专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明公开

EP3374504A2 OPTIMIZED NUCLEIC ACID MOLECULES 审中-公开
公开(公告)号：EP3374504A2
公开(公告)日：2018-09-19
申请号：EP16794593.0
申请日：2016-11-09
申请人： CureVac AG
发明人： BAUMHOF, Patrick , RAUCH, Susanne , KOWALCZYK, Aleksandra , LUTZ, Johannes , JASNY, Edith , PETSCH, Benjamin , THESS, Andreas , SCHLAKE, Thomas , FOTIN-MLECZEK, Mariola , HEIDENREICH, Regina , LAZZARO, Sandra , DÖNER, Fatma , GROßE, Wolfgang
IPC分类号： C12N15/00 , A61K48/00 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/575 , C07K14/205 , C07K2319/00 , C07K2319/40 , C12N15/00 , C12N2760/16122 , C12N2760/16134
摘要： The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g. selected among nucleic acid moieties encoding a polypeptide element, such as a secretory signal peptide (SSP), a multimerization element (dimerization, trimerization, tetramerization and oligomerization), a virus like particle (VLP) forming element, a transmembrane element, a dendritic cell targeting element, an immunological adjuvant element, an element promoting antigen presentation; a 2A peptide; a peptide linker element, elements that extend protein half-life, and/or any other polypeptide or protein. Non-coding nucleic acid moieties may be selected e.g. from the group comprising 3′-UTR, 5′-UTR, IRES element, miRNA moiety, histone stem loop, poly(C) sequence, polyadenylation signal, polyA-sequence. The optimized nucleic acid molecule can further be characterized by the presence of at least one modified nucleoside. The versatility of the present invention allows for rational design of a large variety of different nucleic acid molecules with desired properties.

3. 发明公开

EP3781591A1 NOVEL RSV RNA MOLECULES AND COMPOSITIONS FOR VACCINATION 审中-公开
公开(公告)号：EP3781591A1
公开(公告)日：2021-02-24
申请号：EP19719234.7
申请日：2019-04-17
申请人： CureVac AG
发明人： LUTZ, Johannes , RAUCH, Susanne , HEIDENREICH, Regina , PETSCH, Benjamin
IPC分类号： C07K16/10 , C12N15/67

4. 发明公开

EP3233113A1 EBOLAVIRUS AND MARBURGVIRUS VACCINES 审中-公开
标题翻译： EBAVAVIRUS和MARBURGVIRUS疫苗
公开(公告)号：EP3233113A1
公开(公告)日：2017-10-25
申请号：EP15813814.9
申请日：2015-12-16
申请人： CureVac AG
发明人： RAUCH, Susanne , JASNY, Edith
IPC分类号： A61K39/00 , A61K39/12 , C12N15/67
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/575 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2760/14134 , C12N2760/14234 , C12N2830/50
摘要： The present invention relates to an mRNA sequence, comprising a coding region, encoding at least one antigenic peptide or protein derived from the glycoprotein (GP) and/or the matrix protein 40 (VP40) and/or the nucleoprotein (NP) of a virus of the genus Ebolavirus or Marburgvirus or a fragment, variant or derivative thereof. Additionally, the present invention relates to a composition comprising a plurality of mRNA sequences comprising a coding region, encoding at least one antigenic peptide or protein derived from the glycoprotein (GP) and/or the matrix protein 40 (VP40) and/or the nucleoprotein (NP) of a virus of the genus Ebolavirus or Marburgvirus or a fragment, variant or derivative thereof. Furthermore it also discloses the use of the mRNA sequence or the composition comprising a plurality of mRNA sequences for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the prophylaxis or treatment of Ebolavirus or Marburgvirus infections. The present invention further describes a method of treatment or prophylaxis of Ebolavirus or Marburgvirus infections using the mRNA sequence.
摘要翻译：本发明涉及包含编码至少一种衍生自糖蛋白（GP）和/或基质蛋白40（VP40）和/或病毒核蛋白（NP）的抗原性肽或蛋白质的编码区的mRNA序列埃博拉病毒属或马尔堡病毒属或其片段，变体或衍生物。另外，本发明涉及包含多个mRNA序列的组合物，所述mRNA序列包含编码衍生自糖蛋白（GP）和/或基质蛋白40（VP40）的至少一种抗原性肽或蛋白质的编码区和/或核蛋白（NP）埃博拉病毒属或马尔堡病毒属的病毒或其片段，变体或衍生物。此外，它还公开了mRNA序列或包含多个mRNA序列的组合物用于制备药物组合物，特别是疫苗例如人血清白蛋白的用途。用于预防或治疗埃博拉病毒或马尔堡病毒感染。本发明进一步描述了使用mRNA序列治疗或预防埃博拉病毒或马尔堡病毒感染的方法。

5. 发明公开

EP3986452A1 ROTAVIRUS MRNA VACCINE 审中-公开
公开(公告)号：EP3986452A1
公开(公告)日：2022-04-27
申请号：EP20732947.5
申请日：2020-06-18
申请人： CureVac AG
发明人： RAUCH, Susanne , ROIER, Sandro , PETSCH, Benjamin
IPC分类号： A61K39/12 , A61K38/00 , A61K39/15 , A61P31/14 , C12N15/62 , A61K39/00

6. 发明公开

EP3773702A2 NOVEL YELLOW FEVER NUCLEIC ACID MOLECULES FOR VACCINATION 审中-公开
公开(公告)号：EP3773702A2
公开(公告)日：2021-02-17
申请号：EP19715918.9
申请日：2019-04-05
申请人： CureVac AG
发明人： LUTZ, Johannes , RAUCH, Susanne , HEIDENREICH, Regina , PETSCH, Benjamin
IPC分类号： A61K39/12 , C12N15/67 , A61P31/14

7. 发明公开

EP3558356A2 MERS CORONAVIRUS VACCINE 审中-公开
公开(公告)号：EP3558356A2
公开(公告)日：2019-10-30
申请号：EP17837886.5
申请日：2017-12-22
申请人： CureVac AG
发明人： RAUCH, Susanne
IPC分类号： A61K39/215 , C07K14/165 , A61K39/00

8. 发明公开

EP3993828A1 NUCLEIC ACID BASED COMBINATION VACCINES 审中-实审转让
公开(公告)号：EP3993828A1
公开(公告)日：2022-05-11
申请号：EP21729297.8
申请日：2021-05-27
申请人： CureVac AG
发明人： OOSTVOGELS, Cornelia , PETSCH, Benjamin , RAUCH, Susanne , SCHWENDT, Kim Ellen
IPC分类号： A61K39/12 , A61P31/12 , A61P31/14 , A61K39/00

9. 发明公开

EP3886897A1 CORONAVIRUS VACCINE 审中-实审转让
公开(公告)号：EP3886897A1
公开(公告)日：2021-10-06
申请号：EP21704439.5
申请日：2021-02-03
申请人： CureVac AG
发明人： RAUCH, Susanne , GROSSE, Hans Wolfgang , PETSCH, Benjamin
IPC分类号： A61K39/12 , A61K39/215 , A61P11/00 , A61P31/14

10. 发明公开

EP3452493A1 NUCLEIC ACID MOLECULES AND USES THEREOF 审中-实审转让
公开(公告)号：EP3452493A1
公开(公告)日：2019-03-13
申请号：EP17725524.7
申请日：2017-05-04
申请人： CureVac AG
发明人： RAUCH, Susanne , SCHMIDT, Kim Ellen , PETSCH, Benjamin
IPC分类号： C07K14/005

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式