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1. 发明公开

EP3384931A1 FORMOTEROL SUPERFINE FORMULATION 有权转让
公开(公告)号：EP3384931A1
公开(公告)日：2018-10-10
申请号：EP18173392.4
申请日：2003-02-26
申请人： Chiesi Farmaceutici S.p.A.
发明人： DAVIES, Rebecca Jaine , GANDERTON, David , LEWIS, David Andrew , MEAKIN, Brian John , CHURCH, Tanya Kathleen , BRAMBILLA, Gaetano , FERRARIS, Alessandra
IPC分类号： A61K47/10 , A61K31/485
CPC分类号： A61K9/008 , A61K31/4704 , A61K31/485 , A61K45/06 , A61K47/10 , A61K2300/00
摘要： A pharmaceutical aerosol formulation to be administered by a pressurized metered dose inhaler which comprises as active ingredient (R,R)-(±)-formoterol fumarate in a concentration comprised between 0.003 and 0.192 % w/v, in a solution of liquefied HFA 134a propellant and anhydrous ethanol as co-solvent, wherein the pH is comprised between 3.5 and 4.0 and is adjusted by adding hydrochloric acid, characterised in that the amount of residual water is less than 1500 ppm on the total weight of the formulation and that the fraction of particles equal or less than 1.1 µm delivered on actuation of the inhaler is higher or equal than 30% as defined by the content of the stages S6-AF of an Andersen Cascade Impactor, relatively to the content of the stages S3-AF, according to the method referred to in European Pharmacopoeia, second edition, 1995, part v.5.9.1, pages 15-17.

2. 发明授权

EP1850831B1 PHARMACEUTICAL AEROSOL FORMULATIONS FOR PRESSURIZED METERED DOSE INHALERS COMPRISING A SEQUESTERING AGENT 有权
标题翻译：药物气雾剂制剂用于加压计量吸入器含有多价螯合剂
公开(公告)号：EP1850831B1
公开(公告)日：2015-12-02
申请号：EP06706899.9
申请日：2006-02-13
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： LEWIS, David Andrew , MEAKIN, Brian John , DELCANALE, Maurizio , PIVETTI, Fausto
IPC分类号： A61K9/12 , A61K9/72 , A61K47/02 , A61K31/573 , A61K31/58 , A61K31/4704
CPC分类号： A61K9/008 , A61K31/4704 , A61K31/573 , A61K31/58 , A61K47/02

3. 发明公开

EP2890437A1 AEROSOL INHALATION DEVICE 审中-公开
标题翻译： AEROSOLINHALATIONSVORRICHTUNG
公开(公告)号：EP2890437A1
公开(公告)日：2015-07-08
申请号：EP13759992.4
申请日：2013-08-23
申请人： Chiesi Farmaceutici S.p.A.
发明人： BRAMBILLA, Gaetano , JOHNSON, Robert , LEWIS, David Andrew
IPC分类号： A61M15/00
摘要： Actuators for an aerosol inhalation device containing a housing adapted to receive an aerosol canister containing a pressurized medicament formulation, a mouthpiece portion through which the user inhales, a nozzle block and an orifice and a tubular element extending in the mouthpiece portion from the orifice aperture in a longitudinal axis substantially aligned with a longitudinal axis of the mouthpiece portion provide a significant reduction in the non-respirable, coarse fraction of the emitted aerosol medicament via inertial impaction and retention in the actuator than in the oro-pharynx, with consequent less associated side effects and oral candidiasis in the patient. In addition the presence of the tubular element has minimal, negligible impact on the fine particle dose and on the particle size distribution (PSD) of the delivered particles having aerodynamic diameter lower than 9 mum.
摘要翻译：用于气溶胶吸入装置的致动器，其包含适于容纳包含加压药剂配方的气溶胶罐的壳体，使用者吸入的吸口部分，喷嘴座和孔口以及从所述口部件中的孔口延伸的管状元件基本上与接口部分的纵向轴线对齐的纵向轴线通过惯性冲击和致动器中的保持在方法中比在口咽中显着减少所发射的气溶胶药物的不可呼吸的粗分数，从而导致较少的相关联效果和口腔念珠菌病。此外，管状元件的存在对细颗粒剂量和具有低于9μm的空气动力学直径的输送颗粒的粒度分布（PSD）具有最小的可忽略的影响。

4. 发明授权

EP3494995B1 FORMOTEROL SUPERFINE FORMULATION 有权转让
公开(公告)号：EP3494995B1
公开(公告)日：2020-02-19
申请号：EP19166324.4
申请日：2003-02-26
申请人： Chiesi Farmaceutici S.p.A.
发明人： DAVIES, Rebecca Jaine , GANDERTON, David , LEWIS, David Andrew , MEAKIN, Brian John , CHURCH, Tanya Kathleen , BRAMBILLA, Gaetano , FERRARIS, Alessandra
IPC分类号： A61K47/10 , A61K31/485

5. 发明公开

EP3494995A2 FORMOTEROL SUPERFINE FORMULATION 有权转让
公开(公告)号：EP3494995A2
公开(公告)日：2019-06-12
申请号：EP19166324.4
申请日：2003-02-26
申请人： Chiesi Farmaceutici S.p.A.
发明人： DAVIES, Rebecca Jaine , GANDERTON, David , LEWIS, David Andrew , MEAKIN, Brian John , CHURCH, Tanya Kathleen , BRAMBILLA, Gaetano , FERRARIS, Alessandra
IPC分类号： A61K47/10 , A61K31/485
摘要： A propellant/co-solvent system comprising fully dissolved formoterol, or a stereoisomer, physiologically acceptable salt or solvate thereof, and capable of providing on actuation of a pressurized metered dose inhaler a fraction of at least 30% of emitted particles with an aerodynamic diameter equal or less than 1.1 µm for use in the treatment of a respiratory disorder selected from asthma and chronic obstructive pulmonary disease.

6. 发明公开

EP2613829A1 METERED-DOSE INHALER AND METHOD OF USING THE SAME 有权转让
标题翻译： INHALIERGERÄTMIT ABGEMESSENER DOSIS UND VERWENDUNGSVERFAHRENDAFÜR
公开(公告)号：EP2613829A1
公开(公告)日：2013-07-17
申请号：EP11757244.6
申请日：2011-09-05
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： BRAMBILLA, Gaetano , LEWIS, David Andrew , JOHNSON, Robert , HOWLETT, David
IPC分类号： A61M15/00 , A61J1/20 , B05B11/00 , B65D83/14
CPC分类号： A61M15/009 , A61J1/2037 , A61J1/2089 , A61M15/0003 , B65D83/54 , B65D83/682
摘要： A metered-dose inhaler includes at least one vessel and an actuator for receiving the at least one vessel. The at least one vessel includes a first reservoir containing a first formulation and a second reservoir containing a second formulation. The metered-dose inhaler is actuable when the at least one vessel is received by the actuator. The metered-dose inhaler is configured to simultaneously deliver a first metered dose of the first formulation and a second metered dose of the second formulation upon actuation.
摘要翻译：计量吸入器包括至少一个容器和用于容纳至少一个容器的致动器。所述至少一个容器包括含有第一制剂的第一储存器和含有第二制剂的第二储存器。当至少一个容器被致动器接收时，计量吸入器是可启动的。计量吸入器构造成在致动时同时递送第一制剂的第一计量剂量和第二制剂的第二计量剂量。

7. 发明授权

EP3536344B1 FORMOTEROL SUPERFINE FORMULATION 有权转让
公开(公告)号：EP3536344B1
公开(公告)日：2020-02-19
申请号：EP19171326.2
申请日：2003-02-26
申请人： Chiesi Farmaceutici S.p.A.
发明人： DAVIES, Rebecca Jaine , GANDERTON, David , LEWIS, David Andrew , MEAKIN, Brian John , CHURCH, Tanya Kathleen , BRAMBILLA, Gaetano , FERRARIS, Alessandra
IPC分类号： A61K47/10 , A61K31/485

8. 发明授权

EP2890437B1 AEROSOL INHALATION DEVICE 有权
公开(公告)号：EP2890437B1
公开(公告)日：2019-12-18
申请号：EP13759992.4
申请日：2013-08-23
申请人： Chiesi Farmaceutici S.p.A.
发明人： BRAMBILLA, Gaetano , JOHNSON, Robert , LEWIS, David Andrew
IPC分类号： A61M15/00

9. 发明授权

EP2613828B1 METERED-DOSE INHALER ACTUATOR, METERED-DOSE INHALER 有权转让
公开(公告)号：EP2613828B1
公开(公告)日：2019-11-27
申请号：EP11749866.7
申请日：2011-09-05
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： BRAMBILLA, Gaetano , LEWIS, David Andrew , JOHNSON, Robert
IPC分类号： A61M15/00

10. 发明授权

EP3384931B1 FORMOTEROL SUPERFINE FORMULATION 有权转让
公开(公告)号：EP3384931B1
公开(公告)日：2019-07-24
申请号：EP18173392.4
申请日：2003-02-26
申请人： Chiesi Farmaceutici S.p.A.
发明人： DAVIES, Rebecca Jaine , GANDERTON, David , LEWIS, David Andrew , MEAKIN, Brian John , CHURCH, Tanya Kathleen , BRAMBILLA, Gaetano , FERRARIS, Alessandra
IPC分类号： A61K47/10 , A61K31/485

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