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1. 发明授权

EP0963708B1 Method for the iodine fortification of eggs 有权
标题翻译：一种鸡蛋Iodverstärkung过程
公开(公告)号：EP0963708B1
公开(公告)日：2003-08-06
申请号：EP99303898.3
申请日：1999-05-19
申请人： Biophile Corporation
发明人： Suvanprakorn, Pichit , Tanasugarn, Lerson , Limahksohn, Anusig , Sinawat, Sangsom , Vuthipongse, Prakrom
IPC分类号： A23L1/32 , A23B5/18
CPC分类号： A23L15/30

2. 发明公开

EP2526928A1 Increased Effectiveness of Allylamine Drug Compounds 有权
标题翻译： ErhöhteEffektivitätvon Allylamin-Heilmittelverbindungen
公开(公告)号：EP2526928A1
公开(公告)日：2012-11-28
申请号：EP12169658.7
申请日：2008-02-05
申请人： Biophile Corporation, Ltd
发明人： Suvanprakorn, Pichit , Zaias, Nardo , Vayumhasuwan, Panida
IPC分类号： A61K9/06 , A61K31/131 , A61K31/137
CPC分类号： A61K31/137 , A61K9/0014 , A61K9/127 , A61K9/50 , A61K31/131 , A61K47/10 , A61K47/24 , A61K47/26 , Y10S514/944 , Y10S514/946 , Y10S514/947 , Y10S514/975 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages The allylamine active ingredient is prepared in an acidic environment, which alters the physiochemical properties of the active ingredient resulting in the ingredient having a positive charge The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.
摘要翻译：本发明是用于局部治疗皮肤和皮肤附属物的真菌感染的烯丙胺药物化合物的有效性。烯丙胺活性成分在酸性环境中制备，其改变活性成分的物理化学性质，导致具有正电荷的成分该配方中使用的正电荷和增强剂允许通过皮肤和皮肤附属物增加活性成分的渗透。带正电荷的活性成分或者直接溶解在载体中或溶解在悬浮在载体中的多个珠子中。珠结构使分子带正电荷的活性成分和催化物质通过珠粒结构的扩散，从而通过阻止带正电荷的活性成分和催化物质的相互作用来稳定珠粒内带正电的活性成分，从而延长了定位的保质期充满电的活性成分。

3. 发明授权

EP2526928B1 Increased effectiveness of allylamine drug compounds 有权
公开(公告)号：EP2526928B1
公开(公告)日：2018-12-26
申请号：EP12169658.7
申请日：2008-02-05
申请人： Biophile Corporation, Ltd
发明人： Suvanprakorn, Pichit , Zaias, Nardo , Vayumhasuwan, Panida
IPC分类号： A61P31/10 , A61K9/06 , A61K31/131 , A61K31/137
CPC分类号： A61K31/137 , A61K9/0014 , A61K9/127 , A61K9/50 , A61K31/131 , A61K47/10 , A61K47/24 , A61K47/26 , Y10S514/944 , Y10S514/946 , Y10S514/947 , Y10S514/975 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages The allylamine active ingredient is prepared in an acidic environment, which alters the physiochemical properties of the active ingredient resulting in the ingredient having a positive charge The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.

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