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    • 2. 发明公开
    • Matrix for transdermal drug release
    • Matrixfürdie transdermale Abgabe von Arzneimitteln。
    • EP0338819A2
    • 1989-10-25
    • EP89303914.9
    • 1989-04-20
    • DOW CORNING CORPORATION
    • Sweet, Randall PaulLee, Chi-LongGornowicz, Gerald Alphonse
    • A61K9/70A61M35/00C08G18/61
    • A61K9/7069A61L15/58C08G18/61C08L83/04
    • A transdermal drug delivery system, is provided which includes, in combination, an impermeable backing member, a matrix containing a medicinally active ingredient, and a pressure sensitive adhesive for affixing the system to the skin of a patient; the improvement in such system is based on the fact that said matrix is drug permeable (including to hydrophilic drugs) and is formed of a copolymer which can be softened sufficiently at temperature between 45°C. and 160°C. to incorporate the drugs therein without damage caused by heat or chemical reactions, the matrix being formed of a substantially linear block copolymer which is a reaction product of a polydiorganosiloxane which forms "soft" segments in said reaction product and a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 45°C. and 160°C., said soft segments comprising from 80 to 99 percent by weight, based on the weight of said copolymer, the average molecular weight of the copolymer being between 15,000 and 500,000.
    • 提供了一种透皮药物递送系统,其组合包括不渗透背衬构件,含有药物活性成分的基质和用于将该系统固定在患者皮肤上的压敏粘合剂; 该系统的改进是基于以下事实:所述基质是药物可渗透的(包括亲水性药物),并由共聚物形成,该共聚物可在45℃至160℃之间的温度下充分软化以将药物并入其中 不受热或化学反应引起的损伤,该基质由基本上线性的嵌段共聚物形成,该嵌段共聚物是在所述反应产物中形成“软”链段的聚二有机硅氧烷与形成“硬”链段的二异氰酸酯的反应产物,所述共聚物具有 玻璃化转变温度在45℃至160℃之间,所述软链段占所述共聚物重量的80至99重量%,共聚物的平均分子量在15,000至500,000之间。
    • 6. 发明公开
    • Low-viscosity pressure-adherent silicone elastomer compositions
    • Niedrigviskoser,druckempfindlicher,elastomerer Klebstoff auf der Basis von Siloxanen。
    • EP0360516A2
    • 1990-03-28
    • EP89309428.4
    • 1989-09-18
    • DOW CORNING CORPORATION
    • Sweet, Randall PaulMiller, Patrick JohnMetevia, Virgil Leroy
    • C09J183/04A61L15/00
    • A61K9/7069A61L15/585C08L83/00C09J183/04C08L83/04
    • A pressure-adherent silicone elastomer composition comprising a homogeneous mixture of a silicone pressure sensitive adhesive composition, a crosslinkable silicone elastomer composition and, optionally, a viscosity reducing agent. Specifically, the silicone pressure sensitive adhesive composition is a condensation product, having a plasticity of less than 200 mils, of a benzene-soluble resinous copolymer containing silicon-bonded hydroxyl radicals and consisting essentially of triorganosiloxy units of the formula R₃SiO 1/2 and tetrafunctionalsiloxy units of the formula SiO 4/2 in a ratio of about 0.6 to 0.9 triorganosiloxy units for each tetrafunctionalsiloxy unit present in the copolymer and a polydiorganosiloxane having a viscosity from 100 centipoise to 50,000 centipoise at 25°C.
    • 一种压敏粘合有机硅弹性体组合物,其包含硅氧烷压敏粘合剂组合物,可交联硅氧烷弹性体组合物和任选的粘度降低剂的均匀混合物。 具体地,硅氧烷压敏粘合剂组合物是具有小于200密耳的可塑性的缩合产物,其含有硅键合羟基的苯可溶性树脂共聚物并且基本上由式R3SiO1 / 2的三有机甲硅烷氧基单元和四官能甲硅烷氧基单元组成 对于共聚物中存在的每个四官能团甲硅烷氧基单元,比例为约0.6至0.9的三有机甲硅烷氧基单元的式SiO 4/2,和在25℃粘度为100厘泊至50,000厘泊的聚二有机硅氧烷
    • 7. 发明公开
    • Silicone pressure sensitive adhesive composition containing thermoplastic multi-segmented copolymer
    • Silikon Haftkleber-Zusammensetzung enthaltend thermoplastische,mehrfach segmentierte Copolymere。
    • EP0667382A1
    • 1995-08-16
    • EP95300756.4
    • 1995-02-08
    • DOW CORNING CORPORATION
    • Sweet, Randall PaulUlman, Katherine Lynn
    • C09J183/04C09J7/00
    • C09J183/02C08L83/00C09J183/04
    • A pressure sensitive adhesive composition comprises a mixture of (A) a silicate resin, (B) a silicone fluid, and (C) a thermoplastic multi-segmented copolymer which is a product of the reaction between a diisocyanate and a reactive polyorganosiloxane having two groups reactive with isocyanate thereon. The thermoplastic multi-segmented copolymer comprises from 1 to 40 weight percent hard segments, derived from reactants selected from organic diisocyanates, organic diols and organic diamines, and from 60 to 99 weight percent soft segments, comprising from 15 to 99 weight percent, based on the weight of the thermoplastic multi-segmented copolymer, of polyorganosiloxane units, and from O to 70 weight percent, based on the weight of the thermoplastic multi-segmented copolymer, of polyalkylene oxide units.
    • 压敏粘合剂组合物包含(A)硅酸酯树脂,(B)硅氧烷流体和(C)热塑性多链段共聚物的混合物,其是二异氰酸酯与具有两个基团的反应性聚有机硅氧烷之间的反应的产物 与其上的异氰酸酯反应。 热塑性多分段共聚物包含1至40重量%的硬链段,衍生自选自有机二异氰酸酯,有机二醇和有机二胺的反应物,以及60至99重量%的软链段,包含15至99重量%,基于 热塑性多分段共聚物,聚有机硅氧烷单元的重量,基于热塑性多链段共聚物的重量,从0-70重量%的聚环氧烷单元。