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1. 发明公开

EP0348212A3 Method for determining susceptibility of an organism to a potentially toxic agent 失效
标题翻译：确定有机物对潜在毒性剂的可能性的方法
公开(公告)号：EP0348212A3
公开(公告)日：1990-08-01
申请号：EP89306357.8
申请日：1989-06-23
申请人： ATOMIC ENERGY OF CANADA LIMITED -ENERGIE ATOMIQUE DU CANADA LIMITEE
发明人： Gentner, Norman E. , Morrison, Donald P.
IPC分类号： C12Q1/00
CPC分类号： G01N33/5017 , C12Q1/025
摘要： A method for determining the susceptibility of an organism to a potentially toxic agent comprising: (i) providing a control sample and a treatment sample from cells derived from the organism; (ii) contacting the treatment sample with the potentially toxic agent; (iii) incubating the cells of the treatment and control samples after step (ii), in nutrient medium and then assaying the apparent number of intact cells; and, (iv) determining a measure of susceptibility of the organism to the potentially toxic agent from a comparison of the change in number of apparently intact cells in the control and treatment samples over time. This method can be used to assess the therapeutic regime to give maximum benefit with minimum risk. It can be also used to test applicants for employment where there is an occupational hazard associated with genetoxic agents.

2. 发明公开

EP0348212A2 Method for determining susceptibility of an organism to a potentially toxic agent 失效
标题翻译：检测生物体的灵敏度为具有潜在毒性的试剂的方法。
公开(公告)号：EP0348212A2
公开(公告)日：1989-12-27
申请号：EP89306357.8
申请日：1989-06-23
申请人： ATOMIC ENERGY OF CANADA LIMITED -ENERGIE ATOMIQUE DU CANADA LIMITEE
发明人： Gentner, Norman E. , Morrison, Donald P.
IPC分类号： C12Q1/00
CPC分类号： G01N33/5017 , C12Q1/025
摘要： A method for determining the susceptibility of an organism to a potentially toxic agent comprising: (i) providing a control sample and a treatment sample from cells derived from the organism; (ii) contacting the treatment sample with the potentially toxic agent; (iii) incubating the cells of the treatment and control samples after step (ii), in nutrient medium and then assaying the apparent number of intact cells; and, (iv) determining a measure of susceptibility of the organism to the potentially toxic agent from a comparison of the change in number of apparently intact cells in the control and treatment samples over time. This method can be used to assess the therapeutic regime to give maximum benefit with minimum risk. It can be also used to test applicants for employment where there is an occupational hazard associated with genetoxic agents.
摘要翻译：一种用于确定性采矿方法的生物体的易感性到潜在的毒性剂，其包含：（i）提供的对照样品和从生物体来源的细胞的样品处理; （ⅱ）。使与潜在毒性剂的样品处理; （三）在营养培养基（ⅱ）培养处理的样品和对照样品的细胞AfterStep的和随后测定完整细胞的表观数量; 和，（ⅳ）确定性采矿有机体对潜在毒性剂的敏感性的从随时间在控制和处理样品中显然完整细胞的数目的变化的比较的量度。这种方法可用于评估治疗方案给予以最小的风险最大的利益。它可以因此用来测试就业申请人其中存在与基因毒性剂相关联的职业性风险。

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