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1. 发明公开

EP1284743A2 PREPARATION OF A PATHOGEN INACTIVATED SOLUTION OF RED BLOOD CELLS HAVING REDUCED IMMUNOGENICITY 审中-公开
标题翻译：制备的红血细胞免疫力减弱PATHOGENINAKTIVIERTER解
公开(公告)号：EP1284743A2
公开(公告)日：2003-02-26
申请号：EP01944256.5
申请日：2001-05-31
申请人： Cerus Corporation
发明人： STASSINOPOULOS, Adonis
IPC分类号： A61K35/18 , A61P7/00
CPC分类号： A61K35/16 , A61K35/18
摘要： Compounds and methods are provided for the preparation of a red blood cell composition which has significantly reduced antigenicity and in which any possible pathogen contaminants have been substantially inactivated. The red blood cell compositions are of particular use for introduction into an individual in cases where the potential for an immune reaction is high, for example in alloimmunized blood recipients or in trauma situations where the possibility of transfusion of a mismatched unit of blood is higher. The red blood cell compositions of this invention provide a much lower risk of transfusion associated disease transmission as well as a much lower risk of a transfusion associated immune reaction.

2. 发明公开

EP3247351A1 PREPARATION AND USE OF PLATELET PRODUCTS 无效转让
标题翻译：血小板产品的制备和使用
公开(公告)号：EP3247351A1
公开(公告)日：2017-11-29
申请号：EP16702298.7
申请日：2016-01-15
申请人： Cerus Corporation
发明人： GREENMAN, William , LIN, Lily , STASSINOPOULOS, Adonis
IPC分类号： A61K31/37 , A61K41/00 , A61K35/19 , A61P7/00
CPC分类号： A61K41/0009 , A61K31/37 , A61K35/19 , A61K41/0023 , A61M1/3683 , A61P7/00
摘要： The present disclosure relates to improved methods for the preparation and platelet products for administration to subjects in need thereof

3. 发明公开

EP1838355A1 IMPROVED QUENCHING METHODS FOR RED BLOOD CELL INACTIVATION PROCESS 有权
标题翻译：改进急冷法FOR A红细胞灭活
公开(公告)号：EP1838355A1
公开(公告)日：2007-10-03
申请号：EP05821102.0
申请日：2005-10-31
申请人： Cerus Corporation
发明人： STASSINOPOULOS, Adonis
IPC分类号： A61L2/00 , A61K38/06 , C07K5/02 , A61K31/198
CPC分类号： A61L2/0088 , A01N1/0205 , A01N1/0215 , A61K31/198
摘要： Methods are provided for improved quenching of undesired side reactions upon treating a red blood cell composition with a pathogen inactivating compound comprising a nucleic acid binding ligand and a functional group which is, or which is capable of forming, an electrophilic group. In some embodiments, the improved methods use a suitably high concentration of quencher that comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group, wherein the treatment occurs within a desired pH range to provide sufficient quenching. Preferred quenchers for use in some of the methods include thiols, such as glutathione, which have been suitably neutralized such that addition to a red blood cell composition results in the desired concentration of quencher at a desirable pH range of 6.8 to 8.5.

4. 发明公开

EP1365750A2 METHODS FOR INACTIVATION OF PATHOGENS IN BIOLOGICAL MATERIALS 审中-公开
标题翻译：方法用于灭活的病原体的生物材料
公开(公告)号：EP1365750A2
公开(公告)日：2003-12-03
申请号：EP01275038.6
申请日：2001-12-21
申请人： Cerus Corporation
发明人： STASSINOPOULOS, Adonis , COOK, David
IPC分类号： A61K9/50 , A61K31/47 , A61K35/14 , A61K35/12 , A61K35/16 , A61K35/18 , A61L2/00 , A61P7/00
CPC分类号： A61K9/0026 , A61L2/0082 , A61L2/0088 , A61M1/3687 , Y02A50/473 , Y02A50/481
摘要： Methods are provided for inactivation of pathogens in biomaterials. Pathogen inactivating agents are added to and mixed with biomaterials in an additive solution that is low in chloride and/or hypotonic, resulting in substantial increases in inactivation of bacterial pathogens, particularly Gram negative bacterial pathogens.

5. 发明公开

EP1021414A1 FRANGIBLE COMPOUNDS FOR PATHOGEN INACTIVATION 失效
标题翻译：通过方便FISSILE债券链接，灭活的病原体
公开(公告)号：EP1021414A1
公开(公告)日：2000-07-26
申请号：EP98901776.9
申请日：1998-01-06
申请人： Cerus Corporation
发明人： COOK, David , MERRITT, John , NERIO, Aileen , RAPOPORT, Henry , STASSINOPOULOS, Adonis , WOLLOWITZ, Susan , MATEJOVIC, Jon
IPC分类号： C07D219/10 , C07D493/04 , A61L2/18 , C07F9/64 , C07F9/6561 , C07D405/12
CPC分类号： C07D405/12 , A61L2/0082 , A61M1/0209 , B01J20/28033 , C07D219/10 , C07D493/04 , C07F9/64
摘要： Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in biological materials such as red blood cell preparations and plasma. The compounds and methods may be used to treat materials intended for in vitro or in vivo use, such as clinical testing or transfusion. The compounds are designed to specifically bind to and react with nucleic acid, and then to degrade to form breakdown products. The degradation reaction is preferably slower than the reaction with nucleic acid.

6. 发明公开

EP3684774A1 COMPOSITIONS AND METHODS FOR PATHOGEN INACTIVATION OF PLATELETS 审中-公开
公开(公告)号：EP3684774A1
公开(公告)日：2020-07-29
申请号：EP18808551.8
申请日：2018-09-20
申请人： Cerus Corporation
发明人： GREENMAN, William , STASSINOPOULOS, Adonis , WEINER, Elan , BRINGMANN, Peter , SANTA MARIA, Felicia
IPC分类号： C07D493/04 , A01N1/02 , A61K41/00 , A61J1/10 , A61K31/37 , A61K35/19

7. 发明授权

EP1838355B1 IMPROVED QUENCHING METHODS FOR RED BLOOD CELL INACTIVATION PROCESS 有权
标题翻译：改进急冷法FOR A红细胞灭活
公开(公告)号：EP1838355B1
公开(公告)日：2013-08-14
申请号：EP05821102.0
申请日：2005-10-31
申请人： Cerus Corporation
发明人： STASSINOPOULOS, Adonis
IPC分类号： A61L2/00 , A61K38/06 , C07K5/02 , A61K31/198
CPC分类号： A61L2/0088 , A01N1/0205 , A01N1/0215 , A61K31/198

8. 发明公开

EP1045704A1 METHODS FOR QUENCHING PATHOGEN INACTIVATORS IN BIOLOGICAL MATERIALS 失效
标题翻译：过程用于病原体灭活的生物材料中的淬火
公开(公告)号：EP1045704A1
公开(公告)日：2000-10-25
申请号：EP98933166.5
申请日：1998-07-06
申请人： Cerus Corporation
发明人： COOK, David , STASSINOPOULOS, Adonis
IPC分类号： A61L2/00
CPC分类号： A61L2/0088
摘要： Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating compound that includes a functional group which is, or which is capable of forming, an electrophilic group. In this embodiment, the material is treated with the pathogen inactivating compound and a quencher, wherein the quencher comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group. The electrophilic group on the pathogen inactivating compound is preferably a non-radical cationic group. In one embodiment, the pathogen inactivating compound includes a nucleic acid binding ligand and a mustard group, wherein the mustard group is capable of reacting in situ to form the electrophilic group. Preferred quenchers are thiols, such as glutathione. Biological materials which may be treated include whole blood, red blood cells, blood plasma, and platelets. The methods permit inhibition of the modification of red blood cells in red blood cell containing materials during pathogen inactivation.

9. 发明公开

EP1005531A2 METHOD OF TREATING LEUKOCYTES, LEUKOCYTE COMPOSITIONS AND METHODS OF USE THEREOF 失效
标题翻译： PROCESS议付FOR白细胞，白细胞组合物及其应用
公开(公告)号：EP1005531A2
公开(公告)日：2000-06-07
申请号：EP98936943.4
申请日：1998-07-21
申请人： Cerus Corporation
发明人： GREENMAN, William, M. , GRASS, Joshua, A. , TALIB, Sohel , STASSINOPOULOS, Adonis , HEI, Derek, J. , HEARST, John, E.
IPC分类号： C12N5/06 , C12N15/01 , A61K41/00
CPC分类号： C12N5/0634 , A61K35/15 , A61K35/17 , A61K35/28 , C12N2501/06
摘要： The invention provides methods and compositions for treating leukocytes to arrest proliferation of the leukocytes and render them ineffective in eliciting graft-versus-host disease (GVHD), but effective to enhance engraftment of allongeneic donor cells and promote destruction of diseased cells or pathogens. Leukocyte compositions and methods of use of these compositions in alleviating disease, facilitating various types of immune reconstitution and immunotherapy, and enhancing engraftment of allogeneic donor cells, are also provided.

10. 发明公开

EP3731960A1 SYSTEMS AND METHODS FOR TREATING BIOLOGICAL FLUIDS 审中-公开
公开(公告)号：EP3731960A1
公开(公告)日：2020-11-04
申请号：EP18837134.8
申请日：2018-12-28
申请人： Cerus Corporation
发明人： CHURCH, Daniel , BRINGMANN, Peter , CASTRO, Grace , LU, Thea , REINHARDT, Shelby , SANTA MARIA, Felicia , STASSINOPOULOS, Adonis
IPC分类号： B01J19/12 , A01N1/02 , A61K41/00 , A61L2/00 , A61L2/10 , A61K31/37 , H01L25/075

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