专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3848054A1 NOVEL CYCLIC DINUCLEOTIDE DERIVATIVE AND ANTIBODY-DRUG CONJUGATE THEREOF 审中-实审
公开(公告)号：EP3848054A1
公开(公告)日：2021-07-14
申请号：EP19857433.7
申请日：2019-09-06
申请人： Daiichi Sankyo Company, Limited
发明人： TSUDA, Toshifumi , TABUCHI, Toshiki , WATANABE, Hideaki , KOBAYASHI, Hiroyuki , ISHIZAKI, Masayuki , HARA, Kyoko , WADA, Teiji , ARAI, Masami
IPC分类号： A61K47/68 , A61K31/7084 , A61K47/65 , A61P35/00 , A61P35/02 , A61P43/00 , C07H21/02 , C07K16/00
摘要： Desired is development of novel CDN derivatives having STING agonist activity; and a therapeutic agents and/or therapeutic methods using the novel CDN derivatives for diseases associated with STING agonist activity. Further desired is development of a therapeutic agents and/or therapeutic methods capable of delivering the novel CDN derivatives specifically to targeted cells and organs for diseases associated with STING agonist activity. The present invention provides novel CDN derivatives having potent STING agonist activity, and antibody-CDN derivative conjugates including the novel CDN derivatives.

2. 发明公开

EP3144300A1 METHODS OF PRODUCING 4-CYCLOALKYLOXYBENZENESULFONAMIDES 有权
标题翻译：生产4-环烷氧基苯磺酰胺的方法
公开(公告)号：EP3144300A1
公开(公告)日：2017-03-22
申请号：EP16193142.3
申请日：2013-02-08
申请人： Daiichi Sankyo Company, Limited
发明人： SHINOZUKA, Tsuyoshi , KOBAYASHI, Hiroyuki , SUZUKI, Sayaka , TANAKA, Kyosuke , KIMOTO, Hiroko , DOMON, Yuki
IPC分类号： C07D285/08 , C07D417/12 , C07D403/12 , C07D401/12
CPC分类号： C07D403/12 , C07B2200/13 , C07D285/08 , C07D401/12 , C07D417/12 , Y02P20/55
摘要： A method of producing a compound of formula (I) or a pharmacologically acceptable salt thereof, useful as a therapeutic agent and/or a preventive agent for pain or for a sodium channel associated disease:

Ar 1 and Ar 2 : a heteroaryl group or an aryl group, each optionally substituted; R 1 , R 2 and R 3 : a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group or a C3-C7 cycloalkyl group or a cyano group; R 4 and R 5 : a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group or a C1-C6 alkoxy group; and n: an integer of 1 to 3, comprising a step of removing a protecting group P from the compound of formula (VI):

or a step of reacting a compound of formula (X) and a compound of formula (XI) :

wherein X represents a halogen atom.
摘要翻译：制备用作疼痛或钠通道相关疾病的治疗剂和/或预防剂的式（I）化合物或其药理学上可接受的盐的方法：Ar 1和Ar 2：杂芳基或芳基，各自任选被取代; R 1，R 2和R 3：氢原子，卤素原子，C 1 -C 6烷基，卤代C 1 -C 6烷基，羟基C 1 -C 6烷基，C 1 -C 6烷氧基C 1 -C 6烷基或C 3 -C7环烷基或氰基; R 4和R 5：氢原子，卤素原子，C 1 -C 6烷基，卤代C 1 -C 6烷基，羟基，羟基C 1 -C 6烷基，C 1 -C 6烷氧基C 1 -C 6烷基， C3-C7环烷基或C1-C6烷氧基; 并且n为1至3的整数，所述方法包括从式（VI）化合物除去保护基团P的步骤或使式（X）化合物与式（XI）化合物反应的步骤：其中 X代表卤素原子。

3. 发明授权

EP3144300B1 METHODS OF PRODUCING 4-CYCLOALKYLOXYBENZENESULFONAMIDES 有权
标题翻译：生产4-环烷氧基苯磺酰胺的方法
公开(公告)号：EP3144300B1
公开(公告)日：2017-12-20
申请号：EP16193142.3
申请日：2013-02-08
申请人： Daiichi Sankyo Company, Limited
发明人： SHINOZUKA, Tsuyoshi , KOBAYASHI, Hiroyuki , SUZUKI, Sayaka , TANAKA, Kyosuke , KIMOTO, Hiroko , DOMON, Yuki
IPC分类号： C07D285/08 , C07D417/12 , C07D403/12 , C07D401/12
CPC分类号： C07D403/12 , C07B2200/13 , C07D285/08 , C07D401/12 , C07D417/12 , Y02P20/55
摘要： It is intended to provide a therapeutic agent and/or a preventive agent for pain or a therapeutic agent and/or a preventive agent for a sodium channel associated disease. The present invention provides a compound represented by the following formula (I) or a pharmacologically acceptable salt thereof: Ar 1 and Ar 2 : a heteroaryl group or an aryl group; R 1 , R 2 and R 3 : a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group or a C3-C7 cycloalkyl group or a cyano group; R 4 and R 5 : a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group or a C1-C6 alkoxy group; n: an integer of 1 to 3; and the heteroaryl group or the aryl group optionally has one or two groups independently selected from a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group, a carboxyl group, a cyano group, an amino group, a C1-C3 alkylamino group and a di-Cl-C3 alkylamino group, and when the heteroaryl group or the aryl group has two such groups, the two groups are the same as or different from each other.

4. 发明授权

EP2813491B1 CYCLOALKANE DERIVATIVE 有权转让
标题翻译： CYCLO的烷衍生物
公开(公告)号：EP2813491B1
公开(公告)日：2016-11-02
申请号：EP13746373.3
申请日：2013-02-08
申请人： Daiichi Sankyo Company, Limited
发明人： SHINOZUKA, Tsuyoshi , KOBAYASHI, Hiroyuki , SUZUKI, Sayaka , TANAKA, Kyosuke , KIMOTO, Hiroko , DOMON, Yuki
IPC分类号： C07D285/08 , C07D417/12 , C07D403/12 , C07D401/12 , A61K31/433 , A61K31/427 , A61K31/506 , A61P29/00 , A61P25/00
CPC分类号： C07D403/12 , C07B2200/13 , C07D285/08 , C07D401/12 , C07D417/12 , Y02P20/55
摘要： It is intended to provide a therapeutic agent and/or a preventive agent for pain or a therapeutic agent and/or a preventive agent for a sodium channel associated disease. The present invention provides a compound represented by the following formula (I) or a pharmacologically acceptable salt thereof: Ar 1 and Ar 2 : a heteroaryl group or an aryl group; R 1 , R 2 and R 3 : a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group or a C3-C7 cycloalkyl group or a cyano group; R 4 and R 5 : a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group or a C1-C6 alkoxy group; n: an integer of 1 to 3; and the heteroaryl group or the aryl group optionally has one or two groups independently selected from a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group, a carboxyl group, a cyano group, an amino group, a C1-C3 alkylamino group and a di-Cl-C3 alkylamino group, and when the heteroaryl group or the aryl group has two such groups, the two groups are the same as or different from each other.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式