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1. 发明授权

EP1184467B1 Screening method for gene variation 有权
标题翻译：用于发现基因变异方法
公开(公告)号：EP1184467B1
公开(公告)日：2010-05-05
申请号：EP01307415.8
申请日：2001-08-31
申请人： CANON KABUSHIKI KAISHA
发明人： Yamamoto, Nobuko , Okamoto, Tadashi , Tanaka, Shinya , Suzuki, Tomohiro
IPC分类号： C12Q1/68 , G06F17/00
CPC分类号： C12Q1/6827 , B01J2219/00378 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , C12Q1/6876 , C40B40/06 , C40B60/14 , C12Q2565/513 , C12Q2537/165

2. 发明公开

EP1473085A1 Biochemical reaction cartridge 有权
标题翻译：生物化学实验室
公开(公告)号：EP1473085A1
公开(公告)日：2004-11-03
申请号：EP04007667.1
申请日：2004-03-30
申请人： CANON KABUSHIKI KAISHA
发明人： Numajiri, Yasuyuki , Shimizu, Satoshi , Itoh, Hiroshi , Tanaka, Shinya
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01L3/502738 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L9/527 , B01L2200/0621 , B01L2200/10 , B01L2300/0672 , B01L2300/0816 , B01L2300/1822 , B01L2400/0478 , B01L2400/049 , B01L2400/0683 , B01L2400/0694
摘要： A biochemical reaction cartridge includes a reaction portion, comprising a chamber (11) and a passage, for effecting a biochemical reaction, and a solution storage portion (6), which is isolated or separated from said reaction portion, for storing a solution in a position corresponding to the chamber. The cartridge is provided with a penetrable partition member (10) disposed between said solution storage portion and said reaction portion so as to move the solution from said solution storage portion to the chamber of said reaction portion. The biochemical reaction cartridge is incorporated in a biochemical reaction apparatus.
摘要翻译：生化反应筒包括反应部分，其包括用于进行生物化学反应的室（11）和通道，以及与所述反应部分分离或分离的溶液储存部分（6），用于将溶液储存在与腔室对应的位置。所述盒设置有设置在所述溶液存储部分和所述反应部分之间的可穿透分隔构件（10），以便将溶液从所述溶液储存部分移动到所述反应部分的室。将生化反应盒并入生化反应装置。

3. 发明授权

EP1473085B1 Biochemical reaction cartridge 有权
标题翻译：容器生化反应
公开(公告)号：EP1473085B1
公开(公告)日：2015-07-22
申请号：EP04007667.1
申请日：2004-03-30
申请人： CANON KABUSHIKI KAISHA
发明人： Numajiri, Yasuyuki , Shimizu, Satoshi , Itoh, Hiroshi , Tanaka, Shinya
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01L3/502738 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L9/527 , B01L2200/0621 , B01L2200/10 , B01L2300/0672 , B01L2300/0816 , B01L2300/1822 , B01L2400/0478 , B01L2400/049 , B01L2400/0683 , B01L2400/0694

4. 发明授权

EP1929935B1 Focusing unit and ophthalmic photographing apparatus 有权
标题翻译：聚焦单元和眼科摄像头
公开(公告)号：EP1929935B1
公开(公告)日：2014-06-04
申请号：EP07121928.1
申请日：2007-11-29
申请人： Canon Kabushiki Kaisha
发明人： Tanaka, Shinya , Iwanaga, Tomoyuki , Itoh, Hiroshi
IPC分类号： A61B3/12 , A61B3/14
CPC分类号： A61B3/14

5. 发明公开

EP1929935A1 Focusing unit and ophthalmic photographing apparatus 有权
标题翻译： Fokussierungseinheit und eyemischer Fotoapparat
公开(公告)号：EP1929935A1
公开(公告)日：2008-06-11
申请号：EP07121928.1
申请日：2007-11-29
申请人： Canon Kabushiki Kaisha
发明人： Tanaka, Shinya , Iwanaga, Tomoyuki , Itoh, Hiroshi
IPC分类号： A61B3/12 , A61B3/14
CPC分类号： A61B3/14
摘要： A focusing unit (16) can be inserted into and removed from an illumination light path by rotating around a supporting portion (16c). An index light source (15), a green LED, is attached to the bottom of a base (16a). A transparent acrylic-resin disk (16b) is fixed to the base. A deflection prism (13) is attached to the bottom of the disk. A beam from the light source enters the deflection prism. A focus index forming portion (14) is provided on the top of the disk. In the center of a light-shielding portion (14a) is formed a slit-like opening (14b), under which split prisms (14c, 14d) are provided. Deflected by the prisms, the beam from the light source is split into two, right-half and left-half, directional beams, and combined with an illumination optical system, in the form of two slit images, at the opening.
摘要翻译：聚焦单元（16）可以通过围绕支撑部分（16c）旋转而插入照明光路中并从照明光路中移除。索引光源（15），绿色LED连接到基座（16a）的底部。透明的丙烯酸树脂盘（16b）固定在基座上。偏转棱镜（13）附接到盘的底部。来自光源的光束进入偏转棱镜。焦点指标形成部分（14）设置在盘的顶部。在遮光部（14a）的中心形成有狭缝状的开口（14b），在该狭缝状的开口部（14b）上设有分割棱镜（14c，14d）。由棱镜偏转，来自光源的光束被分成两个，右半部分和左半部分的定向光束，并且在开口处与两个狭缝图像的形式的照明光学系统组合。

6. 发明授权

EP2111785B1 Fundus camera 有权
标题翻译：眼底照相机
公开(公告)号：EP2111785B1
公开(公告)日：2014-12-24
申请号：EP09158077.9
申请日：2009-04-16
申请人： Canon Kabushiki Kaisha
发明人： Itoh, Hiroshi , Tanaka, Shinya , Takai, Motoya
IPC分类号： A61B3/12 , A61B3/14
CPC分类号： A61B3/14

7. 发明公开

EP2111785A1 Fundus camera 有权
标题翻译： Funduskamera
公开(公告)号：EP2111785A1
公开(公告)日：2009-10-28
申请号：EP09158077.9
申请日：2009-04-16
申请人： Canon Kabushiki Kaisha
发明人： Itoh, Hiroshi , Tanaka, Shinya , Takai, Motoya
IPC分类号： A61B3/12 , A61B3/14
CPC分类号： A61B3/14
摘要： A fundus camera includes an optical path splitting unit arranged between a focusing unit and an imaging unit. The optical path splitting unit has characteristics adapted to reflect light of a visible light region and to transmit near-infrared light. The optical path splitting unit retreats from an optical path when a still fundus image is photographed. A quick-return mirror having such characteristics is used as the optical path splitting unit. When near-infrared illumination light having a wavelength of about 850 nm is used, such light can be incident upon the imaging unit without loss of the amount of light. In addition, visible light output from an internal fixation target is projected onto a subject's eye. Further, a cornea diaphragm and a crystalline lens diaphragm are used for observing a fundus with invisible light. Each of the cornea diaphragm and the crystalline lens diaphragm can be changed to another one having a different diameter.
摘要翻译：眼底照相机包括布置在聚焦单元和成像单元之间的光路分离单元。光路分离单元具有适于反射可见光区域的光并透射近红外光的特性。当拍摄静止眼底图像时，光路分离单元从光路退回。具有这种特性的快速返回镜被用作光路分离单元。当使用具有约850nm波长的近红外照明光时，这种光可以入射到成像单元上而不损失光量。此外，从内部固定目标输出的可见光被投射到被检者的眼睛上。此外，角膜隔膜和晶状体膜片用于用不可见光观察眼底。每个角膜片和晶状体镜片可以改变为具有不同直径的另一个。

8. 发明公开

EP1184467A3 Screening method for gene variation 有权
标题翻译：基因变异的筛选方法
公开(公告)号：EP1184467A3
公开(公告)日：2002-09-04
申请号：EP01307415.8
申请日：2001-08-31
申请人： CANON KABUSHIKI KAISHA
发明人： Yamamoto, Nobuko , Okamoto, Tadashi , Tanaka, Shinya , Suzuki, Tomohiro
IPC分类号： C12Q1/68 , G06F17/00
CPC分类号： C12Q1/6827 , B01J2219/00378 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , C12Q1/6876 , C40B40/06 , C40B60/14 , C12Q2565/513 , C12Q2537/165
摘要： A method for screening presence or absence of a variation in a region of a nucleic acid which comprises the steps of (a) preparing a sample containing a test nucleic acid corresponding to the region, (b) preparing a probe having a base sequence fully complementary to a normal sequence of the region, and a plurality of probes each having at least one base not complementary to the normal sequence, (c) fixing the probes in separate regions on a surface of a substrate to prepare a DNA array substrate, (d) reacting the test nucleic acid with the probes on the DNA array substrate, (e) measuring signals in each region where the signals are originated from respective hybrids formed between the test nucleic acid and one of the probes, and (f) determining variation in the test nucleic acid using a pattern of total signals of all regions.
摘要翻译：一种用于筛选核酸区域中是否存在变异的方法，其包括以下步骤：（a）制备含有对应于该区域的测试核酸的样品，（b）制备具有完全互补的碱基序列的探针（c）将所述探针固定在基底表面上的不同区域中以制备DNA阵列基底，（d）将所述探针固定在所述基底表面上的不同区域中以制备DNA阵列基底，（d ）使测试核酸与DNA阵列基质上的探针反应，（e）测量信号源自测试核酸与其中一种探针之间形成的各个杂交体的每个区域中的信号，以及（f）测定测试核酸使用所有区域的总信号模式。

9. 发明公开

EP1184467A2 Screening method for gene variation 有权
标题翻译： Methode zum Auffinden von Genvariationen
公开(公告)号：EP1184467A2
公开(公告)日：2002-03-06
申请号：EP01307415.8
申请日：2001-08-31
申请人： CANON KABUSHIKI KAISHA
发明人： Yamamoto, Nobuko , Okamoto, Tadashi , Tanaka, Shinya , Suzuki, Tomohiro
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , B01J2219/00378 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , C12Q1/6876 , C40B40/06 , C40B60/14 , C12Q2565/513 , C12Q2537/165
摘要： A method for screening presence or absence of a variation in a region of a nucleic acid which comprises the steps of (a) preparing a sample containing a test nucleic acid corresponding to the region, (b) preparing a probe having a base sequence fully complementary to a normal sequence of the region, and a plurality of probes each having at least one base not complementary to the normal sequence, (c) fixing the probes in separate regions on a surface of a substrate to prepare a DNA array substrate, (d) reacting the test nucleic acid with the probes on the DNA array substrate, (e) measuring signals in each region where the signals are originated from respective hybrids formed between the test nucleic acid and one of the probes, and (f) determining variation in the test nucleic acid using a pattern of total signals of all regions.
摘要翻译：一种用于筛选核酸区域中存在或不存在变异的方法，其包括以下步骤：（a）制备含有对应于该区域的测试核酸的样品，（b）制备具有完全互补的碱基序列的探针和多个探针，每个探针各具有至少一个与正常序列不互补的碱基，（c）将探针固定在底物表面上的分离区域中以制备DNA阵列底物，（d 将测试核酸与DNA阵列底物上的探针反应，（e）测量信号源自测试核酸与探针之间形成的相应杂交体的每个区域中的信号，和（f）确定测试核酸使用所有区域的总信号的模式。

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