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1. 发明公开

EP3777879A1 NEUREGULIN FOR TREATING HEART FAILURE 审中-实审
公开(公告)号：EP3777879A1
公开(公告)日：2021-02-17
申请号：EP20186017.8
申请日：2012-10-08
申请人： Zensun (Shanghai) Science & Technology, Co., Ltd.
发明人： Zhou, Mingdong
IPC分类号： A61K38/18 , C07K14/475 , A61P9/04 , A61K45/06 , G01N33/68 , A61K9/00
摘要： The invention provides neuregulin for use in a method of treating chronic heart failure in a patient, wherein the patient has a class II or class III heart function as classified by New York Heart Association (NYHA) heart function classification. The invention also provides a method of selecting a heart failure patient for treatment by neuregulin, which comprises: (i) evaluating heart function class by NYHA heart function classification, and (ii) deciding whether the result of the test is indicative for the treatment by neuregulin, wherein the result of the test is indicative for the treatment by neuregulin when the patient has a class II or class III heart function.

2. 发明公开

EP3308787A1 USE OF COMPOSITION OF VITAMIN COMPLEX IN PREPARING DRUG FOR STIMULATING GASTROINTESTINAL SYSTEM MOTILITY 无效
标题翻译：维生素配合物在制备刺激胃肠系统运动的药物中的应用
公开(公告)号：EP3308787A1
公开(公告)日：2018-04-18
申请号：EP16806787.4
申请日：2016-06-06
申请人： Zensun (Shanghai) Science & Technology, Co., Ltd.
发明人： ZHOU, Mingdong
IPC分类号： A61K31/51 , A61K31/525 , A61K31/455 , A61K31/197 , A61K31/4415 , A61K31/714 , A61K31/4188 , A61K31/519 , A61K31/375 , A61P1/14 , A61P1/04
CPC分类号： A61K31/375 , A23L33/15 , A61K31/197 , A61K31/4188 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/714 , A61K2300/00 , A61P1/04 , A61P1/10 , A61P1/14
摘要： The present invention relates to a composition of multivitamin vitamin B-C, particularly a composition of vitamin B-C for stimulating gastrointestinal (GI) system motility. The composition is suitable for preventing and/or treating conditions or diseases associated with insufficient GI motility.
摘要翻译：本发明涉及用于刺激胃肠（GI）系统运动性的多种维生素维生素B-C的组合物，特别是维生素B-C的组合物。该组合物适用于预防和/或治疗与GI运动不足相关的病症或疾病。

3. 发明授权

EP2808339B1 Neuregulin peptides and their use 有权转让
标题翻译：神经肽 - 肽和德文Verwendung
公开(公告)号：EP2808339B1
公开(公告)日：2017-02-15
申请号：EP14168475.3
申请日：2009-11-09
申请人： Zensun (Shanghai) Science & Technology, Co., Ltd.
发明人： Zhou, Mingdong
IPC分类号： C07K14/475 , A61K38/18 , A61P9/10
CPC分类号： C07K14/4756 , A61K38/00 , A61K38/16 , A61K38/1883 , C07K14/00

4. 发明授权

EP2810653B1 Cell growth inhibition 有权转让
公开(公告)号：EP2810653B1
公开(公告)日：2020-01-08
申请号：EP14175608.0
申请日：2000-06-16
申请人： Zensun (Shanghai) Science & Technology, Co., Ltd.
发明人： Zhou, Mingdong
IPC分类号： A61K39/395 , A61P35/00 , C07K16/32

5. 发明公开

EP3295959A1 CMLCK GENE INTRODUCTION 无效
标题翻译： CMLCK基因介绍
公开(公告)号：EP3295959A1
公开(公告)日：2018-03-21
申请号：EP16792227.7
申请日：2016-06-14
申请人： Zensun (Shanghai) Science & Technology, Co., Ltd.
发明人： ZHOU, Mingdong
IPC分类号： A61K48/00 , A61P9/04
CPC分类号： A61K38/45 , A61K48/00 , A61P9/00 , C12Y207/11018
摘要： The invention relates to compositions and methods for cMLCK gene transfer. In some aspects, the invention provides compositions and methods for treating advanced heart failure in a subject by cMLCK gene transfer, in particular, by administering to a subject an effective amount of a polynucleotide vector that encodes a cMLCK protein, expressing the cMLCK protein from the polynucleotide vector in the heart cells of the subject, and improving ventricular function of the heart. In other aspects, the invention provides compositions and methods for expressing a cMLCK protein in a subject, in particular, by administering to a subject a polynucleotide vector that encodes the cMLCK protein and expressing the cMLCK protein from the polynucleotide vector in the heart cells of the subject, wherein the subject has advanced heart failure.
摘要翻译：本发明涉及用于cMLCK基因转移的组合物和方法。在一些方面，本发明提供了用于通过cMLCK基因转移来治疗受试者的晚期心力衰竭的组合物和方法，具体而言，通过向受试者施用有效量的编码cMLCK蛋白的多核苷酸载体，其表达来自多核苷酸载体在该受试者的心脏细胞中，并改善心脏的心室功能。在其他方面，本发明提供了用于在受试者中表达cMLCK蛋白的组合物和方法，具体而言，通过向受试者施用编码cMLCK蛋白并且在多核苷酸的心脏细胞中表达来自多核苷酸载体的cMLCK蛋白的多核苷酸载体受试者，其中受试者患有晚期心力衰竭。

6. 发明授权

EP2730654B1 Neukinase, a downstream protein of neuregulin 失效转让
标题翻译： Neukinase，ein Downstream-Protein von Neuregulin
公开(公告)号：EP2730654B1
公开(公告)日：2017-03-01
申请号：EP13184566.1
申请日：2007-08-21
申请人： Zensun (Shanghai) Science & Technology, Co., Ltd.
发明人： Zhou, Mingdong
IPC分类号： C12N15/11 , C12N15/12 , C12N15/52 , C12N15/63 , C12N15/85 , C12N15/86 , C12N9/48 , C12N5/16 , C12N5/22 , C07H21/00 , C07K16/16 , A61K38/45 , C07K16/40 , C12Q1/48 , G01N33/68 , C12N9/12
CPC分类号： C07K16/40 , A61K38/45 , C12N9/1205 , C12Q1/485 , G01N33/68 , G01N33/6842 , G01N2333/4756

7. 发明公开

EP3111939A1 VITAMIN D AND ANTIBACTERIAL USES OF COMPOSITION THEREOF 无效
标题翻译：维他命D联合国安全理事会VERWENDUNG EINER ZUSAMMENSETZUNG DAVON
公开(公告)号：EP3111939A1
公开(公告)日：2017-01-04
申请号：EP14876219.8
申请日：2014-12-25
申请人： Zensun (Shanghai) Science & Technology, Co., Ltd.
发明人： ZHOU, Mingdong
IPC分类号： A61K31/59 , A61K9/00 , A61P13/10 , A61P13/02
CPC分类号： A61K31/593 , A61K9/00 , A61K31/59 , A61K31/592 , A61K45/06
摘要： Uses of a vitamin D compound in the preparation of a medicament for preventing or treating cystitis, urethritis and/or urinary tract infection, as well as a pharmaceutical composition, a pharmaceutical preparation and a kit that comprise the vitamin D compound, wherein the vitamin D compound is selected from vitamin D2, vitamin D3, and an active form or analog of the vitamin D3, and wherein the active form of vitamin D 3 is 25-hydroxyvitamin D 3 or 1,25-dihydroxyvitamin D 3 .
摘要翻译：维生素D化合物在制备用于预防或治疗膀胱炎，尿道炎和/或尿路感染的药物中的用途，以及包含维生素D化合物的药物组合物，药物制剂和试剂盒，其中维生素D 化合物选自维生素D2，维生素D3和维生素D3的活性形式或类似物，其中维生素D 3的活性形式为25-羟基维生素D 3或1,25-二羟基维生素D 3。

8. 发明公开

EP3087998A1 NEUREGULIN BASED METHODS FOR TREATING HEART FAILURE 有权
标题翻译：神经调节素治疗心力衰竭的方法
公开(公告)号：EP3087998A1
公开(公告)日：2016-11-02
申请号：EP16160687.6
申请日：2010-06-12
申请人： Zensun (Shanghai) Science & Technology, Co., Ltd.
发明人： Zhou, Mingdong
IPC分类号： A61K38/18 , A61P9/04
CPC分类号： A61K38/1883
摘要： The present invention provides Neuregulin 1 protein or a pharmaceutical composition comprising Neuregulin 1 protein for use in a method for preventing, treating or delaying heart failure in a mammal in need thereof. The invention also provides a kit for preventing, treating or delaying heart failure.
摘要翻译：本发明提供了神经调节蛋白1蛋白或包含神经调节蛋白1蛋白的药物组合物，用于在有此需要的哺乳动物中预防，治疗或延缓心力衰竭的方法中。本发明还提供了用于预防，治疗或延缓心力衰竭的药盒。

9. 发明公开

EP4032901A1 RECOMBINANT HUMAN NEUREGULIN DERIVATIVES AND USE THEREOF 审中-实审
公开(公告)号：EP4032901A1
公开(公告)日：2022-07-27
申请号：EP20865911.0
申请日：2020-09-14
申请人： Zensun (Shanghai) Science & Technology, Co., Ltd.
发明人： ZHOU, Mingdong
IPC分类号： C07K14/705 , A61K38/17 , A61P9/04
摘要： Disclosed is a use of recombinant human neuregulin derivatives in preparing a medicine for preventing, treating, or reducing the progression of cardiovascular diseases in mammals. In particular, the present invention relates to a novel recombinant human NRG-FC protein and a use thereof in the treatment of cardiovascular diseases. The protein has a prolonged half-life and enhanced biological activity.

10. 发明公开

EP3821904A1 FORMULA OF NEUREGULIN PREPARATION 审中-实审
公开(公告)号：EP3821904A1
公开(公告)日：2021-05-19
申请号：EP20195273.6
申请日：2014-12-17
申请人： Zensun (Shanghai) Science & Technology, Co., Ltd.
发明人： Mingdong, Zhou
IPC分类号： A61K38/18 , A61P9/04
摘要： The invention relates to a pharmaceutical formulation of neuregulin (NRG) comprising: (a) a NRG polypeptide, and (b) a buffering agent, wherein said formulation has a pH in a range from about 2.0 to about 5.7. The invention further relates to a lyophilized pharmaceutical formulation of NRG, prepared by lyophilization of the pharmaceutical formulation of the invention, wherein an excipient is added into the pharmaceutical formulation prior to the lyophilization.

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