专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP1278742B1 CHROMENYLMETHYLPYRIMIDINEDIAMINES AS ANTIBACTERIAL AGENTS 有权
标题翻译：作为抗菌剂的铬酸甲基亚氨基二亚胺
公开(公告)号：EP1278742B1
公开(公告)日：2004-12-15
申请号：EP01925562.9
申请日：2001-04-20
申请人： Basilea Pharmaceutica AG
发明人： MOHR, Peter , PFLIEGER, Philippe
IPC分类号： C07D405/06 , C07D405/14 , C07D409/14 , C07D491/20 , C07D493/20 , A61K31/506 , A61P31/04
CPC分类号： C07D405/06 , C07D409/14 , C07D491/10 , C07D493/10 , C07F7/0814

2. 发明授权

EP1230224B1 SUBSTITUIERTE 5-BENZYL-2,4-DIAMINOPYRIMIDINE 有权
标题翻译：取代的5-苄基-2,4-二氨基嘧啶
公开(公告)号：EP1230224B1
公开(公告)日：2004-12-29
申请号：EP00969149.4
申请日：2000-10-27
申请人： Basilea Pharmaceutica AG
发明人： GUERRY, Philippe , MOHR, Peter , MULLER, Marc , MUELLER, Werner , PFLIEGER, Philippe
IPC分类号： C07D239/49 , A61K31/505 , A61P31/04
CPC分类号： C07D239/49 , A61K31/505
摘要： The invention relates to substituted 5-benzyl-2,4-diaminopyrimidines of general formula (A), wherein R1 is C2-C3 alkyl and R2 is heterocyclyl, phenyl or naphthyl, bonded by one of its C-atoms and R3 is C2-C6 alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfamoyl, heterocyclylsulfonyl, heterocyclyalkylsulfonyl or dialkylsulfamoyl; wherein alkyl, cycloalkyl and alkenyl can carry up to 6 carbon atoms alone or in compositions and can carry up to 6 ring members heterocyclically, alone, or in compositions and the groups R?2 and R3¿ can be substituted; and to acid addition salts of compounds. The invention also relates to a method for producing the above 5-benzyl-2,4-diaminopyrimidines, to the intermediate products that are produced, to corresponding medicaments and to the use of 5-benzyl-2,4-diaminopyrimidines as medicinal preparations. The products have antibiotic properties and are useful for combating or preventing infectious diseases.

3. 发明授权

EP1280796B1 PYRIMIDINYL METHYL INDOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY 有权
标题翻译：具有抗菌作用的嘧啶基甲基吲哚衍生物
公开(公告)号：EP1280796B1
公开(公告)日：2004-03-24
申请号：EP01936261.5
申请日：2001-04-20
申请人： Basilea Pharmaceutica AG
发明人： MATTEI, Patrizio , PFLIEGER, Philippe
IPC分类号： C07D403/06 , C07D405/14 , C07D405/12 , C07D209/30 , C07D209/08 , C07D209/04 , A61K31/505
CPC分类号： C07D403/06 , C07D209/08 , C07D405/12 , C07D405/14

4. 发明公开

EP1280796A1 PYRIMIDINYL METHYL INDOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY 有权
标题翻译：具有抗菌作用的嘧啶基甲基吲哚衍生物
公开(公告)号：EP1280796A1
公开(公告)日：2003-02-05
申请号：EP01936261.5
申请日：2001-04-20
申请人： Basilea Pharmaceutica AG
发明人： MATTEI, Patrizio , PFLIEGER, Philippe
IPC分类号： C07D403/06 , C07D405/14 , C07D405/12 , C07D209/30 , C07D209/08 , C07D209/04 , A61K31/505
CPC分类号： C07D403/06 , C07D209/08 , C07D405/12 , C07D405/14
摘要： This invention relates to indole derivatives of the general formula (I) wherein R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfonyl, dialkylsulfamoyl, N-cycloalkyl-N-alkylsulfamoyl, heterocyclylalkyl or phenylalkyl; R2 is hydrogen, halogen, alkyl, alkanoyl, phenyl, phenylalkyl or heterocyclylalkyl; R3 is hydrogen, alkyl; and R4 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfonyl, dialkylsulfamoyl, N-cycloalkyl-N-alkylsulfamoyl, heterocyclylalkyl, or phenylalkyl; and pharmaceutically acceptable acid addition salts of these compounds, there use as therapeutically active substances; medicaments based on these substances, optionally in combination with sulphonamides, and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula (I) and their pharmaceutically acceptable acid addition salts and intermediates for their manufacture.

5. 发明公开

EP1278742A1 CHROMENYLMETHYLPYRIMIDINEDIAMINES AS ANTIBACTERIAL AGENTS 有权
标题翻译：作为抗菌剂的铬酸甲基亚氨基二亚胺
公开(公告)号：EP1278742A1
公开(公告)日：2003-01-29
申请号：EP01925562.9
申请日：2001-04-20
申请人： Basilea Pharmaceutica AG
发明人： MOHR, Peter , PFLIEGER, Philippe
IPC分类号： C07D405/06 , C07D405/14 , C07D409/14 , C07D491/20 , C07D493/20 , A61K31/506 , A61P31/04
CPC分类号： C07D405/06 , C07D409/14 , C07D491/10 , C07D493/10 , C07F7/0814
摘要： This invention is concerned with substituted chromene derivatives of the general formula (I) in which R1 represents alkyl or cycloalkylalkyl, R?2 and R3¿ each independently represent alkyl or cycloalkyl or taken together with the adjacent carbon atom represent a saturated 3- to 6- membered carbocyclic or heterocyclic ring, the alkyl, cycloalkyl, carbocyclic or heterocyclic ring being unsubstituted or substituted, and R4 represents hydrogen, halogen cyano, alkyl, alkylthio, alkenyl, alkynyl, hydroxyalkyl, hydroxyalkynyl, alkoxyalkyl, alkoxyalkynyl, trialkylsilyl, aryl or heteroaryl, and pharmaceutically acceptable acid addition salts of these compounds, their use as therapeutically active substances; medicaments based on these substances, optionally in combination with sulphonamides, and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula (I) and their pharmaceutically acceptable acid addition salts and intermediates for their manufacture.
摘要翻译：本发明涉及通式（Ⅰ）的取代苯并吡喃衍生物，其中R 1代表烷基或环烷基烷基，R 2和R 3各自独立地代表烷基或环烷基或与相邻碳原子一起代表饱和的3-6 烷基，烷基，羟基炔基，烷氧基烷基，烷氧基炔基，三烷基甲硅烷基，芳基或杂芳基，和这些化合物的药学上可接受的酸加成盐，它们作为治疗活性物质的用途; 基于这些物质的药物，任选地与磺酰胺组合以及它们的生产; 这些物质作为药物的用途以及用于生产抗菌活性药物的用途; 以及制备式（I）化合物及其药学上可接受的酸加成盐和用于其制备的中间体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式