专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3998104A1 SYSTEM TO DELIVER ADAPTIVE EPIDURAL AND/OR SUBDURAL ELECTRICAL SPINAL CORD STIMULATION TO FACILITATE AND RESTORE LOCOMOTION AFTER A NEUROMOTOR IMPAIRMENT 审中-公开
公开(公告)号：EP3998104A1
公开(公告)日：2022-05-18
申请号：EP21196454.9
申请日：2014-10-29
申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)
发明人： COURTINE, Grégoire , WENGER, Nikolaus , MARTIN MORAUD, Eduardo , MICERA, Silvestro , BONIZZATO, Marco
IPC分类号： A61N1/36 , A61B5/00
摘要： The present invention provides a closed-loop system for real-time control of epidural electrical stimulation comprising: a) means for applying to a subject neuromodulation with adjustable stimulation parameters, said means a) being operatively connected with b) a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals providing features of motion of said subject, said system b) being operatively connected with c) a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means a) and providing said means a) with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.

2. 发明公开

EP3184145A1 SYSTEM FOR SELECTIVE SPATIOTEMPORAL STIMULATION OF THE SPINAL CORD 有权
标题翻译：系统选择性时空刺激的脊髓
公开(公告)号：EP3184145A1
公开(公告)日：2017-06-28
申请号：EP15201930.3
申请日：2015-12-22
申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)
发明人： BLOCH, Jocelyne , COURTINE, Grégoire , WENGER, Nikolaus , MICERA, Silvestro , CAPOGROSSO, Marco
IPC分类号： A61N1/36
CPC分类号： A61N1/36003 , A61B5/0488 , A61B5/4836 , A61N1/0553 , A61N1/36067 , A61N1/36139
摘要： The present invention refers to systems for selective spatiotemporal electrical neurostimulation of the spinal cord. In particular, it is an object of the invention a system comprising: a signal processing device receiving signals from the subject and operating signal-processing algorithms to elaborate stimulation parameter settings, operatively connected with an Implantable Pulse Generator (IPG) receiving stimulation parameter settings from said signal processing device and able to simultaneously deliver independent current or voltage pulses to one or more multiple electrode arrays; operatively connected with one or more multi-electrode arrays suitable to cover at least a portion of the spinal cord of said subject for applying to said subject a selective spatiotemporal stimulation of the spinal circuits and/or dorsal roots, wherein said IPG is operatively connected with said one or more multi-electrode arrays to provide a multipolar stimulation. Such system advantageously allows achieving effective control of locomotor functions in a subject in need thereof by stimulating the spinal cord, in particular the dorsal roots, with spatiotemporal selectivity.
摘要翻译：本发明涉及用于脊髓的选择性时空电神经刺激的系统。具体而言，本发明的一个目的是提供一种系统，包括：信号处理设备，接收来自受试者的信号并操作信号处理算法以详细阐述刺激参数设置，该刺激参数设置可操作地与从可植入脉冲发生器（IPG）所述信号处理装置并且能够同时传送独立的电流或电压脉冲到一个或多个多电极阵列; 可操作地与一个或多个适合于覆盖所述对象的脊髓的至少一部分的多电极阵列连接，用于向所述对象施加对脊髓回路和/或背根的选择性时空刺激，其中所述IPG可操作地与所述一个或多个多电极阵列提供多极刺激。这样的系统有利地允许通过以时空选择性刺激脊髓，特别是背根来有效控制有需要的受试者的运动功能。

3. 发明授权

EP2854939B1 APPARATUS FOR RESTORING VOLUNTARY CONTROL OF LOCOMOTION IN NEUROMOTOR IMPAIRMENTS 有权
标题翻译：设备恢复朝着NEURO运动障碍的意识的控制
公开(公告)号：EP2854939B1
公开(公告)日：2017-04-19
申请号：EP13736652.2
申请日：2013-05-29
申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)
发明人： COURTINE, Gregoire , MICERA, Silvestro , VON ZITZEWITZ, Joachim
IPC分类号： A61N1/36 , A61H3/00 , A61F5/00
CPC分类号： A61H1/0262 , A61B5/0004 , A61B5/0048 , A61B5/0053 , A61B5/0057 , A61B5/04001 , A61B5/0482 , A61B5/0484 , A61B5/1036 , A61B5/112 , A61B5/1123 , A61B5/1124 , A61B5/4005 , A61B5/4023 , A61B5/4076 , A61B5/4519 , A61B5/4538 , A61B5/4566 , A61B5/4824 , A61B5/4848 , A61B5/70 , A61B5/721 , A61B34/30 , A61B2034/302 , A61B2560/02 , A61H1/001 , A61H1/0229 , A61H2201/0196 , A61H2201/165 , A61H2201/1666 , A61H2201/5007 , A61H2201/5061 , A61H2201/5069 , A61H2230/08 , A61H2230/085 , A61K31/135 , A61K31/496 , A61K31/55 , A61N1/36003 , A61N1/36057 , A63B21/00181 , A63B22/0235 , A63B22/203 , A63B24/0087 , A63B69/0057 , A63B69/0064 , A63B2022/0094 , A63B2022/206 , A63B2213/004 , A63B2220/10 , A63B2220/51 , B25J9/0006
摘要： It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyses. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.

4. 发明公开

EP4378520A1 SYSTEM FOR SELECTIVE SPATIOTEMPORAL STIMULATION OF THE SPINAL CORD 审中-公开
公开(公告)号：EP4378520A1
公开(公告)日：2024-06-05
申请号：EP24164138.0
申请日：2015-12-22
申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)
发明人： BLOCH, Jocelyne , COURTINE, Grègoire , WENGER, Nikolaus , MICERA, Silvestro , CAPOGROSSO, Marco
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/36139 , A61B5/4836
摘要： The present invention refers to systems for selective spatiotemporal electrical neurostimulation of the spinal cord. In particular, it is an object of the invention a system comprising: a signal processing device receiving signals from the subject and operating signal-processing algorithms to elaborate stimulation parameter settings, operatively connected with an Implantable Pulse Generator (IPG) receiving stimulation parameter settings from said signal processing device and able to simultaneously deliver independent current or voltage pulses to one or more multiple electrode arrays; operatively connected with one or more multi-electrode arrays suitable to cover at least a portion of the spinal cord of said subject for applying to said subject a selective spatiotemporal stimulation of the spinal circuits and/or dorsal roots, wherein said IPG is operatively connected with said one or more multi-electrode arrays to provide a multipolar stimulation. Such system advantageously allows achieving effective control of locomotor functions in a subject in need thereof by stimulating the spinal cord, in particular the dorsal roots, with spatiotemporal selectivity.

5. 发明公开

EP3522773A1 INTRAFASCICULAR ELECTRODE IMPLANT 有权
公开(公告)号：EP3522773A1
公开(公告)日：2019-08-14
申请号：EP17791738.2
申请日：2017-09-29
申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)
发明人： RASPOPOVIC, Stanisa , PETRINI, Francesco Maria , MICERA, Silvestro
IPC分类号： A61B5/00 , A61B5/04 , A61N1/05

6. 发明公开

EP3062872A1 SYSTEM TO DELIVER ADAPTIVE EPIDURAL AND/OR SUBDURAL ELECTRICAL SPINAL CORD STIMULATION TO FACILITATE AND RESTORE LOCOMOTION AFTER A NEUROMOTOR IMPAIRMENT 有权
标题翻译：一种用于提供自适应硬膜外和/或硬膜下电脊髓刺激启用和运动能力的恢复到NEURO电机故障
公开(公告)号：EP3062872A1
公开(公告)日：2016-09-07
申请号：EP14790599.6
申请日：2014-10-29
申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)
发明人： COURTINE, Grégoire , WENGER, Nikolaus , MARTIN MORAUD, Eduardo , MICERA, Silvestro , BONIZZATO, Marco
IPC分类号： A61N1/36 , A61B5/00
CPC分类号： A61N1/36067 , A61B5/04001 , A61B5/0476 , A61B5/0488 , A61B5/112 , A61B5/1121 , A61B5/1127 , A61B5/4836 , A61B5/7282 , A61B2562/0219 , A61B2562/0247 , A61N1/0551 , A61N1/36003 , A61N1/36103 , A61N1/36135 , A61N1/36139
摘要： The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: a) means for applying to a subject neuromodulation with adjustable stimulation parameters, said means a) being operatively connected with b) a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system b) being operatively connected with c) a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means a) and providing said means a) with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.

7. 发明公开

EP3558448A1 A SENSORY INFORMATION COMPLIANT SPINAL CORD STIMULATION SYSTEM FOR THE REHABILITATION OF MOTOR FUNCTIONS 有权
公开(公告)号：EP3558448A1
公开(公告)日：2019-10-30
申请号：EP17826212.7
申请日：2017-12-19
申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)
发明人： FORMENTO, Emanuele , CAPOGROSSO, Marco , MICERA, Silvestro , COURTINE, Grégoire , MINASSIAN, Karen
IPC分类号： A61N1/05 , A61N1/36

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式