专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2114927B1 PROCESS FOR THE PREPARATION OF (R)-5-(2-AMINOETHYL)-1-(6,8-DIFLUOROCHROMAN-3-YL)-1,3-DIHYDROIMIDAZOLE-2-THIONE 失效
标题翻译：制备（R）-5-（2-氨基乙基）-1-（6,8-二氟铬恶烷-3-基）-1,3-二氢咪唑-2-硫酮的方法
公开(公告)号：EP2114927B1
公开(公告)日：2017-08-23
申请号：EP08712688.4
申请日：2008-01-31
申请人： BIAL - Portela & Ca., S.A.
发明人： SOARES DA SILVA, Patrício Manuel Vieira Araújo , BELIAEV, Alexander , LEARMONTH, David Alexander
IPC分类号： C07D405/04
CPC分类号： C07D405/04

2. 发明授权

EP2303855B1 CATALYTIC PROCESS FOR ASYMMETRIC HYDROGENATION 失效
标题翻译：催化方法不对称氢化
公开(公告)号：EP2303855B1
公开(公告)日：2014-12-31
申请号：EP09742906.2
申请日：2009-05-06
申请人： BIAL - Portela & Ca., S.A.
发明人： BELIAEV, Alexander , LEARMONTH, David Alexander
IPC分类号： C07D311/04
CPC分类号： C07D405/04 , C07D233/84 , C07D311/04 , C07D487/04

3. 发明公开

EP2297042A2 CATALYTIC ASYMETRIC HYDROGENATION 失效
标题翻译：不对称催化氢化反应
公开(公告)号：EP2297042A2
公开(公告)日：2011-03-23
申请号：EP09721339.1
申请日：2009-03-17
申请人： Bial-Portela & CA, S.A.
发明人： LEARMONTH, David Alexander , BELIAEV, Alexander , LI, Wenge
IPC分类号： C01G55/00 , C07D233/84 , C07D311/74 , C07D335/06 , C07D407/04 , C07D409/04
CPC分类号： C07D311/04 , C07D405/04 , C07F15/0053 , C07F15/008
摘要： A process for preparing the S or R enantiomer of a compound of formula A, (see formula (B) and formula (A)), the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral transition metal catalyst and a source of hydrogen.

4. 发明公开

EP2121668A2 6,8-DICHLORCHROMAN-3-YL-1,3-DIHYDROIMIDAZOLE-2-THIONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS 审中-公开
标题翻译： 6,8- YOU洛尔希ROMAN -3-基-1,3-二氢咪唑-2- THIONDERIVATE及其用途用于治疗心血管疾病的治疗
公开(公告)号：EP2121668A2
公开(公告)日：2009-11-25
申请号：EP08705174.4
申请日：2008-01-31
申请人： BIAL - Portela & Ca., S.A.
发明人： SOARES DA SILVA, Patrício Manuel Vieira Araújo , LEARMONTH, David Alexander , BELIAEV, Alexander
IPC分类号： C07D405/04 , A61K31/352 , A61P9/02
CPC分类号： C07D405/04
摘要： This invention relates to new 6,8-difluorochroman-3-yl-1,3-dihydroimidazole-2-thiones, their preparation, and their use as a medicament.

5. 发明公开

EP2114926A1 PROCESS FOR THE PREPARATION OF (R) -5- (2-AMINOETHYL) -1- (6, 8-DIFLUOROCHROMAN-3-YL) -1, 3-DIHYDROIMIDAZOLE-2-THIONE 审中-公开
标题翻译：用于生产（R）-5-（2-氨基乙基）-1-（6,8- DIFLUORCHROMAN -3-基）-1,3-二氢咪唑-2-硫羰
公开(公告)号：EP2114926A1
公开(公告)日：2009-11-11
申请号：EP08712687.6
申请日：2008-01-31
申请人： BIAL - Portela & Ca., S.A.
发明人： SOARES DA SILVA, Patrício Manuel Vieira Araújo , BELIAEV, Alexander , LEARMONTH, David Alexander
IPC分类号： C07D405/04
CPC分类号： C07D405/04
摘要： A process for making (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione and pharmaceutically acceptable salts thereof, and for making intermediates useful in the formation of said compound.

6. 发明授权

EP2655363B1 CRYSTALLINE FORMS AND PROCESSES FOR THEIR PREPARATION 失效
标题翻译：德国富士康ZU IHRER HERSTELLUNG的KRISTALLINE FORMEN
公开(公告)号：EP2655363B1
公开(公告)日：2017-04-12
申请号：EP11811184.8
申请日：2011-12-21
申请人： Bial-Portela & CA, S.A.
发明人： BELIAEV, Alexander , LEARMONTH, David, Alexander , BROADBELT, Brian , ALBERT, Ekaterina , ANDRES, Patricia
IPC分类号： C07D405/04
CPC分类号： C07D405/04

7. 发明公开

EP2274292A1 CATALYTIC PROCESS FOR ASYMMETRIC HYDROGENATION 审中-公开
标题翻译：催化方法不对称氢化
公开(公告)号：EP2274292A1
公开(公告)日：2011-01-19
申请号：EP09718942.7
申请日：2009-03-13
申请人： Bial-Portela & CA, S.A.
发明人： BELIAEV, Alexander , LEARMONTH, David, Alexander , ALMENA PEREA, Juan José , GEIß, Gerhard , HITZEL, Patrick , KADYROV, Renat , VOIGTLAENDER, David
IPC分类号： C07D311/04
CPC分类号： C07D311/04
摘要： A process for preparing the S or R enantiomer of a compound of formula A, the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral transition metal catalyst and a source of hydrogen, wherein: X is CH
2 , oxygen or sulphur; R
1 , R
2 and R
3 are the same or different and signify hydrogen, halogen, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group; and R
4 is alkyl or aryl, the transition metal catalyst comprising a chiral ligand having the formula wherein each R and R' independently represents alkyl, aryl, aralkyl, alkenyl, alkynyl, alkoxy, aryloxy, alkylthio, arylthio, unsubstituted or substituted cyclic moiety selected from a group consisting of monocyclic or polycyclic saturated or partially saturated carbocyclic or heterocyclic, aromatic or heteroaromatic rings said rings comprising from 4 to 8 atoms and comprising from 0 to 3 heteroatoms, wherein: the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term aryl means an aromatic or heteraromatic group, optionally substituted one or more times by alkyl, alkyloxy, halogen or nitro group; and the term halogen means fluorine, chlorine, bromine or iodine.

8. 发明公开

EP2027118A2 POLYMORPHS OF (R)-5-(2-AMINOETHYL)-1-(6,8-DIFLUOROCHROMAN-3-YL)-1,3-DIHYDROIMIDAZOLE-THIONE HYDROCHLORIDE 审中-公开
标题翻译：（±）-5-（2-氨基乙基）-1-（6,8-二氟-2-羟基苯基）-1,3-二氢吲哚并噻吩并[
公开(公告)号：EP2027118A2
公开(公告)日：2009-02-25
申请号：EP07747763.6
申请日：2007-05-31
申请人： BIAL - Portela & Ca., S.A.
发明人： BELIAEV, Alexander , LEARMONTH, David , SMOLENSKAYA, Valeriya
IPC分类号： C07D413/04 , A61K31/352 , A61P9/02
CPC分类号： A61K31/4178 , C07D405/04
摘要： Polymorphs of (R)-5-(2-Aminoethyl)-l-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione hydrochloride and methods of their preparation.

9. 发明公开

EP1983982A1 DRUG COMBINATIONS 审中-公开
标题翻译：药物的组合
公开(公告)号：EP1983982A1
公开(公告)日：2008-10-29
申请号：EP07709265.8
申请日：2007-01-15
申请人： BIAL - Portela & Ca., S.A.
发明人： LEARMONTH, David Alexander , BELIAEV, Alexander , SOARES DA SILVA, Patrício Manuel Vieira Araújo
IPC分类号： A61K31/4164 , A61P43/00
CPC分类号： A61K31/4164
摘要： A combination comprising at least two components selected from: (i) compounds of formula I: R where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl or alkylaryl group; X signifies CH2, oxygen atom or sulphur atom; n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2; and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof; wherein the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxy carbonyl groups; the term aryl means a phenyl or naphthyl group, optionally substituted by alkyloxy, halogen or nitro group; the term halogen means fluorine, chlorine, bromine or iodine; and (ii) at least one compound from the following classes of compounds: diuretics; beta-adrenergic antagonists; alpha2-adrenergic agonists; alphal -adrenergic antagonists; dual beta- and alpha-adrenergic antagonists; calcium channel blockers; potassium channel activators; anti-arrhythmics; ACE inhibitors; ATI receptor antagonists; renin inhibitors; lipid lowerers, vasopeptidase inhibitors; nitrates; endothelin antagonists; neutral endopeptidase inhibitors; anti-angiotensin vaccines; vasodilators; phosphodiesterase inhibitors; cardiac glycosides; serotonin antagonists; and CNS acting agents.

10. 发明公开

EP2726454A2 PROCESS 失效
标题翻译：程序
公开(公告)号：EP2726454A2
公开(公告)日：2014-05-07
申请号：EP12738246.3
申请日：2012-06-29
申请人： Bial-Portela & CA, S.A.
发明人： BELIAEV, Alexander , WAHNON, Jorge Bruno Reis , LEARMONTH, David Alexander , MADEC, Jonathan , SCHNEIDER, Jean-Marie , MATON, William
IPC分类号： C07C311/19 , C07D403/04
CPC分类号： C07D405/04 , C07C235/80 , C07C311/16 , C07C311/17
摘要： The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式