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1. 发明授权

EP3116874B1 HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL 有权
标题翻译：携带取代的烷基的六氢邻二氮杂萘酚
公开(公告)号：EP3116874B1
公开(公告)日：2018-02-28
申请号：EP15711464.6
申请日：2015-03-13
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , LAKICS, Viktor , REINGRUBER, Anna , MACK, Helmut , PETER, Raimund , RELO, Ana Lucia , SMYTH, Lynette
IPC分类号： C07D471/04 , A61K31/5513 , A61P25/00
CPC分类号： A61K31/5513 , C07D471/04 , C07D471/18
摘要： The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a substituted alkyl radical, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.

2. 发明公开

EP3116874A1 HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL 有权
标题翻译：麻黄碱HITAHYDRODIAZEPINCHINOLINE MIT EINEM SUBSTITUIERTEN ALKYLRADIKAL
公开(公告)号：EP3116874A1
公开(公告)日：2017-01-18
申请号：EP15711464.6
申请日：2015-03-13
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , LAKICS, Viktor , REINGRUBER, Anna , MACK, Helmut , PETER, Raimund , RELO, Ana Lucia , SMYTH, Lynette
IPC分类号： C07D471/04 , A61K31/5513 , A61P25/00
CPC分类号： A61K31/5513 , C07D471/04 , C07D471/18
摘要： The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a substituted alkyl radical, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.
摘要翻译：本发明涉及携带取代的烷基的三环六氢二氮杂喹啉，其制备方法，含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用途制备用于预防或治疗对5-HT 2C受体的调节作出反应的病症和障碍的药物，用于预防或治疗对5-HT 2C受体调节作用的病症和障碍的方法，以及制备这种化合物的方法和组合物。

3. 发明公开

EP3380483A1 HEXAHYDROPYRAZINOBENZ- OR -PYRIDO-OXAZEPINES CARRYING AN OXYGEN-CONTAINING SUBSTITUENT AND USE THEREOF IN THE TREATMENT OF 5-HT2C-DEPENDENT DISORDERS 审中-公开
公开(公告)号：EP3380483A1
公开(公告)日：2018-10-03
申请号：EP16804731.4
申请日：2016-11-24
申请人： Abbvie Deutschland GmbH & Co. KG
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , HOFT, Carolin , LAKICS, Viktor , MACK, Helmut , OELLIEN, Frank , PETER, Raimund , RELO, Ana Lucia
IPC分类号： C07D498/04 , C07D498/14 , A61K31/553 , A61P25/24
CPC分类号： C07D498/04 , A61P25/18 , A61P25/22 , A61P25/24 , C07D498/14
摘要： The present invention relates to compound of formula (I) (I) wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.

4. 发明公开

EP3116873A1 HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL 有权
标题翻译： HEXAHYDRODIAZEPINOCHINOLINE MIT EINEM CYCLISCHEN RADIKAL
公开(公告)号：EP3116873A1
公开(公告)日：2017-01-18
申请号：EP15711463.8
申请日：2015-03-13
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , KOOLMAN, Hannes , LAKICS, Viktor , REINGRUBER, Anna , MACK, Helmut , PETER, Raimund , RELO, Ana Lucia , WANG, Jincheng , ZHAO, Xiaona
IPC分类号： C07D471/04 , A61K31/5513 , A61P25/00
CPC分类号： C07D471/06 , C07D471/04
摘要： The present invention relates to compound of formula (I) as tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, useful for modulating the 5-HT2C receptor and preventing and/or treating conditions and disorders that respond to the modulation of the 5-HT2C receptor. The present invention also relates to methods for producing compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for preventing or treating conditions and disorders that respond to the modulation of the 5-HT2C receptor by administering compounds of formula (1) or pharmaceutical compositions thereof.
摘要翻译：本发明涉及携带环状取代基的三环六氢二氮杂喹啉，其制备方法，含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用于制备用于预防或治疗对5-HT 2C受体的调节作出反应的病症和障碍的药物，用于预防或治疗对5-HT 2C受体的调节作出反应的病症和障碍的方法，以及制备这些化合物的方法和成分。

5. 发明公开

EP3636651A1 HEXAHYDROPYRAZINOBENZ- OR -PYRIDO-OXAZEPINES CARRYING AN OXYGEN-CONTAINING SUBSTITUENT AND USE THEREOF IN THE TREATMENT OF 5-HT2C-DEPENDENT DISORDERS 审中-公开
公开(公告)号：EP3636651A1
公开(公告)日：2020-04-15
申请号：EP19212082.2
申请日：2016-11-24
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , HOFT, Carolin , LAKICS, Viktor , MACK, Helmut , OELLIEN, Frank , PETER, Raimund , RELO, Ana Lucia
IPC分类号： C07D498/04 , C07D498/14 , A61K31/553 , A61P25/24
摘要： The present invention relates to compound of formula (I)

wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT 2C receptor, to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT 2C receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of 5-HT 2C receptor.

7. 发明公开

EP3353155A1 PYRIDYL OR PYRAZINYL COMPOUNDS CARRYING A METHYL-BOUND ALPHA-AMINO ACID AMIDE GROUP 审中-公开
公开(公告)号：EP3353155A1
公开(公告)日：2018-08-01
申请号：EP16770000.4
申请日：2016-09-21
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： BACKFISCH, Gisela , BAKKER, Margaretha , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , HOFT, Carolin , KLING, Andreas , LAKICS, Viktor , MACK, Helmut , OELLIEN, Frank , PETER, Raimund , POHLKI, Frauke , RELO, Ana Lucia
IPC分类号： C07D241/20 , C07D213/56 , A61K31/4439 , A61K31/497 , A61P25/00
CPC分类号： C07D213/56 , C07D241/20
摘要： The present invention relates to pyridyl or pyrazinyl compounds carrying a methyl- bound N-amide moiety derived from an α-amino acid of formula I where the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, and to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of the 5-HT2C receptor.

8. 发明授权

EP3116873B1 HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL 有权
标题翻译：携带环状基团的六氢邻二氮杂萘酚
公开(公告)号：EP3116873B1
公开(公告)日：2018-02-28
申请号：EP15711463.8
申请日：2015-03-13
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , KOOLMAN, Hannes , LAKICS, Viktor , REINGRUBER, Anna , MACK, Helmut , PETER, Raimund , RELO, Ana Lucia , WANG, Jincheng , ZHAO, Xiaona
IPC分类号： C07D471/04 , A61K31/5513 , A61P25/00
CPC分类号： C07D471/06 , C07D471/04
摘要： The present invention relates to compound of formula (I) as tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, useful for modulating the 5-HT2C receptor and preventing and/or treating conditions and disorders that respond to the modulation of the 5-HT2C receptor. The present invention also relates to methods for producing compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for preventing or treating conditions and disorders that respond to the modulation of the 5-HT2C receptor by administering compounds of formula (1) or pharmaceutical compositions thereof.

9. 发明授权

EP2970146B1 ACYLAMINOCYCLOALKYL COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF DOPAMINE D3 RECEPTOR 有权
标题翻译：适用于治疗应答多巴胺D3受体调节的疾病的酰胺基环酰基化合物
公开(公告)号：EP2970146B1
公开(公告)日：2017-11-01
申请号：EP14710261.0
申请日：2014-03-14
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： HAUPT, Andreas , DINGES, Jürgen , UNGER, Liliane , WICKE, Karsten , VAN WATERSCHOOT, Robert , DRESCHER, Karla , RELO, Ana Lucia
IPC分类号： C07D239/42 , C07D403/04 , A61K31/506 , A61P25/00
CPC分类号： C07D295/155 , A61K31/496 , C07D239/42 , C07D403/04

10. 发明公开

EP2970146A1 ACYLAMINOCYCLOALKYL COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF DOPAMINE D3 RECEPTOR 有权
标题翻译： ACYLAMINOCYCLOALKYLVERBINDUNGEN FOR疾病对调制多巴胺D 3受体应答的治疗
公开(公告)号：EP2970146A1
公开(公告)日：2016-01-20
申请号：EP14710261.0
申请日：2014-03-14
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： HAUPT, Andreas , DINGES, Jürgen , UNGER, Liliane , WICKE, Karsten , VAN WATERSCHOOT, Robert , DRESCHER, Karla , RELO, Ana Lucia
IPC分类号： C07D239/42 , A61K31/506 , A61P25/00
CPC分类号： C07D295/155 , A61K31/496 , C07D239/42 , C07D403/04
摘要： The present invention relates to novel acylaminocycloalkyl compounds, in particular to the compounds of the formula I as described herein and to their salts and N-oxides. The compounds possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of the dopamine D3 receptor. In formula I, the variables have the following meanings: m is 1 or 2, n is 1 or 2, A is selected from the group consisting of CH
2 , CH
2 CH
2 , CHFCH
2 and CF
2 CH
2 , R
1 is an oxygen containing cyclic radical selected such as C
3 -C
6 cycloalkyl, which carries one or two oxygen containing radicals selected from the group consisting of OH, C
1 -C
2 -alkoxy, fluorinated C
1 -C
2 -alkoxy, and a carbonyl oxygen,, R
2 is selected from the group consisting of hydrogen, OH and fluorine, R
3a is selected from the group consisting of hydrogen and methyl, R
3b is selected from the group consisting of hydrogen and methyl, R
4 is branched C
4 -C
6 alkyl or branched fluorinated C
4 -C
6 alkyl, and R
5 is inter alia C
1 -C
6 alkyl, fluorinated C
1 -C
3 alkyl, C
1 -C
2 -alkoxy-C
1 -C
4 -alkyl, fluorinated C
1 -C
2 -alkoxy-C
1 -C
4 -alkyl, hydroxy-C
1 -C
4 -alkyl, fluorinated hydroxy-C
1 -C
4 -alkyl, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C
3 -C
5 cycloalkyl, fluorinated C
3 -C
5 cycloalkyl, etc.
摘要翻译：本发明涉及新颖的化合物acylaminocycloalkyl，特别是我在和它们的盐和N-氧化物中描述的下式的化合物。这些化合物具有有价值的治疗性质和是合适的，特别是用于治疗疾病并于多巴胺D3受体的调节有反应的。 2 1或2，m是1或，n为A的选自CH 2，CH 2 CH 2，CHFCH2和CF 2 CH 2的选择，R 1是含有氧的环状基团中选择检查作为C3：在式I中，变量具有以下含义 C6环烷基，其携带选自OH中选择的一个或两个氧含有自由基，C1-C2烷氧基，氟化的C 1 -C 2 - 烷氧基，和具有羰基氧，R 2是选自氢由......组成，OH和氟，R 3A为选自氢和甲基中选择，R 3b中选自氢和甲基中选择，R 4是支链的C4-C6烷基或支链氟代C 4 -C 6烷基，而R5是尤其C1-C6烷基，C1-C3氟代烷基，C1-C2烷氧基-C 1 -C 4 - 烷基，氟化的C 1 -C 2 - 烷氧基-C 1 -C 4 - 烷基，羟基-C 1 -C 4 - 烷基，氟化的羟基-C 1 -C 4 - 烷基，氧杂环丁烷基，氟化氧杂环丁基，氧杂环戊基，氧杂环戊基氟化，C3-C5环烷基，氟化的C 3 -C 5环烷基，等等。

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