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1. 发明公开

EP3843826A1 FLUID DELIVERY SYSTEMS AND METHODS 审中-实审转让
公开(公告)号：EP3843826A1
公开(公告)日：2021-07-07
申请号：EP19853399.4
申请日：2019-08-26
申请人： Alcyone Lifesciences, Inc.
发明人： SINGH, Deep Arjun , FREUND, Jonathan , ANAND, PJ , WASHBURN, Thomas T. , EAST, Andrew William , ABRUZZO, Elsa Chi
IPC分类号： A61M31/00 , A61M39/02 , A61M39/04 , B29C65/58

2. 发明公开

EP3881876A1 MICROFLUIDIC DRUG DELIVERY DEVICES 审中-公开
公开(公告)号：EP3881876A1
公开(公告)日：2021-09-22
申请号：EP21157393.6
申请日：2012-08-01
申请人： Alcyone Lifesciences, Inc.
发明人： ANAND, PJ , SINGH, Deep, Arjun
IPC分类号： A61M5/168 , A61M25/00 , A61B5/03 , A61M5/172 , A61B5/145 , A61B5/00
摘要： A microfluidic convection-enhanced-delivery (CED) device, comprising:
a shank portion (14) on a support scaffold (12);
a fluid delivery conduit (416) having an inlet port and a plurality of outlet ports (428), the delivery conduit formed in or on the shank portion and comprising first and second upstream lumens (434, 436) and a single downstream lumen (438);
a flow restriction formed within the conduit at a merge of the first and second upstream lumens into the single downstream lumen, the flow restriction being configured to adjust a pressure of fluid being directed through the at least one fluid delivery conduit;
wherein the flow restriction comprises a constricted region of the at least one fluid delivery conduit;
wherein the plurality of outlet ports (428) are formed in the upstream lumens and in the single downstream lumen respectively and are formed in an outermost surface of the microfluidic CED device.

3. 发明公开

EP3490638A1 AUTOMATED DRUG DELIVERY SYSTEMS AND METHODS 审中-公开
公开(公告)号：EP3490638A1
公开(公告)日：2019-06-05
申请号：EP17835317.3
申请日：2017-07-28
申请人： Alcyone Lifesciences, Inc.
发明人： ANAND, PJ , ARZUMAND, Ayesha , BROPHY, Morgan , EAST, Andrew , EBERL, Gregory, R. , SINGH, Deep, Arjun
IPC分类号： A61M5/145

4. 发明公开

EP3399922A1 METHODS AND DEVICES FOR TREATING STROKE 审中-公开
公开(公告)号：EP3399922A1
公开(公告)日：2018-11-14
申请号：EP17736216.7
申请日：2017-01-04
申请人： Alcyone Lifesciences, Inc.
发明人： ANAND, PJ , EKHOLM, John , SINGH, Deep Arjun
IPC分类号： A61B8/12 , A61B17/22 , A61M3/02 , A61M25/00
CPC分类号： A61B17/22 , A61B90/10 , A61B2017/22079 , A61B2017/22082 , A61B2017/22084 , A61B2017/22088 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/008 , A61M25/0102 , A61M2025/0008 , A61M2210/0693
摘要： Methods and devices are disclosed herein that allow for infusion and aspiration through a single device. The device can be used to treat a stroke by delivering the device to the site of a blood clot and simultaneously or sequentially infusing a thrombolytic or other drug into the clot and aspirating the dissolving clot from the patient. The methods and devices can advantageously permit more efficient thrombolytic infusion and clot aspiration. Modular systems are also disclosed, as are methods of treating subdural hematoma or other conditions.

5. 发明公开

EP3131617A1 SYSTEMS AND METHODS FOR SHUNTING FLUID 有权转让
标题翻译： SYSTEME UND VERFAHREN ZUM SCHLEUSEN EINERFLÜSSIGKEIT
公开(公告)号：EP3131617A1
公开(公告)日：2017-02-22
申请号：EP15779584.0
申请日：2015-04-18
申请人： Alcyone Lifesciences, Inc.
发明人： EAST, Andrew , BROPHY, Morgan , SINGH, Deep Arjun , ANAND, PJ , DEGON, Robert , FALLON, Timothy , WALLER, Allison , ATTAR, Matthew
IPC分类号： A61M27/00
摘要： Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.
摘要翻译：本文提供的系统和方法通常涉及分流流体，例如在治疗脑积水中分流脑脊液。提供自清洁导管，其包括分开的尖端，其被配置为使得在其中插入导管的空腔中的脉动流动可导致尖端彼此撞击，从而清除障碍物。还提供带内置流量指示器的导管。示例性流量指示器包括从导管的内表面径向向内延伸并且包括可成像部分（例如，在磁共振成像（MRI）下可见的部分）的突出部。可以使用MRI检测由流体流过导管引起的流量指示器的移动，从而提供关于导管是部分地还是完全阻塞的可靠指示。本文还公开了用于冲洗分流系统的系统和方法，以及用于打开通过分流系统的辅助流体路径的各种系统和方法。

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