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1. 发明公开

EP1101110A1 METHOD AND APPARATUS FOR DETERMINING ANTICOAGULANT THERAPY FACTORS 失效
标题翻译：用于确定治疗方法和设备因素抗凝
公开(公告)号：EP1101110A1
公开(公告)日：2001-05-23
申请号：EP98938216.3
申请日：1998-07-31
申请人： Carroll, Wallace E. , Jackson, R. David
发明人： Carroll, Wallace E. , Jackson, R. David
IPC分类号： G01N33/48
摘要： A method and apparatuses are disclosed for determining an anticoagulant therapy factor (ATF), a corrected anticoagulant therapy factor and a modified anticoagulant therapy factor, all selectively used for monitoring oral anticoagulant therapy to help prevent excessive bleeding or deleterious blood clots that might otherwise occur before, during or after surgery. The anticoagulant therapy factor, the corrected anticoagulant therapy factor, and a modified anticoagulant therapy factor are based upon disclosed methods for determining the fibrinogen tranformation rate which, in turn, is dependent on a maximum acceleration point for fibronogen conversion.

2. 发明授权

EP2546637B1 Method and apparatus for determining anticoagulant therapy factors 有权
标题翻译：测定Antikoagulanstherapiefaktoren的方法和装置
公开(公告)号：EP2546637B1
公开(公告)日：2014-05-14
申请号：EP12163048.7
申请日：2012-03-07
申请人： Carroll, Wallace E. , Jackson, R. David
发明人： Carroll, Wallis E. , Jackson, R. David
IPC分类号： G01N21/82 , G01N33/49 , G01N33/86
CPC分类号： G01N21/82 , G01N33/4905 , G01N33/86 , G01N2333/75 , G01N2333/968

3. 发明公开

EP2515097A3 Spectrometric device 审中-公开
标题翻译：测定设备
公开(公告)号：EP2515097A3
公开(公告)日：2014-05-07
申请号：EP12163033.9
申请日：2012-03-07
申请人： Carroll, Wallace E. , Jackson, R. David
发明人： Carroll, Wallace E. , Jackson, R. David
IPC分类号： G01N21/25 , G01N21/82 , G01N33/49 , G01N21/51
CPC分类号： G01N21/255 , G01J3/42 , G01N21/51 , G01N21/82 , G01N33/49 , G01N33/4905 , G01N2021/3185 , G01N2201/0621
摘要： The present invention provides improved spectrometric devices useful for measuring optical quantities of a component, including a solid state LED emitter, having at least one wavelength that is matched to the wavelength that is useful for the spectral analysis of the component of interest, a photodetection cell and an optimizing configuration and permits control of the LED emitter and the detector sensitivity to provide a range of detection for the signals corresponding to the optical density of a sample being analyzed and that affords sensitivity for a desired component of a sample by minimizing the error associated with electronic components and signals. Preferred embodiments also include configurations for determining an anticoagulant therapy value that may be used to determine treatment for a patient.

4. 发明授权

EP1101110B1 METHOD AND APPARATUS FOR DETERMINING ANTICOAGULANT THERAPY FACTORS 失效
标题翻译：用于确定治疗方法和设备因素抗凝
公开(公告)号：EP1101110B1
公开(公告)日：2004-09-29
申请号：EP98938216.3
申请日：1998-07-31
申请人： Carroll, Wallace E. , Jackson, R. David
发明人： Carroll, Wallace E. , Jackson, R. David
IPC分类号： G01N33/48

5. 发明公开

EP2546637A1 Method and apparatus for determining anticoagulant therapy factors 有权
标题翻译： Verfahren und Vorrichtung zur Bestimmung von Antikoagulanstherapiefaktoren
公开(公告)号：EP2546637A1
公开(公告)日：2013-01-16
申请号：EP12163048.7
申请日：2012-03-07
申请人： Carroll, Wallace E. , Jackson, R. David
发明人： Carroll, Wallace E. , Jackson, R. David
IPC分类号： G01N21/82 , G01N33/49 , G01N33/86
CPC分类号： G01N21/82 , G01N33/4905 , G01N33/86 , G01N2333/75 , G01N2333/968
摘要： Methods and apparatus are disclosed for determining new anticoagulant therapy factors for monitoring oral anticoagulant therapy to help prevent excessive bleeding or deleterious blood clots that might otherwise occur before, during or after surgery. The inventive methods and apparatus provide an International Normalization Ratio (INR) based on a coagulation reaction with a blood sample of a living being. Embodiments include methods and apparatus for determining an anticoagulant therapy factor without requiring use of a mean normal prothrombin time determination or an ISI, and may be carried out with the patient sample and a coagulation reagent, where the coagulation reagent may be selected from a number of coagulation reagents. One embodiment provides an INRs value which is determined from a prothrombin time (PT or T1) of a patient blood sample and a theoretical end of test time (TEOT), where a theoretical clotting area is used to determine the INRs value according to the expression, INRs= T1*TEOT * MUL, where MUL is a multiplier that takes into account pixel parity and sampling times. The INRs may be used to determine a course of treatment for a patient or other living being without regard to the specific coagulation regent used to generate the coagulation data (e.g., time and optical activity values).
摘要翻译：公开了用于确定用于监测口服抗凝血剂治疗的新型抗凝血剂治疗因子的方法和装置，以帮助预防手术之前，期间或之后可能出现的过度出血或有害的血块。本发明的方法和装置基于与生物的血液样品的凝血反应提供国际标准化比例（INR）。实施方案包括用于确定抗凝血剂治疗因子而不需要使用平均正常凝血酶原时间测定或ISI的方法和装置，并且可以与患者样品和凝血试剂一起进行，其中凝血试剂可以选自凝血试剂。一个实施方案提供了从患者血液样品的凝血酶原时间（PT或T1）和测试时间（TEOT）的理论终点确定的INR值，其中使用理论凝血区域根据表达式确定INR值，INRs = T1 * TEOT * MUL，其中MUL是考虑像素奇偶校验和采样时间的乘数。 INR可以用于确定患者或其他生物的治疗过程，而不考虑用于产生凝血数据的特定凝血剂（例如时间和光学活性值）。

6. 发明公开

EP2515097A2 Spectrometric device 审中-公开
标题翻译： Spektrometrische Vorrichtung
公开(公告)号：EP2515097A2
公开(公告)日：2012-10-24
申请号：EP12163033.9
申请日：2012-03-07
申请人： Carroll, Wallace E. , Jackson, R. David
发明人： Carroll, Wallace E. , Jackson, R. David
IPC分类号： G01N21/25 , G01N21/82
CPC分类号： G01N21/255 , G01J3/42 , G01N21/51 , G01N21/82 , G01N33/49 , G01N33/4905 , G01N2021/3185 , G01N2201/0621
摘要： The present invention provides improved spectrometric devices useful for measuring optical quantities of a component, including a solid state LED emitter, having at least one wavelength that is matched to the wavelength that is useful for the spectral analysis of the component of interest, a photodetection cell and an optimizing configuration and permits control of the LED emitter and the detector sensitivity to provide a range of detection for the signals corresponding to the optical density of a sample being analyzed and that affords sensitivity for a desired component of a sample by minimizing the error associated with electronic components and signals. Preferred embodiments also include configurations for determining an anticoagulant therapy value that may be used to determine treatment for a patient.
摘要翻译：本发明提供了可用于测量包括固态LED发射器的组件的光学量的改进的光谱测量装置，其具有与用于感兴趣组件的光谱分析的波长匹配的至少一个波长，光电检测单元和优化配置，并允许对LED发射器和检测器灵敏度的控制，以提供与所分析的样品的光密度相对应的信号的检测范围，并通过最小化相关误差来提供对样品的期望分量的灵敏度具有电子元件和信号。优选实施方案还包括用于确定可用于确定患者治疗的抗凝治疗值的配置。

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