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    • 4. 发明公开
    • AMIDE COMPOUNDS, COMPOSITIONS AND APPLICATIONS THEREOF
    • AMIDVERBINDUNGEN,ZUSAMMENSETZUNGEN UND ANWENDUNGEN DAVON
    • EP2758375A1
    • 2014-07-30
    • EP12787909.6
    • 2012-09-21
    • Advinus Therapeutics Limited
    • KHARUL, RajendraBHUNIYA, DebnathMOOKHTIAR, Kasim A.SINGH, UmeshHAZARE, AtulPATIL, SatishDATRANGE, LaxmikantTHAKKAR, Mahesh
    • C07D213/60C07D241/14C07D401/12C07D413/12A61K31/33A61P25/00
    • C07D401/12A61K31/4439A61K31/444A61K31/497A61K31/675A61K45/06C07D213/75C07D401/14C07D409/12C07D413/12C07D417/12C07D471/04C07F9/65616
    • The present disclosure relates to substituted amide compounds that are inhibitors of Fatty Acid Amide Hydrolase (FAAH), their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them. These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Fatty Acid Amide Hydrolase (FAAH), such as pain including acute and post operative pain, chronic pain, cancer pain, cancer chemotherapy induced pain, neuropathic pain, nociceptive pain, inflammatory pain, back pain, pain due to disease of various origin such as: diabetic neuropathy, neurotropic viral disease including human immunodeficient virus (HIV), herpes zoster such as post herpetic neuralgia; polyneuropathy, neurotoxicity, mechanical nerve injury, carpal tunnel syndrome, immunologic mechanisms like multiple sclerosis; sleep disorders, anxiety and depression disorders, inflammatory disorders, weight and eating disorders, Parkinson's disease, addiction, spasticity, hypertension or other disorders. The disclosure also relates to the process of preparation of the amide compounds. Formula (1). The present disclosure also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    • 本公开涉及作为脂肪酸酰胺水解酶(FAAH),其立体异构体,互变异构体,前药,多晶型物,溶剂合物,药学上可接受的盐和含有它们的药物组合物的抑制剂的取代的酰胺化合物。 这些化合物可用于治疗,预防,预防,治疗或辅助治疗与抑制脂肪酸酰胺水解酶(FAAH)相关的所有医学病症,如疼痛,包括急性和术后疼痛,慢性疼痛,癌症疼痛,癌症 化疗引起的疼痛,神经性疼痛,伤害性疼痛,炎症性疼痛,背痛,各种原因疾病引起的疼痛,如:糖尿病性神经病,包括人类免疫缺陷病毒(HIV)在内的神经营养性病毒性疾病,疱疹后遗神经痛等带状疱疹; 多发性神经病,神经毒性,机械性神经损伤,腕管综合征,多发性硬化等免疫机制; 睡眠障碍,焦虑和抑郁症,炎性疾病,体重和进食障碍,帕金森病,成瘾,痉挛,高血压或其他障碍。 本公开还涉及酰胺化合物的制备方法。 本公开还涉及制备这些化合物的方法以及含有它们的药物组合物。