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1. 发明公开

EP0641219A1 BIODEGRADABLE BURSTING RELEASE SYSTEM 失效
标题翻译：生物可降解SYSTEM FOR脉冲式的解放。
公开(公告)号：EP0641219A1
公开(公告)日：1995-03-08
申请号：EP93907402.0
申请日：1993-03-10
申请人： CAMBRIDGE SCIENTIFIC, INC.
发明人： GRESSER, Joseph, D. , WISE, Donald, L. , JIMOH, Abdul, Ganiyu , AUGENSTEIN, Don, C. , KUETHE, Dean, O. , TRANTOLO, Debra, J.
IPC分类号： A61K9
CPC分类号： A61K9/0024
摘要： A biodegradable polymeric multiphasic release system of one or more biodegradable bursting units capable of delivering biologically active substances in a burst or pulse at predetermined times and a method for constructing those units is disclosed. The individual bursting units of the system may take the form of a biodegradable, membrane coated capsule (12) surrounding a core material which may include an active agent. The membrane ruptures after a predetermined time upon exposure to water or bodily, or other aqueous environmental fluids. The bursting units may be used in any situation in which a controlled pulsed release of an active substance is desired. The predetermined time release of each bursting unit is controlled by the composition of the core material, the initial radius and wall thickness of the membrane and the porosity of the membrane. The core material may also contain a chemical composition which generates gas as fluid is drawn into the bursting unit thus adding an additional design variable for predetermined bursts. A cylindrical bursting unit (10) of the invention describes biodegradable, biocompatible cylinder (open ended) shell (12) or capsule filled with a bioactive agent or other carrier/core components (14). A polylactic-co-glycolic acid (PGLA) copolymer membrane (16), fastened with a medical grade adhesive (such as ''silastic'') (20).

2. 发明公开

EP0915684A1 MATERIAL FOR BUFFERED RESORBABLE INTERNAL FIXATION DEVICES AND METHOD FOR MAKING SAME 失效
标题翻译：材料为缓冲吸收内固定装置及其制造方法
公开(公告)号：EP0915684A1
公开(公告)日：1999-05-19
申请号：EP97917081.0
申请日：1997-03-27
申请人： CAMBRIDGE SCIENTIFIC, INC.
发明人： GRESSER, Joseph, D. , TRANTOLO, Debra, J. , LANGER, Robert , KLIBANOV, Alexander, M. , WISE, Donald, L. , VIGNEAUX, Stevan
IPC分类号： A61K47 , A61F2 , A61K9 , A61L27
CPC分类号： A61L27/58 , A61F2210/0004 , A61K9/1611 , A61K9/1617 , A61K9/1647 , A61K9/2009 , A61K9/2027 , A61K9/204 , A61L27/18 , C08L69/00 , C08L67/04
摘要： A bioerodible implantable material, comprising a bioerodible polymer that produces acidic products upon hydrolytic degradation, and a buffering compound that buffers the acidic products and maintains the local pH within a desired range. The buffer compound acts to reduce the inflammatory foreign body response generated by the acidic products and reduces the sterile abscess condition that occurs at the site of the bioerodible implant materials of the prior art. Materials made according to the invention may be used for internal fixation devices (IFDs) for bone repair.

3. 发明公开

EP1499267A2 BIORESORBABLE OSTEOCONDUCTIVE COMPOSITIONS FOR BONE REGENERATION 审中-公开
标题翻译：生物可吸收骨传导组合物用于骨骼再生
公开(公告)号：EP1499267A2
公开(公告)日：2005-01-26
申请号：EP03715983.7
申请日：2003-02-05
申请人： CAMBRIDGE SCIENTIFIC, INC.
发明人： WISE, Donald, L. , TRANTOLO, Debra, J. , LEWANDROWSKI, Kai-Uwe , GRESSER, Joseph, D.
IPC分类号： A61F2/28
CPC分类号： A61L27/58 , A61L27/443 , A61L27/446 , A61L27/46 , A61L27/56 , A61L2430/02 , C08L67/04
摘要： Bioresorbable osteoconductive compositions and methods of using the composition as a scaffold for bone repair in periodontal, alveolar or maxillary regeneration, bony cranial defects, and spinal regeneration are disclosed. The bioresorbable compositions contain a bioresorbable polymer, a micro or nano particulate filler and a pore creating substance. The bioresorbable polymer can be electronically unsaturated and cross-linkable with a cross-linking agent. The micro or nano filler can be any natural biocompatible material such as a metals, calcium carbonate, carbon, a biocompatible synthetic material, or a bioceramics such as hydroxyapatite. The pore creating substance can be an efferverscent agent such as a carbonate and an acid.

4. 发明公开

EP1003441A1 BIOERODIBLE POLYMERIC SEMI-INTERPENETRATING NETWORK ALLOYS FOR SURGICAL PLATES AND BONE CEMENTS, AND METHOD FOR MAKING SAME 失效
标题翻译：可生物侵蚀，半网状网络交联聚合物合金外科板和骨水泥和生产方法
公开(公告)号：EP1003441A1
公开(公告)日：2000-05-31
申请号：EP98918232.4
申请日：1998-04-16
申请人： CAMBRIDGE SCIENTIFIC, INC.
发明人： WISE, Donald, L. , GRESSER, Joseph, D. , TRANTOLO, Debra, J. , HSU, Y., Y.
IPC分类号： A61F2/00 , A61F2/28 , A61K33/42 , C08G81/00 , C08G85/00 , C08J3/28 , C08K3/32
CPC分类号： A61L27/58 , A61B17/80 , A61B17/866 , A61B17/8833 , A61B2017/00004 , A61F2/28 , A61F2002/2817 , A61F2002/30004 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2250/0014 , A61L27/26 , A61L27/48 , A61L2430/02 , Y10S525/903 , C08L35/02 , C08L67/04
摘要： A bioerodible polymeric semi-IPN alloy which comprises a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation; a second bioerodible polymer, which provides a biopolymeric scaffolding or internal reinforcement; and optionally a buffering compound that buffers the acidic products within a desired pH range. In a preferred embodiment, the second bioerodible polymer comprises polypropylene fumarate (PPF), which is cross-linked, desirably by a vinyl monomer such as vinyl pyrrolidone (VP) to form the biopolymeric scaffolding which provides the semi-IPN with dimensional and geometric stability.

5. 发明公开

EP1119316A1 BUFFERED RESORBABLE INTERNAL FIXATION DEVICES AND METHODS FOR MAKING MATERIAL THEREFORE 审中-公开
标题翻译：缓冲吸收内固定装置和方法未使用材料的生产THERE
公开(公告)号：EP1119316A1
公开(公告)日：2001-08-01
申请号：EP99954728.4
申请日：1999-10-04
申请人： CAMBRIDGE SCIENTIFIC, INC.
发明人： GRESSER, Joseph, D. , TRANTOLO, Debra, J. , LANGER, Robert , KLIBANOV, Alexander, M. , WISE, Donald, L.
IPC分类号： A61F2/02 , A61F2/28
CPC分类号： A61L27/46 , A61B17/866 , A61B2017/00004 , A61F2/28 , A61F2/2875 , A61F2/30965 , A61F2/442 , A61F2/4455 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30062 , A61F2002/30133 , A61F2002/30261 , A61F2002/30785 , A61F2002/30789 , A61F2002/30904 , A61F2002/30952 , A61F2002/4475 , A61F2210/0004 , A61F2230/0015 , A61F2230/0082 , A61F2310/00293 , A61K9/1611 , A61K9/1617 , A61K9/1647 , A61K9/2009 , A61K9/2027 , A61K9/204 , A61L27/18 , A61L27/58 , A61L31/127 , A61L31/148 , C08L67/04 , C08L69/00
摘要： An internal fixation device and a bioerodible implantable material useful therefor comprise a bioerodible polymer that produces acidic products or low molecular weight resorbable fragments upon hydrolytic degradation, and a buffering or neutralizing agent in sufficiently high concentration to moderate the rate of change of pH of said bioerodible material during bioerosion. The buffering or neutralizing agent acts to reduce the inflammatory foreign body response generated by the acidic products and reduces the sterile abscess condition that occurs at the site of the bioerodible implant materials of the prior art. Internal fixation devices (IFDs) according to the invention are useful, for example, for the repair, replacement or reconstruction of damaged bone in any area of the body.

6. 发明公开

EP1104267A1 OSTEOINDUCTION OF CORTICAL BONE ALLOGRAFTS BY COATING WITH BIOPOLYMERS SEEDED WITH RECIPIENT PERIOSTEAL BONE CELLS 有权
标题翻译：异体骨的成骨移植物皮质关于生物聚合物与骨膜细胞定居
公开(公告)号：EP1104267A1
公开(公告)日：2001-06-06
申请号：EP99942186.0
申请日：1999-08-12
申请人： CAMBRIDGE SCIENTIFIC, INC.
发明人： LEWANDROWSKI, Kai-Uwe , BONDRE, Shrikar , TRANTOLO, Debra, J. , CATTANEO, Maurice, V. , GRESSER, Joseph, D. , WISE, Donald, L.
IPC分类号： A61F2/28
CPC分类号： A61L27/3804 , A61F2/0077 , A61F2/06 , A61F2/30767 , A61F2002/2835 , A61F2002/30062 , A61F2002/30064 , A61F2002/4648 , A61F2210/0004 , A61F2310/00353 , A61L27/34 , A61L27/3608 , A61L27/3625 , A61L27/365 , A61L27/3847 , A61L27/3895 , A61L2430/02 , A61L27/58 , A61L27/56 , A61L27/38 , C08L67/04 , C08L73/02 , C08L77/00 , C08L67/00
摘要： A method by which immune responses to cortical bone grafts and other substrates (e.g., cement, IPN, etc.) can be minimized and at the same time graft osteoinductive potential can be improved, and improved graft substrate materials are disclosed. The method of the invention provides new types of bone grafts that incorporate into host bone more thoroughly and more rapidly, eliminating long-term complications, such as fracture, non-union, infection, and rejection. In the method of the invention, bone grafts or other substrates are modified to have an osteoinductive surface modification that the recipient's body will accept as its own tissue type and therefore will not reject or otherwise cause to fail. The osteoinductive surface modification comprises a biopolymer matrix coating that is seeded with periosteal cells that have been previously harvested either from the graft recipient or from an allogenic or xenogenic donor source.

7. 发明公开

EP1011545A1 RESORBABLE INTERBODY SPINAL FUSION DEVICES 有权
标题翻译： RESORBIERBARES SPONDYLODESEIMPLANTAT
公开(公告)号：EP1011545A1
公开(公告)日：2000-06-28
申请号：EP98939338.4
申请日：1998-08-11
申请人： CAMBRIDGE SCIENTIFIC, INC.
发明人： GRESSER, Joseph, D. , TRANTOLO, Debra, J. , LANGER, Robert, S. , LEWANDROWSKI, Kai-Uwe , KLIBANOV, Alexander, M. , WISE, Donald, L.
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/30965 , A61F2/442 , A61F2002/2835 , A61F2002/30062 , A61F2002/30112 , A61F2002/30133 , A61F2002/30153 , A61F2002/30179 , A61F2002/30217 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30868 , A61F2002/30904 , A61F2002/30957 , A61F2210/0004 , A61F2230/0004 , A61F2230/0015 , A61F2230/0019 , A61F2230/0058 , A61F2230/0067 , Y10S623/926
摘要： A resorbing interbody fusion device (10) for use in spinal fixation is disclosed. The device (10) is composed of 25 % to 100 % bio-resorbing or resorbing material. A preferred resorbing spinal fusion device (10) is in the shape of a tapered wedge having a top face (11), a bottom face (12), side faces (13), a front end (14), and a back end (15). The surfaces of the top (11), and bottom (12) faces each have serration (16) to aid in anchoring the device (10) to the surrounding bone. The fusion device (10) preferably has holes (17) of convenient diameter to facilitate resorption of the polymer from which the device has been made.

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