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1. 发明公开

EP0882707A1 NOVEL TRICYCLIC COMPOUNDS AND DRUG COMPOSITIONS CONTAINING THE SAME 失效
标题翻译： NEIZ TRIZYKLISCHE VERBINDUNGEN UND ARZNEIMITTELZUSAMMENSETZUNGEN DIEE ENTHALTEN
公开(公告)号：EP0882707A1
公开(公告)日：1998-12-09
申请号：EP96942564.4
申请日：1996-12-18
申请人： Asahi Kasei Kogyo Kabushiki Kaisha
发明人： MIYOSHI, Shiro , OGAWA, Kohei
IPC分类号： C07C311/37 , C07C311/08 , C07C311/13 , C07C307/10 , C07D209/88 , C07D307/91 , C07D333/76 , A61K31/40 , A61K31/34 , A61K31/38 , A61K31/135
CPC分类号： C07D307/91 , C07C307/10 , C07C311/08 , C07C311/37 , C07C2603/18 , C07D209/88 , C07D333/76
摘要： Compounds represented by general formula (I) or salts thereof, a process for producing the same, and intermediates therefor, wherein R represents hydrogen or methyl; R 1 represents hydrogen, hologeno, hydroxy, benzyloxy, amino, or hydroxymethyl; R 2 represents hydrogen, hydroxymethyl, NHR 3 , SO 2 NR 4 R 4 , or nitro; R 6 represents hydrogen or lower alkyl; and X represents nitrogen, oxygen, sulfur, or methylene, provided that when X represents nitrogen, oxygen, or sulfur, then R 9 represents hydrogen, one of R 7 an R 8 represents hydrogen, and the other thereof represents hydrogen, amino, acetylamino, or hydroxy, and when X represents methylene, then R 7 and R 8 each represents hydrogen and R 9 represents hydrogen, amino, etc. They have a β-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc.
摘要翻译：由通式（I）表示的化合物或其盐，其制备方法及其中间体，其中R表示氢或甲基; R 1表示氢，氢原子，羟基，苄氧基，氨基或羟甲基; R 2表示氢，羟甲基，NHR 3，SO 2 NR 4 R 4或硝基; R 6表示氢或低级烷基; 并且X表示氮，氧，硫或亚甲基，条件是当X表示氮，氧或硫时，R 9表示氢，R 7和R 8中的一个表示氢，而另一个表示氢，氨基，乙酰氨基或羟基，当X代表亚甲基时，R 7和R 8各自表示氢，R 9表示氢，氨基等。它们具有β-3肾上腺素受体激动剂并且可用作治疗和预防糖尿病，肥胖症，高脂血症等的药物

2. 发明公开

EP0997458A1 NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME 失效
标题翻译：与饱和环，并含有医疗机构制剂三环领带
公开(公告)号：EP0997458A1
公开(公告)日：2000-05-03
申请号：EP98928532.5
申请日：1998-06-17
申请人： Asahi Kasei Kogyo Kabushiki Kaisha
发明人： MIYOSHI, Shiro , OGAWA, Kohei
IPC分类号： C07D209/88 , C07D209/94 , C07D307/91 , C07D333/76 , A61K31/34 , A61K31/38 , A61K31/40
CPC分类号： C07D307/91 , C07D209/88 , C07D333/76
摘要： Compounds represented by general formula (I) or their salts, having β 3 -adrenoceptor agonism and being efficacious when employed in drugs for treating and preventing diabetes, obesity, hyperlipemia, etc. wherein R represents hydrogen or methyl; R 1 represents hydrogen, halogeno, hydroxy, benzyloxy, amino or hydroxymethyl; R 2 represents hydrogen, hydroxymethyl, NHR 3 , SO 2 NR 4 R 4 ', or nitro (wherein R 3 represents hydrogen, methyl, SO 2 R 5 , formyl or CONHR 6 '; R 5 represents lower alkyl, benzyl or NR 4 R 4 '; R 4 and R 4 ' may be the same or different and each represents hydrogen, lower alkyl or benzyl; and R 6 ' represents hydrogen or lower alkyl); R 6 represents hydrogen or lower alkyl; n is 1 or 2; X represents secondary nitrogen, oxygen or sulfur; and when n is 1, then one of R 7 and R 8 represents hydrogen while another represents hydrogen, amino, acetylamino or hydroxy, or when n is 2, then R 8 represents hydrogen while R 7 represents hydrogen, amino, acetylamino or hydroxy.
摘要翻译：由通式（I）或它们的盐所表示的化合物，具有β-3肾上腺素受体激动作用和为有效的当药物用于治疗和预防糖尿病，肥胖，高脂血症，等等worinřdarstellt氢或甲基; [R <1> darstellt氢，卤素，羟基，苄氧基，氨基或羟甲基; [R <2> darstellt氢，羟甲基，NHR <3>，SO 2 NR <4> - [R <4> '或硝基（worin氢 - [R <3> darstellt，甲基，SO 2 <5>，甲酰基或CONHR <6>'; [R <5> darstellt低级烷基，苄基或NR <4> - [R <4> 'R <4>和R <4>' 可以相同或不同，并且各自darstellt氢，低级烷基或苄基;和R <6 >“darstellt氢或低级烷基）; [R <6> darstellt氢或低级烷基; n是1或2; X darstellt仲氮，氧或硫; 当n是1时，则R的一<7>和R <8> darstellt氢，而另一个darstellt氢，氨基，乙酰氨基或羟基，或者，当n为2时，则R <8> darstellt氢，而[R <7> darstellt 氢，氨基，乙酰氨基或羟基。

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