专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1740171A1 INDOL-1-YL-ACETIC ACID DERIVATIVES 有权
标题翻译：吲哚-1-基乙酸的衍生物
公开(公告)号：EP1740171A1
公开(公告)日：2007-01-10
申请号：EP05715820.6
申请日：2005-03-08
申请人： Actelion Pharmaceuticals Ltd.
发明人： FECHER, Anja , FRETZ, Heinz , HILPERT, Kurt , RIEDERER, Markus
IPC分类号： A61K31/40 , C07D209/00
CPC分类号： A61K31/405 , A61K31/40 , A61K31/4709 , A61K31/55 , C07D209/18 , C07D209/30 , C07D209/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/06
摘要： The invention relates to indol-1-yl-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds.

2. 发明授权

EP1725553B1 TETRAHYDROPYRIDOINDOLE DERIVATIVES 有权转让
标题翻译： TETRAHYDROPYRIDOINDOLDERIVATE
公开(公告)号：EP1725553B1
公开(公告)日：2008-05-07
申请号：EP05715779.4
申请日：2005-03-07
申请人： Actelion Pharmaceuticals Ltd.
发明人： FRETZ, Heinz , FECHER, Anja , HILPERT, Kurt , RIEDERER, Markus
IPC分类号： C07D471/04 , A61K31/437 , A61P11/06 , A61P35/02 , A61P37/08
CPC分类号： C07D471/04
摘要： The invention relates to tetrahydropyridoindole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions comprising one or more of those compounds and methods of treatment comprising administration of said compounds.

3. 发明公开

EP1833791A2 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS 有权
标题翻译： -2,3,4,9-四氢-1H-咔唑衍生物ALS CRTH2受体的拮抗剂
公开(公告)号：EP1833791A2
公开(公告)日：2007-09-19
申请号：EP05850906.8
申请日：2005-12-22
申请人： Actelion Pharmaceuticals Ltd.
发明人： FECHER, Anja , FRETZ, Heinz , RIEDERER, Markus
IPC分类号： C07D209/88 , A61K31/404 , A61P37/00
CPC分类号： C07D209/88
摘要： The invention relates to novel tetrahydro-l H-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to patients.

4. 发明公开

EP1784182A1 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS 审中-公开
标题翻译： 2 - 硫烷基 - 苯并咪唑-1-基 - 乙酸衍生物作为CRTH2拮抗剂
公开(公告)号：EP1784182A1
公开(公告)日：2007-05-16
申请号：EP05778612.1
申请日：2005-08-23
申请人： Actelion Pharmaceuticals Ltd.
发明人： FRETZ, Heinz , HILPERT, Kurt , RIEDERER, Markus , STEGER, Matthias , POTHIER, Julien , GUDE, Markus
IPC分类号： A61K31/4184 , A61K31/425 , A61K31/4439 , A61K31/445 , A61K31/4709 , A61P1/00 , A61P1/04 , A61P5/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P27/02
摘要： The invention relates to 2-sulfanyl-benzoimidazol-1-yl-acetic acid derivatives and their use as potent 'chemoattractant receptor-homologous molecule expressed on Th2 cells' antagonists in the treatment of prostaglandin mediated diseases, to pharmaceutical compositions containing these derivatives and to processes for their preparation.

5. 发明公开

EP1638540A2 PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS 审中-公开
标题翻译：国际卫生条例草案中的吡唑啉酮衍生物
公开(公告)号：EP1638540A2
公开(公告)日：2006-03-29
申请号：EP04739938.1
申请日：2004-06-16
申请人： Actelion Pharmaceuticals Ltd.
发明人： HOUILLE, Olivier , FRETZ, Heinz , HILPERT, Kurt , RIEDERER, Markus , GILLER, Thomas , VALDENAIRE, Oliver
IPC分类号： A61K31/00
CPC分类号： C07D401/04 , A61K31/4152 , A61K31/4155 , C07C45/00 , C07C45/62 , C07C45/673 , C07C45/68 , C07C45/71 , C07C47/542 , C07C47/548 , C07C47/565 , C07C47/575 , C07C309/65 , C07C2601/08 , C07D231/32
摘要： Pyrazolidinedione derivatives of the general formula (I), wherein R1 is hydrogen, optionally substituted alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl or alkanoyl; and R2 is aryl or heteroaryl; tautomers thereof; geometric isomers thereof and tautomers of these geometric isomers, including mixtures of individual compounds of formula (I), or tautomers thereof, and their geometric isomers, or tautomers thereof, pharmaceutically acceptable acid addition salts of compounds which are basic; pharmaceutically acceptable salts of compounds containing acidic groups with bases; pharmaceutically acceptable esters of compounds containing hydroxy or carboxy groups; prodrugs of compounds in which a prodrug forming group is present; as well as hydrates or solvates thereof; are active as platelet adenosine diphosphate receptor antagonists and can be used for the prevention and/or treatment of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, particularly thrombosis, and, respectively, for the manufacture of corresponding medicaments. Some, albeit not all, of the compounds of the above formula (I) are novel.
摘要翻译：通式（I）的吡唑烷二酮衍生物，其中R 1是氢，任选取代的烷基，环烷基，芳基，芳基烷基，杂芳基或杂芳基烷基; 并且R 2是芳基或杂芳基; 互变异构体其几何异构体和这些几何异构体的互变异构体，包括式（I）的各化合物或其互变异构体的混合物及其几何异构体或其互变异构体; 碱性化合物的药学上可接受的酸加成盐; 含有酸性基团的化合物的药学上可接受的盐与碱; 含有羟基或羧基的化合物的药学上可接受的酯; 其中存在前药形成基团的化合物的前药; 以及其水合物或溶剂合物; 作为血小板二磷酸腺苷受体拮抗剂是有活性的，可用于预防和/或治疗心血管和脑血管疾病或与血小板聚集特别是血栓形成有关的病症的内脏，肝和肾血管的外周血管，分别用于制造相应的药物。上述式（I）化合物的一些（尽管不是全部）是新的。

6. 发明授权

EP1833791B1 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS 有权
标题翻译： -2,3,4,9-四氢-1H-咔唑衍生物ALS CRTH2受体的拮抗剂
公开(公告)号：EP1833791B1
公开(公告)日：2011-08-03
申请号：EP05850906.8
申请日：2005-12-22
申请人： Actelion Pharmaceuticals Ltd.
发明人： FECHER, Anja , FRETZ, Heinz , RIEDERER, Markus
IPC分类号： C07D209/88 , A61K31/404 , A61P37/00
CPC分类号： C07D209/88
摘要： The invention relates to novel tetrahydro-l H-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to patients.

7. 发明授权

EP1740171B1 INDOL-1-YL-ACETIC ACID DERIVATIVES 有权
标题翻译：吲哚-1-基乙酸的衍生物
公开(公告)号：EP1740171B1
公开(公告)日：2010-06-09
申请号：EP05715820.6
申请日：2005-03-08
申请人： Actelion Pharmaceuticals Ltd.
发明人： FECHER, Anja , FRETZ, Heinz , HILPERT, Kurt , RIEDERER, Markus
IPC分类号： A61K31/40 , C07D209/00
CPC分类号： A61K31/405 , A61K31/40 , A61K31/4709 , A61K31/55 , C07D209/18 , C07D209/30 , C07D209/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/06
摘要： The invention relates to indol-1-yl-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds.

8. 发明公开

EP1725553A1 TETRAHYDROPYRIDOINDOLE DERIVATIVES 有权转让
标题翻译：四氢吡啶并吲哚衍生物
公开(公告)号：EP1725553A1
公开(公告)日：2006-11-29
申请号：EP05715779.4
申请日：2005-03-07
申请人： Actelion Pharmaceuticals Ltd.
发明人： FRETZ, Heinz , FECHER, Anja , HILPERT, Kurt , RIEDERER, Markus
IPC分类号： C07D471/04 , A61K31/437 , A61P11/06 , A61P35/02 , A61P37/08
CPC分类号： C07D471/04
摘要： The invention relates to tetrahydropyridoindole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions comprising one or more of those compounds and methods of treatment comprising administration of said compounds.
摘要翻译：本发明涉及四氢吡啶并吲哚衍生物及其在制备药物组合物中作为活性成分的用途。本发明还涉及相关方面，包括制备化合物的方法，包含一种或多种这些化合物的药物组合物以及包括施用所述化合物的治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式