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1. 发明公开

EP3251722A1 MICROPROJECTION ARRAY HAVING A BENEFICIAL AGENT CONTAINING COATING AND METHOD OF FORMING THE COATING THEREON 有权
标题翻译：具有含涂层的有益剂的微喷射阵列和形成涂层的方法
公开(公告)号：EP3251722A1
公开(公告)日：2017-12-06
申请号：EP17175113.4
申请日：2002-04-20
申请人： ALZA Corporation
发明人： Cormier, Michael J , Daddona, Peter E , Johnson, Juanita A , Young, Wendy A
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0014 , A61K9/0021 , A61K47/42 , A61M2037/0007 , A61M2037/0023 , A61M2037/0053
摘要： A method of forming a solid coating on microprojections in a microprojection array, comprising the steps of: (a) applying a liquid composition comprising one or more beneficial agents, a biocompatible carrier and a volatile liquid to the microprojections; (b) drying said liquid composition on said microprojections; (c) optionally, repeating steps (a) and (b) one or more times, to form said solid coating on said microprojections in the microprojection array, wherein the solid coating is adapted to allow release of the one or more beneficial agents from the coating upon hydration of the coating, and wherein said liquid composition has a beneficial agent concentration of from 1% to 30% by weight, and wherein the weight ratio of all biocompatible carriers to all beneficial agents ranges from 0.2:1 to 5:1. Also provided is a device for delivering a beneficial agent through the stratum corneum, comprising a plurality of microprojections and a solid coating obtainable by the method of the invention disposed upon at least a portion of the microprojections.
摘要翻译：包括以下步骤：（a）将包含一种或多种有益物质，生物相容性载体和挥发性液体的液体组合物施加到微喷射体上;（b）在微喷射体阵列中形成固体涂层，（b）干燥所述微喷射体上的所述液体组合物; （c）任选地，重复步骤（a）和（b）一次或多次以在所述微突出物阵列中的所述微突物上形成所述固体涂层，其中所述固体涂层适于允许所述一种或多种有益试剂从并且其中所述液体组合物具有1重量％至30重量％的有益剂浓度，并且其中所有生物相容性载体与所有有益剂的重量比在0.2：1至5：1的范围内。还提供了用于通过角质层递送有益剂的装置，其包含多个微突出物和通过设置在至少一部分微突出物上的本发明方法可获得的固体涂层。

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