会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 6. 发明公开
    • METHOD FOR PREPARING HALOGENATED 3-OXOCARBOXYLATES CARRYING A 2-ALKOXYMETHYLIDENE OR A 2-DIALKYLAMINOMETHYLIDENE GROUP
    • 制备携带2-烷氧基亚甲基或2-二烷基氨基亚甲基的卤代3-氧代羧酸酯的方法
    • EP3178813A1
    • 2017-06-14
    • EP15198729.4
    • 2015-12-09
    • BASF SE
    • KLAUBER, Eric GeorgeGOCKEL, BirgitMAYER, HorstFRASSETTO, Timo
    • C07D231/04C07C67/343C07C69/738
    • C07C67/343C07C69/738
    • The present invention relates to a process for preparing compounds of the formula I,

      wherein
      R 1 and R 2
      are each independently from one another selected from hydrogen, fluorine, bromine, chlorine and trifluoromethyl,
      R 3
      is selected from fluorine chlorine and trifluoromethyl,
      R 4
      is selected from C 1 -C 4 -alkyl, and
      X
      is either -OR 5 or -NR 6 R 7 , wherein R 5 is selected from C 1 -C 4 -alkyl, and R 6 and
      R 7
      are each independently from one another selected from C 1 -C 4 -alkyl,

      which comprises the reaction of a compound of the formula II

      with a reagent of the formula III,

      wherein the variables R 1 , R 2 , R 3 , R 4 , R 5 and X given in formulae II and III have the above defined meanings,
      in the presence of a catalyst selected from Brønsted acids, ammonium salts of Brønsted acids and Lewis acids;
      wherein the reaction is performed essentially in the absence of a carboxylic acid anhydride.
    • 本发明涉及制备式I化合物的方法,其中R 1和R 2各自彼此独立地选自氢,氟,溴,氯和三氟甲基,R 3选自氟氯和三氟甲基,R 4选自 C 1 -C 4烷基,并且X是-OR 5或-NR 6 R 7,其中R 5选自C 1 -C 4烷基,并且R 6和R 7各自彼此独立地选自C 1 -C 4烷基,其包括 在选自布朗斯台德酸的催化剂存在下,式II化合物与式III试剂(其中式II和III中给出的变量R 1,R 2,R 3,R 4,R 5和X具有上述定义) ,布朗斯台德酸和路易斯酸的铵盐; 其中该反应基本上在不存在羧酸酐的情况下进行。