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1. 发明公开

EP2847338A4 METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED TARGETED INTEGRATION OF TRANSGENES 有权转让
标题翻译： FOR NUKLEASEVERMITTELTEN方法和的组合物靶向转基因整合
公开(公告)号：EP2847338A4
公开(公告)日：2015-12-09
申请号：EP13788413
申请日：2013-05-07
申请人： SANGAMO BIOSCIENCES INC , DOW AGROSCIENCES LLC
发明人： COST GREGORY J , URNOV FYODOR , AINLEY WILLIAM M , PETOLINO JOSEPH F , SAMUEL JAYAKUMAR PON , WEBB STEVEN R , SASTRY-DENT LAKSHMI
IPC分类号： C12N15/87 , C12N5/10 , C12N15/00
CPC分类号： C12N15/8201 , C12N15/102 , C12N15/8209 , C12N15/8213 , C12N15/8216 , C12N15/8241 , C12N15/8247 , C12N15/8274 , C12N15/8278 , C12N15/8286 , C12N15/85 , C12N15/87 , C12N2800/80 , Y02A40/162
摘要： Disclosed herein are methods and compositions for homology-independent targeted insertion of donor molecules into the genome of a cell.
摘要翻译：公开在用于同源性无关的目标供体分子的插入细胞的基因组中的方法和组合物。

2. 发明公开

EP2981166A4 METHODS AND COMPOSITIONS FOR INTEGRATION OF AN EXOGENOUS SEQUENCE WITHIN THE GENOME OF PLANTS 有权转让
标题翻译：方法和组合物外源序列在植物的基因组整合
公开(公告)号：EP2981166A4
公开(公告)日：2017-03-01
申请号：EP14778180
申请日：2014-04-02
申请人： DOW AGROSCIENCES LLC , SANGAMO BIOSCIENCES INC
发明人： AINLEY W MICHAEL , GUSCHIN DMITRY Y , HAYDEN MATTHEW , ISENEGGER DANIEL , MASON JOHN , MILLER JEFFREY C , PETOLINO JOSEPH F , RAN YIDONG , SAWBRIDGE TIM , SPANGENBERG GERMAN , WEBB STEVEN R
IPC分类号： A01H1/00
CPC分类号： C12N15/8213 , C12N15/8274 , C12N15/8278 , C12N15/90 , C12N2800/80
摘要： Disclosed herein are methods and compositions for parallel or sequential transgene stacking in plants to produce plants with selected phenotypes.
摘要翻译：公开在用于并行或顺序堆叠的转基因植物，以产生与选定的表型的植物的方法和组合物。

3. 发明公开

EP2491127A4 ENGINEERED ZINC FINGER PROTEINS TARGETING PLANT GENES INVOLVED IN FATTY ACID BIOSYNTHESIS 有权转让
标题翻译：工业自动化ZINKFINGERPROTEINE ZUR ABZIELUNG AUF在FETUREURE BIOSYNTHESE INVOLVITETE PFLANZENGENE
公开(公告)号：EP2491127A4
公开(公告)日：2013-04-03
申请号：EP10825333
申请日：2010-10-22
申请人： DOW AGROSCIENCES LLC , SANGAMO BIOSCIENCES INC
发明人： DEKELVER RUSSELL , GUPTA MANJU , MILLER JEFFREY C , NOVAK STEPHEN , PETOLINO JOSEPH F
IPC分类号： C12N15/82 , A01H5/00 , C12N5/04
CPC分类号： C12N15/8218 , C07K14/415 , C12N9/22 , C12N15/8216 , C12N15/8247 , C12Y203/01041 , C12Y301/00
摘要： The present dislosure relates to engineered zinc finger proteins that target genes in plants involved in fatty acid biosynthesis. Methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification are also provided.
摘要翻译：本发明涉及到涉及脂肪酸生物合成的植物中的基因的工程化锌指蛋白。还提供了使用这种锌指蛋白调节基因表达，基因失活和靶向基因修饰的方法。

4. 发明公开

EP2525649A4 EXCISION OF TRANSGENES IN GENETICALLY MODIFIED ORGANISMS 有权转让
标题翻译：遗传转化生物体系中的维生素转运蛋白（EXZISION VON TRANSGENEN IN GENETISCH MODIFIZITENTEN ORGANISMEN）
公开(公告)号：EP2525649A4
公开(公告)日：2013-07-31
申请号：EP11735267
申请日：2011-01-21
申请人： DOW AGROSCIENCES LLC
发明人： RUSSELL SEAN , PETOLINO JOSEPH F
IPC分类号： A01H5/00 , C12N9/22 , C12N15/29 , C12N15/82
CPC分类号： C12N15/8213 , A01H1/02 , C12N9/22 , C12N15/8241 , C12N15/8265
摘要： A method for deleting a region of DNA in a plant. In some embodiments, the method comprises transforming a plant with a nucleic acid molecule, wherein the nucleic acid molecule encodes one or more zinc finger nuclease(s) (ZFNs) operably linked to one or more tissue-specific promoter(s), e.g., a pollen-specific promoter. Methods include excising native genes in a plant. Accordingly, in some embodiments, ZFNs are engineered that recognize sequences that flank native plant genes. In further embodiments, ZFNs are expressed under the control of developmental stage-specific promoters, such that, for example, nucleic acid sequences are specifically excised in plants during relatively late stages of development. Nucleic acid molecules useful for carrying out disclosed methods and plants produced by the methods are included.
摘要翻译：一种删除植物中DNA区域的方法。在一些实施方案中，所述方法包括用核酸分子转化植物，其中所述核酸分子编码与一种或多种组织特异性启动子可操作地连接的一个或多个锌指核酸酶（ZFN），例如，花粉特异性启动子。方法包括在植物中切除天然基因。因此，在一些实施方案中，ZFN被工程化以识别与天然植物基因相邻的序列。在进一步的实施方案中，ZFN在发育阶段特异性启动子的控制下表达，使得例如在相对较晚的发育阶段在植物中特异性切除核酸序列。包括用于实施所公开的方法的核酸分子和通过该方法生产的植物。

5. 发明公开

EP3136842A4 HAPLOID MAIZE TRANSFORMATION 审中-公开
公开(公告)号：EP3136842A4
公开(公告)日：2017-11-29
申请号：EP15785964
申请日：2015-04-24
申请人： DOW AGROSCIENCES LLC
发明人： PETOLINO JOSEPH F , STRANGE TONYA L , SAMUEL JAYAKUMAR PON , BLUE RYAN C , SIMPSON MATTHEW A
IPC分类号： A01H5/00 , C12N15/82 , C12N15/87
CPC分类号： C12N15/8213
摘要： Disclosed are methods for transformation of an androgenic-derived, haploid cell line with a site-specific nuclease. In some embodiments, the androgenic-derived, haploid cell line is a maize microspore-derived plant tissue culture. In addition, the disclosure provides a method for modifying, e.g., by mutating or targeting and integrating donor DNA into, a specific locus of a haploid or dihaploid tissue genome. The disclosure further provides methods for regenerating a whole plant from the haploid or dihaploid tissue that contains either the mutation at a specific genomic locus or a donor DNA integrated within a specific genomic locus may be obtained from the subject disclosure.

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