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1. 发明公开

EP2401289A1 ALTERATION AND MODULATION OF PROTEIN ACTIVITY BY VARYING POST-TRANSLATIONAL MODIFICATION 审中-公开
标题翻译：修订和蛋白质活性的调节由不同的修改对翻译
公开(公告)号：EP2401289A1
公开(公告)日：2012-01-04
申请号：EP10746882.9
申请日：2010-02-26
申请人： Battelle Energy Alliance, LLC
发明人： THOMPSON, David, N. , REED, David, W. , THOMPSON, Vicki, S. , LACEY, Jeffrey, A. , APEL, William, A.
IPC分类号： C07K14/195 , C12P21/02
CPC分类号： C12P21/005 , C07K14/195 , C12N9/1048 , C12N9/2437 , C12N9/248
摘要： Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or more glycosyltransferases and/or post-translational modification proteins.

2. 发明公开

EP2242841A1 THERMAL AND ACID TOLERANT BETA-XYLOSIDASES, GENES ENCODING, RELATED ORGANISMS, AND METHODS 审中-公开
标题翻译：热和酸稳定的β-木糖苷酶，编码基因为相关机构和程序
公开(公告)号：EP2242841A1
公开(公告)日：2010-10-27
申请号：EP09703173.6
申请日：2009-01-23
申请人： Battelle Energy Alliance, LLC
发明人： THOMPSON, David, N. , THOMPSON,Vicki, S. , SCHALLER, Kastli , APEL, William, A. , REED, David, W. , LACEY, Jeffrey, A. , APEL, William, A.
IPC分类号： C12N9/42 , D21C1/00
CPC分类号： C12Y302/01037 , C12N9/2402 , C12N9/248 , C12N9/2482 , C12Y302/01055 , D21C5/005 , D21C11/0007
摘要： Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof are provided. Further provided are methods of at least partially degrading xylotriose and/or xylobiose using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof.

3. 发明公开

EP2971286A2 ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL OR SOURCE OF A BIOLOGICAL MATERIAL 审中-公开
标题翻译：用于鉴定生物材料的个体或来源的抗体概况，方法和设备
公开(公告)号：EP2971286A2
公开(公告)日：2016-01-20
申请号：EP14770227.8
申请日：2014-03-12
申请人： Battelle Energy Alliance, LLC
发明人： APEL, William, A. , THOMPSON, Vicki, S. , LACEY, Jeffrey, A. , PARK, Shawna
IPC分类号： C40B30/04 , C40B40/10 , G01N33/53
CPC分类号： G01N33/6854
摘要： A sample of a biological material having individual-specific antibodies is contacted with an array of less than about 200 proteins on a support to bind some of the individual-specific antibodies to the proteins of the array to form immune complexes. A detection agent with an interacting protein for conjugation to a marker is applied to the array to detect the immune complexes and obtain an antibody profile, which is compared to a known antibody profile obtained from an individual. The array may further include control spots including human IgG to form control complexes and volume assessment spots including volume determination proteins to form volume complexes. Intensity of the control complexes may be detected to determine if results of the identifying are complete. Intensity of the volume complexes may be detected to determine if a volume of the sample is sufficient for an accurate result.
摘要翻译：使具有个体特异性抗体的生物材料样品与载体上小于约200个蛋白质的阵列接触，以将一些个体特异性抗体与阵列的蛋白质结合以形成免疫复合物。将具有用于与标记物缀合的相互作用蛋白质的检测剂应用于阵列以检测免疫复合物并获得抗体谱，其与从个体获得的已知抗体谱相比较。阵列可以进一步包括对照斑点，包括人IgG以形成对照复合物和包括体积测定蛋白质在内的体积评估点以形成体积复合物。可以检测对照复合物的强度以确定鉴定的结果是否完整。可以检测体积复合物的强度以确定样品的体积是否足以获得准确的结果。

4. 发明公开

EP2478363A2 IDENTIFICATION OF DISCRIMINANT PROTEINS THROUGH ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL 审中-公开
标题翻译：识别歧视性蛋白能个人识别抗体分析和方法及装置
公开(公告)号：EP2478363A2
公开(公告)日：2012-07-25
申请号：EP10819278.2
申请日：2010-09-17
申请人： Battelle Energy Alliance, LLC
发明人： APEL, William, A. , THOMPSON, Vicki, S. , LACEY, Jeffrey, A. , GENTILLON, Cynthia, A.
IPC分类号： G01N33/53
CPC分类号： G01N33/6845
摘要： A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.

5. 发明公开

EP2257566A2 THERMOPHILIC AND THERMOACIDOPHILIC SUGAR TRANSPORTER GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND RELATED ORGANISMS, METHODS 审中-公开
标题翻译： THERMO AUDIOPHILE和THERMOACIDOPHILE糖转运蛋白基因和酶从酸杆菌的脂环酸及任何相关的生物程序
公开(公告)号：EP2257566A2
公开(公告)日：2010-12-08
申请号：EP09755307.7
申请日：2009-02-26
申请人： Battelle Energy Alliance, LLC
发明人： THOMPSON, David, N. , APEL, William, A. , THOMPSON, Vicki, S. , REED, David, W. , LACEY, Jeffrey, A.
IPC分类号： C07H21/04 , C07K14/00
CPC分类号： C07K14/195
摘要： Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from
Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides and nucleic acid sequences from
Alicyclobacillus acidocaldarius .

6. 发明公开

EP2245143A2 THERMOPHILIC AND THERMOACIDOPHILIC METABOLISM GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND RELATED ORGANISMS, METHODS 审中-公开
标题翻译： THERMO AUDIOPHILE和THERMOACIDOPHILE代谢的基因和酶从酸杆菌的脂环酸和相关生物和方法
公开(公告)号：EP2245143A2
公开(公告)日：2010-11-03
申请号：EP09755308.5
申请日：2009-02-26
申请人： Battelle Energy Alliance, LLC
发明人： THOMPSON, Vicki, S. , APEL, William, A. , REED, David, W. , LEE, Brady, D. , THOMPSON, David, N. , ROBERTO, Francisco , LACEY, Jeffrey, A.
IPC分类号： C12N9/00 , C12N15/00 , C12N5/00
CPC分类号： C12N9/88 , C12N9/00 , C12N9/1029 , C12N15/74 , C12N15/75 , C12Y203/01009 , C12Y402/01055
摘要： Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering metabolism in a cell using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.

7. 发明公开

EP2245040A2 TRANSCRIPTIONAL CONTROL IN ALICYCLOBACILLUS ACIDOCALDARIUS AND ASSOCIATED GENES, PROTEINS, AND METHODS 审中-公开
标题翻译：控制转录的脂环热硫化叶菌，因此相关基因，蛋白质和方法
公开(公告)号：EP2245040A2
公开(公告)日：2010-11-03
申请号：EP09743132.4
申请日：2009-02-20
申请人： Battelle Energy Alliance, LLC
发明人： LEE, Brady, D. , THOMPSON, David, N. , APEL, William, A. , THOMPSON, Vicki, S. , REED, David, W. , LACEY, Jeffrey, A.
IPC分类号： C07H21/04 , C07K17/00
CPC分类号： C12N15/635 , C07K14/195 , C12N15/74
摘要： Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of modulating transcription or transcription or transcriptional control using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.

8. 发明公开

EP2235174A1 THERMOPHILIC AND THERMOACIDOPHILIC BIOPOLYMER- DEGRADING GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND RELATED ORGANISMS, METHODS 审中-公开
标题翻译： THERMO AUDIOPHILE和THERMOACIDOPHILE BIOPOLYMERABBAUGENE，酶从酸杆菌的脂环酸和相关生物和方法
公开(公告)号：EP2235174A1
公开(公告)日：2010-10-06
申请号：EP09709191.2
申请日：2009-01-29
申请人： Battelle Energy Alliance, LLC
发明人： THOMPSON, David, N. , APEL, William, A. , THOMPSON, Vicki, S. , REED, David, W. , LACEY, Jeffrey, A. , HENRICKSEN, Emily, D.
IPC分类号： C12N9/24 , C07H21/04
CPC分类号： C12Y302/01055 , C12N9/2402 , C12N15/52 , Y02W10/45
摘要： Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius.

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