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1. 发明授权

EP1539731B1 NOVEL COMPOUNDS 有权
标题翻译：新化合物
公开(公告)号：EP1539731B1
公开(公告)日：2008-01-02
申请号：EP03738863.4
申请日：2003-07-15
申请人： AstraZeneca AB
发明人： METE, Antonio , WALTERS, Iain
IPC分类号： C07D333/34 , A61K31/381 , A61P29/00
CPC分类号： C07D333/38
摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, M, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
摘要翻译：提供了新的式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，M，T，U，Y，V和W如说明书中所定义。以及它们的制备方法，含有它们的组合物以及它们在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂，因此特别适用于治疗或预防炎性疾病和疼痛。

2. 发明公开

EP1539732A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新化合物
公开(公告)号：EP1539732A1
公开(公告)日：2005-06-15
申请号：EP03765417.5
申请日：2003-07-15
申请人： AstraZeneca AB
发明人： METE, Antonio , WALTERS, Iain
IPC分类号： C07D333/34 , A61K31/381 , A61P29/00
CPC分类号： C07D333/34
摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R10, M, Q, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
摘要翻译：提供了式（I）的新化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 10，M，Q，T，U，Y，V和W如说明书中所定义。以及它们的制备方法，含有它们的组合物以及它们在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂，因此特别适用于治疗或预防炎性疾病和疼痛。

3. 发明授权

EP1257556B1 THIAZOLOPYRIMIDINES AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权
标题翻译：噻唑并嘧啶及其作为趋化因子受体活性调节剂
公开(公告)号：EP1257556B1
公开(公告)日：2004-06-16
申请号：EP01906447.6
申请日：2001-02-07
申请人： AstraZeneca AB
发明人： BONNERT, Roger , CAGE, Peter , HUNT, Fraser , JEWELL, Robert , WALTERS, Iain
IPC分类号： C07D513/04 , A61K31/519 , A61P11/00 , A61P17/06 , A61P29/00
CPC分类号： C07D513/04
摘要： The invention provides certain thiazolopyrimidine compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

4. 发明公开

EP1539731A1 NOVEL COMPOUNDS 有权
标题翻译：新ROUTES
公开(公告)号：EP1539731A1
公开(公告)日：2005-06-15
申请号：EP03738863.4
申请日：2003-07-15
申请人： AstraZeneca AB
发明人： METE, Antonio , WALTERS, Iain
IPC分类号： C07D333/34 , A61K31/381 , A61P29/00
CPC分类号： C07D333/38
摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, M, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

5. 发明授权

EP1539731B9 NOVEL COMPOUNDS 有权
公开(公告)号：EP1539731B9
公开(公告)日：2008-08-20
申请号：EP03738863.4
申请日：2003-07-15
申请人： AstraZeneca AB
发明人： METE, Antonio , WALTERS, Iain
IPC分类号： C07D333/34 , A61K31/381 , A61P29/00
CPC分类号： C07D333/38
摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, M, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

6. 发明授权

EP1328319B1 7-AMINO-2-ALKYLTHIOPTERIDIN-4-YL-AMINES FOR THE TREATMENT OF CHEMOKINE-RELATED DISEASES 有权
标题翻译： 7-氨基-2- ALKYLTHIOPTERIDIN -4- YL-胺类疾病治疗CHEMOKINASSOZIIERTEN
公开(公告)号：EP1328319B1
公开(公告)日：2007-01-03
申请号：EP01977001.5
申请日：2001-10-16
申请人： AstraZeneca AB
发明人： BONNERT, Roger , WALTERS, Iain
IPC分类号： A61P17/06 , A61P29/00
CPC分类号： C07D475/06
摘要： Pteridine compounds of formula (I) in which R?1, R2, R3 and R4¿ are as specified in the claims, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in the treatment of inflammatory diseases such as psoriasis, rheumatoid arthritis, diseases in which angiogenesis is assocated with raised CXCR2 chemokine levels (diabetic retinopathy) and COPD. The compounds are ligands for chemokine receptors and medical indications mentioned in the description include: diseases of the respiratory tract (COPDD, asthma, bronchitis, rhinitis, fibroid lung, pneumonia, etc.), diseases of the bones and joints (arthritis, etc.), skin-diseases (psoriasis, etc), diseases of the gastrointestinal tract, diseases in other tissues and systemic disease (multipe sclerosis, atherosclerosis, AIDS, type 1 diabetes, leprosy, sepsis, etc.), allograft rejection, cancers, cystic fibrosis, stroke, burn wounds, skin ulcers, reproductive disease and more.

7. 发明公开

EP1257556A1 THIAZOLOPYRIMIDINES AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权
标题翻译：噻唑并嘧啶及其作为趋化因子受体活性调节剂
公开(公告)号：EP1257556A1
公开(公告)日：2002-11-20
申请号：EP01906447.6
申请日：2001-02-07
申请人： AstraZeneca AB
发明人： BONNERT, Roger , CAGE, Peter , HUNT, Fraser , JEWELL, Robert , WALTERS, Iain
IPC分类号： C07D513/04 , A61K31/519 , A61P11/00 , A61P17/06 , A61P29/00
CPC分类号： C07D513/04
摘要： The invention provides certain thiazolopyrimidine compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

8. 发明公开

EP1328319A1 7-AMINO-2-ALKYLTHIOPTERIDIN-4-YL-AMINES FOR THE TREATMENT OF CHEMOKINE-RELATED DISEASES 有权
标题翻译：用于治疗与趋化因子有关的疾病的7-氨基-2-烷基哌啶-4-基 - 胺
公开(公告)号：EP1328319A1
公开(公告)日：2003-07-23
申请号：EP01977001.5
申请日：2001-10-16
申请人： AstraZeneca AB
发明人： BONNERT, Roger , WALTERS, Iain
IPC分类号： A61P17/06 , A61P29/00
CPC分类号： C07D475/06
摘要： Pteridine compounds of formula (I) in which R?1, R2, R3 and R4¿ are as specified in the claims, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in the treatment of inflammatory diseases such as psoriasis, rheumatoid arthritis, diseases in which angiogenesis is assocated with raised CXCR2 chemokine levels (diabetic retinopathy) and COPD. The compounds are ligands for chemokine receptors and medical indications mentioned in the description include: diseases of the respiratory tract (COPDD, asthma, bronchitis, rhinitis, fibroid lung, pneumonia, etc.), diseases of the bones and joints (arthritis, etc.), skin-diseases (psoriasis, etc), diseases of the gastrointestinal tract, diseases in other tissues and systemic disease (multipe sclerosis, atherosclerosis, AIDS, type 1 diabetes, leprosy, sepsis, etc.), allograft rejection, cancers, cystic fibrosis, stroke, burn wounds, skin ulcers, reproductive disease and more.
摘要翻译：其中R 1，R 2，R 3和R 4如权利要求中所述的式（I）的蝶啶化合物，其制备中使用的方法和中间体，含有它们的药物组合物以及它们在治疗炎性疾病例如牛皮癣，类风湿性关节炎，其中血管发生与升高的CXCR2趋化因子水平（糖尿病视网膜病变）和COPD相关的疾病。该化合物是趋化因子受体的配体，说明书中提及的医学适应症包括：呼吸道疾病（COPDD，哮喘，支气管炎，鼻炎，纤维性肺，肺炎等），骨骼和关节疾病（关节炎等）），皮肤疾病（牛皮癣等），胃肠道疾病，其他组织中的疾病和全身性疾病（多发性硬化，动脉粥样硬化，艾滋病，1型糖尿病，麻风病，败血症等），同种异体移植排斥，癌症，纤维化，中风，烧伤，皮肤溃疡，生殖系统疾病等等。

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