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1. 发明公开

EP4186505A1 USE OF PALOVAROTENE IN TREATMENT AGAINST HBV VIRUS 审中-实审
公开(公告)号：EP4186505A1
公开(公告)日：2023-05-31
申请号：EP21821809.7
申请日：2021-06-01
申请人： Yang Sheng Tang Company, Ltd. , Xiamen University
发明人： ZHANG, Tianying , CAO, Jiali , SHI, Tianshu , MA, Jian , WANG, Shaojuan , YUAN, Quan , ZHANG, Jun , XIA, Ningshao
IPC分类号： A61K31/415 , A61P31/20
摘要： The present application relates to the field of antiviral treatment of hepatitis B, and specifically relates to the use of a compound represented by formula I in treatment against HBV virus.

2. 发明授权

EP2860188B1 POLYPEPTIDES AND ANTIBODIES FOR TREATING HBV INFECTION AND RELATED DISEASES 有权转让
公开(公告)号：EP2860188B1
公开(公告)日：2020-10-21
申请号：EP13804161.1
申请日：2013-06-06
申请人： Xiamen University , Yang Sheng Tang Company, Ltd.
发明人： YUAN, Quan , ZHANG, Tianying , LUO, Wenxin , CHEN, Yixin , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/02 , C07K16/28 , A61K39/29

3. 发明公开

EP3360896A1 ANTIBODY TO HEPATITIS B SURFACE ANTIGEN AND USE THEREOF 审中-实审
公开(公告)号：EP3360896A1
公开(公告)日：2018-08-15
申请号：EP16853117.6
申请日：2016-10-09
申请人： Xiamen University , Yang Sheng Tang Company, Ltd.
发明人： LUO, Wenxin , ZHOU, Bing , ZHANG, Juan , YUAN, Quan , ZHANG, Tianying , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K16/10 , C12N15/13 , C12N15/63 , C12N5/10 , A61K39/395 , A61P31/14 , A61P1/16
CPC分类号： A61K39/395 , C07K16/10 , C12N5/10 , C12N15/63
摘要： The invention provides an antibody (in particular, a humanized antibody) against hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding the same, a method for preparing the same, and a pharmaceutical composition comprising the same. The invention also provides use of the antibody and pharmaceutical composition. The antibody and pharmaceutical composition according to the invention can be used for preventing and/or treating HBV infection or a disease associated with HBV infection (such as Hepatitis B), for neutralizing HBV virulence in a subject (such as human), or for reducing the serum level of HBV DNA and/or HBsAg in a subject.

4. 发明公开

EP1461357A2 NOVEL HEV ANTIGENIC PEPTIDE AND METHODS 有权
标题翻译：新型HEV抗原肽和方法
公开(公告)号：EP1461357A2
公开(公告)日：2004-09-29
申请号：EP00960932.2
申请日：2000-09-28
申请人： Yang Sheng Tang Company, Ltd.
发明人： NG,Mun,HonDept.of Microbio.The Uni.of Hong Kong , IM,StanleyDept.of Microbio.The Uni.of Hong Kong , ZHANG,Ji-ZhongDep.of Microbio.The Uni. HongKong
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K39/00 , C07K16/10 , C07K2319/00 , C12N2770/28122 , G01N33/5767 , Y10S435/975
摘要： A highly immunoreactive viral peptide, pE2, is disclosed which is derived form the carboxy-terminal end region of ORF2 region of the hepatitis E virus (HEV) genome. A unique feature of the novel pE2 peptide is that it possesses conformational antigenic determinants which are only exposed when monomers of the peptide associate with one another through non-covalent interactions to naturally form homodimers. The novel pE2 peptide is proven to be highly reactive with sera from patients having current or past infection with HEV which suggests that the homodimer may mimic certain structural features of the HEV capsid protein. Furthermore, the antigenic activity of the pE2 peptide is strictly conformational in nature and therefore, exhibits immunochemical reactivity only when the peptide exists in a dimeric form. Consequently, the antigenic activity is lost upon dissociation of the dimers, but the activity is restored when the monomers reassociate to form dimers. Moreover, diagnostic methods useful in detecting and diagnosing HEV infection, and the use of a vaccine composition effective in preventing hepatitis E virus infection in which the novel pE2 peptide is utilized are also disclosed.
摘要翻译：公开了高度免疫反应性病毒肽pE2，其衍生自戊型肝炎病毒（HEV）基因组的ORF2区的羧基末端区域。新型pE2肽的独特特征是它具有构象性抗原决定簇，其仅在肽的单体通过非共价相互作用相互缔合以自然形成同型二聚体时才暴露。证明新型pE2肽与来自患有目前或过去感染HEV的患者的血清高度反应，这表明同源二聚体可以模拟HEV衣壳蛋白的某些结构特征。此外，pE2肽的抗原活性在本质上是严格构象的，因此只有当肽以二聚体形式存在时才表现出免疫化学反应性。因此，二聚体解离后抗原活性丧失，但当单体重新缔合形成二聚体时活性恢复。此外，还公开了可用于检测和诊断HEV感染的诊断方法，以及使用有效预防戊型肝炎病毒感染的疫苗组合物，其中使用新的pE2肽。

5. 发明公开

EP3974446A1 ANTI-HEPATITIS B VIRUS ANTIBODIES AND USE THEREOF 审中-实审
公开(公告)号：EP3974446A1
公开(公告)日：2022-03-30
申请号：EP20808887.2
申请日：2020-05-22
申请人： Xiamen University , Yang Sheng Tang Company, Ltd.
发明人： LUO, Wenxin , JIANG, Yichao , YU, Chao , CHEN, Xiaoqing , TANG, Jixian , YUAN, Quan , ZHANG, Tianying , XIA, Ningshao
IPC分类号： C07K16/08 , C12N15/13 , C12P21/00 , A61K39/42 , A61K31/20
摘要： Antibodies (especially humanized antibodies) against the hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding same, a method for preparing same, and a pharmaceutical composition containing same. The anti-HBsAg antibodies have a higher binding affinity to HBsAg at a neutral pH than at an acidic pH, thereby significantly enhancing virus clearance efficiency and prolonging virus inhibition time. The antibodies and pharmaceutical composition may be used to prevent and/or treat HBV infections or diseases related to HBV infection (such as hepatitis B) for use in neutralizing the virulence of HBV in the body of a subject (such as a human) to reduce a serum level of HBV DNA and/or HBsAg in the body of the subject, or to activate a humoral immune response of a subject (such as a person infected with chronic HBV or a patient who has chronic hepatitis B) against HBV.

6. 发明公开

EP3656854A1 VIRUS FOR TREATING TUMORS 审中-实审
公开(公告)号：EP3656854A1
公开(公告)日：2020-05-27
申请号：EP18835927.7
申请日：2018-07-18
申请人： Xiamen University , Yang Sheng Tang Company, Ltd.
发明人： CHENG, Tong , WANG, Wei , WAN, Junkai , FU, Wenkun , YE, Xiangzhong , ZHANG, Jun , XIA, Ningshao
IPC分类号： C12N7/00 , C12N15/11 , A61K35/76 , A61P35/00
摘要： Provided are an enterovirus D68 (EV-D68) or a modified form thereof, or a nucleic acid molecule comprising a genomic sequence or cDNA sequence of the EV-D68 or a modified form thereof, or a complementary sequence of the genomic sequence or cDNA sequence, or a pharmaceutical composition comprising the EV-D68 or a modified form thereof, or the nucleic acid molecule, and use of the EV-D68 or a modified form thereof, or the nucleic acid molecule in the manufacture of a pharmaceutical composition for treating a tumor.

7. 发明公开

EP3617317A1 PEPTIDE CARRIER FOR DISPLAYING TARGET POLYPEPTIDE AND USE THEREOF 审中-实审
公开(公告)号：EP3617317A1
公开(公告)日：2020-03-04
申请号：EP18754095.0
申请日：2018-02-05
申请人： Xiamen University , Yang Sheng Tang Company, Ltd.
发明人： ZHANG, Tianying , YUAN, Quan , GUO, Xueran , WEI, Minxi , KANG, Xiaozhen , ZHANG, Jun , XIA, Ningshao
IPC分类号： C12N15/51 , C12N15/62 , C07K14/02 , C07K19/00 , A61K39/29 , A61P31/12
摘要： The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.

8. 发明公开

EP3594328A1 RECOMBINANT HERPES SIMPLEX VIRUS AND USE THEREOF 审中-实审
公开(公告)号：EP3594328A1
公开(公告)日：2020-01-15
申请号：EP18764074.3
申请日：2018-02-28
申请人： Xiamen University , Yang Sheng Tang Company, Ltd.
发明人： HUANG, Chenghao , LUO, Yong , YUAN, Quan , ZHANG, Jun , XIA, Ningshao
IPC分类号： C12N7/00 , C12N15/869 , C12N5/10 , A61K35/763 , A61P35/00
摘要： The invention relates to the field of virology and tumor therapy. In particular, the present invention provides a recombinant herpes simplex virus (HSV) capable of specifically replicating at a high level in a tumor cell and effectively killing the tumor cell, but replicating at low levels in normal cells, thereby the recombinant herpes simplex virus of the present invention not only has high lethality against tumor cells, but also has significantly decreased side effects (especially neurotoxicity). Further, the present invention relates to a viral vector constructed based on the recombinant herpes simplex virus, a pharmaceutical composition comprising the recombinant herpes simplex virus or the viral vector, and the use of the recombinant herpes simplex virus or the viral vector. The recombinant herpes simplex virus of the present invention can be used to infect and kill tumor cells, and can be used for gene drug delivery into tumor cells for gene therapy.

9. 发明授权

EP2377410B1 PROCESSED FRUIT JUICE OR ITS FRUIT JUICE CONCENTRATE OF CITRUS L., NEWHALL NAVEL, THEIR PREPARATION METHOD AND PRODUCT CONTAINING THEM 有权
标题翻译：加工的果汁或其柑橘果实汁液浓缩物，NEWHALL NAVEL，其制备方法和包含它们的产品
公开(公告)号：EP2377410B1
公开(公告)日：2018-02-28
申请号：EP10731019.5
申请日：2010-01-11
申请人： Yang Sheng Tang Company, Ltd.
发明人： SHI, Yonghui
IPC分类号： A23L2/02 , A23L2/04 , A23L2/06 , A23L2/08 , A23L2/00 , A23L2/46 , A23L2/68
CPC分类号： A23L2/10 , A23L2/06 , A23L2/08 , A23L2/46 , A23L2/68 , A23V2002/00
摘要： The present invention relates to processed citrus fruit raw juice or the concentrate thereof, the preparation thereof, products comprising them, and uses thereof in the manufacture of various edible products.

10. 发明公开

EP2377410A4 PROCESSED ORIGINAL FRUIT JUICE OR ITS FRUIT JUICE CONCENTRATE OF CITRUS L., THEIR PREPARATION METHOD AND PRODUCT CONTAINING THEM 有权
标题翻译：处理的原果汁或柑橘属，制备工艺浓缩果汁和含本产品
公开(公告)号：EP2377410A4
公开(公告)日：2013-10-30
申请号：EP10731019
申请日：2010-01-11
申请人： YANG SHENG TANG COMPANY LTD
发明人： SHI YONGHUI
IPC分类号： A23L2/02 , A23L2/00 , A23L2/04 , A23L2/06 , A23L2/08 , A23L2/46 , A23L2/68 , A23L19/00
CPC分类号： A23L2/10 , A23L2/06 , A23L2/08 , A23L2/46 , A23L2/68 , A23V2002/00
摘要： The present invention relates to processed citrus fruit raw juice or the concentrate thereof, the preparation thereof, products comprising them, and uses thereof in the manufacture of various edible products.

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