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1. 发明公开

EP2116256A1 TRANSDERMAL IMMUNE PREPARATION, METHOD FOR PRODUCTION OF THE SAME, AND TRANSDERMAL IMMUNIZATION METHOD USING THE SAME 审中-公开
标题翻译：变形金刚IMMUNPRÄPARAT，VERFAHREN ZU SEINER HERSTELLUNG UND TRANSDERMALES IMMUNISIERUNGSVERFAHREN DAMIT
公开(公告)号：EP2116256A1
公开(公告)日：2009-11-11
申请号：EP08712105.9
申请日：2008-02-28
申请人： Cosmed Pharmaceutical Co., Ltd. , Osaka University
发明人： NAKAGAWA, Shinsaku , OKADA, Naoki , FUJITA, Takuya , KAMIYAMA, Fumio , QUAN, Ying-shu
IPC分类号： A61K39/02 , A61K9/70 , A61K31/7088 , A61K39/00 , A61K39/002 , A61K39/12 , A61K39/35 , A61K39/39 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/36 , A61P37/04 , A61P43/00
CPC分类号： A61K31/7088 , A61K9/7053 , A61K9/7061 , A61K39/00 , A61K39/12 , A61K39/235 , A61K39/292 , A61K39/35 , A61K48/0041 , A61K48/005 , A61K48/0075 , A61K2039/53 , A61K2039/54 , A61K2039/555 , C12N2710/10034 , C12N2730/10134
摘要： This invention is concernced with transdermal immune preparations which can exhibit a high immunological activity without containing any adjuvant, methods for producing the preparation, and transdermal immunization methods using the preparation.
The transdermal immune preparations can regulate the immune response by applying the preparation to an intact skin, and which comprises a base material and an antigen or artificial synthetic nucleic acid laminated on the surface of the base material; the methods for producing transdermal immune preparations which comprises putting drops of an aqueous solution or suspension prepared by dissolving or suspending an antigen in water or a water-containing alcohol on the surface of a base material in order for the water or the water-containing alcohol to be absorbed in the base material, thereby forming an layer containing the antigen in a concentrated state on the surface of the base material; and the transdermal immunization methods which is haracterized by applying the transdermal immune preparation to an intact skin to regulate the immune response.
摘要翻译：本发明涉及可以在不含任何佐剂的情况下表现出高免疫学活性的透皮免疫制剂，制备该制剂的方法和使用该制剂的透皮免疫方法。透皮免疫制剂可以通过将制剂应用于完整皮肤来调节免疫应答，并且其包含层压在基材表面上的基材和抗原或人造合成核酸; 用于生产透皮免疫制剂的方法，其包括将通过将抗原溶解或悬浮在水或含水醇中而制备的水溶液或悬浮液滴在基材表面上以使水或含水醇被吸收在基材中，从而在基材的表面上形成浓缩状态的含有抗原的层; 以及通过将透皮免疫制剂应用于完整皮肤以调节免疫应答而被表达的透皮免疫方法。

2. 发明公开

EP2915557A1 RETINOIC ACID MICRONEEDLE 有权
标题翻译：维甲酸MICRONEEDLE
公开(公告)号：EP2915557A1
公开(公告)日：2015-09-09
申请号：EP13850016.0
申请日：2013-11-01
申请人： Cosmed Pharmaceutical Co., Ltd. , Osaka University , Public University Corporation Nara Medical University
发明人： QUAN, Ying-shu , KAMIYAMA, Fumio , SAITO, Mio , NAKAGAWA, Shinsaku , OKADA, Naoki , HIROBE, Sachiko , ASADA, Hideo
IPC分类号： A61M37/00 , A61K9/10 , A61K31/05 , A61K31/203 , A61K47/36 , A61P17/00
CPC分类号： A61K31/203 , A61K9/0021 , A61K31/122 , A61K31/375 , A61M37/00 , A61M2037/0046 , A61K2300/00
摘要： An object to be achieved by the present invention is to provide a microneedle array which is able to supply effectively retinoic acid to the skin and effective in treating pimples, stains or wrinkles.
The retinoic acid microneedle array comprises: a microneedle array having a microneedle substrate 5 and microneedles 1 disposed on the microneedle substrate 5; and a drug retained on the microneedles 1 and containing a water-swelling polymer and retinoic acid.
摘要翻译：本发明要实现的目的是提供一种微针阵列，其能够有效地向皮肤提供视黄酸并有效治疗丘疹，斑点或皱纹。视黄酸微针阵列包括：微针阵列，其具有微针基体5和设置在微针基体5上的微针1; 以及保留在微针1上并含有水溶胀聚合物和视黄酸的药物。

3. 发明授权

EP2915557B1 RETINOIC ACID MICRONEEDLE 有权
标题翻译：维甲酸MICRONEEDLE
公开(公告)号：EP2915557B1
公开(公告)日：2018-05-09
申请号：EP13850016.0
申请日：2013-11-01
申请人： Cosmed Pharmaceutical Co., Ltd. , Osaka University , Public University Corporation Nara Medical University
发明人： QUAN, Ying-shu , KAMIYAMA, Fumio , SAITO, Mio , NAKAGAWA, Shinsaku , OKADA, Naoki , HIROBE, Sachiko , ASADA, Hideo
IPC分类号： A61M37/00 , A61K9/10 , A61K31/05 , A61K31/203 , A61K47/36 , A61P17/00
CPC分类号： A61K31/203 , A61K9/0021 , A61K31/122 , A61K31/375 , A61M37/00 , A61M2037/0046 , A61K2300/00
摘要： An object to be achieved by the present invention is to provide a microneedle array which is able to supply effectively retinoic acid to the skin and effective in treating pimples, stains or wrinkles. The retinoic acid microneedle array comprises: a microneedle array having a microneedle substrate 5 and microneedles 1 disposed on the microneedle substrate 5; and a drug retained on the microneedles 1 and containing a water-swelling polymer and retinoic acid.

4. 发明公开

EP4159266A1 HIGH-PERFORMANCE MICRO-NEEDLE ARRAY 审中-实审
公开(公告)号：EP4159266A1
公开(公告)日：2023-04-05
申请号：EP21812732.2
申请日：2021-05-24
申请人： Cosmed Pharmaceutical Co., Ltd.
发明人： QUAN, Ying-shu , LI, Ying-zhe , KAJIYAMA, Kenji , SAITO, Mio , YAMASHITA, Hirofumi , KAMIYAMA, Fumio
IPC分类号： A61M37/00
摘要： Provided is a micro-needle array in which all fine needles can be more easily inserted into the skin regardless of positions where the fine needles of the micro-needle array are located on a substrate. The micro-needle array includes: a substrate; and a plurality of micro-needles arranged on one surface of the substrate. Tip parts of the plurality of micro-needles have a height difference, and the micro-needles have a needle length of 80 um or more and 2000 um or less. The height difference of the plurality of micro-needles is preferably based on unevenness of the substrate.

5. 发明公开

EP4159240A1 BEAUTY MICRONEEDLE ARRAY 审中-实审
公开(公告)号：EP4159240A1
公开(公告)日：2023-04-05
申请号：EP21818496.8
申请日：2021-05-28
申请人： Cosmed Pharmaceutical Co., Ltd.
发明人： QUAN, Ying-shu , KONDOU, Naoko , TANAKA, Hiroshi , KAMIYAMA, Fumio
IPC分类号： A61K45/00 , A61P3/04 , A61K9/00 , A61K36/00 , A61K47/36 , A61K38/46 , A61M37/00 , A61K31/047 , A61K31/165 , A61K31/198 , A61K31/205 , A61K31/522 , A61K31/575 , A61K31/685 , A61K31/7076
摘要： Provided is a new means for administering a valuable substance having a fat dissolving action. A microneedle preparation including at least one of a lipolytic agent, a fat dissolving agent, or a fat metabolism promoting agent, the microneedle preparation being intended for fat reduction and/or partial slenderizing and/or skin tightening, and a microneedle preparation including a microneedle array containing a water-soluble polymer as a base and one or more selected from the group consisting of a lipase, a phosphatidylcholine, and deoxycholic acid.

6. 发明授权

EP3047871B1 MICRONEEDLE PATCH APPLICATION DEVICE AND PATCH HOLDER 有权
标题翻译： MICRONEEDLE PATCH应用程序设备和PATCH HOLDER
公开(公告)号：EP3047871B1
公开(公告)日：2018-05-02
申请号：EP13894024.2
申请日：2013-09-18
申请人： Cosmed Pharmaceutical Co., Ltd.
发明人： QUAN, Ying-shu , KAMIYAMA, Fumio
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2205/8281
摘要： Provided is a device for surely and easily applying a microneedle patch to a skin. In a case body 2, a pressing member 3 having a tip surface 3a is disposed such that the pressing member is biased in a first direction X1 by a first biasing member. The movement in the first direction X1 is locked by a locking member 7 and a locking part 3g so that the pressing member 3 is brought into a locked state. The locked state is released by pressing a tip of a lock-releasing member 11 against the skin. When the locked state is released, a tip surface 3a of the pressing member 3 is moved in the first direction X1 and the tip surface 3a applies the microneedle patch to the skin.

7. 发明公开

EP3960228A1 APPLICATOR 2 OF WATER-SOLUBLE SHEET-LIKE FORMULATION 无效
公开(公告)号：EP3960228A1
公开(公告)日：2022-03-02
申请号：EP20795886.9
申请日：2020-04-24
申请人： Cosmed Pharmaceutical Co., Ltd.
发明人： QUAN, Ying-shu , TANAKA, Hiroshi , KAMIYAMA, Fumio
IPC分类号： A61M35/00 , A61M37/00
摘要： Provided is a further stable method of moisture supply from an applicator having a nozzle attached thereto and configured to supply moisture from the back surface of a water-soluble sheet-like formulation. A nozzle for hold and dissolution of a water-soluble sheet-like formulation, the nozzle including a nozzle having an end portion having a flat surface having a size such that a water-soluble sheet-like formulation can be held, the end portion having at least one hole, the flat surface being smooth excluding the at least one hole, and ring-like foam disposed around a periphery of the end portion of the nozzle; a nozzle for hold and dissolution of a water-soluble sheet-like formulation, the nozzle including a nozzle having an end portion having a flat surface having a size such that a water-soluble sheet-like formulation can be held, the end portion having at least one hole, the flat surface having an uneven portion excluding the at least one hole, and ring-like foam disposed around a periphery of the end portion of the nozzle; and an applicator of a water-soluble sheet-like formulation, the applicator including a liquid container and the nozzle for hold and dissolution of a water-soluble sheet-like formulation.

8. 发明授权

EP3275500B1 MICRONEEDLE AND METHOD FOR PRODUCING SAME 有权
公开(公告)号：EP3275500B1
公开(公告)日：2020-11-18
申请号：EP15886513.9
申请日：2015-12-10
申请人： Cosmed Pharmaceutical Co., Ltd.
发明人： QUAN, Ying-shu , LI, Ying-zhe , SAITO, Mio , KITAOKA, Shouta , KAMIYAMA, Fumio
IPC分类号： A61M37/00 , A61K9/00

9. 发明授权

EP2957316B1 MEDICINE-HOLDING MICRONEEDLE ARRAY AND PROCESS FOR PRODUCING SAME 有权
公开(公告)号：EP2957316B1
公开(公告)日：2019-12-11
申请号：EP14751057.2
申请日：2014-02-10
申请人： Cosmed Pharmaceutical Co., Ltd.
发明人： QUAN, Ying-shu , KAMIYAMA, Fumio , YAMADA, Tomoya
IPC分类号： A61M37/00 , A61L31/00

10. 发明公开

EP3563900A1 MICRONEEDLE ARRAY COATED WITH DRUG 有权
公开(公告)号：EP3563900A1
公开(公告)日：2019-11-06
申请号：EP17888505.9
申请日：2017-12-28
申请人： Cosmed Pharmaceutical Co., Ltd.
发明人： QUAN, Ying-shu , SAITO, Mio , YAMASHITA, Hirofumi , KAMIYAMA, Fumio
IPC分类号： A61M37/00
摘要： To provide a practical microneedle preparation which solves a problem that, even if a tip portion of the microneedle could be quantitatively coated with the drug, the drug remained in the stratum corneum when actually applying the microneedle array as a transdermal absorption preparation.
A microneedle array having needles with a length of 350 µm to 900 µm, and a tip apex diameter of 20 µm to 100 µm, including drug-coated portions, and comprising a non-biosoluble polymer as a base, wherein a lower end of each drug-coated portion is 200 µm or more away from a root of the needle.

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