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1. 发明公开

EP2903985A1 SPIROCYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF 审中-公开
标题翻译： SPIROCYCLISCHE VERBINDUNGEN，ZUSAMMENSETZUNGEN UND MEDISINISCHE ANWENDUNGEN DAVON
公开(公告)号：EP2903985A1
公开(公告)日：2015-08-12
申请号：EP13814644.4
申请日：2013-10-01
申请人： Advinus Therapeutics Limited
发明人： KOUL, Summon , BHUNIYA, Debnath , MOOKHTIAR, Kasim , BHOSALE, Sandeep , KURHADE, Suresh , NAIK, Keshav , VELAYUTHAM, Ravikumar , SALUNKHE, Videsh
IPC分类号： C07D413/14 , C07D413/12 , C07D271/113 , C07D451/02 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D498/04 , C07D271/113 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/04 , C07D487/04
摘要： The present disclosure relates to a series of spirocyclic compounds of formula (I), their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates, hydrates, N-Oxides, Co crystals and formulations thereof. The disclosure also relates to process of preparation of these spirocyclic compounds. Formula (I). These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of acyl CoA diacyl glycerol acyltransferase 1 (DGAT1).
摘要翻译：这些化合物可用于治疗，预防，预防，治疗或辅助治疗与抑制酰基CoA二酰基甘油酰基转移酶1（DGAT1）相关的所有医学病症。

2. 发明公开

EP2838898A1 SUBSTITUTED HETERO-BICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF 有权转让
标题翻译：杂化合物，组合物及其医疗用途
公开(公告)号：EP2838898A1
公开(公告)日：2015-02-25
申请号：EP13737672.9
申请日：2013-04-18
申请人： Advinus Therapeutics Limited
发明人： THAKKAR, Mahesh , KOUL, Summon , BHUNIYA, Debnath , MOOKHTIAR, Kasim , KURHADE, Santosh , MUNOT, Yogesh
IPC分类号： C07D413/14 , A61K31/519 , C07D403/14 , A61P19/02
CPC分类号： C07D519/00 , A61K31/519 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The present disclosure provides hetero-biclyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by Bruton's tyrosine kinase (Btk) activity, The disclosure also relates to the process of preparation of compounds of Formula (I). These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Bruton's tyrosine kinase (Btk), such as inflammatory and/or autoimmune disorder, cell proliferation, rheumatoid arthritis, psoriasis, psoriatic arthritis, transplant rejection, graft-versus-host disease, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, B-cell malignancies, systemic lupus, erythematosus or other disorders.

3. 发明授权

EP2838898B1 SUBSTITUTED HETERO-BICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF 有权转让
标题翻译：卫生组织VERBINDUNGEN，ZUSAMMENSETZUNGEN UND DEREN MEDISISCHE VERWENDUNG
公开(公告)号：EP2838898B1
公开(公告)日：2017-01-18
申请号：EP13737672.9
申请日：2013-04-18
申请人： Advinus Therapeutics Limited
发明人： THAKKAR, Mahesh , KOUL, Summon , BHUNIYA, Debnath , MOOKHTIAR, Kasim , KURHADE, Santosh , MUNOT, Yogesh
IPC分类号： C07D413/14 , A61K31/519 , C07D403/14 , A61P19/02
CPC分类号： C07D519/00 , A61K31/519 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04

4. 发明公开

EP2758375A1 AMIDE COMPOUNDS, COMPOSITIONS AND APPLICATIONS THEREOF 审中-公开
标题翻译： AMIDVERBINDUNGEN，ZUSAMMENSETZUNGEN UND ANWENDUNGEN DAVON
公开(公告)号：EP2758375A1
公开(公告)日：2014-07-30
申请号：EP12787909.6
申请日：2012-09-21
申请人： Advinus Therapeutics Limited
发明人： KHARUL, Rajendra , BHUNIYA, Debnath , MOOKHTIAR, Kasim A. , SINGH, Umesh , HAZARE, Atul , PATIL, Satish , DATRANGE, Laxmikant , THAKKAR, Mahesh
IPC分类号： C07D213/60 , C07D241/14 , C07D401/12 , C07D413/12 , A61K31/33 , A61P25/00
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/675 , A61K45/06 , C07D213/75 , C07D401/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07F9/65616
摘要： The present disclosure relates to substituted amide compounds that are inhibitors of Fatty Acid Amide Hydrolase (FAAH), their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them. These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Fatty Acid Amide Hydrolase (FAAH), such as pain including acute and post operative pain, chronic pain, cancer pain, cancer chemotherapy induced pain, neuropathic pain, nociceptive pain, inflammatory pain, back pain, pain due to disease of various origin such as: diabetic neuropathy, neurotropic viral disease including human immunodeficient virus (HIV), herpes zoster such as post herpetic neuralgia; polyneuropathy, neurotoxicity, mechanical nerve injury, carpal tunnel syndrome, immunologic mechanisms like multiple sclerosis; sleep disorders, anxiety and depression disorders, inflammatory disorders, weight and eating disorders, Parkinson's disease, addiction, spasticity, hypertension or other disorders. The disclosure also relates to the process of preparation of the amide compounds. Formula (1). The present disclosure also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
摘要翻译：本公开涉及作为脂肪酸酰胺水解酶（FAAH），其立体异构体，互变异构体，前药，多晶型物，溶剂合物，药学上可接受的盐和含有它们的药物组合物的抑制剂的取代的酰胺化合物。这些化合物可用于治疗，预防，预防，治疗或辅助治疗与抑制脂肪酸酰胺水解酶（FAAH）相关的所有医学病症，如疼痛，包括急性和术后疼痛，慢性疼痛，癌症疼痛，癌症化疗引起的疼痛，神经性疼痛，伤害性疼痛，炎症性疼痛，背痛，各种原因疾病引起的疼痛，如：糖尿病性神经病，包括人类免疫缺陷病毒（HIV）在内的神经营养性病毒性疾病，疱疹后遗神经痛等带状疱疹; 多发性神经病，神经毒性，机械性神经损伤，腕管综合征，多发性硬化等免疫机制; 睡眠障碍，焦虑和抑郁症，炎性疾病，体重和进食障碍，帕金森病，成瘾，痉挛，高血压或其他障碍。本公开还涉及酰胺化合物的制备方法。本公开还涉及制备这些化合物的方法以及含有它们的药物组合物。

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