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1. 发明公开

EP2684878A1 DIPYRIDYLAMINE DERIVATIVE 审中-公开
标题翻译： DIPYRIDYLAMINDERIVAT ALS GLUCOKINASE ACTIVATOR
公开(公告)号：EP2684878A1
公开(公告)日：2014-01-15
申请号：EP12754741.2
申请日：2012-03-08
申请人： Daiichi Sankyo Company, Limited
发明人： KANEKO, Satoru , TSURUOKA, Hiroyuki , HONZUMI, Masatoshi , ABE, Manabu , YOSHIDA, Taishi
IPC分类号： C07D401/14 , A61K31/444 , A61K31/506 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P43/00 , C07D413/14
CPC分类号： C07D413/14 , A61K31/444 , A61K31/506 , C07D401/14
摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof:

[wherein,
R 2 represents a C 6 -C 10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, a C 1 -C 6 alkyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group B, or the like; X represents a single bond, an oxygen atom, a sulfur atom, or the like; R 2 represents a C 6 -C 10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, or the like; R 3 represents a 1H-tetrazol-5-yl group or a 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl group; Substituent Group A represents the group of substituents selected from a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 halogenated alkyl group, a hydroxy group, a C 1 -C 6 hydroxyalkyl group, or the like; and, Substituent Group B represents the group of substituents selected from a halogen atom, a C 3 -C 6 cycloalkyl group that may be substituted with one C 1 -C 6 hydroxyalkyl group, a hydroxy group, a C 1 -C 6 alkoxy group, a C 2 -C 7 alkylcarbonyl group, a C 2 -C 7 alkoxycarbonyl group, or the like].
摘要翻译：本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，是由通式（I）表示的化合物或其药理学上可接受的盐：[其中，R 2表示C 6 -C 10芳基可以被独立地选自取代基组A的1至5个基团取代的基团，可以被独立地选自取代基组B的1至5个基团取代的C 1 -C 6烷基等 ; X表示单键，氧原子，硫原子等; R 2表示可以被独立地选自取代基组A的1至5个基团取代的C 6 -C 10芳基等; R 3表示1H-四唑-5-基或5-氧代-4,5-二氢 - [1,2,4]恶二唑-3-基; 取代基组A表示选自卤素原子，C 1 -C 6烷基，C 1 -C 6卤代烷基，羟基，C 1 -C 6羟烷基等的取代基; 并且取代基B代表选自卤素原子，可以被一个C 1 -C 6羟烷基取代的C 3 -C 6环烷基，羟基，C 1 -C 6烷氧基，C 2 -C 7烷基羰基，C 2 -C 7烷氧基羰基等〕。

2. 发明公开

EP3915558A1 SUBSTITUENT-INCLUDING UREA COMPOUND 审中-实审
公开(公告)号：EP3915558A1
公开(公告)日：2021-12-01
申请号：EP20744530.5
申请日：2020-01-23
申请人： Daiichi Sankyo Company, Limited
发明人： KAWAI, Junya , IWAMOTO, Osamu , UMEZAKI, Yuma , NAKAJIMA, Katsuyoshi , TSURUOKA, Hiroyuki , SAITO, Keiji , KURIKAWA, Nobuya , NISHIHAMA, Natsumi , TANAKA, Shinji , OGITANI, Momoko , HONDA, Tomohiro , SAITOH, Wataru , SONEDA, Tsuyoshi , OHKAWA, Nobuyuki
IPC分类号： A61K31/437
摘要： An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases. The present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof.

(Each symbol in Formula (1) has the same definition as that described in the specification.)

3. 发明公开

EP2349997A1 ATROPISOMERS OF (HYDROXYALKYL) PYRROLE DERIVATIVES 有权转让
标题翻译：作者（羟烷基）吡咯阻转异构体
公开(公告)号：EP2349997A1
公开(公告)日：2011-08-03
申请号：EP09737501.8
申请日：2009-10-07
申请人： Exelixis, Inc. , Daiichi Sankyo Company, Limited
发明人： NUSS, John , WILLIAMS, Matthew , MOHAN, Raju , MARTIN, Richard , WANG, Tie-Lin , AOKI, Kazumasa , TSURUOKA, Hiroyuki , HAYASHI, Noriyuki , HOMMA, Tsuyoshi
IPC分类号： C07D207/34 , A61K31/40 , A61P9/00
CPC分类号： C07D207/34
摘要： The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases. The compound is an atropisomer of a compound represented by the following general formula (I ) : wherein R
1 represents a C1-C3 alkyl group; R
2 represents a 2-hydroxy- C4-C6 alkyl group; R
3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R
4 represents a hydrogen atom, a halogeno group and the like; R
5 represents a C1-C3 alkyl group; and R
6 represents a hydrogen atom, a halogeno group and the like] or atropisomers thereof.

4. 发明公开

EP2133330A1 ATROPISOMER OF PYRROLE DERIVATIVE 有权
标题翻译： ATROPISOMER EINES PYRROLDERIVATS
公开(公告)号：EP2133330A1
公开(公告)日：2009-12-16
申请号：EP08740010.7
申请日：2008-04-08
申请人： Daiichi Sankyo Company, Limited
发明人： AOKI, Kazumasa , TSURUOKA, Hiroyuki , HAYASI, Noriyuki , YOSHIDA, Juri , ASOH, Yusuke
IPC分类号： C07D207/34 , A61K31/40 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/12 , A61P43/00
CPC分类号： C07D207/34
摘要： [Object] A prophylactic or therapeutic agent for a cardiovascular disease is provided.
[Means for Resolution] An atropisomer of a compound represented by the following general formula (I):

(wherein R 1 is a C1-C3 alkyl group or a hydroxy-C1-C3 alkyl group; and R 2 is a hydrogen atom or a C1-C3 alkoxy group).
摘要翻译：提供了一种用于心血管疾病的预防或治疗剂。 [解决方法]由以下通式（I）表示的化合物的阻转异构体：（其中R 1是C 1 -C 3烷基或羟基-C 1 -C 3烷基; R 2是氢原子或 C1-C3烷氧基）。

5. 发明授权

EP2349997B1 ATROPISOMERS OF (HYDROXYALKYL) PYRROLE DERIVATIVES 有权转让
标题翻译：作者（羟烷基）吡咯阻转异构体
公开(公告)号：EP2349997B1
公开(公告)日：2015-08-12
申请号：EP09737501.8
申请日：2009-10-07
申请人： Exelixis, Inc. , Daiichi Sankyo Company, Limited
发明人： NUSS, John , WILLIAMS, Matthew , MOHAN, Raju , MARTIN, Richard , WANG, Tie-Lin , AOKI, Kazumasa , TSURUOKA, Hiroyuki , HAYASHI, Noriyuki , HOMMA, Tsuyoshi
IPC分类号： C07D207/34 , A61K31/40 , A61P9/00
CPC分类号： C07D207/34

6. 发明授权

EP2349996B1 1-PHENYLPYRROLE COMPOUNDS 有权转让
标题翻译： 1-苯基吡咯化合物
公开(公告)号：EP2349996B1
公开(公告)日：2014-01-01
申请号：EP09793339.4
申请日：2009-10-07
申请人： Exelixis, Inc. , Daiichi Sankyo Company, Limited
发明人： NUSS, John , WILLIAMS, Matthew , MOHAN, Raju , MARTIN, Richard , WANG, Tie-lin , TSURUOKA, Hiroyuki , AOKI, Kazumasa , HONZUMI, Masatoshi , ASOH, Yusuke , SAITO, Keiji , HOMMA, Tsuyoshi
IPC分类号： C07D207/34 , C07D207/335 , A61K31/405 , A61P9/12 , A61P9/10 , A61P13/12 , A61P5/42 , A61P7/10
CPC分类号： C07D207/34

7. 发明授权

EP2133330B1 ATROPISOMER OF PYRROLE DERIVATIVE 有权
标题翻译：吡咯的阻转
公开(公告)号：EP2133330B1
公开(公告)日：2014-01-01
申请号：EP08740010.7
申请日：2008-04-08
申请人： Daiichi Sankyo Company, Limited
发明人： AOKI, Kazumasa , TSURUOKA, Hiroyuki , HAYASHI, Noriyuki , YOSHIDA, Juri , ASOH, Yusuke
IPC分类号： C07D207/34 , A61K31/40 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/12 , A61P43/00
CPC分类号： C07D207/34
摘要： [Object] A prophylactic or therapeutic agent for a cardiovascular disease is provided. [Means for Resolution] An atropisomer of a compound represented by the following general formula (I): (wherein R 1 is a C1-C3 alkyl group or a hydroxy-C1-C3 alkyl group; and R 2 is a hydrogen atom or a C1-C3 alkoxy group).

8. 发明公开

EP2349996A1 1-PHENYLPYRROLE COMPOUNDS 有权转让
标题翻译： 1-苯基吡咯化合物
公开(公告)号：EP2349996A1
公开(公告)日：2011-08-03
申请号：EP09793339.4
申请日：2009-10-07
申请人： Exelixis, Inc. , Daiichi Sankyo Company, Limited
发明人： NUSS, John , WILLIAMS, Matthew , MOHAN, Raju , MARTIN, Richard , WANG, Tie-lin , TSURUOKA, Hiroyuki , AOKI, Kazumasa , HONZUMI, Masatoshi , ASOH, Yusuke , SAITO, Keiji , HOMMA, Tsuyoshi
IPC分类号： C07D207/335 , A61K31/405 , A61P9/12 , A61P9/10 , A61P13/12 , A61P5/42 , A61P7/10
CPC分类号： C07D207/34
摘要： The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein R
1 represents a C1 -C3 alkyl group; R
2 represents a hydroxy -C1 -C4 alkyl group and the like; R
3 represents a halogeno group, a halogeno-C1 -C3 alkyl group and the like; R
4 represents a hydrogen atom, a halogeno group and the like,- R
5 represents a sulfamoyl group or a C1-C3 alkylsulf onyl group; R
6 represents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing.
摘要翻译：本发明包含用于预防和/或治疗心血管疾病，肾病，纤维化，原发性醛固酮增多症或水肿的化合物。该化合物具有以下通式（I）：其中R 1代表C 1 -C 3烷基; R 2表示羟基-C 1 -C 4烷基等; R 3表示卤代基，卤代-C 1 -C 3烷基等; R 4表示氢原子，卤代基等，-R 5表示氨磺酰基或C 1 -C 3烷基磺酰基， R 6表示氢原子，卤代基等]或前述的N-氧化物，阻转异构体或前述的药学上可接受的盐。

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