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1. 发明授权

EP2465574B1 Systems for thermally-induced renal neuromodulation 有权转让
标题翻译：热诱导肾神经调节系统
公开(公告)号：EP2465574B1
公开(公告)日：2015-10-28
申请号：EP11191392.7
申请日：2007-06-28
申请人： Ardian, Inc.
发明人： Zarins, Denise , Clark, Benjamin J. , Thai, Erik , Wu, Andrew
IPC分类号： A61B18/12 , A61B18/08 , A61N1/36 , A61N1/40 , A61B18/14 , A61N1/05 , A61B18/02 , A61N5/06 , A61N7/02 , A61F7/10 , A61B18/18 , A61B17/22 , A61F7/12
CPC分类号： A61B18/1233 , A61B18/12 , A61B18/1206 , A61B18/14 , A61B18/1492 , A61B18/1815 , A61B90/39 , A61B2017/00084 , A61B2017/22054 , A61B2017/22068 , A61B2018/00023 , A61B2018/00214 , A61B2018/0022 , A61B2018/00261 , A61B2018/00279 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00636 , A61B2018/00666 , A61B2018/00702 , A61B2018/00714 , A61B2018/00755 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875 , A61B2018/00994 , A61B2018/143 , A61B2018/1432 , A61B2018/144 , A61B2018/1475 , A61F7/007 , A61F7/10 , A61F7/12 , A61F2007/0056 , A61F2007/0075 , A61F2007/126 , A61N1/0558 , A61N1/057 , A61N1/06 , A61N1/36007 , A61N1/36017 , A61N1/403 , A61N5/0601 , A61N5/0622 , A61N7/02 , A61N7/022 , A61N2005/0612 , A61N2007/0026 , A61N2007/003
摘要： Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulatoin may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feel or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

2. 发明公开

EP2626025A3 Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation 审中-公开
标题翻译：设备，系统和方法来实现血管内，热致肾欧元调制
公开(公告)号：EP2626025A3
公开(公告)日：2014-01-01
申请号：EP13159001.0
申请日：2009-08-14
申请人： Ardian, Inc.
发明人： Wu, Andrew , Clark, Benjamin, J. , Zarins, Denise , Thai, Erik
IPC分类号： A61B18/14 , A61B18/10 , A61N7/02
CPC分类号： A61B18/1492 , A61B2017/00212 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00702 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61N2007/003
摘要： Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

3. 发明公开

EP2626023A3 Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation 有权转让
公开(公告)号：EP2626023A3
公开(公告)日：2013-12-18
申请号：EP13158998.8
申请日：2009-08-14
申请人： Ardian, Inc.
发明人： Wu, Andrew , Clark, Benjamin, J. , Zarins, Denise , Thai, Erik
IPC分类号： A61B18/14 , A61B18/10 , A61N7/02
CPC分类号： A61B18/1492 , A61B2017/00212 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00702 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61N2007/003
摘要： Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

4. 发明公开

EP2626023A2 Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation 有权转让
公开(公告)号：EP2626023A2
公开(公告)日：2013-08-14
申请号：EP13158998.8
申请日：2009-08-14
申请人： Ardian, Inc.
发明人： Wu, Andrew , Clark, Benjamin, J. , Zarins, Denise , Thai, Erik
IPC分类号： A61B18/14 , A61B18/10 , A61N7/02
CPC分类号： A61B18/1492 , A61B2017/00212 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00702 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61N2007/003
摘要： Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

5. 发明公开

EP2218479A2 Methods and systems for thermally-induced renal neuromodulation 审中-公开
标题翻译：方法和系统热诱导肾神经调节
公开(公告)号：EP2218479A2
公开(公告)日：2010-08-18
申请号：EP10159584.1
申请日：2007-06-28
申请人： Ardian, Inc.
发明人： Demarais, Denise , Zadno, Nicolas , Clark, Benjamin , Thai, Erik , Wu, Andrew
IPC分类号： A61N7/02
CPC分类号： A61B18/1233 , A61B18/12 , A61B18/1206 , A61B18/14 , A61B18/1492 , A61B18/1815 , A61B90/39 , A61B2017/00084 , A61B2017/22054 , A61B2017/22068 , A61B2018/00023 , A61B2018/00214 , A61B2018/0022 , A61B2018/00261 , A61B2018/00279 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00636 , A61B2018/00666 , A61B2018/00702 , A61B2018/00714 , A61B2018/00755 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875 , A61B2018/00994 , A61B2018/143 , A61B2018/1432 , A61B2018/144 , A61B2018/1475 , A61F7/007 , A61F7/10 , A61F7/12 , A61F2007/0056 , A61F2007/0075 , A61F2007/126 , A61N1/0558 , A61N1/057 , A61N1/06 , A61N1/36007 , A61N1/36017 , A61N1/403 , A61N5/0601 , A61N5/0622 , A61N7/02 , A61N7/022 , A61N2005/0612 , A61N2007/0026 , A61N2007/003
摘要： Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulatoin may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feel or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

6. 发明公开

EP2204134A1 Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation 有权转让
标题翻译：用于实现血管内热诱导肾神经调节的装置，系统和方法
公开(公告)号：EP2204134A1
公开(公告)日：2010-07-07
申请号：EP09167937.3
申请日：2009-08-14
申请人： Ardian, Inc.
发明人： Wu, Andrew , Clark, Benjamin J , Zarins, Denise , Thai, Erik
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00212 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00702 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61N2007/003
摘要： Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.
摘要翻译：本文公开了用于通过血管内通路实现热诱导肾神经调节的装置，系统和方法。例如，本申请的一个方面涉及并入有包括细长轴的处理装置的设备，系统和方法。细长轴的尺寸和构造经由血管内路径将热元件传递到肾动脉。热诱导的肾神经调节可以通过直接和/或通过间接应用热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。

7. 发明公开

EP2092957A1 Methods and systems for thermally-induced renal neuromodulation 有权转让
标题翻译： Systemefürwärmeinduzierterenale Neuromodulation
公开(公告)号：EP2092957A1
公开(公告)日：2009-08-26
申请号：EP09156661.2
申请日：2007-06-28
申请人： Ardian, Inc.
发明人： Demarais, Denise , Zadno, Nicolas , Clark, Benjamin, J. , Thai, Erik , Wu, Andrew
IPC分类号： A61N1/36 , A61N1/40 , A61B18/14 , A61B18/08 , A61B18/12
摘要： Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulatoin may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feel or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
摘要翻译：提供了热诱导的肾神经调节的方法和系统。热诱导的肾神经胶质瘤可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者感觉或灌注神经纤维的血管结构来实现。在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。在一些实施方案中，热诱导的肾神经调节通过脉冲热疗法的递送来实现。

8. 发明公开

EP2465574A1 Systems for thermally-induced renal neuromodulation 有权转让
标题翻译：热诱导肾神经调节系统
公开(公告)号：EP2465574A1
公开(公告)日：2012-06-20
申请号：EP11191392.7
申请日：2007-06-28
申请人： Ardian, Inc.
发明人： Zarins, Denise , Clark, Benjamin J. , Thai, Erik , Wu, Andrew
IPC分类号： A61N1/36 , A61N1/40 , A61B18/14 , A61N1/05 , A61B18/02 , A61B18/08 , A61B18/12
CPC分类号： A61B18/1233 , A61B18/12 , A61B18/1206 , A61B18/14 , A61B18/1492 , A61B18/1815 , A61B90/39 , A61B2017/00084 , A61B2017/22054 , A61B2017/22068 , A61B2018/00023 , A61B2018/00214 , A61B2018/0022 , A61B2018/00261 , A61B2018/00279 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00636 , A61B2018/00666 , A61B2018/00702 , A61B2018/00714 , A61B2018/00755 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875 , A61B2018/00994 , A61B2018/143 , A61B2018/1432 , A61B2018/144 , A61B2018/1475 , A61F7/007 , A61F7/10 , A61F7/12 , A61F2007/0056 , A61F2007/0075 , A61F2007/126 , A61N1/0558 , A61N1/057 , A61N1/06 , A61N1/36007 , A61N1/36017 , A61N1/403 , A61N5/0601 , A61N5/0622 , A61N7/02 , A61N7/022 , A61N2005/0612 , A61N2007/0026 , A61N2007/003
摘要： Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulatoin may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feel or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
摘要翻译：提供了用于热诱导的肾神经调节的方法和系统。热诱导的肾神经调节蛋白可以通过直接和/或通过间接应用热能来加热或冷却有助于肾功能的神经纤维或感受或灌注神经纤维的血管结构来实现。在一些实施例中，非目标组织或热能输送元件的神经纤维的参数可以经由一个或多个传感器来监测以控制热诱导的神经调节。在一些实施例中，可以提供保护元件以减少在非目标组织中诱发的热损伤程度。在一些实施方案中，热诱导的肾神经调节通过递送脉冲式热疗来实现。

9. 发明授权

EP2092957B1 Systems for thermally-induced renal neuromodulation 有权转让
标题翻译：对于热诱导肾神经调节系统
公开(公告)号：EP2092957B1
公开(公告)日：2011-01-05
申请号：EP09156661.2
申请日：2007-06-28
申请人： Ardian, Inc.
发明人： Demarais, Denise , Zadno, Nicolas , Clark, Benjamin, J. , Thai, Erik , Wu, Andrew
IPC分类号： A61N1/36 , A61N1/40 , A61B18/14 , A61B18/08 , A61B18/12
摘要： Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulatoin may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feel or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

10. 发明公开

EP2206476A1 Apparatus, systems and methods for achieving intravascular, thermally-induced renal neuromodulation 审中-公开
标题翻译：设备，系统和方法来实现血管内，热致肾欧元调制
公开(公告)号：EP2206476A1
公开(公告)日：2010-07-14
申请号：EP09168202.1
申请日：2009-08-14
申请人： Ardian, Inc.
发明人： Wu, Andrew , Clark, Benjamin J , Zarins, Denise , Thai, Erik
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00212 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00702 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61N2007/003
摘要： Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

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