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1. 发明公开

EP3981419A1 BIOULTRABOND - A NOVEL SEALANT, GLUE OR FILLER FOR BIOLOGICAL TISSUES 审中-实审
公开(公告)号：EP3981419A1
公开(公告)日：2022-04-13
申请号：EP20200721.7
申请日：2020-10-08
申请人： Albert-Ludwigs-Universität Freiburg
发明人： SCHILLER, Stefan , RESCH, Anna , HUBER, Matthias
IPC分类号： A61K38/01 , A61K38/39 , A61P41/00 , C07K14/435 , C07K14/78 , C07K19/00
摘要： The present invention pertains to a novel sealant, glue or filler for biological tissues based on a biodegradable, cross-linkable fusion protein having the formula (I) ULD-(L) n -ULD, wherein ULD is an ubiquitin-like-domain, forming tetrameric protein structures, and (L) is a linker sequence, preferably a peptide or protein sequence having 5-2500 aa. The particular advantage of the current system lies in its great variability and low toxicity towards the recipient biological tissue, preferably a mammalian, e.g. a human, or any animal species. Moreover, the novel tissue sealant allows providing sealants, glues or fillers with high elasticity, adhesiveness and high resistance, which can be applied to a (wet) biological tissue within minutes. The present invention also pertains to medical uses of the novel biological tissue sealant, glue or filler and to methods of treatment using the same.

2. 发明授权

EP2854863B1 PROTEIN ASSEMBLER 有权转让
标题翻译：蛋白质组装
公开(公告)号：EP2854863B1
公开(公告)日：2017-11-01
申请号：EP13730816.9
申请日：2013-05-28
申请人： Albert-Ludwigs-Universität Freiburg
发明人： SCHILLER, Stefan , HUBER, Matthias
IPC分类号： C12N15/66
CPC分类号： C07K14/78 , A61K47/6435 , C12N15/1031 , C12N15/66

3. 发明公开

EP2854863A2 PROTEIN ASSEMBLER 有权转让
标题翻译： PROTEINASSEMBLER
公开(公告)号：EP2854863A2
公开(公告)日：2015-04-08
申请号：EP13730816.9
申请日：2013-05-28
申请人： Albert-Ludwigs-Universität Freiburg
发明人： SCHILLER, Stefan , HUBER, Matthias
IPC分类号： A61K47/48 , C07K14/78
CPC分类号： C07K14/78 , A61K47/6435 , C12N15/1031 , C12N15/66
摘要： The present invention relates to a method for assembling (monomeric or oligomeric) proteins and peptide structures to multimeric protein or peptide structures. The present invention also provides a method for preparing peptide based polymers by crosslinking such multimeric proteins or peptides obtainable according to the inventive method and their use as polymers, for amphiphilic applications, as protein based detergents, for forming artificial organelles, etc. Disclosed are furthermore novel protein or peptide structures, nucleic acids encoding same and cloning and expression vectors suitable for carrying out the inventive method for assembling multimeric proteins or peptides. The novel method for assembling proteins and peptide structures may be furthermore be used as a novel scalable peptide generator technique, which are also described, by preparing first a multimeric protein or peptide structure using the inventive method and then specifically degrading the multimeric protein or peptide structure into its monomeric or smaller units.
摘要翻译：本发明涉及将（单体或寡聚）蛋白质和肽结构组装成多聚体蛋白质或肽结构的方法。本发明还提供了一种通过将根据本发明方法获得的多聚体蛋白质或多肽或其作为聚合物，作为蛋白质类洗涤剂的两亲应用的用途，用于形成人造细胞器等的交联来制备基于肽的聚合物的方法。还公开了新的蛋白质或肽结构，编码它们的核酸以及适于实施用于组装多聚体蛋白质或肽的本发明方法的克隆和表达载体。此外，用于组装蛋白质和肽结构的新颖方法还可以用作新的可缩放肽产生剂技术，其也通过使用本发明的方法首先制备多聚体蛋白质或肽结构，然后特异性降解多聚体蛋白质或肽结构进入其单体或更小的单位。

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