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1. 发明公开

EP2598140A2 COMPOUNDS AND METHODS FOR SKIN REPAIR 有权
标题翻译：前列腺素EP4激动剂使用在肌肤的护理
公开(公告)号：EP2598140A2
公开(公告)日：2013-06-05
申请号：EP11744157.6
申请日：2011-07-29
申请人： Allergan, Inc.
发明人： JIANG, Guang L. , BURK, Robert M. , IM, Wha Bin , BEDDINGFIELD, Frederick C. , WHEELER, Larry A. , WHITCUP, Scott M.
IPC分类号： A61K31/381 , A61K31/343 , A61K9/00 , A61K8/42 , A61K8/49 , A61K31/167 , A61K31/4015 , A61K31/421 , A61K31/519 , A61P17/02 , A61Q19/08
CPC分类号： A61K31/381 , A61K8/49 , A61K2800/91 , A61Q19/08
摘要： The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.

2. 发明公开

EP2694120A1 DEVICES, COMPOSITIONS AND METHODS UTILIZING EP4 AND EP2 RECEPTOR AGONISTS FOR PREVENTING, REDUCING OR TREATING CAPSULAR CONTRACTURE 审中-公开
标题翻译：装置，组合和方法用于预防，减少使用和EP4- EP2受体激动剂或治疗囊
公开(公告)号：EP2694120A1
公开(公告)日：2014-02-12
申请号：EP11746361.2
申请日：2011-07-29
申请人： Allergan, Inc.
发明人： JIANG, Guang-Liang , IM, Wha Bin , BEDDINGFIELD, Frederick C. , WHEELER, Larry A. , WHITCUP, Scott M. , AHLUWALIA, Gurpreet
IPC分类号： A61L15/40 , A61L27/34 , A61L27/54
CPC分类号： A61L15/44 , A61L15/40 , A61L27/34 , A61L27/54 , A61L2300/436 , A61L2430/04 , C08L89/00
摘要： Provided are devices, compositions and methods utilizing EP
4 and EP
2 receptor agonists for preventing, reducing, or treating capsular contracture occurring in response to the implantation of breast prostheses.

3. 发明公开

EP2646034A1 METHODS FOR TREATING DISEASES OF THE RETINA 审中-公开
标题翻译：方法视网膜疾病的治疗
公开(公告)号：EP2646034A1
公开(公告)日：2013-10-09
申请号：EP11810917.2
申请日：2011-11-18
申请人： Allergan, Inc.
发明人： KUSARI, Jyotirmoy X. , ZHOU, Sheila X. , TIAN, Mingting , PADILLO, Edwin U. , RAO, Sandhya S. , GIL, Daniel W. , WHEELER, Larry A.
IPC分类号： A61K31/5513 , A61P27/02
CPC分类号： A61K31/5513 , A61K31/551 , Y10S514/912
摘要： Disclosed herein is a method of treating disorders of the retina comprising administering to a patient in need of such treatment a compound selected from the group consisting of olanzapine, certain of its metabolites, clozapine, and n-desmethyl clozapine.

4. 发明授权

EP0835110B2 USE OF (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINES IN TREATING OCULAR NEURAL INJURY 失效
标题翻译：作者（2-咪唑啉-2-基 - 氨基）喹喔啉使用眼神经损伤的治疗
公开(公告)号：EP0835110B2
公开(公告)日：2011-06-15
申请号：EP96923317.0
申请日：1996-06-17
申请人： ALLERGAN, INC.
发明人： WHEELER, Larry A. , WOLDEMUSSIE, Elizabeth , LAI, Ronald K.
IPC分类号： A61K31/495
CPC分类号： A61K31/498 , A61K31/495 , Y10S514/912
摘要： A method according to which neuroprotection is conferred upon ocular nerve cells by administration of a drug of formula (I) to the optic nerve and/or retina of a mammal within a period prior to or following an insult to ocular nerve cells but prior to cell death, wherein the 2-imidazolin-2-ylamino group may be in either the 5- or 6-position of the quinoxaline nucleus; x, y and z may be in any of the remaining 5-, 6-, 7- or 8-positions and are selected from hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; and R is an optional substituent in either the 2- or 3-position of the quinoxaline nucleus and may be hydrogen, lower alkyl or lower alkoxy is disclosed.

5. 发明公开

EP2120962A1 METHODS AND COMPOSITIONS FOR TREATING GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：方法和组合物胃肠道疾病的治疗
公开(公告)号：EP2120962A1
公开(公告)日：2009-11-25
申请号：EP07855057.1
申请日：2007-12-11
申请人： ALLERGAN, INC.
发明人： JIANG, Guang Liang , IM, Wha Bin , WHEELER, Larry A.
IPC分类号： A61K31/559 , A61P1/04
CPC分类号： A61K31/559 , A61K9/2018 , A61K9/4825 , A61K9/5078 , A61K31/122 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/40 , A61K31/404 , A61K31/407 , A61K31/415 , A61K31/421 , A61K31/5415 , A61K31/603 , A61K31/616 , A61K31/635 , A61K45/06 , A61K2300/00
摘要： Methods are provided directed to administering a therapeutically effective amount of a prostaglandin EP4 agonist component to a mammal afflicted with or prone to affliction with a disease or condition selected from an esophageal ulcer, alcohol gastropathy, a duodenal ulcer, a gastric ulcer, non-steroidal anti- inflammatory drug-induced gastroenteropathy and intestinal ischemia. Such administration results in treating or preventing the disease or condition.

6. 发明公开

EP2605777A1 EP2 OR EP4 AGONISTS FOR TREATING CORNEAL HAZE 审中-公开
标题翻译： EP2或EP4激动剂治疗角膜混浊
公开(公告)号：EP2605777A1
公开(公告)日：2013-06-26
申请号：EP11748855.1
申请日：2011-08-17
申请人： Allergan, Inc.
发明人： JIANG, Guang-Liang , IM, Wha Bin , WHEELER, Larry A. , WHITCUP, Scott M.
IPC分类号： A61K31/559 , A61P27/02
CPC分类号： A61K31/381 , A61K9/0048 , A61K9/0051 , A61K31/4015 , A61K31/4025 , A61K31/539 , A61K31/559 , A61K2300/00
摘要： Disclosed herein are compositions and methods for treating corneal haze. Compositions and methods of use comprise therapeutically effective amounts of compounds that agonize the EP2 and/or EP4 receptor. Adminstration of the disclosed compounds can prevent and treat corneal haze development.

7. 发明公开

EP2582386A2 IL-10 AND METHODS OF TREATING OCULAR AND OTHER DISEASES 审中-公开
标题翻译： IL-10和用于治疗患眼和其他疾病的方法
公开(公告)号：EP2582386A2
公开(公告)日：2013-04-24
申请号：EP11731583.8
申请日：2011-06-16
申请人： Allergan, Inc.
发明人： STERN, Michael E. , SCHAUMBURG, Christopher S. , SIEMASKO, Karyn F. , WHEELER, Larry A.
IPC分类号： A61K38/20 , A61K9/00 , A61P27/02
CPC分类号： C07K14/005 , A61K9/0048 , A61K38/162 , A61K38/2066 , C12N2710/24033
摘要： Disclosed herein TPV1 is a method of treating ocular and systemic conditions by administering IL-10 and TPV134R polypeptides.

8. 发明授权

EP0723447B1 USE OF (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES 失效
标题翻译：使用（2-咪唑啉-2-基 - 氨基）QUINOXALINDERIVATEN
公开(公告)号：EP0723447B1
公开(公告)日：2002-12-11
申请号：EP94928623.1
申请日：1994-09-19
申请人： Allergan, Inc.
发明人： BURKE, James A. , GARST, Michael E. , WHEELER, Larry A.
IPC分类号： A61K31/495 , A61P9/10 , A61P25/00 , A61P29/00
CPC分类号： A61K31/498 , A61K31/495
摘要： A method of treating a mammal comprises administering to a mammal an effective amount to provide a desired therapeutic effect in the mammal of a compound selected from the group consisting of those having formula (I), and pharmaceutically acceptable acid addition salts thereof and mixtures thereof, wherein R1 and R2 each is selected from the group consisting of alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms, the 2-imidazolin-2-ylamino group may be in any of the 5-, 6-, 7- or 8- positions of the quinoxaline nucleus, and R3, R4 and R5 each is located in one of the remaining 5-, 6-, 7- or 8- positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals containing 1 to 3 carbon atoms. Such compounds, when administered to a mammal, provide desired therapeutic effects, such as reduction in peripheral pain, anesthetization of the central nervous system, constriction of one or more blood vessels, reduction in or prevention of at least one effect of ischemia, decongestion of one or more nasal passages, reduction of at least one effect of an inflammatory disorder, increase in renal fluid flow, and alteration in the rate of fluid transport in the gastrointestinal tract.

9. 发明授权

EP2598140B1 PROSTANOID EP4 AGONISTS FOR USE IN TREATING A SKIN BLEMISH 有权
标题翻译：前列腺素EP4激动剂使用在肌肤的护理
公开(公告)号：EP2598140B1
公开(公告)日：2015-01-14
申请号：EP11744157.6
申请日：2011-07-29
申请人： ALLERGAN, INC.
发明人： JIANG, Guang L. , BURK, Robert M. , IM, Wha Bin , BEDDINGFIELD, Frederick C. , WHEELER, Larry A. , WHITCUP, Scott M.
IPC分类号： A61K31/381 , A61K31/343 , A61K9/00 , A61K8/42 , A61K8/49 , A61K31/167 , A61K31/4015 , A61K31/421 , A61K31/519 , A61P17/02 , A61Q19/08
CPC分类号： A61K31/381 , A61K8/49 , A61K2800/91 , A61Q19/08

10. 发明授权

EP0835110B1 USE OF (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINES IN TREATING OCULAR NEURAL INJURY 失效
标题翻译：作者（2-咪唑啉-2-基 - 氨基）喹喔啉使用用于治疗AUGENNERFVERLETZUNG
公开(公告)号：EP0835110B1
公开(公告)日：2006-04-05
申请号：EP96923317.0
申请日：1996-06-17
申请人： ALLERGAN, INC.
发明人： WHEELER, Larry A. , WOLDEMUSSIE, Elizabeth , LAI, Ronald K.
IPC分类号： A61K31/495
CPC分类号： A61K31/498 , A61K31/495 , Y10S514/912

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