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1. 发明公开

EP3682970A1 VORRICHTUNG ZUM ABTRENNEN EINES ÜBERSTANDS EINER FLÜSSIGEN PROBE 审中-实审
公开(公告)号：EP3682970A1
公开(公告)日：2020-07-22
申请号：EP20154836.9
申请日：2012-03-23
申请人： Boehringer Ingelheim Microparts GmbH
发明人： SCHOEN, Christian , THIELE, Tanja
IPC分类号： B01L3/14 , G01N33/49 , A61M1/34
摘要： Es wird eine Vorrichtung zum Abtrennen eines Überstands einer flüssigen Probe vorgeschlagen, wobei die Vorrichtung einen Ablauf für den Überstand und eine dem Ablauf zugeordnete Ventileinrichtung aufweist, wobei sich der Ablauf oberhalb eines Rückhaltebereichs, der in einem unteren Bereich des Aufnahmeraums gebildet ist, in den Aufnahmeraum öffnet, so dass bei geöffneter Ventileinrichtung der Überstand der Probe nur oberhalb des Rückhaltebereichs aus dem Aufnahmeraum abfließt, wobei der Rückhaltebereich von einem Boden des Aufnahmeraums gebildet ist, wobei der Boden im Wesentlichen trichterartig ausgebildet ist, wobei der Ablauf (5) röhrchenartig ausgebildet ist.

2. 发明公开

EP2688675A1 VORRICHTUNG UND VERFAHREN ZUM ABTRENNEN EINES ÜBERSTANDS EINER FLÜSSIGEN PROBE SOWIE VERWENDUNG EINER VENTILEINRICHTUNG MIT EINER LÖSLICHEN MEMBRAN 审中-公开
标题翻译：装置及方法液体样品和阀门装置的使用与可溶性Reed讨论LEVEL分离
公开(公告)号：EP2688675A1
公开(公告)日：2014-01-29
申请号：EP12710096.4
申请日：2012-03-23
申请人： Boehringer Ingelheim Microparts GmbH
发明人： SCHOEN, Christian , THIELE, Tanja
IPC分类号： B01L3/14 , G01N33/49
CPC分类号： B01L3/5021 , A61M1/34 , A61M1/3403 , B01D63/00 , B01D71/10 , B01D2311/2676 , B01J19/00 , B01L3/14 , B01L2300/0864 , B01L2400/0677 , C12Q1/22 , E21B25/00 , E21B25/08 , G01N33/49 , G01N33/80
摘要： The invention relates to a device and method for removing a supernatant of a liquid sample, wherein a drain is closed by a water-soluble membrane, which dissolves after a certain time, and therefore the supernatant of the sample is automatically led away after centrifugation. The water-soluble membrane generally can also be used for other purposes to temporarily retain a liquid in an accommodating space.
摘要翻译：的装置和用于分离液体样品的上清液的方法，提出了在其中插座是由水溶性膜封闭并溶解后的一定时间长度如此做了样品的上清被自动离心后流走，水溶性膜可以在原则上可因此被用于其它目的用于在保持室暂时保持液体。

3. 发明授权

EP2654955B1 VERFAHREN ZUM MISCHEN WENIGSTENS EINER PROBENLÖSUNG MIT REAGENZIEN 有权
标题翻译：方法将至少一种样品溶液试剂
公开(公告)号：EP2654955B1
公开(公告)日：2015-07-15
申请号：EP11794751.5
申请日：2011-12-13
申请人： Boehringer Ingelheim Microparts GmbH
发明人： LANGE, Berthold , SCHOEN, Christian , EICHMANN, Tobias
IPC分类号： B01L3/00 , B01F1/00 , B01F7/00 , B01F7/16 , B01F11/00 , B01F13/00 , B01F15/02 , G01N35/10
CPC分类号： B01L3/50273 , B01F1/0011 , B01F7/00033 , B01F7/0015 , B01F7/00291 , B01F7/161 , B01F11/008 , B01F13/0059 , B01F15/0205 , B01F15/0212 , B01L2200/16 , B01L2400/0475 , B01L2400/0633 , B01L2400/065 , B01L2400/0683 , G01N2035/1055 , G01N2035/1058

4. 发明公开

EP2485841A1 FÜGEVERFAHREN UND FÜGEVERBINDUNG FÜR MIKROFLUIDISCHE BAUTEILE 审中-公开
标题翻译：接合方法添加连接对于组件微流控
公开(公告)号：EP2485841A1
公开(公告)日：2012-08-15
申请号：EP10760703.8
申请日：2010-10-05
申请人： Boehringer Ingelheim Microparts GmbH
发明人： SCHOEN, Christian , JOEDICKE, Thorsten , KUROWSKI, Dirk
IPC分类号： B01L3/00 , B29C65/60 , B81C3/00
CPC分类号： B29C65/606 , B01L3/502707 , B01L2200/025 , B01L2200/0689 , B01L2300/0816 , B01L2300/0887 , B29C65/08 , B29C65/8207 , B29C65/8215 , B29C66/12461 , B29C66/24221 , B29C66/5412 , B29C66/542 , B29C66/71 , B29C66/81417 , B29C66/81422 , B29C66/8322 , B29C66/91411 , B29C66/91421 , B29C66/919 , B29C66/91921 , B29C66/91933 , B29C66/91943 , B29C66/929 , B29C66/949 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2033/12 , B29K2069/00 , B29K2071/00 , B29L2031/756 , B81B2201/058 , B81C3/001 , B81C2203/032 , B81C2203/051 , B29K2067/00 , B29K2023/38
摘要： The invention relates to joining plastic components into a microfluidic cartridge (20). The invention in particular relates to cartridges (20) for diagnostic analysis devices. The cartridge (20) comprises a fluidically conductive floor element (11), a cover (2), and a film (3) disposed between the elements (1, 2). The cover (2) or the floor element (1) and the film (3) comprise a filling opening (5) for filling microfluidic channels (4) in one of the elements having sample fluid. Pins (6) formed integrally with one of the board-shaped elements (1, 2) engage in corresponding holes (7) in the film (3) and the associated element (1, 2) for each. By means of deforming a pin (6), a friction fit is produced between a deformed pin and the wall of a hole, and a head (9) contacting the associated substrate in a form-fitting manner is formed. For the joining process, a press tool (12) is placed on a head end (9) of a pin (6) at a predetermined pressure P, and heat transfer into the pin (6) takes place during a weld time ts. The pin material is brought to above the glass transition temperature and/or the melting point, and a friction fit between the pin (6) and the wall of the hole (7) is formed by flowing the pin material in the hole (7).

5. 发明公开

EP2268405A2 VORRICHTUNG ZUR PLASMASEPARATION 有权
标题翻译： DEVICE FOR血浆分离
公开(公告)号：EP2268405A2
公开(公告)日：2011-01-05
申请号：EP09714713.6
申请日：2009-02-26
申请人： Boehringer Ingelheim Microparts Gmbh
发明人： BLANKENSTEIN, Gert , BARTOS, Holger , PETERS, Ralf-Peter , SCHOEN, Christian
IPC分类号： B01L3/00
CPC分类号： B01L3/502753 , B01D29/014 , B01D29/05 , B01D61/18 , B01D63/08 , B01D63/087 , B01D63/088 , B01D2201/0415 , B01D2201/44 , B01L3/502715 , B01L2300/0681 , B01L2300/0864 , B01L2400/0406 , G01N33/491
摘要： The invention relates to an apparatus for separating blood, more particularly an apparatus (1) for absorbing blood (19) and separating blood components, e.g. blood plasma, as a sample liquid (2). Said apparatus (1) comprises a feeding device (13) for absorbing the blood (2), a device (15) for separating blood components as a sample liquid (2), a duct which preferably absorbs the sample liquid (2) exclusively by means of capillary forces, and a device for filling the duct (3) with sample liquid (2) in an inlet or feeding zone (18) of the duct (3). The separating device (15), in particular a membrane, is curved, especially convexly shaped, and the apex of said curved, especially convex shape projects into the filling device.

6. 发明公开

EP2654955A1 VERFAHREN ZUM MISCHEN WENIGSTENS EINER PROBENLÖSUNG MIT WENIGSTENS EINEM REAGENZ UND VORRICHTUNG 有权
标题翻译：方法将至少一种样品溶液试剂
公开(公告)号：EP2654955A1
公开(公告)日：2013-10-30
申请号：EP11794751.5
申请日：2011-12-13
申请人： Boehringer Ingelheim Microparts GmbH
发明人： LANGE, Berthold , SCHOEN, Christian , EICHMANN, Tobias
IPC分类号： B01L3/00 , B01F1/00 , B01F7/00 , B01F7/16 , B01F11/00 , B01F13/00 , B01F15/02 , G01N35/10
CPC分类号： B01L3/50273 , B01F1/0011 , B01F7/00033 , B01F7/0015 , B01F7/00291 , B01F7/161 , B01F11/008 , B01F13/0059 , B01F15/0205 , B01F15/0212 , B01L2200/16 , B01L2400/0475 , B01L2400/0633 , B01L2400/065 , B01L2400/0683 , G01N2035/1055 , G01N2035/1058
摘要： The invention relates to a method for mixing at least one sample solution (P) having at least one reagent (R) in at least one chamber (2) of a microfluidic cartridge (MC), and to a device for carrying out the method. According to the invention, at least one reagent (R) is added to the sample solution (P) by means of at least one displaceable component (11) and brought into contact with same. The loss of sample liquid (P) and analyte can thus be reduced. The invention further relates to a device for carrying out the method.

7. 发明授权

EP2552586B1 BAUTEIL EINES BIOSENSORS UND VERFAHREN ZUR HERSTELLUNG 有权
公开(公告)号：EP2552586B1
公开(公告)日：2020-07-29
申请号：EP11709899.6
申请日：2011-03-10
申请人： Boehringer Ingelheim Microparts GmbH
发明人： SCHOEN, Christian , WAGENER, Michael
IPC分类号： B01L3/00

8. 发明授权

EP2268405B1 VORRICHTUNG ZUR PLASMASEPARATION 有权
公开(公告)号：EP2268405B1
公开(公告)日：2017-01-04
申请号：EP09714713.6
申请日：2009-02-26
申请人： Boehringer Ingelheim Microparts Gmbh
发明人： BLANKENSTEIN, Gert , BARTOS, Holger , PETERS, Ralf-Peter , SCHOEN, Christian
IPC分类号： G01N33/49 , B01L3/00
CPC分类号： B01L3/502753 , B01D29/014 , B01D29/05 , B01D61/18 , B01D63/08 , B01D63/087 , B01D63/088 , B01D2201/0415 , B01D2201/44 , B01L3/502715 , B01L2300/0681 , B01L2300/0864 , B01L2400/0406 , G01N33/491

9. 发明公开

EP2552586A1 BAUTEIL EINES BIOSENSORS UND VERFAHREN ZUR HERSTELLUNG 有权
标题翻译：成分在制造一个生物传感器和方法
公开(公告)号：EP2552586A1
公开(公告)日：2013-02-06
申请号：EP11709899.6
申请日：2011-03-10
申请人： Boehringer Ingelheim Microparts GmbH
发明人： SCHOEN, Christian , WAGENER, Michael
IPC分类号： B01L3/00
摘要： The invention relates to a component (4) of a biosensor, comprising at least one first device (6) for receiving a sample liquid, wherein the device (6) is connected via a distributor channel (7) to further receiving devices (8 to 11), into each of which a feed channel (71, 72, 73, 74) branching off from the distributor channel (7) opens, and the feed channels (71, 72, 73, 74) are arranged in succession in flow direction (S) of the sample liquid passed on through the distributor channel (7). In accordance with the invention, it is envisaged that, in the distributor channel (7), in each case between two immediately successive feed channels (71, 72; 72, 73; 73, 74) in flow direction (S), at least one region (K) for at least temporary slowing or stoppage of the capillary flow of the sample liquid has been inserted. It is thus possible to control the capillary flow of the sample liquid such that always only one receiving device (8, 9, 10, 11) is filled with the volume flow of sample liquid available before the next is filled, and effectively simultaneous filling of the receiving devices (8, 9, 10, 11) is prevented. This leads to rapid and complete filling of the respective receiving device (8, 9, 10, 11). Additionally presented is a process with which the regions (K) can be inserted into the distributor channel (7) in a simple manner.

10. 发明公开

EP2451575A2 PLASMA SEPARATION RESERVOIR 审中-公开
标题翻译： PLASMAABSCHEIDUNGSRESERVOIR
公开(公告)号：EP2451575A2
公开(公告)日：2012-05-16
申请号：EP10726046.5
申请日：2010-06-08
申请人： Boehringer Ingelheim Microparts GmbH
发明人： BLANKENSTEIN, Gert , SCHOEN, Christian
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/50273 , B01L3/502746 , B01L3/502753 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/165 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , B01L2400/088 , G01N33/491 , Y10T137/0318 , Y10T137/794
摘要： The invention relates to a microfluidic apparatus for producing a volume flow that is uniform over time in a metering process. In various solution processes or reaction processes it is essential to have a specified given volume flow or mass flow of fluid available to ensure reliable dissolution of the reagent or ensure that the reaction takes place. In microfluidic apparatus in which separation of particles from a fluid, particularly blood, is carried out through a membrane, the volume flow through the membrane decreases continuously. In order to achieve a uniform volume flow during metering, it is envisaged that first of all a reservoir is filled from a first channel, so that the contents of the reservoir can then be fed to the metering process by opening a fluid stop. The emptying of the reservoir takes place with a uniform volume flow of 0.05 microliters per second to 10 microliters per second.

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