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1. 发明授权

EP2076307B1 IMPLANTABLE APPARATUS FOR ENDOLYMPHATIC DRUG DELIVERY 有权
标题翻译：可植入装置给药ACTIVE内淋巴囊
公开(公告)号：EP2076307B1
公开(公告)日：2012-02-15
申请号：EP07837256.2
申请日：2007-08-23
申请人： Cardiac Pacemakers, Inc.
发明人： SHUROS, Allan , KRAMER, Andrew, P. , BAYNHAM, Tamara, Colette , CAWTHRA, James , BROOKE, M., Jason
IPC分类号： A61M25/00 , A61M5/142 , A61N1/00
CPC分类号： A61M5/14276 , A61M1/3613 , A61M25/1011 , A61M2025/0057 , A61M2025/0063 , A61M2202/0405 , A61N1/056 , A61N1/36135
摘要： Described herein are a method and apparatus for introducing instrumentation like an implantable drug delivery apparatus (1200) with a balloon catheter (1111) and sensors into the lymphatic system. It can be used for physiological monitoring and/or delivery of therapy. Such instrumentation, for example, may include one or more sensors for measuring physiological variables and/or one or more instruments for delivering therapy that is adapted to be disposed within a lymphatic vessel.

2. 发明公开

EP2254661A1 METHOD AND APPARATUS FOR PHRENIC STIMULATION DETECTION 失效
标题翻译：设备：隔膜起搏检测
公开(公告)号：EP2254661A1
公开(公告)日：2010-12-01
申请号：EP09709478.3
申请日：2009-02-10
申请人： Cardiac Pacemakers, Inc.
发明人： BROOKE, M., Jason
IPC分类号： A61N1/37 , A61N1/368
CPC分类号： A61N1/371 , A61B5/04001 , A61B5/042 , A61B5/0488 , A61B5/1107 , A61B5/4029 , A61B5/4848 , A61B2562/0219 , A61N1/3601 , A61N1/36585 , A61N1/3684 , A61N1/3706 , A61N1/3712 , A61N1/372
摘要： Approaches for characterizing a phrenic stimulation threshold, a cardiac capture threshold, a maximum device parameter, and a minimum device parameter are described. A plurality of cardiac pacing pulses can be delivered by using a cardiac pacing device, a pacing parameter of the plurality of cardiac pacing pulses being changed between delivery of at least some of the pulses. One or more sensor signals can be evaluated to detect stimulation of the phrenic nerve by one or more of the plurality of cardiac pacing pluses. The evaluation of the one or more sensor signals and the pacing parameter can be compared to determine if a phrenic stimulation threshold is at least one of higher than a maximum device parameter and lower than a minimum device parameter.

3. 发明授权

EP2291222B1 APPARATUS TO ENSURE CONSISTENT LEFT VENTRICULAR PACING 有权
标题翻译：设备技术确保一致的左心室一步一步
公开(公告)号：EP2291222B1
公开(公告)日：2015-11-25
申请号：EP09743488.0
申请日：2009-05-05
申请人： Cardiac Pacemakers, Inc.
发明人： MASKARA, Barun , DING, Jiang , BROOKE, M., Jason
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/371 , A61N1/3627 , A61N1/3682 , A61N1/3684

4. 发明授权

EP1899004B1 SYSTEM FOR NEURAL CONTROL OF RESPIRATION 有权
标题翻译：系统的神经控制呼吸
公开(公告)号：EP1899004B1
公开(公告)日：2011-03-16
申请号：EP06771862.7
申请日：2006-06-01
申请人： CARDIAC PACEMAKERS, INC.
发明人： CAPARSO, Anthony , LIBBUS, Imad , BROOKE, M., Jason , LEE, Kent , KWOK, Jonathan , PU, Yachuan
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

5. 发明公开

EP2291222A1 METHOD AND APPARATUS TO ENSURE CONSISTENT LEFT VENTRICULAR PACING 有权
标题翻译：设备技术确保一致的左心室一步一步
公开(公告)号：EP2291222A1
公开(公告)日：2011-03-09
申请号：EP09743488.0
申请日：2009-05-05
申请人： Cardiac Pacemakers, Inc.
发明人： MASKARA, Barun , DING, Jiang , BROOKE, M., Jason
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/371 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method of operating a cardiac therapy system to deliver cardiac resynchronization therapy (CRT) pacing that includes pacing both ventricles or pacing only the left ventricle is described. Delivery of the CRT pacing to one or both ventricles is scheduled for a cardiac cycle. If an intrinsic depolarization of a ventricle is detected during a pacing delay of the ventricle, then the scheduled CRT pacing to the ventricle is inhibited for the cycle. The intrinsic interval of the ventricle, such as the intrinsic atrioventricular interval concluded by the intrinsic depolarization, is measured. During a subsequent cardiac cycle, the pacing delay of the ventricle is decreased to be less than or equal to the measured intrinsic interval. Capture of the ventricle is verified after pacing is delivered during the subsequent cardiac cycle.

6. 发明授权

EP2344022B1 MORPHOLOGY FEATURE EVALUATION IN IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：植入式医疗器械的形貌特征评估
公开(公告)号：EP2344022B1
公开(公告)日：2017-08-30
申请号：EP09788973.7
申请日：2009-07-22
申请人： Cardiac Pacemakers, Inc.
发明人： DONG, Yanting , BROOKE, M., Jason , LI, Dan , STALSBERG, Kevin, J.
IPC分类号： A61B5/0452 , A61N1/365 , A61N1/37
CPC分类号： A61B5/0452 , A61B5/0002 , A61B5/04525 , A61N1/365 , A61N1/3702

7. 发明授权

EP2254661B1 APPARATUS FOR PHRENIC STIMULATION DETECTION 失效
标题翻译：设备：隔膜起搏检测
公开(公告)号：EP2254661B1
公开(公告)日：2015-10-07
申请号：EP09709478.3
申请日：2009-02-10
申请人： Cardiac Pacemakers, Inc.
发明人： BROOKE, M., Jason
IPC分类号： A61N1/37 , A61N1/368
CPC分类号： A61N1/371 , A61B5/04001 , A61B5/042 , A61B5/0488 , A61B5/1107 , A61B5/4029 , A61B5/4848 , A61B2562/0219 , A61N1/3601 , A61N1/36585 , A61N1/3684 , A61N1/3706 , A61N1/3712 , A61N1/372

8. 发明公开

EP2344022A2 MORPHOLOGY FEATURE EVALUATION IN IMPLANTABLE MEDICAL DEVICES 有权
标题翻译： B UNG UNG EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP2344022A2
公开(公告)日：2011-07-20
申请号：EP09788973.7
申请日：2009-07-22
申请人： Cardiac Pacemakers, Inc.
发明人： DONG, Yanting , BROOKE, M., Jason , LI, Dan , STALSBERG, Kevin, J.
IPC分类号： A61B5/00 , A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0002 , A61B5/04525 , A61N1/365 , A61N1/3702
摘要： An apparatus comprises an implantable sensor, which provides a plurality of physiologic sensor signals of a subject, and a processor. The processor includes a feature module and a detection module. The feature module is configured to identify a feature in the sensor signals and to determine a measure of quality of the feature in the sensor signals. The detection module is configured to perform a morphology analysis of a subsequent portion of at least one of the sensor signals using the feature when the measure of quality of the feature satisfies a quality measure threshold.
摘要翻译：一种装置包括可植入传感器，其提供对象的多个生理传感器信号和处理器。处理器包括特征模块和检测模块。特征模块被配置为识别传感器信号中的特征并且确定传感器信号中特征的质量的度量。所述检测模块被配置为当所述特征的质量的量度满足质量测量阈值时，使用所述特征来对所述传感器信号中的至少一个的后续部分进行形态分析。

9. 发明公开

EP2188012A1 METHOD AND APPARATUS TO PERFORM ELECTRODE COMBINATION SELECTION 审中-公开
标题翻译：方法和装置用于选择复合电极
公开(公告)号：EP2188012A1
公开(公告)日：2010-05-26
申请号：EP08795112.5
申请日：2008-08-07
申请人： Cardiac Pacemakers, Inc.
发明人： SATHAYE, Alok , BROOKE, M., Jason , TOCKMAN, Bruce , ACUNA, Andrea, E.
IPC分类号： A61N1/372
CPC分类号： A61N1/3708 , A61N1/36185 , A61N1/3627 , A61N1/3684 , A61N1/3686 , A61N1/37 , A61N1/3706 , A61N1/371 , A61N1/37211 , A61N1/37241 , A61N1/3962
摘要： The present invention involves approaches for selecting one or more electrode combinations. Various method embodiments can include means for implanting a plurality of cardiac electrodes supported by one or more leads in a patient, attaching the one or more leads to a patient external analyzer circuit, means for delivering electrical stimulation to the patient's heart using the plurality of cardiac electrodes and the analyzer circuit, means for evaluating, for each electrode combination of a plurality of electrode combinations of the plurality of cardiac electrodes, one or more first parameters and one or more second parameters produced by the electrical stimulation delivered using the electrode combination, the first parameters supportive of cardiac function consistent with a prescribed therapy and the second parameters not supportive of cardiac function consistent with the prescribed therapy, means for selecting one or more electrode combinations of the plurality of cardiac electrodes based on the evaluation, the one or more electrode combinations selected as being associated with the one or more first parameters and less associated with the one or more second parameters relative to other electrode combinations of the plurality of cardiac electrodes, means for programming an implantable pacing circuit to deliver a cardiac pacing therapy that preferentially uses the selected one or more electrode combinations relative to other electrode combinations of the plurality of cardiac electrodes, means for detaching the one or more leads from the analyzer circuit, means for attaching the one or more leads to the implantable pacing circuit, and means for implanting the implantable pacing circuit.

10. 发明公开

EP2076307A2 IMPLANTABLE APPARATUS FOR ENDOLYMPHATIC DRUG DELIVERY 有权
标题翻译：可植入装置给药ACTIVE内淋巴囊
公开(公告)号：EP2076307A2
公开(公告)日：2009-07-08
申请号：EP07837256.2
申请日：2007-08-23
申请人： Cardiac Pacemakers, Inc.
发明人： SHUROS, Allan , KRAMER, Andrew, P. , BAYNHAM, Tamara, Colette , CAWTHRA, James , BROOKE, M., Jason
IPC分类号： A61M25/00 , A61M5/142 , A61N1/00
CPC分类号： A61M5/14276 , A61M1/3613 , A61M25/1011 , A61M2025/0057 , A61M2025/0063 , A61M2202/0405 , A61N1/056 , A61N1/36135
摘要： Described herein are a method and apparatus for introducing instrumentation like an implantable drug delivery apparatus (1200) with a balloon catheter (1111) and sensors into the lymphatic system. It can be used for physiological monitoring and/or delivery of therapy. Such instrumentation, for example, may include one or more sensors for measuring physiological variables and/or one or more instruments for delivering therapy that is adapted to be disposed within a lymphatic vessel.

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