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1. 发明公开

EP4385977A1 DIFLUOROMETHYLATION REACTION OF HETEROCYCLIC RING USING TETRAFLUOROETHYLENE 审中-实审
公开(公告)号：EP4385977A1
公开(公告)日：2024-06-19
申请号：EP22855860.7
申请日：2022-08-08
申请人： AGC INC.
发明人： NOMURA, Yoshitaka , SUZUKI, Haruya
IPC分类号： C07D215/12
CPC分类号： C07D215/12
摘要： The aim of the present invention is to provide an easy and inexpensive method for producing difluoromethyl-substituted aromatic heterocyclic compounds in good yield. Furthermore, the aim of the present invention is to provide an easy and inexpensive method for producing aromatic heterocycle-substituted difluoroacetic acid derivatives in good yield.
The present invention relates to a method for producing a difluoromethyl-substituted aromatic heterocyclic compound having a partial structure represented by the formula (IIa), which comprises reacting an N-oxido aromatic heterocyclic compound having a partial structure represented by the formula (Ia) with tetrafluoroethylene in the presence of a base, in a solvent selected from an aromatic hydrocarbon solvent, an ester solvent and an ether solvent.

wherein each symbol is as described in the description.
Furthermore, the present invention relates to a method for producing an aromatic heterocycle-substituted difluoroacetic acid derivative having a partial structure represented by the formula (IIIb), which comprises reacting an N-oxido aromatic heterocyclic compound having a partial structure represented by the formula (Ib) with tetrafluoroethylene in the presence of a compound represented by the formula (IIb): R-YH and a base, in a solvent selected from an aromatic hydrocarbon solvent, an ester solvent and an ether solvent.

wherein each symbol is as described in the description.

2. 发明公开

EP4101842A1 METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED AROMATIC HETEROCYCLIC COMPOUND 审中-实审
公开(公告)号：EP4101842A1
公开(公告)日：2022-12-14
申请号：EP21750160.0
申请日：2021-02-03
申请人： AGC INC.
发明人： NOMURA, Yoshitaka , ANRAKU, Eiichiro
IPC分类号： C07D213/26 , C07D215/12 , C07D215/16 , C07D233/22 , C07D233/26 , C07D237/30 , C07D241/42 , C07D277/64
摘要： The aim of the present invention is to provide a method capable of easily and inexpensively producing difluoromethyl-substituted aromatic heterocyclic compounds in good yield.
The present invention relates to a method for producing a difluoromethyl-substituted aromatic heterocyclic compound having a partial structure represented by the formula (II), which comprises reacting an N-oxido aromatic heterocyclic compound having a partial structure represented by the formula (I) with tetrafluoroethylene, in a solvent selected from an aromatic hydrocarbon solvent, an ester solvent and an ether solvent,

wherein each symbol is as described in the description.

3. 发明公开

EP4101843A1 METHOD FOR PRODUCING AROMATIC HETEROCYCLIC RING-SUBSTITUTED DIFLUOROACETIC ACID DERIVATIVE 审中-实审
公开(公告)号：EP4101843A1
公开(公告)日：2022-12-14
申请号：EP21750438.0
申请日：2021-02-03
申请人： AGC INC.
发明人： NOMURA, Yoshitaka , ANRAKU, Eiichiro
IPC分类号： C07D213/26 , C07D215/16 , C07D233/26 , C07D237/30 , C07D241/44 , C07D277/64
摘要： The aim of the present invention is to provide a method capable of easily and inexpensively producing aromatic heterocycle-substituted difluoroacetic acid derivatives.
The present invention relates to a method for producing an aromatic heterocycle-substituted difluoroacetic acid derivative having a partial structure represented by the formula (III), which comprises reacting an N-oxido aromatic heterocyclic compound having a partial structure represented by the formula (I) with tetrafluoroethylene in the presence of a compound represented by the formula (II): R-YH, in a solvent selected from an aromatic hydrocarbon solvent, an ester solvent and an ether solvent.

wherein each symbol is as described in the description.

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