瓣膜膨胀时，外裙部具有纵向松弛并且当瓣膜塌陷时平躺在框架上。对角编织的内裙部可以与框架轴向延伸。相邻小叶的侧翼可延伸穿过并固定到框架的窗框部分以形成连合。当阀压接到输送轴上时，窗框部分可相对于周围框架部分径向向内凹陷。

5. 发明公开

EP4228551A1 TISSUE-BASED REINFORCED HEART VALVES 审中-实审
公开(公告)号：EP4228551A1
公开(公告)日：2023-08-23
申请号：EP21802511.2
申请日：2021-10-11
申请人： Edwards Lifesciences Corporation
发明人： TOD, Tara, J. , VAN NEST, Mark , NGUYEN, Kiem, Bao , GUI, Liqiong , HOANG, Lien, Huong Thi , NGUYEN, Son, V. , SHANG, Hao
IPC分类号： A61F2/24

6. 发明公开

EP3917454A1 HEART VALVE SEALING ASSEMBLIES 审中-实审
公开(公告)号：EP3917454A1
公开(公告)日：2021-12-08
申请号：EP20708363.5
申请日：2020-01-29
申请人： Edwards Lifesciences Corporation
发明人： CHEN, Harvey, H. , NGUYEN, Son, V. , NGUYEN, Devine, D. , GEORGE, Diana, Marie , YAMBAO, August, R. , RAO, Jyoti, B. , KORNSWIET, Alyssa, E. , AI, Lisong , TANG, Stephen, W. , ROMERO, Edward , DANG, Kevin, K. , FRANCIS, Meena , CAMPBELL, Louis, A. , KIM, Grace, Myong
IPC分类号： A61F2/24

7. 发明授权

EP3485848B1 PROSTHETIC HEART VALVE 有权
公开(公告)号：EP3485848B1
公开(公告)日：2020-09-16
申请号：EP18210741.7
申请日：2011-10-05
申请人： Edwards Lifesciences Corporation
发明人： LEVI, Tamir , NGUYEN, Son, V. , BENICHOU, Netanel , MAIMON, David , YOHANAN, Ziv , GUROVICH, Nik , FELSEN, Bella , DADONKIN, Larisa
IPC分类号： A61F2/24

8. 发明公开

EP3322383A1 PROSTHETIC HEART VALVE 有权
公开(公告)号：EP3322383A1
公开(公告)日：2018-05-23
申请号：EP16825207.0
申请日：2016-07-14
申请人： Edwards Lifesciences Corporation
发明人： NGUYEN-THIEN-NHON, Diana , GEISER, Timothy, A. , WOOD, Larry, L. , SIRIMANNE, Dinesh, L. , NGUYEN, Son, V. , LEVI, Tamir, S. , GUROVICH, Nikolay , BUKIN, Michael
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2002/072 , A61F2210/0076 , A61F2220/0075 , A61F2230/0026 , A61F2230/0093 , A61F2250/0003 , A61F2250/0039 , A61F2250/0069
摘要： An implantable prosthetic valve can comprise an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration, the frame defining an axial direction extending from the inflow end to the outflow end, a leaflet structure positioned within the frame and secured thereto, and an annular outer skirt positioned around an outer surface of the frame, wherein the outer skirt comprises an inflow edge secured to the frame at a first location, an outflow edge comprising a plurality of alternating projections and notches, wherein the projections are secured to the frame at a second location, and the notches are not directly secured to the frame, an intermediate portion between the inflow edge and the outflow edge that comprises a plurality of openings.

9. 发明授权

EP2278944B1 Prosthetic mitral valve 有权
标题翻译：人工二尖瓣
公开(公告)号：EP2278944B1
公开(公告)日：2016-03-23
申请号：EP09739503.2
申请日：2009-04-27
申请人： Edwards Lifesciences Corporation
发明人： ROWE, Stanton, J. , CHAU, Mark , NGUYEN, Son, V.
IPC分类号： A61F2/90 , A61F2/24
CPC分类号： A61F2/2418 , A61B17/0401 , A61B2017/00243 , A61B2017/0417 , A61B2017/0496 , A61F2/2427 , A61F2/2436 , A61F2/2457 , A61F2/90 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2250/0039 , A61L27/3625 , A61L27/50 , A61L2430/20
摘要： A prosthetic mitral valve assembly (260) is disclosed, which comprises a radially-compressible and self-expandable stent (10) having a non-uniform cross-sectional shape, the stent (10) including an upper portion (12) having an enlarged or flared end (14) that tapers to a lower portion (16) having a reduced diameter to generally conform the contours of the native leaflets within the native valve, the flared end (14) of the upper portion (12) being positioned above or just below an annulus (30) of the native mitral valve (24). It is further characterized by having a substantially D-shape cross-section configured to conform to the natural opening of the native mitral valve, the D-shape cross-section including a substantially straight portion (262) configured to extend along an anterior side of the native mitral valve and a substantially curved portion (264) configured to extend along a posterior side of the native mitral valve. The prosthetic mitral valve assembly (260) furhter comprises a valve (18) mounted within said stent, the valve having leaflets (62) replacing the function of the native mitral valve; wherein said mitral valve assembly (260) is mountable in a compressed state on the distal end of a delivery catheter (124) for insertion through the apex and into the heart.

10. 发明公开

EP4056150A1 LOW PROFILE TRANSCATHETER HEART VALVE 审中-实审
公开(公告)号：EP4056150A1
公开(公告)日：2022-09-14
申请号：EP22160976.1
申请日：2009-06-08
申请人： Edwards Lifesciences Corporation
发明人： HARITON, Ilia , BENICHOU, Netanel , NITZAN, Yaacov , FELSEN, Bella , NGUYEN-THIEN-NH, Diana , KHANNA, Rajesh , NGUYEN, Son, V. , LEVI, Tamir , PELLED, Itai
IPC分类号： A61F2/24 , A61F2/95
摘要： An implantable prosthetic valve (10), according to one embodiment, comprises a frame (12), a leaflet structure (14), and a skirt member (16). The frame can have a plurality of axial struts (20) interconnected by a plurality of circumferential struts (22, 24). The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.

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