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1. 发明公开

EP3509661A1 VENTRICULAR ASSIST DEVICE 有权
公开(公告)号：EP3509661A1
公开(公告)日：2019-07-17
申请号：EP17755167.8
申请日：2017-08-18
申请人： Abiomed Europe GmbH
发明人： NIX, Christoph , LUNZE, Katrin , SIESS, Thorsten , ABOULHOSN, Walid
IPC分类号： A61M1/10

2. 发明公开

EP3311859A1 VENTRICULAR ASSIST DEVICE CONTROL 有权
标题翻译：心室辅助装置控制
公开(公告)号：EP3311859A1
公开(公告)日：2018-04-25
申请号：EP16194558.9
申请日：2016-10-19
申请人： Abiomed Europe GmbH
发明人： SIESS, Thorsten , ABOULHOSN, Walid , NIX, Christoph , LUNZE, Katrin
IPC分类号： A61M1/10
CPC分类号： A61M1/1086
摘要： A control device (100) for a ventricular assist device, VAD (50), with settable speed levels, the control device (100) comprising an input (101) configured to receive at least one measuring signal (LVP meas ) related to a physiological condition of the circulatory system of a patient (P) receiving heart assistance by the VAD (50), wherein the control device (100) is configured to derive an actual value (EDLVP; FG) of at least one characteristic parameter of the heart (H) from one or more of the at least one measuring signal (LVP meas) and to provide a refined actual value (EDLVP*; FG*) of the at least one characteristic parameter in which effects of physiologically caused fluctuations are eliminated or reduced; and an output (105) configured to output an updated setting value (n VAD set ) for the speed level, wherein the control device (100) is configured to produce the updated setting value (n VAD set ) based on the refined actual value (EDLVP*; FG*) and a predeterminable set-point value (EDLVP set ; FG set ). A VAD (50) for assistance of a heart, comprising the control device (100), wherein the VAD (50) is preferably a non-pulsatile rotational blood pump, wherein further preferably the blood pump is catheter-based. A method for obtaining a refined actual value of at least one characteristic parameter of the heart (H), the method comprising receiving at least one measuring signal (LVP meas ) related to a physiological condition of the circulatory system of a patient (P); deriving an actual value (EDLVP; FG) of at least one characteristic parameter of the heart (H) from one or more of the at least one measuring signal (LVP meas) ; processing the actual value (EDLVP; FG) or the one or more of the at least one measuring signal (LVP meas ) to provide the refined actual value (EDLVP*; FG*) in which physiologically caused fluctuations are eliminated or reduced. A method for controlling the speed level of a ventricular assist device, VAD (50), with settable speed levels, the method comprising obtaining the refined actual value of at least one characteristic parameter of the heart (H); and producing an updated setting value (n VAD set ) for the speed level based on the refined actual value (EDLVP*; FG*) and a predeterminable set-point value (EDLVP set ).
摘要翻译：一种用于具有可设定的速度水平的心室辅助装置VAD（50）的控制装置（100），所述控制装置（100）包括被配置为接收与生理状况有关的至少一个测量信号（LVPmeas）的输入端（101）（50）接收心脏辅助的患者（P）的循环系统的控制装置（100），其中所述控制装置（100）被配置为导出心脏的至少一个特征参数（H）的实际值（EDLVP; FG））从所述至少一个测量信号（LVPmeas）中的一个或多个测量信号中除去或减少生理上引起的波动的影响的至少一个特征参数的精细实际值（EDLVP *; FG *）; 和输出（105），其被配置为输出用于所述速度等级的更新后的设置值（nVADset），其中，所述控制装置（100）被配置为基于所述精炼后的实际值（EDLVP *; FG *）和一个可预设的设定值（EDLVPset; FGset）。一种用于心脏辅助的VAD（50），包括控制装置（100），其中VAD（50）优选为非脉动式旋转血液泵，其中进一步优选血液泵是基于导管的。一种用于获得心脏（H）的至少一个特征参数的细化的实际值的方法，该方法包括接收与患者（P）的循环系统的生理状况相关的至少一个测量信号（LVPmeas）; 从所述至少一个测量信号（LVPmeas）中的一个或更多个导出所述心脏（H）的至少一个特征参数的实际值（EDLVP; FG）; 处理实际值（EDLVP; FG）或至少一个测量信号（LVPmeas）中的一个或多个以提供消除或减少生理上引起的波动的精细实际值（EDLVP *; FG *）。一种用于以可设定的速度水平来控制心室辅助装置VAD（50）的速度水平的方法，所述方法包括获得所述心脏（H）的至少一个特征参数的细化的实际值; 并基于精炼的实际值（EDLVP *; FG *）和可预定的设定点值（EDLVPset）为速度等级产生更新的设定值（nVADset）。

3. 发明公开

EP4398953A1 SYSTEM AND METHOD FOR VENTRICULAR ASSISTANCE SUPPORT DURING EXTRACORPOREAL MEMBRANE OXYGENATION 审中-实审
公开(公告)号：EP4398953A1
公开(公告)日：2024-07-17
申请号：EP22823143.7
申请日：2022-09-07
申请人： Abiomed Europe GmbH
发明人： NIX, Christoph , BOENSCH, Stefan , LUNZE, Katrin
IPC分类号： A61M1/36 , A61M60/109 , A61M60/13 , A61M60/216 , A61M60/38 , A61M60/531
CPC分类号： A61M60/13 , A61M60/216 , A61M60/38 , A61M60/109 , A61M60/531 , A61M1/3666 , A61M2205/336520130101 , A61M2205/333120130101

4. 发明授权

EP3287155B1 BLOOD PUMP 有权
公开(公告)号：EP3287155B1
公开(公告)日：2019-10-09
申请号：EP17186897.9
申请日：2017-08-18
申请人： Abiomed Europe GmbH
发明人： NIX, Christoph , LUNZE, Katrin , SIESS, Thorsten , ABOULHOSN, Walid
IPC分类号： A61M1/10

5. 发明公开

EP4364786A3 VENTRICULAR ASSIST DEVICE 审中-实审
公开(公告)号：EP4364786A3
公开(公告)日：2024-08-14
申请号：EP24165747.7
申请日：2017-08-18
申请人： Abiomed Europe GmbH
发明人： NIX, Christoph , LUNZE, Katrin , SIESS, Thorsten , ABOULHOSN, Walid
IPC分类号： A61M60/569 , A61M60/178 , A61M60/216 , A61M60/237 , A61M60/422 , A61M60/523 , A61M60/531 , A61M60/538 , A61M60/546 , A61M60/816 , A61M60/857 , A61M60/13
CPC分类号： A61M60/13 , A61M60/178 , A61M60/237 , A61M60/538 , A61M60/546 , A61M60/523 , A61M60/531 , A61M60/569 , A61M60/816 , A61M60/857 , A61M60/422 , A61M60/216
摘要： A control device (100) for controlling the rotational speed (nVAD(t)) of a non-pulsatile ventricular assist device, VAD, (50) uses an event-based within-a-beat control strategy, wherein the control device is configured to alter the rotational speed of the VAD within the cardiac cycle of the assisted heart and to synchronize the alteration of the rotational speed with the heartbeat by at least one sequence of trigger signals (σ(t)) that is related to at least one predetermined characteristic event in the cardiac cycle. Further, a VAD (50) for assistance of a heart comprises the control device (100) for controlling the VAD, wherein the VAD is preferably a non-pulsatile rotational, for example catheter-based, blood pump.

6. 发明公开

EP4364786A2 VENTRICULAR ASSIST DEVICE 审中-实审
公开(公告)号：EP4364786A2
公开(公告)日：2024-05-08
申请号：EP24165747.7
申请日：2017-08-18
申请人： Abiomed Europe GmbH
发明人： NIX, Christoph , LUNZE, Katrin , SIESS, Thorsten , ABOULHOSN, Walid
IPC分类号： A61M60/569
CPC分类号： A61M60/13 , A61M60/178 , A61M60/237 , A61M60/538 , A61M60/546 , A61M60/523 , A61M60/531 , A61M60/569 , A61M60/816 , A61M60/857 , A61M60/422 , A61M60/216
摘要： A control device (100) for controlling the rotational speed (nVAD(t)) of a non-pulsatile ventricular assist device, VAD, (50) uses an event-based within-a-beat control strategy, wherein the control device is configured to alter the rotational speed of the VAD within the cardiac cycle of the assisted heart and to synchronize the alteration of the rotational speed with the heartbeat by at least one sequence of trigger signals (σ(t)) that is related to at least one predetermined characteristic event in the cardiac cycle. Further, a VAD (50) for assistance of a heart comprises the control device (100) for controlling the VAD, wherein the VAD is preferably a non-pulsatile rotational, for example catheter-based, blood pump.

7. 发明公开

EP4201467A1 BLOOD PUMP 审中-实审
公开(公告)号：EP4201467A1
公开(公告)日：2023-06-28
申请号：EP23152469.5
申请日：2018-08-17
申请人： Abiomed Europe GmbH
发明人： NIX, Christoph , LUNZE, Katrin , SIESS, Thorsten , ABOULHOSN, Walid
IPC分类号： A61M60/13 , A61M60/178 , A61M60/216 , A61M60/237 , A61M60/422 , A61M60/523 , A61M60/531 , A61M60/538 , A61M60/546 , A61M60/569 , A61M60/816 , A61M60/857
摘要： The invention concerns a control device (100) for controlling a blood flow Q pump (t) of an intravascular blood pump (50) for percutaneous insertion into a patient's blood vessel, the blood pump (50) comprising a pump unit (52) with a drive unit (51) for driving the pump unit and configured to convey blood from a blood flow inlet (54) towards a blood flow outlet (56), wherein the control device (100) is configured to operate the blood pump (50) in a selectable zero-flow control mode, wherein a blood flow command signal Q pump set (t) is selected, and the control device comprises a first controller (401) and a second controller (402), wherein the first controller (401) is configured to control the blood flow Q pump (t) by adjusting a speed command signal n pump- set (t) for the drive unit (51), and the second controller (402) is configured to control a drive speed n pump (t) of the drive unit (51). Further, the invention concerns a corresponding method for controlling a blood flow Q pump (t) of an intravascular blood pump (50), as well as a control device (100) configured to carry out the method. Finally, the invention concerns a system comprising an intravascular blood pump (50) for assistance of a heart and the control device (100) controlling the blood pump (50).

8. 发明公开

EP3528863A1 VENTRICULAR ASSIST DEVICE CONTROL 有权
公开(公告)号：EP3528863A1
公开(公告)日：2019-08-28
申请号：EP17791997.4
申请日：2017-10-16
申请人： Abiomed Europe GmbH
发明人： SIESS, Thorsten , ABOULHOSN, Walid , NIX, Christoph , LUNZE, Katrin
IPC分类号： A61M1/10

9. 发明公开

EP3287155A1 BLOOD PUMP 有权
标题翻译：血泵
公开(公告)号：EP3287155A1
公开(公告)日：2018-02-28
申请号：EP17186897.9
申请日：2017-08-18
申请人： Abiomed Europe GmbH
发明人： NIX, Christoph , LUNZE, Katrin , SIESS, Thorsten , ABOULHOSN, Walid
IPC分类号： A61M1/10
摘要： The invention concerns a control device (100) for controlling a blood flow Q VAD (t) of a percutaneous inserable ventricular assist device, VAD, (50), the VAD (50) comprising a pump unit (52) with a drive unit (51) for driving the pump unit and configured to convey blood from a blood flow inlet (54) towards a blood flow outlet (56), wherein the control device (100) is configured to operate the VAD (50) in a selectable zero-flow control mode, wherein a blood flow command signal Q VAD set (t) is selected, and the control device comprises a first controller (401) and a second controller (402), wherein the first controller (401) is configured to control the blood flow Q VAD (t) by adjusting a speed command signal n VAD set (t) for the drive unit (51), and the second controller (402) is configured to control a drive speed n VAD (t) of the drive unit (51). Further, the invention concerns a corresponding method for controlling a blood flow Q VAD (t) of a percutaneous insertable VAD (50), as well as a control device (100) configured to carry out the method. Finally, the invention concerns a system comprising a VAD (50) for assistance of a heart and the control device (100) controlling the VAD (50).
摘要翻译：本发明涉及一种用于控制经皮不可分离的心室辅助装置VAD（50）的血流量QVAD（t）的控制装置（100），所述VAD（50）包括具有驱动单元（51）的泵单元（52）），用于驱动泵单元并且构造成将血液从血流入口（54）朝向血流出口（56）输送，其中控制装置（100）被配置成以可选择的零流量操作VAD 其中血流指令信号QVADset（t）被选择，并且控制装置包括第一控制器（401）和第二控制器（402），其中第一控制器（401）被配置为控制血流量QVADset （t）调整驱动单元（51）的速度指令信号nVADset（t），并且第二控制器（402）配置成控制驱动单元（51）的驱动速度nVAD（t）。此外，本发明涉及用于控制经皮可插入VAD（50）的血流量QVAD（t）的相应方法，以及配置成实施该方法的控制装置（100）。最后，本发明涉及一种包括用于协助心脏的VAD（50）和控制VAD（50）的控制装置（100）的系统。

10. 发明公开

EP3854448A1 VENTRICULAR ASSIST DEVICE 有权
公开(公告)号：EP3854448A1
公开(公告)日：2021-07-28
申请号：EP21162363.2
申请日：2017-08-18
申请人： Abiomed Europe GmbH
发明人： NIX, Christoph , LUNZE, Katrin , SIESS, Thorsten , ABOULHOSN, Walid
IPC分类号： A61M60/13 , A61M60/178 , A61M60/237 , A61M60/523 , A61M60/531 , A61M60/538 , A61M60/546 , A61M60/569
摘要： A control device (100) for controlling the rotational speed ( n VAD (t) ) of a non-pulsatile ventricular assist device, VAD, (50) uses an event-based within-a-beat control strategy, wherein the control device is configured to alter the rotational speed of the VAD within the cardiac cycle of the assisted heart and to synchronize the alteration of the rotational speed with the heartbeat by at least one sequence of trigger signals (σ(t)) that is related to at least one predetermined characteristic event in the cardiac cycle. Further, a VAD (50) for assistance of a heart comprises the control device (100) for controlling the VAD, wherein the VAD is preferably a non-pulsatile rotational, for example catheter-based, blood pump.

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