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1. 发明公开

EP0833825A1 6-CARBOXAMIDO DIHYDROPYRAN DERIVATIVES 失效
标题翻译： -6-甲酰二氢吡喃衍生物
公开(公告)号：EP0833825A1
公开(公告)日：1998-04-08
申请号：EP96911872.0
申请日：1996-05-13
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： CHERRY, Peter Glaxo Wellcome , HOWES, Peter Glaxo Wellcome , SMITH, Paul Glaxo Wellcome , SOLLIS, Stephen Glaxo Wellcome
IPC分类号： A61K31 , A61P31 , C07D309 , C07D405 , C07D409
CPC分类号： C07D405/12 , C07D309/28 , C07D409/12
摘要： Compounds of formula (I), wherein R1 represents OR?5, SR5, NR5R6, N(OR5)R6¿ or N(NR5R6)R6; X represents OH, N¿3?, NR?3R4 or NR4CO¿2R15; Y represents H or NHR2; R2 represents a group SO¿2?R?7 or COR7; R3¿ represents H, C¿1-6?alkyl or C(=NR?8)NR9R10; R4¿ represents H or C¿1-6?alkyl; R?5¿ represents H, C¿1-20?alkyl, C3-8cycloalkyl, C2-20alkenyl, C2-20alkynyl, CHR?11COR12¿ or C¿1-20?alkyl substituted by one or more groups selected from NR?13R14, NR13COR14, CO¿2R?13, OR13, C¿3-8cycloalkyl and optionally substituted aryl; each R6 independently represents H, C¿1-6?alkyl, C3-8cycloalkyl, C2-6alkenyl, C2-20alkynyl, aryl or C1-4alkyl substituted by one or more groups selected from NR?13R14, COR13, C¿3-8cycloalkyl, CN, N3, OR13 and optionally substituted aryl; or R?5 and R6¿ together form a C¿2-6? hydrocarbon chain which may optionally contain a group NR?13¿ which chain is optionally substituted by 1, 2, 3 or 4 groups selected from oxo and C¿1-6?alkyl groups which groups may optionally be substituted by hydroxy or optionally substituted aryl; R?7¿ represents C¿1-6?alkyl optionally substituted by one or more halogen atoms, C3-8cycloalkyl or optionally substituted aryl; R?8, R9 and R10¿ each independently represent H, C¿1-6?alkyl, amino, hydroxy, cyano or nitro; R?11¿ represents the side chain of a D- or L-amino acid; R12 represents NR?13R14, OR13 or R13¿; each R13 and each R14 independently represents H, C¿1-6?alkyl or optionally substituted arylC1-4alkyl; R?15¿ represents C¿1-6?alkyl; and their pharmaceutically acceptable derivatives are neuraminidase inhibitors useful in the treatment of viral infections.

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