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1. 发明公开

EP2317977A2 PHARMACEUTICAL COMPOSITION HAVING RELATIVELY LOW IONIC STRENGTH 有权
标题翻译：以相对低离子强度的药物组合物
公开(公告)号：EP2317977A2
公开(公告)日：2011-05-11
申请号：EP09792023.5
申请日：2009-08-28
申请人： Alcon Research, Ltd.
发明人： GHOSH, Malay , CHOWHAN, Masood, A.
IPC分类号： A61K9/08
CPC分类号： A61K9/0048 , A61K9/0043 , A61K9/0046 , A61K9/1276 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18
摘要： The present invention is directed to the provision of pharmaceutical compositions such as multi-dose, ophthalmic compositions. The compositions possess sufficient antimicrobial activity to satisfy preservative efficacy requirements in the United States and/or Europe. The compositions have relatively low ionic strengths to assist in maintaining such efficacy.

2. 发明公开

EP2278953A2 SELF-PRESERVED EMULSIONS 有权
标题翻译：自持乳液
公开(公告)号：EP2278953A2
公开(公告)日：2011-02-02
申请号：EP09767290.1
申请日：2009-05-27
申请人： Alcon Research, Ltd.
发明人： CHOWHAN, Masood, A. , GHOSH, Malay
IPC分类号： A61K9/00 , A61K9/107 , A61K47/00 , A61K47/14 , A61K47/18 , A61K47/24
CPC分类号： A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K9/107 , A61K9/1075 , A61K47/14 , A61K47/18 , A61K47/24
摘要： The use of multifunctional synthetic compounds to both stabilize and preserve therapeutic emulsions is described. The multifunctional synthetic compounds have unique molecular arrangement wherein a phosphate group is linked to one, two or three quaternary ammonium functionalities via a substituted propenyl group, and each quaternary ammonium functionality is further linked to at least one long hydrocarbon chain. The pharmaceutical emulsions which include these multifunctional compounds may be prepared without heating or homogenization, and do may not require the use of any additional stabilizing or preserving agents.

3. 发明授权

EP2278953B1 SELF-PRESERVED EMULSIONS 有权
标题翻译：自持乳液
公开(公告)号：EP2278953B1
公开(公告)日：2016-05-04
申请号：EP09767290.1
申请日：2009-05-27
申请人： Alcon Research, Ltd
发明人： CHOWHAN, Masood, A. , GHOSH, Malay
IPC分类号： A61K9/00 , A61K9/107 , A61K47/00 , A61K47/14 , A61K47/18 , A61K47/24
CPC分类号： A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K9/107 , A61K9/1075 , A61K47/14 , A61K47/18 , A61K47/24

4. 发明公开

EP2928475A1 FINAFLOXACIN SUSPENSION COMPOSITIONS 有权转让
标题翻译： FINAFLOXACIN混悬液组合物
公开(公告)号：EP2928475A1
公开(公告)日：2015-10-14
申请号：EP13860388.1
申请日：2013-11-22
申请人： Alcon Research, Ltd.
发明人： BOUDREAUX, Brent, G. , BRIDLE, Mark, J. , HUYNH, Bryan, H. , GHOSH, Malay , CHOWHAN, Masood, A. , ALANI, Laman , KABRA, Bhagwati, P.
IPC分类号： A61K31/5383 , A61K9/00
CPC分类号： A61K31/5383 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K9/10 , A61K31/573 , A61K47/02 , A61K47/38
摘要： The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a suspension composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin free base or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.

5. 发明授权

EP2317977B1 PHARMACEUTICAL COMPOSITION HAVING RELATIVELY LOW IONIC STRENGTH 有权
标题翻译：以相对低离子强度的药物组合物
公开(公告)号：EP2317977B1
公开(公告)日：2014-07-23
申请号：EP09792023.5
申请日：2009-08-28
申请人： Alcon Research, Ltd.
发明人： GHOSH, Malay , CHOWHAN, Masood, A.
IPC分类号： A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K9/127
CPC分类号： A61K9/0048 , A61K9/0043 , A61K9/0046 , A61K9/1276 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18

6. 发明公开

EP2448587A1 COMPOSITIONS COMPRISING FINAFLOXACIN AND METHODS FOR TREATING OPHTHALMIC, OTIC, OR NASAL INFECTIONS 有权转让
标题翻译：组合物FINAFLOXACIN和用于治疗眼病，耳部感染或鼻方法
公开(公告)号：EP2448587A1
公开(公告)日：2012-05-09
申请号：EP10732580.5
申请日：2010-07-02
申请人： Alcon Research, Ltd.
发明人： STROMAN, David, W. , CHOWHAN, Masood, A. , APPELL, Kenneth, C.
IPC分类号： A61K31/5383 , A61K31/5395 , A61K9/00 , A61P31/04 , A61P27/02
CPC分类号： A61K31/5383 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K31/535 , A61K31/5395 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.

7. 发明授权

EP2448587B1 COMPOSITIONS COMPRISING FINAFLOXACIN AND METHODS FOR TREATING OPHTHALMIC, OTIC, OR NASAL INFECTIONS 有权转让
公开(公告)号：EP2448587B1
公开(公告)日：2018-08-22
申请号：EP10732580.5
申请日：2010-07-02
申请人： Alcon Research, Ltd.
发明人： STROMAN, David, W. , CHOWHAN, Masood, A. , APPELL, Kenneth, C.
IPC分类号： A61K31/5383 , A61K31/5395 , A61K9/00 , A61P31/04 , A61P27/02 , A61K31/535 , A61K45/06
CPC分类号： A61K31/5383 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K31/535 , A61K31/5395 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.

8. 发明公开

EP2482798A1 OLOPATADINE COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：奥洛他定组合物及其用途
公开(公告)号：EP2482798A1
公开(公告)日：2012-08-08
申请号：EP10762842.2
申请日：2010-10-01
申请人： Alcon Research, Ltd.
发明人： SCHNEIDER, L., Wayne , HAN, Wesley, Wehsin , CHOWHAN, Masood, A.
IPC分类号： A61K9/00 , A61K31/335 , A61K31/435 , A61K45/06
CPC分类号： A61K31/5377 , A61K9/0014 , A61K9/0043 , A61K9/0048 , A61K31/335 , A61K31/435 , A61K31/496
摘要： The invention provides solution compositions comprising olopatadine and a PDE4 inhibitor compound of Formula (I). The invention also provides methods for treating allergic and inflammatory diseases. More particularly, the present invention relates to formulations of olopatadine and their use for treating and/or preventing allergic or inflammatory disorders of the eye, nose, skin, and ear.
摘要翻译：本发明提供了包含奥洛他定和式（I）的PDE4抑制剂化合物的溶液组合物。本发明还提供了治疗变应性和炎性疾病的方法。更具体地说，本发明涉及奥洛他定制剂及其用于治疗和/或预防眼睛，鼻子，皮肤和耳朵的变应性或炎性疾病的用途。

9. 发明公开

EP2155271A1 PHOSPHOLIPID COMPOSITIONS FOR CONTACT LENS CARE AND PRESERVATION OF PHARMACEUTICAL COMPOSITIONS 有权
标题翻译： KONSERVIERUNG PHARPHOLIPIDZUSAMMENSETZUNGEN ZUR KONTAKTLINSENPFLEGE KONSERVIERUNG PHARMAZEUTISCHER ZUSAMMENSETZUNGEN
公开(公告)号：EP2155271A1
公开(公告)日：2010-02-24
申请号：EP08755679.1
申请日：2008-05-16
申请人： Alcon Research, Ltd.
发明人： GHOSH, Malay , CHOWHAN, Masood, A. , SCHNEIDER, L. Wayne.
IPC分类号： A61L12/14
CPC分类号： A61L12/143 , A01N57/12 , A61L2/18
摘要： The use of certain synthetic phospholipids to preserve pharmaceutical compositions from microbial contamination is described. The synthetic phospholipids have unique molecular arrangements wherein a phosphate group is linked to a quaternary ammonium functionality via a substituted-propenyl group, and the quaternary ammonium functionality is further linked to at least one long hydrocarbon chain. Such molecular arrangements are what make the phospholipids of formula (I) highly water soluble, e.g., the length of the hydrocarbon chain assists to maintain solubility and efficacy of the molecules for the uses described herein. The synthetic phospholipids described herein have been found to be particularly useful as antimicrobial preservatives for ophthalmic, otic and nasal pharmaceutical compositions, especially ophthalmic compositions. These compounds may also be utilized to disinfect contact lenses. The invention is based in-part upon a finding that the antimicrobial activity of the synthetic phospholipids is affected by the ionic strength of the compositions in which the compounds are contained. The provision of compounds having limited ionic strengths is therefore preferred.
摘要翻译：描述了使用某些合成磷脂来保护药物组合物免受微生物污染。合成磷脂具有独特的分子结构，其中磷酸基通过取代的丙烯基与季铵官能团连接，并且季铵官能团进一步连接至至少一个长烃链。这样的分子结构使得式（I）的磷脂高度水溶性，例如烃链的长度有助于保持分子用于本文所述用途的溶解度和功效。已经发现本文所述的合成磷脂特别可用作眼用，耳用和鼻用药物组合物，特别是眼用组合物的抗微生物防腐剂。这些化合物也可用于消毒隐形眼镜。本发明部分地基于以下发现：合成磷脂的抗微生物活性受包含化合物的组合物的离子强度的影响。因此优选提供具有有限离子强度的化合物。

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