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2. 发明公开

EP3231412A3 AQUEOUS DENTAL GLASS IONOMER COMPOSITION 审中-实审
标题翻译：水性牙科玻璃离聚体组合物
公开(公告)号：EP3231412A3
公开(公告)日：2017-10-25
申请号：EP16169725.5
申请日：2016-05-13
申请人： DENTSPLY DETREY GmbH , Dentsply Sirona Inc.
发明人： RENN, Caroline , ELSNER, Oliver , MAIER, Maximilian , SZILLAT, Florian , KLEE, Joachim E. , WEBER, Christoph , WALZ, Uwe , SCHEUFLER, Christian , RITTER, Helmut , LICHKUS, Andrew Murray , JIN, Xiaoming
IPC分类号： A61K6/083
CPC分类号： A61K6/0835 , C08L33/00 , C08L33/10 , C08L33/08
摘要： The present invention relates to an aqueous dental glass ionomer composition comprising
(A) a reactive particulate glass,
(B) a water-soluble, polymerizable polymer comprising acidic groups, which is reactive with the particulate glass in a cement reaction, whereby the polymerizable polymer has a polymer backbone and pendant groups having one or more polymerizable carbon-carbon double bonds, wherein the polymerizable polymer is obtainable by a process comprising
a) a step of polymerizing a mixture comprising
(i) a first polymerizable monomer comprising at least one optionally protected carboxylic acid group and a first polymerizable organic moiety, and optionally
(ii) a second copolymerizable monomer comprising one or more optionally protected primary and/or secondary hydroxyl and/or amino group(s) and a second polymerizable organic moiety, for obtaining an water-soluble polymer;

b) a step of coupling to the water-soluble polymer a compound having a polymerizable moiety and a functional group reactive with an optionally protected carboxylic acid group of repeating units derived from the first polymerizable monomer or an optionally protected hydroxyl and/or amino group of repeating units derived from the second copolymerizable monomer in the water-soluble polymer obtained in step a), wherein the optionally protected carboxylic acid group and the optionally protected hydroxyl and/or amine group are deprotected, so that polymerizable pendant groups are linked to the backbone by ester groups, urethane groups and/or amide groups,
and, optionally, a step of deprotecting the protected carboxylic acid group after step a) or step b), for obtaining a polymerizable polymer;
(C) a hydrolysis-stable, water-soluble monomer having a single polymerizable double bond and optionally a carboxylic acid group or hydroxyl group; and
(D) a polymerization initiator system.
摘要翻译：本发明涉及含水牙科玻璃离聚物组合物，其包含（A）反应性颗粒状玻璃，（B）包含酸性基团的水溶性可聚合聚合物，其在水泥反应中与颗粒玻璃反应，由此可聚合聚合物具有一个或多个可聚合碳 - 碳双键的聚合物骨架和侧基，其中所述可聚合聚合物可通过包括以下步骤的方法获得：a）聚合包含以下的混合物的步骤：（i）第一可聚合单体，其包含至少一个任选保护的（ii）包含一个或多个任选保护的伯羟基和/或仲羟基和/或氨基和第二可聚合有机部分的第二可共聚单体以获得水可溶性聚合物; b）将具有可聚合部分和官能团的化合物偶联到水溶性聚合物的步骤，所述官能团与由第一可聚合单体衍生的重复单元或任选被保护的羟基和/或氨基的任选保护的羧酸基团反应在步骤a）中获得的水溶性聚合物中衍生自第二可共聚单体的重复单元，其中将任选保护的羧酸基团和任选保护的羟基和/或胺基团脱保护，使得可聚合侧基连接至主链通过酯基团，氨基甲酸酯基团和/或酰胺基团，以及任选地，在步骤a）或步骤b）之后对被保护的羧酸基团进行脱保护以获得可聚合聚合物的步骤; （C）具有单一可聚合双键和任选的羧酸基团或羟基的水解稳定的水溶性单体; 和（D）聚合引发剂体系。

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