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1. 发明授权

EP1879450B1 ANTIMICROBIAL POLYMER COMPOSITIONS AND THE USE THEREOF 有权
标题翻译：抗微生物聚合物组合物及其
公开(公告)号：EP1879450B1
公开(公告)日：2017-01-11
申请号：EP06760142.7
申请日：2006-05-18
申请人： ETHICON, INC.
发明人： ERNETA, Modesto , DILUCCIO, Robert
IPC分类号： A01N25/10 , A01N59/16 , A01P1/00 , A61L17/14 , A61L31/10 , A61L31/16 , C09D5/14 , C09D5/16
CPC分类号： A61L31/16 , A01N59/16 , A61L31/10 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A01N25/10 , A01N25/34 , A01N37/36 , A01N2300/00

2. 发明公开

EP1879450A2 ANTIMICROBIAL POLYMER COMPOSITIONS AND THE USE THEREOF 有权
标题翻译：国际志愿者联合会（ANTIMIKROBIELLE POLYMERZUSAMMENSETZUNGEN UND IHRE VERWENDUNG）
公开(公告)号：EP1879450A2
公开(公告)日：2008-01-23
申请号：EP06760142.7
申请日：2006-05-18
申请人： ETHICON, INC.
发明人： ERNETA, Modesto , DILUCCIO, Robert
IPC分类号： A01N25/10 , A01N59/16 , A01P1/00 , A61L17/14 , A61L31/10 , A61L31/16 , C09D5/14 , C09D5/16
CPC分类号： A61L31/16 , A01N59/16 , A61L31/10 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A01N25/10 , A01N25/34 , A01N37/36 , A01N2300/00
摘要： An antimicrobial composition comprising: a complex of an anionic polyester with an antimicrobial metal wherein the anionic polyester has at least one carboxylic acid group. A medical device having an antimicrobial composition comprising: a complex of an anionic polyester with an antimicrobial metal wherein the anionic polyester has at least one carboxylic acid group.
摘要翻译：一种抗微生物组合物，其包含：阴离子聚酯与抗微生物金属的络合物，其中所述阴离子聚酯具有至少一个羧酸基团。一种具有抗微生物组合物的医疗装置，包括：阴离子聚酯与抗微生物金属的复合物，其中阴离子聚酯具有至少一个羧酸基团。

3. 发明公开

EP2197509A1 ANTIMICROBIAL POLYMER COMPOSITIONS AND THE USE THEREOF 有权
标题翻译：抗微生物聚合物组合物及其
公开(公告)号：EP2197509A1
公开(公告)日：2010-06-23
申请号：EP08837962.3
申请日：2008-09-29
申请人： Ethicon, Inc.
发明人： ERNETA, Modesto , PRIEWE, Joerg
IPC分类号： A61L31/06 , A61L31/10 , C08L67/04
CPC分类号： A61L31/06 , A61L31/10 , C08L67/04
摘要： An antimicrobial composition. The antimicrobial composition includes a complex of an anionic polyester with a monomelic amidoamine a complex of an anionic polyester with a monomeric amidoamine or an organic cation, wherein the monomelic amidoamine comprises: (R1,2)N - R3-NH-CO-R4 wherein: R1 = H, Alkyl, Aryl, HO-(CH2CH2-O-)n-, MeO-(CH2CH2-O-)n -, HO-(CH2)n-; R2 = H, Alkyl, Aryl, HO-(CH2CH2-O-) n -, MeO-(CH2CH2-O-) n -, HO-(CH2)n-; R3 = Alkyl, Aryl, -(CH2CH2-O-)-(CH2-)n; R4 = Alkyl, Aryl, -(CH2CH2-O-)-(CH2-)n - CH3, -0-CH3, -0-C2H5, - O-C3H7; and n= 1-30; and wherein the organic cation comprises: (+) (R1,2,3)N - R4-NH-CO-R5 wherein: R1 = H, Alkyl, Aryl, HO-(CH2CH2-O-)n-, MeO-(CH2CH2-O-) n -, HO-(CH2)n-; R2 = H, Alkyl, Aryl, HO-(CH2CH2-O-) n -, MeO-(CH2CH2-O-) n, HO-(CH2)n-; R3 = H, Alkyl, Aryl, -(CH2CH2-O-)-(CH2-)n; R4,5 = H, Alkyl, Aryl, -(CH2CH2-O-)-(CH2-)n -CH3, - 0-CH3, -0-C2H5, -0-C3H7; and n= 1-30; and the anionic polyester is selected from the group consisting of an anionic polyester having at least one carboxylic group, a sulfonic acid polymer, and a phosphoric acid polymer. A medical device having an antimicrobial composition that includes a complex of an anionic polyester with a monomeric amidoamine having at least one amide group and at least one amine group, wherein the amine group is either a primary amine, or a secondary amine, or a tertiary amine, or a quaternary amine, or a combination thereof and the anionic polyester has at least one carboxylic group is also provided.

4. 发明公开

EP2523699A1 ANTIMICROBIAL POLYMER COMPOSITIONS AND THE USE THEREOF 有权
标题翻译：抗微生物聚合物组合物及其
公开(公告)号：EP2523699A1
公开(公告)日：2012-11-21
申请号：EP11701176.7
申请日：2011-01-13
申请人： Ethicon, Inc
发明人： ERNETA, Modesto , DI LUCCIO, Robert
IPC分类号： A61L17/00 , A61L17/10 , A61L17/12 , A61L24/00 , A61L24/04 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/16 , C08K3/00 , C08K3/08 , C08K5/098 , C08L67/04
摘要： An antimicrobial composition comprising an ionic complex of an anionic polyester with an antimicrobial metal, wherein the anionic polyester has an ion exchange capacity from about 0.19 meq/g to about 1.0 meq/g.

5. 发明公开

EP2285863A1 ABSORBABLE COPOLYESTERS OF POLY(ETHOXYETHYLENE DIGLYCOLATE) AND GLYCOLIDE 失效转让
标题翻译：葡聚糖乙二醇（乙氧基乙二醇）
公开(公告)号：EP2285863A1
公开(公告)日：2011-02-23
申请号：EP09735706.5
申请日：2009-04-21
申请人： Ethicon, Inc.
发明人： GENSINI, Michel , ERNETA, Modesto , ANDJELIC, Sasa , ZHOU, Jianguo, Jack
IPC分类号： C08G63/91 , A61L31/06
CPC分类号： A61L17/12 , A61L31/06 , C08G63/664 , C08J3/16 , C08J2367/04 , D01D5/0985 , D01F6/84 , D04H1/435 , D04H1/56 , Y10T442/626 , C08L67/04
摘要： A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres. Additionally, a method of melt blowing an absorbable copolyester composition and a nonwoven construct are disclosed.
摘要翻译：一种半结晶吸收性共聚酯组合物，其包含缩聚聚酯与至少一种内酯的反应产物，其中所述缩聚聚酯包括二甘醇酸和/或其衍生物与二甘醇的反应产物; 共聚聚酯包含基于共聚酯总重量的约30至60重量％的缩聚聚酯。还可以使用包括这种共聚酯和包含这种共聚酯的可吸收微球的可吸收缝合线的医疗装置和制造这种可吸收的微球的方法。另外，公开了一种熔融吹塑可吸收共聚酯组合物和非织造构造物的方法。

6. 发明公开

EP2084229A2 ABSORBABLE COPOLYESTERS OF POLY(ETHOXYETHYLENE DIGLYCOLATE) AND GLYCOLIDE 有权
标题翻译： POLY（ETHOXYETHYLENDIGLYKOLAT）和乙交酯的可吸收共聚酯
公开(公告)号：EP2084229A2
公开(公告)日：2009-08-05
申请号：EP07868602.9
申请日：2007-10-29
申请人： Ethicon, Inc
发明人： ANDJELIC, Sasa , ERNETA, Modesto , GENSINI, Michel
IPC分类号： C08L67/04
CPC分类号： A61L17/12 , A61L31/06 , C08G63/664 , Y10T442/626 , C08L67/04
摘要： A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres.

7. 发明授权

EP2285863B1 ABSORBABLE COPOLYESTERS OF POLY(ETHOXYETHYLENE DIGLYCOLATE) AND GLYCOLIDE 失效转让
标题翻译：聚（乙氧基亚乙基二甘醇酸酯）和乙二醇的可吸收共聚酯
公开(公告)号：EP2285863B1
公开(公告)日：2017-11-15
申请号：EP09735706.5
申请日：2009-04-21
申请人： Ethicon, Inc.
发明人： GENSINI, Michel , ERNETA, Modesto , ANDJELIC, Sasa , ZHOU, Jianguo, Jack
IPC分类号： A61L17/12 , C08J3/16 , C08G63/664 , D04H1/435 , D04H1/56 , D01D5/098 , D01F6/84 , A61L31/06
CPC分类号： A61L17/12 , A61L31/06 , C08G63/664 , C08J3/16 , C08J2367/04 , D01D5/0985 , D01F6/84 , D04H1/435 , D04H1/56 , Y10T442/626 , C08L67/04

8. 发明公开

EP2855583A1 MECHANICALLY STRONG ABSORBABLE POLYMERIC BLEND COMPOSITIONS OF PRECISELY CONTROLLABLE ABSORPTION RATES, PROCESSING METHODS, AND PRODUCTS THEREFROM 有权转让
标题翻译：提供准确的应税吸收速度，加工及制品机械物固定吸收的聚合物共混物组合
公开(公告)号：EP2855583A1
公开(公告)日：2015-04-08
申请号：EP13727745.5
申请日：2013-05-22
申请人： Ethicon, Inc
发明人： ERNETA, Modesto , STEIGER, Daniel , JAMIOLKOWSKI, Dennis D.
IPC分类号： C08L67/04 , A61B17/06 , A61L17/12
CPC分类号： A61L17/12 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/005 , A61L27/26 , A61L27/54 , A61L2300/202 , A61L2300/404 , A61L2300/606 , A61L2430/00 , B29C45/00 , B29C47/00 , B29C49/00 , B29L2031/753 , C08J3/005 , C08J2367/04 , C08J2467/04 , C08L67/04 , Y10T442/10 , Y10T442/3976 , Y10T442/40 , Y10T442/696
摘要： Novel absorbable polymer blends are disclosed. The blends are useful for manufacturing medical devices having engineered degradation and breaking strength retention in vivo. The blends consist of a first absorbable polymeric component and a second absorbable polymeric component. The weight average molecular weight of the first polymeric component is higher than the weight average molecular weight of the second polymeric component. At least at least one of said components is at least partially end-capped by a carboxylic acid group. Further aspects are medical devices made therefrom.

9. 发明授权

EP2197509B1 ANTIMICROBIAL POLYMER COMPOSITIONS AND THE USE THEREOF 有权
标题翻译：抗微生物聚合物组合物及其
公开(公告)号：EP2197509B1
公开(公告)日：2011-04-20
申请号：EP08837962.3
申请日：2008-09-29
申请人： Ethicon, Inc.
发明人： ERNETA, Modesto , PRIEWE, Joerg
IPC分类号： A61L31/06 , A61L31/10 , C08L67/04
CPC分类号： A61L31/06 , A61L31/10 , C08L67/04
摘要： An antimicrobial composition. The antimicrobial composition includes a complex of an anionic polyester with a monomelic amidoamine a complex of an anionic polyester with a monomeric amidoamine or an organic cation, wherein the monomelic amidoamine comprises: (R1,2)N - R3-NH-CO-R4 wherein: R1 = H, Alkyl, Aryl, HO-(CH2CH2-O-)n-, MeO-(CH2CH2-O-)n -, HO-(CH2)n-; R2 = H, Alkyl, Aryl, HO-(CH2CH2-O-) n -, MeO-(CH2CH2-O-) n -, HO-(CH2)n-; R3 = Alkyl, Aryl, -(CH2CH2-O-)-(CH2-)n; R4 = Alkyl, Aryl, -(CH2CH2-O-)-(CH2-)n - CH3, -0-CH3, -0-C2H5, - O-C3H7; and n= 1-30; and wherein the organic cation comprises: (+) (R1,2,3)N - R4-NH-CO-R5 wherein: R1 = H, Alkyl, Aryl, HO-(CH2CH2-O-)n-, MeO-(CH2CH2-O-) n -, HO-(CH2)n-; R2 = H, Alkyl, Aryl, HO-(CH2CH2-O-) n -, MeO-(CH2CH2-O-) n, HO-(CH2)n-; R3 = H, Alkyl, Aryl, -(CH2CH2-O-)-(CH2-)n; R4,5 = H, Alkyl, Aryl, -(CH2CH2-O-)-(CH2-)n -CH3, - 0-CH3, -0-C2H5, -0-C3H7; and n= 1-30; and the anionic polyester is selected from the group consisting of an anionic polyester having at least one carboxylic group, a sulfonic acid polymer, and a phosphoric acid polymer. A medical device having an antimicrobial composition that includes a complex of an anionic polyester with a monomeric amidoamine having at least one amide group and at least one amine group, wherein the amine group is either a primary amine, or a secondary amine, or a tertiary amine, or a quaternary amine, or a combination thereof and the anionic polyester has at least one carboxylic group is also provided.

10. 发明公开

EP2268700A1 COPOLYMERS OF -CAPROLACTONE AND GLYCOLIDE FOR MELT BLOWN NONWOVEN APPLICATIONS 有权
标题翻译：共聚物AUS EPSILON-CAPROLACTON- UND GLYCOLIDFÜRSCHMELZGEBLASENE VLIESANWENDUNGEN
公开(公告)号：EP2268700A1
公开(公告)日：2011-01-05
申请号：EP09734363.6
申请日：2009-04-21
申请人： ETHICON, INC.
发明人： ERNETA, Modesto , JAMIOLKOWSKI, Dennis, D. , ZHOU, Jianguo, Jack , ANDJELIC, Sasa
IPC分类号： C08G63/00
CPC分类号： C08G63/08 , B29C47/0014 , B29C47/385 , B29C47/6087 , B29C47/889 , B29C2947/92514 , B29C2947/9259 , B29C2947/92704 , B29C2947/92885 , B29C2947/92895 , B29C2947/92904 , D04H1/56 , D04H3/02 , D04H3/16 , Y10T442/68
摘要： Copolymers exhibiting the following combinations of properties, including without limitation, ε-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dl_/g as measured in a 0.1 g/dl solution of HFIP at 25
0 C; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein.
摘要翻译：表现出以下组合性能的共聚物，包括但不限于约12至约70摩尔％的乙酸己酯，其量为约30至约88摩尔％，结晶度为约10至约88摩尔％通过DSC测量为50％或通过DSC测量为约10至约50J / g，并且在25℃下以0.1g / dl HFIP溶液测量的特性粘度为约0.5至约1.45dL / g。 ; 本文描述了熔融吹制由其制备的共聚物和非织造构造物的方法。

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