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1. 发明授权

EP1809597B1 AMINOETHYLAROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR 有权
标题翻译： FOR疾病对多巴胺D 3受体RESPONSE APPROPRIATE AMINOETHYLAROMATISCHE连接的调制处理
公开(公告)号：EP1809597B1
公开(公告)日：2012-01-11
申请号：EP05795920.7
申请日：2005-10-14
申请人： Abbott GmbH & Co. KG
发明人： DRESCHER, Karla , HAUPT, Andreas , UNGER, Liliane , TURNER, Sean, C. , BRAJE, Wilfried , GRANDEL, Roland
IPC分类号： C07C311/29 , C07C311/21 , C07D213/76 , C07D207/09 , C07C317/22 , C07C317/14 , A61K31/18 , A61K31/44 , A61P25/18
CPC分类号： C07D213/76 , C07C311/21 , C07C311/29 , C07C2601/02 , C07D207/09
摘要： The present invention relates to aromatic compounds of the formula (I) wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical Ra and wherein Ar may also carry 1 or 2 radicals Rb; X is N or CH; E is CR6R7 or NR3; R1 is C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated Cl-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4-alkenyl, formyl or C1-C3-alkylcarbonyl; R1a is H, C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4-alkenyl, or R1a and R2 together are (CH2)n with n being 2, 3 or 4, or R1a and R2a together are (CH2)n with n being 2, 3 or 4; R2 and R2a are independently of each other H, C1-C4-alkyl or fluorinated C1-C4-alkyl or R2a and R2 together are (CH2)m with m being 1, 2, 3, 4 or 5; R3 is H or C1-C4-alkyl; R6, R7 independently of each other are selected from H, fluorine, C1-C4-alkyl and fluorinated C1-C4-alkyl or together form a moiety (CH2)p with p being 2, 3, 4 or 5; and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula (I) or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.
摘要翻译：本发明涉及到我worin变量具有权利要求书和说明书中给出的定义的式的芳族化合物。因此，本发明涉及使用式I化合物或用于制备用于医学病症易于与多巴胺D 3受体配体治疗的治疗药物组合物的药学上可接受的盐。

2. 发明授权

EP1613596B1 N-[(PIPERAZINYL)HETARYL]ARYLSULFONAMIDE COMPOUNDS WITH AFFINITY FOR THE DOPAMINE D3 RECEPTOR 有权
标题翻译： N - [（哌嗪基）杂芳基]用亲和对多巴胺D 3受体的芳基磺酰胺衍生物
公开(公告)号：EP1613596B1
公开(公告)日：2008-03-12
申请号：EP04726985.7
申请日：2004-04-13
申请人： Abbott GmbH & Co. KG
发明人： BRAJE, Wilfried , HAUPT, Andreas , LUBISCH, Wilfried , GRANDEL, Roland , DRESCHER, Karla, c/o Abbott GmbH & Co. KG , GENESTE, Hervé , UNGER, Liliane , SAUER, Daryl, R. , TURNER, Sean, C.
IPC分类号： C07D213/76 , C07D239/48 , C07D487/08 , C07D213/74 , A61K31/44 , A61K31/505 , A61P13/12 , A61P25/18
CPC分类号： C07D213/74 , C07D213/76 , C07D239/48 , C07D239/50 , C07D403/04 , C07D403/14 , C07D487/08
摘要： The invention relates to N-[(piperazinyl)hetaryl]arylsulfonamide compounds of the general formula (I ) in which Q is a bivalent, 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents Ra which is/are selected, independently of each other, from halogen, CN, NO2, C02R4, COR5, C1-C4-alkyl and C1-C4-haloalkyl; Ar is phenyl or a 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents Rb, which is/are selected from halogen, NO2, CN, C02R4, COR5, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl and C1-C4-haloalkyl, with it also being possible for two radicals Rb which are bonded to adjacent C atoms of Ar to be together C3-C4-alkylene; R1 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl, C1-C4-hydroxyalkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C4-alkenyl or C3-C4-alkynyl; with the radicals n, R1, R2, R3, R4 and R5 having the meanings given in the patent claims, to the N-oxides and to the physiologically tolerated acid addition salts of these compounds and to pharmaceutical compositions which comprise at least one N-[(piperazinyl)hetaryl]arylsulfonamide compound as claimed in one of claims 1 to 10 and/or at least one physiologically tolerated acid addition salt of I and/or an N-oxide of I, where appropriate together with physiologically acceptable carriers and/or auxiliary substances for treating diseases which respond to influencing by dopamine D3 receptor antagonists or agonists, in particular for treating diseases of the central nervous system and disturbances of kidney function.

3. 发明授权

EP1812416B1 ARYLSULFONYLMETHYL OR ARYLSULFONAMIDE SUBSTITUTED AROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR 有权
标题翻译： ARYLSULFONYLMETHYL- OR芳基磺酰胺取代的芳族化合物，其治疗疾病都适合于多巴胺D3受体反应的调制
公开(公告)号：EP1812416B1
公开(公告)日：2013-08-21
申请号：EP05800649.5
申请日：2005-10-14
申请人： Abbott GmbH & Co. KG
发明人： DRESCHER, Karla , HAUPT, Andreas , UNGER, Liliane , TURNER, Sean, C. , BRAJE, Wilfried , GRANDEL, Roland , HENRY, Christophe
IPC分类号： C07D311/04 , C07D215/38 , C07C211/19 , A61K31/13 , A61K31/47 , A61K31/35 , A61P25/16
CPC分类号： C07C311/21 , C07C311/29 , C07C311/44 , C07C2601/02 , C07C2602/10 , C07D207/10 , C07D211/10 , C07D215/38 , C07D239/84 , C07D263/32 , C07D277/82 , C07D311/04 , C07D413/04 , C07D491/04

4. 发明授权

EP1812389B1 AZABICYCLOHEPTYL COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR 有权
标题翻译：多巴胺D3受体的调节的治疗病症的吸引力SUITABLE AZABICYCLOHEPTYLVERBINDUNGEN
公开(公告)号：EP1812389B1
公开(公告)日：2011-08-17
申请号：EP05797348.9
申请日：2005-10-14
申请人： Abbott GmbH & Co. KG
发明人： DRESCHER, Karla , HAUPT, Andreas , UNGER, Liliane , TURNER, Sean, C. , BRAJE, Wilfried , GRANDEL, Roland
IPC分类号： C07D209/52 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/00 , A61P25/28
CPC分类号： C07D401/12 , C07D209/52 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to a compound of the formula (I) wherein R1 is H, C1-C6-alkyl which may be substituted by C3-C6-cycloalkyl, fluorinated C1-C6-alkyl, C3-C6-cycloalkyl, fluorinated C3-C6-cycloalkyl, C3-C6-alkenyl, fluorinated C3-C6-alkenyl, formyl, acetyl or propionyl; A is phenylene, pyridylene, pyrimidylene, pyrazinylene, pyridazinylene or thiophenylene, which can be substituted by one ore more substituents selected from halogen, methyl, methoxy and CF3; E is NR5 or CH2, wherein R5 is H or C1-C3-alkyl; Ar is a cyclic radical selected from the group consisting of phenyl, a 5- or 6-membered heteroaromatic radical comprising as ring members 1, 2 or 3 heteroatoms selected from N, O and S and a phenyl ring fused to a saturated or unsaturated 5- or 6-membered carbocyclic or heterocyclic ring, where the heterocyclic ring comprises as ring members 1, 2 or 3 heteroatoms selected from N, O and S and/or 1, 2 or 3 heteroatom-containing groups each independently selected from NR8, where R8 is H, C1-C4-alkyl, fluorinated C1-C4-alkyl, C1-C4-alkylcarbonyl or fluorinated C1-C4-alkylcarbonyl, and where the cyclic radical Ar may carry 1, 2 or 3 substituents Ra; wherein the variable Ra has the meanings given in the claims and in the description; and physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula (I) or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.

5. 发明授权

EP1257551B1 HETEROZYKLISCHE VERBINDUNGEN UND DEREN ANWENDUNG ALS PARP-INHIBITOREN 有权
标题翻译：杂环化合物和它们作为PARP抑制剂
公开(公告)号：EP1257551B1
公开(公告)日：2007-09-05
申请号：EP01911528.6
申请日：2001-01-25
申请人： Abbott GmbH & Co. KG
发明人： LUBISCH, Wilfried , KOCK, Michael , HÖGER, Thomas , GRANDEL, Roland , MÜLLER, Reinhold , SCHULT, Sabine
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I), wherein; either A1 or A2 represents CONH¿2?, and the other radical A?2 or A1¿ represents hydrogen, chlorine, fluorine, bromine, iodine C¿1?-C6 alkyl, OH, nitro, CF3, CN, NR?11R12¿, NH-CO-R13, O-C1-C4 alkyl; X1 can represent N and C-R2; X2, independent of X1, can represent N and C-R2; R2 can represent hydrogen, C¿1?-C6 alkyl, C1-C4 alkyl-phenyl, phenyl; B can represent an unsaturated, saturated or partially unsaturated monocyclic, bicyclic or tricyclic ring having a maximum of 15 carbon atoms, an unsaturated, saturated or partially unsaturated monocyclic, bicyclic or tricyclic ring having a maximum of 14 carbon atoms and 0 to 5 nitrogen atoms, 0 to 2 oxygen atoms or 0 to 2 sulfur atoms, which can each still be substituted with an R?4¿ and a maximum of 3 of the same or different radicals R5, and; R?1, R4, R5, R11-R13¿ have the meanings as cited in Claim No. 1. The invention also relates to the tautomeric forms, and possible enantiomeric and diastereomeric forms of said compounds, to the prodrugs thereof and to their use as PARP inhibitors.

6. 发明公开

EP1809598A1 AMINOMETHYL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR 有权
标题翻译：多巴胺D3受体的调节的治疗病症的吸引力SUITABLE氨甲基双环芳香化合物
公开(公告)号：EP1809598A1
公开(公告)日：2007-07-25
申请号：EP05798340.5
申请日：2005-10-14
申请人： Abbott GmbH & Co. KG
发明人： DRESCHER, Karla , HAUPT, Andreas , UNGER, Liliane , TURNER, Sean, C. , BRAJE, Wilfried , GRANDEL, Roland
IPC分类号： C07C317/34 , C07D209/14 , C07D209/62 , C07D235/14 , A61K31/136 , A61P25/00 , A61K31/145 , A61K31/403 , A61K31/407 , A61K31/4174
CPC分类号： C07D471/04 , C07D209/14 , C07D209/62 , C07D235/14
摘要： The present invention relates to an aminomethyl substituted bicyclic aromatic compound of the formula (I) wherein Ar is a cyclic radical selected from the group consisting of phenyl, a 5- or 6-membered C-bound heteroaromatic radical comprising as ring member 1, 2 or 3 heteroatoms which are, independently of each other, selected from O, S and N, and a phenyl ring fused to a saturated or unsaturated 5- or 6-membered carbocyclic or heterocyclic ring, where the heterocyclic ring comprises as ring members 1, 2 or 3 heteroatoms selected from N, O and S and/or 1, 2 or 3 heteroatom-containing groups each independently selected from NR8, where R8 is H, C1-C4-alkyl, fluorinated C1-C4-alkyl, C1-C4-alkylcarbonyl or fluorinated C1-C4-alkylcarbonyl, and where the cyclic radical Ar may carry 1, 2 or 3 substituents Ra, wherein the variable Ra has the meanings given in the claims and in the description; X is a covalent bond or N-R2, CHR2, CHR2CH2, N or C-R2; Y is N-R2a, CHR2a, CHR2aCH2 or CHR2aCH2CH2; is a single bond or a double bond; E is CH2 or NR3; R1 is H, C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4-alkenyl, formyl or C1-C3-alkylcarbonyl; R1a is H, C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-alkenyl, R2 and R2a each independently are H, CH3, CH2F, CHF2 or CF3 or R1a and R2 or R1a and R2a together are (CH2)n with n being 1, 2 or 3; R3 is H or C1-C4-alkyl; R4 and R5 independently of each other are H, C1-C4-alkyl, fluorinated C1-C4-alkyl or C1-C4-alkoxy or may form, together with N, a 4-, 5- or 6-membered saturated or unsaturated ring; R6 and R7 independently of each other are H or halogen; and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula (I) or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.

7. 发明授权

EP1177178B1 HETEROZYKLISCH SUBSTITUIERTE BENZIMIDAZOLE, DEREN HERSTELLUNG UND ANWENDUNG 有权
标题翻译：杂环取代的苯并咪唑，生产和应用
公开(公告)号：EP1177178B1
公开(公告)日：2004-12-29
申请号：EP00927088.5
申请日：2000-04-27
申请人： Abbott GmbH & Co. KG
发明人： LUBISCH, Wilfried , KOCK, Michael , HÖGER, Thomas , GRANDEL, Roland , HOLZENKAMP, Uta , SCHULT, Sabine , MÜLLER, Reinhold
IPC分类号： C07D235/18 , C07D235/20 , C07D401/04 , C07D403/04 , C07D417/04 , C07D413/04 , C07D409/04 , C07D471/04 , C07D401/14 , C07D405/04 , A61K31/415
CPC分类号： C07D401/04 , C07D235/18 , C07D403/04
摘要： The present invention relates to novel benzimidazoles, the production thereof and the utilisation as inhibitors of the enzyme poly(ADP-ribose)polymerase or PARP (EC 2.4.2.30) for producing medicaments.

8. 发明公开

EP1463731A1 DIBENZODIAZEPINE DERIVATES, THEIR PREPARATION AND USE 有权
标题翻译： Dibenzodiazepine衍生物，生产和使用
公开(公告)号：EP1463731A1
公开(公告)日：2004-10-06
申请号：EP03729243.0
申请日：2003-01-10
申请人： Abbott GmbH & Co. KG
发明人： LUBISCH, Wilfried , GRANDEL, Roland , BRAJE, Wilfried , SUBKOWSKI, Thomas , MÜLLER, Reinhold , WERNET, Wolfgang , DRESCHER, Karla
IPC分类号： C07D487/06 , A61K31/5517 , A61P9/10
CPC分类号： C07D487/06
摘要： The invention relates to compounds of the formula (I) and their tautomeric forms, possible enantiomeric and diastereomeric forms and their prodrugs, and to their preparation and use, where A, B, R1 and X1 have the meanings given in the description.

9. 发明授权

EP2013179B1 ARYLOXYETHYLAMINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR 有权
标题翻译： FOR THE多巴胺D3受体有吸引力的病症适合... ARYLOXYETHYLAMINVERBINDUNGEN的调制处理
公开(公告)号：EP2013179B1
公开(公告)日：2011-01-19
申请号：EP07728098.0
申请日：2007-04-13
申请人： Abbott GmbH & Co. KG
发明人： GRANDEL, Roland , BRAJE, Wilfried Martin , HAUPT, Andreas , TURNER, Sean Colm , LANGE, Udo , DRESCHER, Karla , UNGER, Liliane
IPC分类号： C07D213/76 , C07D239/69 , A61K31/4439 , A61K31/506 , A61P25/16 , A61P25/24 , A61P25/28
CPC分类号： C07D213/76 , C07D239/69
摘要： The present invention relates to aryloxyethylamine compounds of the formula (I) and the physiologically tolerated acid addition salts thereof. The variables have the meanings given in the claims and the description. The invention also relates to the use of a compound of the formula (I) or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.

10. 发明授权

EP1171424B1 CYCLOALKYLSUBSTITUIERTE BENZIMIDAZOLE UND IHRE VERWENDUNG ALS PARP INHIBITOREN 有权
标题翻译：环苯并咪唑类和它们作为PARP抑制剂
公开(公告)号：EP1171424B1
公开(公告)日：2009-05-27
申请号：EP00918867.3
申请日：2000-04-11
申请人： Abbott GmbH & Co. KG
发明人： LUBISCH, Wilfried , KOCK, Michael , HÖGER, Thomas , GRANDEL, Roland , SCHULT, Sabine , MÜLLER, Reinhold
IPC分类号： C07D235/06 , C07D403/08 , C07D401/08 , A61K31/4184 , A61P25/00
CPC分类号： C07D235/14
摘要： The invention relates to a compound of formula (I) or (II), wherein A represents a saturated or mono-unsaturated carbocycle containing 3 to 8 carbon atoms which can also have a condensed benzol ring, whereby the rings can also be substituted with one or two different or identical radicals; R1 represents hydrogen, chlorine, fluorine, bromine, iodine, branched and unbranched C¿1?-C6-alkyl, OH, nitro, CF3, CN, NR?11R12¿, NH-CO-R13, O-C1-C4 alkyl; and R2 represents hydrogen, branched and unbranched C¿1?-C6 alkyl, C1-C4 alkyl-phenyl. The invention also relates to the tautomeric forms, possible enantiomeric and diastereomeric forms, possible cis-trans isomers on the rings in A and their prodrugs. The substituted benzimidazoles of general formulas (I) and (II) are inhibitors of poly(ADP-ribose) polymerase (PARP), or poly(ADP-ribose) synthase (PARS), as it is also known and can be used for the treatment or prophylaxis of diseases which are associated with the increased enzyme activity of this enzyme.

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