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1. 发明公开

EP2260942A3 Protease Inhibitor Sample Collection System 审中-公开
标题翻译：采样系统含有蛋白酶抑制剂
公开(公告)号：EP2260942A3
公开(公告)日：2011-03-09
申请号：EP10178663.0
申请日：2003-05-13
申请人： Becton, Dickinson and Company , Haywood, Bruce , Dastane, Ajit , Lin, Fu-Chung
发明人： Haywood, Bruce , Dastane, Ajit , Lin, Fu-Chung
IPC分类号： B01L3/00 , B01L3/14 , A61B5/15
CPC分类号： A61B5/417 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150274 , A61B5/150351 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150893 , A61B5/154 , A61J1/05 , A61J1/12 , A61J7/00 , A61J7/0053 , B01L3/02 , B01L3/50 , B01L3/5082 , B01L2200/16 , B01L2300/0609 , C12M23/12 , C12M33/04 , G01N35/1095 , Y10T436/2525 , Y10T436/25375
摘要： The invention provides an apparatus for collecting a biological sample such as a whole blood sample, directly from a patient.

2. 发明公开

EP2260942A2 Protease Inhibitor Sample Collection System 审中-公开
标题翻译： Probenahmesystem mit蛋白酶
公开(公告)号：EP2260942A2
公开(公告)日：2010-12-15
申请号：EP10178663.0
申请日：2003-05-13
申请人： Becton, Dickinson and Company , Haywood, Bruce , Dastane, Ajit , Lin, Fu-Chung
发明人： Haywood, Bruce , Dastane, Ajit , Lin, Fu-Chung
IPC分类号： B01L3/00 , B01L3/14 , A61B5/15
CPC分类号： A61B5/417 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150274 , A61B5/150351 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150893 , A61B5/154 , A61J1/05 , A61J1/12 , A61J7/00 , A61J7/0053 , B01L3/02 , B01L3/50 , B01L3/5082 , B01L2200/16 , B01L2300/0609 , C12M23/12 , C12M33/04 , G01N35/1095 , Y10T436/2525 , Y10T436/25375
摘要： The invention provides an apparatus for collecting a biological sample such as a whole blood sample, directly from a patient.
摘要翻译：本发明提供一种用于从患者直接收集生物样品例如全血样品的装置。

3. 发明公开

EP1106253A2 Device and method for separating components of a fluid sample 有权
标题翻译： Vorrichtung zur Trennung von Bestandteilen einerflüssigenProbe
公开(公告)号：EP1106253A2
公开(公告)日：2001-06-13
申请号：EP00126243.5
申请日：2000-12-01
申请人： Becton, Dickinson and Company
发明人： DiCesare, Paul C. , Radziunas, Jeffrey P. , Losada, Rober Joseph , Lin, Fu-Chung
IPC分类号： B01L3/14
CPC分类号： B01L3/50215
摘要： A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising a deformable bellows, a ballast mounted to the lower end of the bellows, and a float is engageable with an upper end of the bellows. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the ballast to move toward the bottom of the tube and causes an elongation and narrowing of the bellows. The separator then moves down the tube and stabilizes in a position between the separated phases of the fluid sample. Termination of the centrifugal load enables the bellows to return to its original condition in sealing engagement with the walls of the tube. The dense formed phase of the fluid sample will lie between the separator and the bottom of the tube, while less dense liquid phase of the fluid sample will be the separator.
摘要翻译：用于分离流体样品的较重和较轻馏分的装置和方法。该装置包括多个构件，其包括容器中的容器和复合元件。复合元件是包括可变形波纹管的隔板，安装在波纹管的下端的压载物，浮子可与波纹管的上端接合。将流体样品输送到容器并且使装置进行离心，由此离心负载使压载物朝向管的底部移动并引起波纹管的伸长和变窄。然后分离器向下移动管并稳定在流体样品的分离相之间的位置。离心负载的终止使得波纹管能够恢复到与管的壁密封接合的初始状态。流体样品的致密成形相位将位于分离器和管的底部之间，而流体样品的较不致密的液相将是分离器。

4. 发明公开

EP1031380A2 Blood collection assembly and method for its manufacture 有权
标题翻译：采血组件和它们的制备方法
公开(公告)号：EP1031380A2
公开(公告)日：2000-08-30
申请号：EP00101819.1
申请日：2000-01-28
申请人： Becton, Dickinson and Company
发明人： Serpentino, Peter , Lin, Fu-Chung , Shankar, Hariharan , Weir, Theodore S.
IPC分类号： B01L3/14
CPC分类号： B01L3/50825 , A61B5/15003 , A61B5/150274 , A61B5/150351 , A61B5/150396 , A61B5/150519 , A61B5/150732 , A61B5/154 , Y10T436/108331
摘要： An assembly for collection of a blood sample includes a hydrophobic plastic tube and a non-exudable block or graft copolymer having a hydrophobic domain compatible with and interpenetrated in the matrix of the tube plastic and a hydrophilic domain which provides a hydrophilic interior wall surface to the container. The invention includes a method to make the container.

5. 发明公开

EP1106250A3 Device and method for separating components of a fluid sample 有权
公开(公告)号：EP1106250A3
公开(公告)日：2003-11-05
申请号：EP00125384.8
申请日：2000-12-01
申请人： Becton Dickinson and Company
发明人： Lin, Fu-Chung , DiCesare, Paul , Radziunas, Jeffrey
IPC分类号： B01L3/14
CPC分类号： B01L3/5021 , B01L3/50215 , B01L3/50825 , B01L2400/0605 , B01L2400/0638 , Y10T436/25375
摘要： A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a flexible collapsible inner container disposed within a substantially rigid outer container. A closure seals the open top end of the outer container. A filter assembly is sealingly mounted to the open top end of the inner container. The filter assembly further includes a filter support having a slit valve registered with the filter. The slit valve opens in response to fluid pressure created by the lighter fractions for permitting the lighter fractions to flow therethrough. A fluid sample is delivered to the inner container and the device is subjected to centrifugation whereby the centrifugal load causes the filter assembly to move toward the bottom end of the outer container and thereby enable the lighter fraction of the fluid sample to flow through the slit valve and into the space between the inner and outer conatiners. The slit valve closes upon termination of the centrifugal load such that separation between the heavier and lighter fractions of the fluid sample are maintained.

6. 发明公开

EP1106253A3 Device and method for separating components of a fluid sample 有权
标题翻译：装置和方法用于液体样品的组分的分离
公开(公告)号：EP1106253A3
公开(公告)日：2003-10-29
申请号：EP00126243.5
申请日：2000-12-01
申请人： Becton, Dickinson and Company
发明人： DiCesare, Paul C. , Radziunas, Jeffrey P. , Losada, Rober Joseph , Lin, Fu-Chung
IPC分类号： B01L3/14 , G01N33/49
CPC分类号： B01L3/50215
摘要： A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising a deformable bellows, a ballast mounted to the lower end of the bellows, and a float is engageable with an upper end of the bellows. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the ballast to move toward the bottom of the tube and causes an elongation and narrowing of the bellows. The separator then moves down the tube and stabilizes in a position between the separated phases of the fluid sample. Termination of the centrifugal load enables the bellows to return to its original condition in sealing engagement with the walls of the tube. The dense formed phase of the fluid sample will lie between the separator and the bottom of the tube, while less dense liquid phase of the fluid sample will be the separator.

7. 发明公开

EP1005909A3 Centrifuge tube with round separation element, liner and cap 有权
标题翻译：离心管具有圆形分隔构件主体和帽
公开(公告)号：EP1005909A3
公开(公告)日：2002-06-12
申请号：EP99124313.0
申请日：1999-12-06
申请人： Becton, Dickinson and Company
发明人： DiCesare, Paul C. , Karg, Jeffrey , Lin, Fu-Chung
IPC分类号： B01L3/14 , G01N33/49
CPC分类号： B01L3/50215
摘要： A device and method is provided for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents. The constituents include a container, a liner in the container and a composite element in the liner for separating the fractions of a fluid sample. The separator comprises a specific density at a target density range as defined by separable fluid components densities. A fluid sample is delivered to the liner and then the device is subjected to centrifugation whereby the centrifugal load causes the liner to deform and the composite element migrates into the fluid sample and stabilizes between the heavier and lighter fractions of the fluid sample. The liner will resiliently return to its initial configuration upon termination of the centrifugal load such that the liner sealingly engages the composite element and separates the heavier and lighter fractions of the fluid sample

8. 发明公开

EP1106250A2 Device and method for separating components of a fluid sample 有权
标题翻译：用于分离流体样品成分的装置和方法
公开(公告)号：EP1106250A2
公开(公告)日：2001-06-13
申请号：EP00125384.8
申请日：2000-12-01
申请人： Becton, Dickinson and Company
发明人： Lin, Fu-Chung , DiCesare, Paul , Radziunas, Jeffrey
IPC分类号： B01L3/14
CPC分类号： B01L3/5021 , B01L3/50215 , B01L3/50825 , B01L2400/0605 , B01L2400/0638 , Y10T436/25375
摘要： A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a flexible collapsible inner container disposed within a substantially rigid outer container. A closure seals the open top end of the outer container. A filter assembly is sealingly mounted to the open top end of the inner container. The filter assembly further includes a filter support having a slit valve registered with the filter. The slit valve opens in response to fluid pressure created by the lighter fractions for permitting the lighter fractions to flow therethrough. A fluid sample is delivered to the inner container and the device is subjected to centrifugation whereby the centrifugal load causes the filter assembly to move toward the bottom end of the outer container and thereby enable the lighter fraction of the fluid sample to flow through the slit valve and into the space between the inner and outer conatiners. The slit valve closes upon termination of the centrifugal load such that separation between the heavier and lighter fractions of the fluid sample are maintained.
摘要翻译：一种用于分离流体样品的较重和较轻部分的装置和方法。该装置包括设置在基本刚性的外部容器内的柔性可折叠内部容器。封闭件密封外部容器的开放顶端。过滤器组件密封地安装到内部容器的敞开顶端。过滤器组件还包括具有与过滤器配准的狭缝阀的过滤器支撑件。狭缝阀响应于较轻组分产生的流体压力而打开，以允许较轻组分流过其中。流体样本被输送到内部容器并且该装置经受离心作用，由此离心负载导致过滤器组件向外部容器的底端移动，从而使流体样本的较轻部分流过狭缝阀并进入内部和外部集装箱之间的空间。狭缝阀在离心负载结束时关闭，以保持流体样品的较重和较轻部分之间的分离。

9. 发明公开

EP1031380A3 Blood collection assembly and method for its manufacture 有权
标题翻译：采血组件和它们的制备方法
公开(公告)号：EP1031380A3
公开(公告)日：2001-01-17
申请号：EP00101819.1
申请日：2000-01-28
申请人： Becton, Dickinson and Company
发明人： Serpentino, Peter , Lin, Fu-Chung , Shankar, Hariharan , Weir, Theodore S.
IPC分类号： B01L3/14
CPC分类号： B01L3/50825 , A61B5/15003 , A61B5/150274 , A61B5/150351 , A61B5/150396 , A61B5/150519 , A61B5/150732 , A61B5/154 , Y10T436/108331
摘要： An assembly for collection of a blood sample includes a hydrophobic plastic tube and a non-exudable block or graft copolymer having a hydrophobic domain compatible with and interpenetrated in the matrix of the tube plastic and a hydrophilic domain which provides a hydrophilic interior wall surface to the container. The invention includes a method to make the container.

10. 发明公开

EP0384331A3 Blood partitioning composition 失效
标题翻译：血液分离组合物
公开(公告)号：EP0384331A3
公开(公告)日：1991-01-30
申请号：EP90103096.5
申请日：1990-02-17
申请人： Becton Dickinson and Company
发明人： Pradhan, Shrinkant P. , Narayanan, Sheshadri , Lin, Fu-Chung
IPC分类号： G01N33/49
CPC分类号： G01N33/5002 , G01N33/491 , Y10T436/10 , Y10T436/25
摘要： The invention relates to a blood partitioning composition characterized by an admixture forming a thixotropic gel, said gel comprising
(a) a dual resin component including a hydrocarbon of lower density combined with a chlorinated hydrocarbon of higher density; (b) a radiation stabilizer; (c) a network stabilizer; (d) a thixotropic agent; and (e) a pigment.

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