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1. 发明公开

EP4373977A1 UTILISATION DU VIRUS TORQUE TENO (TTV) EN TANT QUE MARQUEURS POUR DETERMINER LE RISQUE DE COMPLICATION CHEZ UN PATIENT ADMIS AU SEIN D'UN ETABLISSEMENT DE SANTE 审中-实审
公开(公告)号：EP4373977A1
公开(公告)日：2024-05-29
申请号：EP22754486.3
申请日：2022-07-19
申请人： BIOMERIEUX , Bioaster
发明人： MALLET, François
IPC分类号： C12Q1/70
CPC分类号： C12Q1/70 , C12Q1/705

2. 发明公开

EP1446484A1 SEQUENCE NUCLEOTIDIQUE CODANT POUR UNE PROTEINE D INTERET MO DIFIE, VECTEUR D EXPRESSION ET PROCEDE D OBTENTIO N 有权
标题翻译： NUCLEIC所需的蛋白质有关代码
公开(公告)号：EP1446484A1
公开(公告)日：2004-08-18
申请号：EP02796858.5
申请日：2002-11-21
申请人： BIOMERIEUX
发明人： MALLET, François , CHEYNET, Valérie , ORIOL, Guy , ALLARD, Laure , NOVELLI-ROUSSEAU, Armelle
IPC分类号： C12N15/09 , C12N1/21
CPC分类号： C07K14/005 , C12N11/06 , C12N2740/16222
摘要： The invention concerns a nucleotide sequence coding for a modified protein of interest, said protein of interest having, after purification and immobilization, at least the same biological activity as the native protein of interest and being directly usable, said sequence comprising at least a gene coding for said protein of interest, a nucleotide fragment, called polyK, coding for a succession of at least six lysine residues, and a nucleotide fragment, called polyH, coding for a succession of at least six histidine residues; a vector comprising such a sequence; and a method for obtaining a purifiable and immobilized modified protein of interest.

3. 发明授权

EP1981904B9 DOMAINE PEPTIDIQUE NECESSAIRE A L'INTERACTION ENTRE L'ENVELOPPE D'UN VIRUS APPARTENANT AU GROUPE D'INTERFERENCE DE HERV-W ET UN RECEPTEUR HASCT 有权转让
标题翻译： DOMAINE PEPTIDIQUE NECESSAIRE A L'INTERACTION ENTRE L'ENVELOPPE D'UNVIRUS APPARTENANT AU GROUPE D'INTERFERENCE DE HERV-W ET UN RECEPTEUR HASCT
公开(公告)号：EP1981904B9
公开(公告)日：2017-09-13
申请号：EP07730950.8
申请日：2007-02-09
申请人： Biomerieux S.A.
发明人： MALLET, François , ORIOL, Guy , CHEYNET, Valérie
IPC分类号： C07K14/15
CPC分类号： C07K14/005 , A61K38/162 , A61K39/12 , A61K39/21 , C07K16/1036 , C07K2317/34 , C12N7/00 , C12N2740/10022 , C12N2740/10034 , C12N2740/10063 , G01N2333/15

4. 发明授权

EP1981904B1 DOMAINE PEPTIDIQUE NECESSAIRE A L'INTERACTION ENTRE L'ENVELOPPE D'UN VIRUS APPARTENANT AU GROUPE D'INTERFERENCE DE HERV-W ET UN RECEPTEUR HASCT 有权转让
标题翻译：肽结构域从HERV-W病毒的情况下，足以与甲HASCT受体相互作用
公开(公告)号：EP1981904B1
公开(公告)日：2017-04-05
申请号：EP07730950.8
申请日：2007-02-09
申请人： Biomerieux S.A.
发明人： MALLET, François , ORIOL, Guy , CHEYNET, Valérie
IPC分类号： C07K14/15
CPC分类号： C07K14/005 , A61K38/162 , A61K39/12 , A61K39/21 , C07K16/1036 , C07K2317/34 , C12N7/00 , C12N2740/10022 , C12N2740/10034 , C12N2740/10063 , G01N2333/15

5. 发明授权

EP1794320B1 MÉTHODE POUR GÉNÉRER DES TRANSCRITS 有权
标题翻译：用于生产TRANSCRIPTS
公开(公告)号：EP1794320B1
公开(公告)日：2008-06-04
申请号：EP05805383.6
申请日：2005-09-23
申请人： BIOMERIEUX
发明人： MALLET, François , ORIOL, Guy , PICHON, Jean-Philippe
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6865 , C12Q2521/301
摘要： The invention concerns a method for generating transcripts from: at least one RNA sequence to be amplified including a 'primer' region and a region of interest; an amplification primer including a promoter region, and a region capable of being hybridized on said 'primer' region of the RNA sequence to be amplified. Said method is implemented at constant temperature, and comprises the following steps: a) hybridizing said primer with the RNA to be amplified, b) elongating the primer through a reverse transcriptase enzymatic activity so as to generate a complementary deoxyribonucleic acid (cDNA) of the RNA to be amplified, c) cleaving the RNA to be amplified, hybridized on said cDNA, by an enzyme having a ribonuclease H activity, to obtain RNA fragments to be amplified, hybridized on said cDNA, d) elongating the ends of said RNA fragments to be amplified by a reverse transcriptase enzyme and strand displacement, to obtain RNA-DNA/DNA hybrids, e) obtaining RNA transcripts from the RNA-DNA/DNA hybrids formed at step d) by an enzyme having an RNA polymerase activity.

6. 发明授权

EP3227813B1 PROCÉDÉ D'ESTIMATION DE L'AFFINITÉ SONDE-CIBLE D'UNE PUCE A ADN ET PROCÉDÉ DE FABRICATION D'UNE PUCE A ADN 有权
公开(公告)号：EP3227813B1
公开(公告)日：2020-02-12
申请号：EP15808766.8
申请日：2015-11-30
申请人： Biomerieux , Hospices Civils De Lyon
发明人： BECKER, Jérémy , PEROT, Philippe , MALLET, François
IPC分类号： G16B25/20

7. 发明公开

EP3227813A1 PROCÉDÉ D'ESTIMATION DE L'AFFINITÉ SONDE-CIBLE D'UNE PUCE A ADN ET PROCÉDÉ DE FABRICATION D'UNE PUCE A ADN 有权
标题翻译： PROCÉDÉD'ESTIMATION DE L'AFFINITÉSONDE-CIBLE D'UNE PUCE A ADN ETPROCÉDÉDE FABRICATION D'UNE PUCE A ADN
公开(公告)号：EP3227813A1
公开(公告)日：2017-10-11
申请号：EP15808766.8
申请日：2015-11-30
申请人： Biomerieux , Hospices Civils De Lyon
发明人： BECKER, Jérémy , PEROT, Philippe , MALLET, François
IPC分类号： G06F19/20
摘要： The invention relates to a method for estimating the affinity
ϕ of a first DNA strand, or "probe", for hybridizing to a second DNA strand, or "target", to form a hybrid having a length L
bp , wherein the method comprises: in each division of a set of
M divisions of the hybrid, counting of the number of times that each hybrid in a set of
P DNA strand hybrids is present in said division, wherein said hybrids have a length
k shorter which is than length L
bp , or "
k -hybrids"; for each combination of mismatches of a set of L mismatch combinations in a hybrid having length L
bp , determining whether said pair of mismatches is present in said hybrid; and calculating the affinity
ϕ according to the relation: (see formula (I)) in which: - ∀(
m ,
p ) ∈ [1,
Μ ] x [1,
P ],
β
p,m is a predetermined scalar quantifying the contribution to the affinity
ϕ of the p
th
k -hybrid of the set of
P k -hybrids when this p
th k-hybrid is present in the n
th area of said division, and x
m,p is the number of times that this p
th
k -hybrid is counted for said hybrid in the m
th area of said division; and α is a real term.
摘要翻译：本发明涉及用于估计第一DNA链或“探针”与第二DNA链或“靶”杂交以形成具有长度L bp的杂合体的亲和力的方法，其中所述方法包括：在所述杂种的一组M个划分的每个划分中，计数一组P个DNA链杂交体中的每个杂种存在于所述划分中的次数，其中所述杂种具有比长度L bp短的长度k ，或“k-杂种”; 对于具有长度L bp的杂合体中的一组L错配组合的每个错配组合，确定所述错配对是否存在于所述杂合体中; 并且根据以下关系式计算亲和度：其中：其中：∀（m，p）∈[1，M] x [1，P]，βp，m是一个预先确定的标量，当该第p个k-杂种存在于所述除法的第n个区域中时，对该组k个杂种的第p个k-杂种的亲和力的贡献，以及xm，p是该p 对所述分区的第m个区域中的所述混合动力车计数第k个混合动力车; α是一个实际的术语。

8. 发明授权

EP1446484B1 SEQUENCE NUCLEOTIDIQUE CODANT POUR UNE PROTEINE D INTERET MODIFIÉ; VECTEUR D EXPRESSION ET PROCEDE D OBTENTION 有权
标题翻译： NUCLEIC所需的蛋白质有关代码
公开(公告)号：EP1446484B1
公开(公告)日：2010-03-10
申请号：EP02796858.5
申请日：2002-11-21
申请人： BIOMERIEUX
发明人： MALLET, François , CHEYNET, Valérie , ORIOL, Guy , ALLARD, Laure , NOVELLI-ROUSSEAU, Armelle
IPC分类号： C12N15/09 , C12N1/21
CPC分类号： C07K14/005 , C12N11/06 , C12N2740/16222
摘要： The invention concerns a nucleotide sequence coding for a modified protein of interest, said protein of interest having, after purification and immobilization, at least the same biological activity as the native protein of interest and being directly usable, said sequence comprising at least a gene coding for said protein of interest, a nucleotide fragment, called polyK, coding for a succession of at least six lysine residues, and a nucleotide fragment, called polyH, coding for a succession of at least six histidine residues; a vector comprising such a sequence; and a method for obtaining a purifiable and immobilized modified protein of interest.

9. 发明公开

EP1981904A2 DOMAINE PEPTIDIQUE NECESSAIRE A L'INTERACTION ENTRE L'ENVELOPPE D'UN VIRUS APPARTENANT AU GROUPE D'INTERFERENCE DE HERV-W ET UN RECEPTEUR HASCT 有权转让
标题翻译：肽结构域从HERV-W病毒的情况下，足以与甲HASCT受体相互作用
公开(公告)号：EP1981904A2
公开(公告)日：2008-10-22
申请号：EP07730950.8
申请日：2007-02-09
申请人： Biomerieux S.A.
发明人： MALLET, François , ORIOL, Guy , CHEYNET, Valérie
IPC分类号： C07K14/15
CPC分类号： C07K14/005 , A61K38/162 , A61K39/12 , A61K39/21 , C07K16/1036 , C07K2317/34 , C12N7/00 , C12N2740/10022 , C12N2740/10034 , C12N2740/10063 , G01N2333/15
摘要： The invention relates to a peptide domain required for interaction between the envelope of a virus pertaining to the HERV-W interference group and an hASCT receptor, comprising an N end point and a C end point. Said peptide domain is defined, at the N end point thereof, by a pattern formed by the amino acids L (Z)α-proline-cysteine-X-cysteine in which Z is any amino acid, α is a whole number between 2 and 30, and X is any amino acid, and at the C end point thereof, by a pattern formed by the amino acids serine-aspartic acid-Xa-Xb-Xc-Xd-Xe-aspartic acid-Xf Xg-(Z)β in which Xa, Xb, Xc, Xd, Xe, Xf Xg are any amino acids, Z is any amino acid, β is a whole number between 15 and 25, preferably 20. The peptide domain comprises, between the N end point and the C end point , at least one pattern selected from the following patterns: a pattern formed by the amino acids cysteine-tyrosine-X2-X3-X4-X5- X6-cysteine in which X2, X3, X4, X5, X6 are any amino acids, and a pattern formed by the amino acids cysteine-X7-X8-X9-X10-X11- X12- X13-X14-X15-cysteine-trytophane in which X7, X8, X9, X10, X11, X12, X13, X14, X15 are any amino acids.

10. 发明公开

EP1794320A1 MÉTHODE POUR GÉNÉRER DES TRANSCRITS 有权
标题翻译：用于生产TRANSCRIPTS
公开(公告)号：EP1794320A1
公开(公告)日：2007-06-13
申请号：EP05805383.6
申请日：2005-09-23
申请人： BIOMERIEUX
发明人： MALLET, François , ORIOL, Guy , PICHON, Jean-Philippe
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6865 , C12Q2521/301
摘要： The invention concerns a method for generating transcripts from: at least one RNA sequence to be amplified including a 'primer' region and a region of interest; an amplification primer including a promoter region, and a region capable of being hybridized on said 'primer' region of the RNA sequence to be amplified. Said method is implemented at constant temperature, and comprises the following steps: a) hybridizing said primer with the RNA to be amplified, b) elongating the primer through a reverse transcriptase enzymatic activity so as to generate a complementary deoxyribonucleic acid (cDNA) of the RNA to be amplified, c) cleaving the RNA to be amplified, hybridized on said cDNA, by an enzyme having a ribonuclease H activity, to obtain RNA fragments to be amplified, hybridized on said cDNA, d) elongating the ends of said RNA fragments to be amplified by a reverse transcriptase enzyme and strand displacement, to obtain RNA-DNA/DNA hybrids, e) obtaining RNA transcripts from the RNA-DNA/DNA hybrids formed at step d) by an enzyme having an RNA polymerase activity.

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