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1. 发明授权

EP1615615B1 TAMPER-RESISTANT PRODUCTS FOR OPIOID DELIVERY 有权转让
标题翻译： MISSBRAUCHSSICHERE OPIOID-FREISETZENDE PRODUKTE
公开(公告)号：EP1615615B1
公开(公告)日：2010-02-24
申请号：EP04759980.8
申请日：2004-04-19
申请人： EURO-CELTIQUE S.A.
发明人： OSHLACK, Benjamin , VAN BUSKIRK, Glenn , CHASIN, Mark , HUANG, Hua-Pin , VASHI, Vijay
IPC分类号： A61K9/14 , A61P25/04 , A61K31/485
CPC分类号： A61K9/2081 , A61K9/1617 , A61K9/1635 , A61K9/282 , A61K9/2826 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5084 , A61K9/5123 , A61K9/5138 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Disclosed in certain embodiments is a dosage form comprising a plurality of extruded particles comprising an adverse agent or antagonist and a layer disposed about the particles.
摘要翻译：在某些实施方案中公开的是包含多个包含不利剂或拮抗剂的挤出颗粒和围绕颗粒设置的层的剂型。

2. 发明公开

EP0912575A1 IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY 失效
标题翻译：法化学化合物与PDE-IV抑制效果合成
公开(公告)号：EP0912575A1
公开(公告)日：1999-05-06
申请号：EP97930217.0
申请日：1997-06-06
申请人： Euro-Celtique S.A.
发明人： CHASIN, Mark , HOFER, Peter , CAVALLA, David
IPC分类号： A61K31 , A61P11 , A61P29 , A61P43 , C07D473
CPC分类号： C07D473/34
摘要： Novel and improved methods for preparing 3-substituted adenines and 3,8-di-substituted 6-aminopurine derivatives for use as cyclic nucleotide phosphodiesterase inhibitors are provided.

3. 发明授权

EP0785775B1 MELT-EXTRUDED ORALLY ADMINISTRABLE OPIOID FORMULATIONS 失效
标题翻译：熔融挤出可口服给药的制剂和阿片
公开(公告)号：EP0785775B1
公开(公告)日：2004-01-07
申请号：EP95939928.8
申请日：1995-11-03
申请人： EURO-CELTIQUE S.A.
发明人： OSHLACK, Benjamin , CHASIN, Mark , HUANG, Hua-Pin , SACKLER, David
IPC分类号： A61K9/14 , A61K9/22 , A61K9/52
CPC分类号： A61K9/1635 , A61K9/145 , A61K9/1617 , A61K9/1652 , A61K9/1694 , A61K9/2018 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2095 , Y10S514/951 , Y10S514/962
摘要： Bioavailable sustained release oral opioid analgesic dosage forms, comprising a plurality of multiparticulates produced via melt extrusion techniques are disclosed.

4. 发明授权

EP1045849B1 PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY 有权
标题翻译： WITH磷酸二酯酶IV阻燃性能的嘌呤衍生物
公开(公告)号：EP1045849B1
公开(公告)日：2003-07-02
申请号：EP98963053.8
申请日：1998-12-11
申请人： Euro-Celtique S.A.
发明人： CAVALLA, David , CHASIN, Mark , HOFER, Peter , GEHRIG, Andre , WINTERGERST, Peter
IPC分类号： C07D473/34 , A61K31/52
CPC分类号： C07D473/30 , C07D473/34
摘要： Disclosed are compounds of formula (I), wherein R3 is selected from the group consisting of C¿1-10? alkyl, C1-10 alkenyl, C3-10 cycloalkyl, C4-10 cycloalkylalkyl or C3-10 cycloalkenyl, wherein said alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or cycloalkenyl is optionally substituted in one position with hydroxy; or benzyl, wherein said benzyl is optionally substituted in one or two positions with halogen, alkoxy, cycloalkoxy or polycycloalkyl, and wherein said alkyl moiety of said alkoxy or cycloalkoxy substituent is optionally substituted in one position with hydroxy; R?8¿ is selected from the group consisting of hydrogen, C¿1-10? alkyl, C1-10 alkenyl, C3-10 cycloalkyl, C4-10 cycloalkylalkyl or C3-10 cycloalkenyl, wherein said alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or cycloalkenyl is optionally substituted in one position with hydroxy; or benzyl, wherein said benzyl is optionally substituted in one or two positions with halogen, alkoxy, cycloalkoxy or polycycloalkyl, and wherein said alkyl moiety of said alkoxy or cycloalkoxy is optionally substituted in one position with hydroxy; R?6a and R6b¿ are independently selected from the group consisting of hydrogen, C¿1-10? alkyl, C1-10 alkenyl, C3-10 cycloalkyl, C4-10 cycloalkylalkyl, or C3-10 cycloalkenyl, wherein said alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or cycloalkenyl is optionally substituted in one position with hydroxy; and pharmaceutically acceptable salts thereof.

5. 发明公开

EP1044201A1 3-SUBSTITUTED ADENINES VIA2-THIOXANTHINES 审中-公开
标题翻译： 3-取代的腺嘌呤VIA 2-硫代黄嘌呤
公开(公告)号：EP1044201A1
公开(公告)日：2000-10-18
申请号：EP98962064.6
申请日：1998-12-10
申请人： Euro-Celtique S.A.
发明人： CAVALLA, David , CHASIN, Mark , HOFER, Peter
IPC分类号： C07D473/34
CPC分类号： C07D473/30 , C07D473/34
摘要： With the above and other objects in view, the present invention comprises compounds having general formula (I): wherein Z is selected from the group consisting of alkyl groups such as alkylene groups such as CH2, CH2CH2, CH(CH3); alkenyl groups such as CH CH; alkynyl groups such as C C; and NH, N(C1-C3 alkyl), O, S, C(O)CH2 and OCH2; R?1 and R2¿ are selected from the group consisting of hydrogen and a C¿1?-C8 straight or branched alkyl or a C3-C8 cycloalkyl; R?3¿ is a C¿1?-C12 straight or branched alkyl; R?4¿ is a C¿3?-C10 cycloalkyl optionally substituted with OH or C3-C10 cycloalkenyl optionally substituted with OH; and R?8¿ is a C¿1?-C8 straight or branched alkyl or a C3-C8 cycloalkyl, optionally substituted with OH; and methods of synthesis.

6. 发明授权

EP0912575B1 PROCESSES FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY 失效
标题翻译：法化学化合物与PDE-IV抑制效果合成
公开(公告)号：EP0912575B1
公开(公告)日：2005-02-02
申请号：EP97930217.1
申请日：1997-06-06
申请人： Euro-Celtique S.A.
发明人： CHASIN, Mark , HOFER, Peter , CAVALLA, David
IPC分类号： C07D473/34 , C07D473/30 , C07D473/40
CPC分类号： C07D473/34
摘要： Novel and improved methods for preparing 3-substituted adenines and 3,8-di-substituted 6-aminopurine derivatives for use as cyclic nucleotide phosphodiesterase inhibitors are provided.

7. 发明授权

EP1202628B1 NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS 有权
标题翻译：新的低级胺和硫代吡咯烷化合物
公开(公告)号：EP1202628B1
公开(公告)日：2004-10-13
申请号：EP00953925.5
申请日：2000-08-09
申请人： EURO-CELTIQUE S.A.
发明人： CHASIN, Mark , HOFER, Peter , CAVALLA, David
IPC分类号： A01N43/54 , A61K31/505 , A61K31/52 , C07D487/04
CPC分类号： C07D473/38 , C07D473/30
摘要： Disclosed are compounds of formula (I) wherein R3, R6, R8 are as described herein. The compounds are effective selective PDE IV inhibitors.
摘要翻译：公开了式（I）的化合物，其中R 3，R 6，R 8如本文所述。这些化合物是有效的选择性PDE IV抑制剂。

8. 发明公开

EP1045849A1 PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY 有权
标题翻译： WITH磷酸二酯酶IV阻燃性能的嘌呤衍生物
公开(公告)号：EP1045849A1
公开(公告)日：2000-10-25
申请号：EP98963053.8
申请日：1998-12-11
申请人： Euro-Celtique S.A.
发明人： CAVALLA, David , CHASIN, Mark , HOFER, Peter , GEHRIG, Andre , WINTERGERST, Peter
IPC分类号： C07D473/34 , A61K31/52
CPC分类号： C07D473/30 , C07D473/34
摘要： Disclosed are compounds of formula (I), wherein R3 is selected from the group consisting of C¿1-10? alkyl, C1-10 alkenyl, C3-10 cycloalkyl, C4-10 cycloalkylalkyl or C3-10 cycloalkenyl, wherein said alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or cycloalkenyl is optionally substituted in one position with hydroxy; or benzyl, wherein said benzyl is optionally substituted in one or two positions with halogen, alkoxy, cycloalkoxy or polycycloalkyl, and wherein said alkyl moiety of said alkoxy or cycloalkoxy substituent is optionally substituted in one position with hydroxy; R?8¿ is selected from the group consisting of hydrogen, C¿1-10? alkyl, C1-10 alkenyl, C3-10 cycloalkyl, C4-10 cycloalkylalkyl or C3-10 cycloalkenyl, wherein said alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or cycloalkenyl is optionally substituted in one position with hydroxy; or benzyl, wherein said benzyl is optionally substituted in one or two positions with halogen, alkoxy, cycloalkoxy or polycycloalkyl, and wherein said alkyl moiety of said alkoxy or cycloalkoxy is optionally substituted in one position with hydroxy; R?6a and R6b¿ are independently selected from the group consisting of hydrogen, C¿1-10? alkyl, C1-10 alkenyl, C3-10 cycloalkyl, C4-10 cycloalkylalkyl, or C3-10 cycloalkenyl, wherein said alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or cycloalkenyl is optionally substituted in one position with hydroxy; and pharmaceutically acceptable salts thereof.

9. 发明公开

EP3150228A3 TAMPER-RESISTANT PRODUCTS FOR OPIOID DELIVERY 审中-公开
标题翻译：用于阿片类物质输送的防篡改产品
公开(公告)号：EP3150228A3
公开(公告)日：2017-06-28
申请号：EP15181540.4
申请日：2004-04-19
申请人： EURO-CELTIQUE S.A.
发明人： OSHLACK, Benjamin , CHASIN, Mark , HUANG, Hua-Pin , VAN BUSKIRK, Glenn , VASHI, Vijay
IPC分类号： A61K9/14 , A61P25/04 , A61K31/485 , A61K45/06 , A61K9/16 , A61K9/20 , A61K9/50
CPC分类号： A61K9/2081 , A61K9/1617 , A61K9/1635 , A61K9/282 , A61K9/2826 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5084 , A61K9/5123 , A61K9/5138 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Disclosed in certain embodiments is a dosage form comprising a plurality of extruded particles comprising an adverse agent or antagonist and a layer disposed about the particles.
摘要翻译：在某些实施方案中公开了包含多个挤出颗粒的剂型，所述挤出颗粒包含不利剂或拮抗剂和围绕所述颗粒设置的层。

10. 发明公开

EP3150228A2 TAMPER-RESISTANT PRODUCTS FOR OPIOID DELIVERY 审中-公开
标题翻译：手工制作ZUR VERABREICHUNG VON OPIOIDEN
公开(公告)号：EP3150228A2
公开(公告)日：2017-04-05
申请号：EP15181540.4
申请日：2004-04-19
申请人： EURO-CELTIQUE S.A.
发明人： OSHLACK, Benjamin , CHASIN, Mark , HUANG, Hua-Pin , VAN BUSKIRK, Glenn , VASHI, Vijay
IPC分类号： A61K45/06 , A61K9/16 , A61K9/20 , A61K9/28 , A61K9/48 , A61K9/50 , A61K9/51 , A61K31/485
CPC分类号： A61K9/2081 , A61K9/1617 , A61K9/1635 , A61K9/282 , A61K9/2826 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5084 , A61K9/5123 , A61K9/5138 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Disclosed in certain embodiments is a dosage form comprising a plurality of extruded particles comprising an adverse agent or antagonist and a layer disposed about the particles.
摘要翻译：在某些实施方案中公开的是包含多个包含不利剂或拮抗剂的挤出颗粒和围绕颗粒设置的层的剂型。

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